Schizophrenia with and without obsessive-compulsive symptoms:a comparative analysis of performance on trail making test and disability on WHOD AS

作     者：Apala Singh Ram Pratap Beniwal Triptish Bhatia Smita Neelkanth Deshpande Apala Singh;Ram Pratap Beniwal;Triptish Bhatia;Smita Neelkanth Deshpande

作者机构：Department of PsychiatryGovind Ballabh Pant Institute of Postgraduate Medical Education and Research(G.I.P.M.E.R.)New DelhiDelhiIndia Department of Psychiatry&Drug De-addictionCentre of Excellence in Mental HealthAtal Bihari Vajpayee Institute of Medical Sciences(ABVIMS)&Dr Ram Manohar Lohia HospitalNew DelhiDelhiIndia 

出 版 物：《General Psychiatry》 (综合精神医学（英文）)

年 卷 期：2020年第33卷第6期

页      面：406-412页

核心收录：

学科分类：0402[教育学-心理学(可授教育学、理学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100205[医学-精神病与精神卫生学] 1009[医学-特种医学] 10[医学] 

基　　金：FIC NIH HHS [D43 TW009114] Funding Source: Medline 

主　　题：trail performance matched 

摘      要：Background Presence of obsessive-compulsive symptoms(0CS)affects performance on tests of some cognitive functions,such as the trail making test(TMT),and may affect the level of disability in schizophrenia(SZ).Aim s The aim of the present study was to compare performance on TMT and disability on WHO Disability Assessment Schedule(WHODAS)in persons with SZ with and without 0CS in a cross-sectional *** Persons with SZ(n=200)fulfilling DSM-V(Diagnostic and Statistical Manual)diagnostic criteria were assessed on Yale Brown Obsessive Compulsive Scale(YB0CS)and divided into two groups based on presence or absence of *** and WHODAS V.2.0 were *** two groups as a whole,as well as a subsample matched on age,gender and age of onset were *** Out of 200 persons with SZ,37(18.5%)reported *** OCS group took a significantly longer mean time to complete TMT-A(Z=-3.02,p=0.003)as well as TMT-B(Z=-3.551,p0.001).Significant correlations were found between TMT-A and total YB0CS Scores(r=0.351,p=0.033),as well as TMT-A and YB0CS compulsion scores(r=0.404,p=0.013)but not with TMT-B *** OCS group reported greater disability in all domains separately as well as on average WHODAS Scores(Z=-5.969,p0.001).Significant correlations were found between YB0CS obsession scores and YBOCS total scores with average WHODAS Scores(r=0.614,p0.001 and r=0.406,p=0.013,respectively).We obtained essentially similar results with the matched subsample as well as with the entire *** Persons with SZ and comorbid OCS had significantly poorer performance on TMTs and greater disability in comparison to persons with SZ *** of disability correlated with severity of OCS.