检索结果-南通市图书馆

A case study of multi-seam coal mine entry stability analysis with strength reduction method

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2016年第2期26卷 193-198页

作者： Tulu Ihsan Berk Esterhuizen Gabriel S. Klemetti Ted Murphy michael M. Sumner James sloan michael Ground Control Branch NIOSH Office of Mine Safety and Health Research Pittsburgh PA 15216 USA Lone Mountain Processing Inc. St. Charles VA 24282 USA

In this paper,the advantage of using numerical models with the strength reduction method(SRM) to evaluate entry stability in complex multiple-seam conditions is demonstrated.A coal mine under variable topography from the Central Appalachian region is used as a case *** this mine,unexpected roof conditions were encountered during development below previously mined *** mapping and observation of ground conditions were used to quantify the success of entry support systems in three room-and-pillar *** model analyses were initially conducted to estimate the stresses induced by the multiple-seam mining at the locations of the affected *** SRM was used to quantify the stability factor of the supported roof of the entries at selected *** SRM-calculated stability factors were compared with observations made during the site visits,and the results demonstrate that the SRM adequately identifies the unexpected roof conditions in this complex *** is concluded that the SRM can be used to effectively evaluate the likely success of roof supports and the stability condition of entries in coal mines.

关键词： Coal mine ground control Multiple seam mining Phase 2 FLAC3D Strength reduction method Roof supports

Example Based Everything

在线全文

学校读者我要写书评

暂无评论

软件学报 2000年第9期11卷 1140-1140页

作者： Cohen F michael sloan Peter-Pike Rose Charles Colburn Alex Liu Zicheng Microsoft Research One Microsoft Way Redmond 美国 980 52

Mantle plumes,triple junctions and transforms:A reinterpretation of Pacific Cretaceous-Tertiary LIPs and the Laramide connection

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2020年第4期11卷 1133-1144页

作者： michael Fletcher Derek A.Wyman Sabin Zahirovic EarthByte Group School of GeosciencesUniversity of SydneySydneyNew South Wales2006Australia

The Shatsky and Hess Rises,the Mid-Pacific Mountains and the Line Islands large igneous provinces(LIPs) present different challenges to conventional plume *** the genesis of these LIPs is important not only for a more complete understanding of mantle plumes and plume-generated magmatism,but also for establishing the role of subducted LIP conjugates in the evolution of the Laramide orogeny and other circum-Pacific orogenic events,which are related to the development of large porphyry *** past difficulties in developing consistent geodynamic models for these LIPs,it is useful to consider whether viable alternative geodynamic scenarios may be provided by recent concepts such as melt channel networks and channel-associated lineaments,along with the "two mode"model of melt generation,where a deeply-sourced channel network is superimposed on the plume,evolving and adapting over millions of years.A plume may also interact with transform faults in close proximity to a mid ocean ridge,with the resultant bathymetric character strongly affected by the relative age difference of lithosphere across the *** results suggest that the new two-mode melt models resolve key persistent issues associated with the Shatsky Rise and other LIPs and provide evidence for the existence of a conduit system within plumes that feed deeply-sourced material to the plume head,with flow maintained over considerable *** conduit system eventually breaks down during plume-ridge separation and may do so prior to the plume head being freed from the triple junction or spreading *** is evidence for not only plume head capture by a triple junction but also for substantial deformation of the plume stem as the distance between the stem and anchored plume head *** evidence suggests that young transforms can serve as pathways for plume material migration,at least in certain plume head-transform configurations.A fortuitous similarity between the path of the

关键词： Mantle plume Shatsky rise Hess rise Mid-pacific mountains Laramide orogeny

Machine learning for the discovery of molecular recognition based on single-walled carbon nanotube corona-phases

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 1265-1277页

作者： Xun Gong Nicholas Renegar Retsef Levi michael S.Strano Massachusetts Institute of Technology Department of Chemical EngineeringCambridgeMAUSA Massachusetts Institute of Technology Operations Research CenterCambridgeMAUSA Massachusetts Institute of Technology Sloan School of ManagementCambridgeMAUSA

Nanoparticle corona phase(CP)design offers a unique approach toward molecular recognition(MR)for sensing ***-walled carbon nanotube(SWCNT)CPs can additionally transduce MR through its band-gap photoluminescence(PL).While DNA oligonucleotides have been used as SWCNT CPs,no generalized scheme exists for MR prediction de novo due to their sequence-dependent three-dimensional *** work generated the largest DNA-SWCNT PL response library of 1408 elements and leveraged machine learning(ML)techniques to understand MR and DNA sequence dependence through local(LFs)and high-level features(HLFs).Out-of-sample analysis of our ML model showed significant correlations between model predictions and actual sensor responses for 6 out of 8 experimental *** HLF combinations were found to be uniquely correlated with different ***,models utilizing both LFs and HLFs show improvement over that with HLFs alone,demonstrating that DNA-SWCNT CP engineering is more complex than simply specifying molecular properties.

关键词： walled carbon utilizing

The past, present, and future of targeted therapeutic approaches in patients with diffuse pleural mesotheliomas

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2023年第1期9卷 194-209页

作者： michael Offin Bailey Fitzgerald Marjorie G.Zauderer Deborah Doroshow Thoracic Oncology Service Department of MedicineMemorial Sloan Kettering Cancer CenterWeill Cornell Medical CollegeNew YorkNY 10065USA Division of Hematology and Medical Oncology Tisch Cancer InstituteIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA

Despite our growing understanding of the genomic landscape of diffuse pleural mesotheliomas(DPM),there has been limited success in targeted therapeutic strategies for the *** review summarizes attempts to develop targeted therapies in DPM,focusing on the following targets being clinically explored in recent and ongoing clinical trials:vascular endothelial growth factor,mesothelin,BRCA1-associated protein 1,Wilms tumor 1 protein,NF2/YAP/TAZ,CDKN2,methylthioadenosine phosphorylase,v-domain Ig suppressor T-cell activation,and argininosuccinate synthetase *** preclinical data for these targets are promising,few have efficaciously translated to benefit our *** efforts should seek to expand the availability of preclinical models that faithfully recapitulate DPM biology,develop clinically relevant biomarkers,and refine patient selection criteria for clinical trials.

关键词： Mesothelioma targeted therapy biomarkers genomics

美国国家卒中协会对短暂性脑缺血发作诊治体系的推荐意见

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际脑血管病杂志 2011年第9期19卷 644-648页

作者： S. Claibome Johnston Gregory W. Albers Philip B. Gorelick Ethan Cumbler Jeffrey Klingman michael A. Ross Meg Brisgs Jean Carlton Edward P. sloan Uzma Vaince 李海峰（译）洪宇（译）王琦（译） From the Departments of Neurology and Epidemiology and Biostatistics University of California San Francisco San Francisco CA Department of Neurology and Neurological Sciences Stanford University Medical Center Stanford CA Department of Neurology and Rehabilitation University of Illinois at Chicago Chicago IL Hospitalist Section University of Colorado Denver Denver CO Department of Neurology Kaiser Permanente Walnut Creek CA Department of Emergency Medicine Emory University School of Medicine Atlanta GA Stroke Program Evergreen Hospital Medical Center Kirkland WA Legacy Health Portland OR Department of Emergency Medicine University of Illinois at Chicago Chicago IL Cedar Crest Hospitalist Program Lehigh Valley Health Network. AllentownPA 青岛大学医学院附属医院神经内科 266003

短暂性脑缺血发作（transient ischemic attack，TIA）很常见，预示短期卒中风险很高。有关TIA患者紧急评价和治疗的循证推荐意见已经发表。然而，这些推荐意见的可靠和一致的执行需要对现有TIA诊治体系做出相应的改变。美国国家卒中协... 详细信息

短暂性脑缺血发作（transient ischemic attack，TIA）很常见，预示短期卒中风险很高。有关TIA患者紧急评价和治疗的循证推荐意见已经发表。然而，这些推荐意见的可靠和一致的执行需要对现有TIA诊治体系做出相应的改变。美国国家卒中协会召集了一个多学科专家小组，提出了医院内TIA诊治体系主要内容的推荐意见，以提高对TIA患者的诊疗质量。专家小组推荐医院制定标准化方案，以确保对TIA患者实施快速和完整的评价和处理，特别关注对卒中高危患者进行紧急而密切的观察。

关键词：短暂性脑缺血发作卒中协会诊治美国 TIA患者专家小组标准化方案高危患者

经颅多普勒超声（TCD）的实践标准——第2部分：临床适应证和预期结果

在线全文

学校读者我要写书评

暂无评论

国际脑血管病杂志 2012年第1期20卷 1-11页

作者： Andrei V. Alexandrov michael A. sloan Charles H. Tegeler David N. Newell Alan Lumsden Zsolt Garami Christopher R. Levy Lawrence K.S. Wong Colleen Douville Manfred Kaps 李海峰（译）李宏（译）李展秀（译） From the Comprehensive Stroke Center University of Alabama at Birmingham Birmingham AL 青岛大学医学院附属医院神经内科

引言：经颅多普勒（transcranial Doppler，TCD）已被证实为一种安全有效的生理学超声检查技术。尽管成像设备可以在结构影像的基础上显示颅内血流，但成像性双功能超声或非成像性TCD检查提供的最终结果是通过频谱波形来评价生理学血流... 详细信息

引言：经颅多普勒（transcranial Doppler，TCD）已被证实为一种安全有效的生理学超声检查技术。尽管成像设备可以在结构影像的基础上显示颅内血流，但成像性双功能超声或非成像性TCD检查提供的最终结果是通过频谱波形来评价生理学血流参数。总结概要：多学科专家小组确定的TCD临床适应证包括：镰状细胞病、恼缺血、右向左分流（right—to—left shunt，RLS）、蛛网膜下腔出血、脑死亡以及围手术期或术中监测。TCD检查可常规应用于住院或门诊患者的一些临床实践活动：通过完整或部分TCD检查以检测正常、狭窄或闭塞的颅内血管和侧支循环来判断动脉闭塞位置，并进一步完善颈动脉超声或无创性血管造影结果；通过血管运动反应性检查来识别首发或复发性卒中的高危患者；通过栓子监测对脑栓塞进行实时检查、定位和量化；在怀疑反常性栓塞或考虑分流封堵术治疗的患者中进行RLS检测；对溶栓治疗进行监测以促进血管再通和检测再闭塞；在血管内支架置入术、颈动脉内膜切除术和心脏外科手术中进行监测以发现围手术期栓塞、血栓形成、低灌注或高灌注。结论：通过界定实践范围，这些标准将在TCD检查的申请、检查和评价过程中给开申请单的医生、发报告的医生以及第三方提供帮助。

关键词： TCD 适应证应用结果

Intraoperative Gastric Tube Intubation: A Summary of Case Studies and Review of the Literature

在线全文

学校读者我要写书评

暂无评论

Open Journal of Anesthesiology 2017年第3期7卷 43-62页

作者： michael Long Melissa Machan Luis Tollinche Department of Anesthesiology and Critical Care Medicine Memorial Sloan Kettering Cancer Center New York USA Barry University College of Health Sciences Hollywood USA Department of Anesthesiology Plantation General Hospital Plantation USA

Study Objective: Establish complications and risk factors that are associated with blind tube insertion, evaluate the validity of correct placement verification methods, establish the rationales supporting its employment by anesthesia providers, and describe various deployment facilitators described in current literature. Measurements: An exhaustive literature review of the databases Medline, CINAHL, Cochrane Collaboration, Scopus, and Google Scholar was performed applying the search terms “gastric tube”, “complications”, “decompression”, “blind insertion”, “perioperative”, “intraoperative” in various order sequences. A five-year limit was applied to limit the number and timeliness of articles selected. Main Results: Patients are exposed to potentially serious morbidity and mortality from blindly inserted gastric tubes. Risk factors associated with malposition include blind insertion, the presence of endotracheal tubes, altered sensorium, and previous tube misplacements. Pulmonary aspiration risk prevention remains the only indication for anesthesia-related intraoperative use. There are no singularly effective tools that predict or verify the proper placement of blindly inserted gastric tubes. Current placement facilitation techniques are perpetuated through anecdotal experience and technique variability warrants further study. Conclusion: In the absence of aspiration risk factors or the need for surgical decompression in ASA classification I & II patients, a moratorium should be instituted on the elective use of gastric tubes.

关键词： Nasogastric Tube Orogastric Tube Gastric Tube Perioperative Intraoperative Anesthesia Blind Insertion

α核素用于放射治疗:从基础放射化学到临床研究(第二部分)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华核医学与分子影像杂志 2020年第11期40卷 761-768页

作者： Sophie Poty Lynn C.Francesconi michael R.McDevitt michael J.Morris Jason S.Lewis 杨晖关志伟(译) 徐白萱(审校) Department of Radiology and Program in Molecular Pharmacology Memorial Sloan Kettering Cancer CenterNew YorkNew York Department of Chemistry Hunter CollegeNew YorkNew York Graduate Center of City University of New York New YorkNew York Department of Radiology Weill Cornell Medical CollegeNew YorkNew York Department of Medicine Memorial Sloan Kettering Cancer CenterNew YorkNew York Departments of Radiology and Pharmacology Weill Cornell Medical CollegeNew YorkNew York 解放军总医院第一医学中心核医学科北京100853

利用放射源将具有细胞毒性的电离辐射作用到病灶处的方法可以追溯到20世纪初,起源于镭的发现及其能够产生的生理作用。α核素在放射治疗应用于临床肿瘤学领域中备受关注。该综述的第一部分探讨了基本的放射化学、高细胞杀伤效力和α核... 详细信息

利用放射源将具有细胞毒性的电离辐射作用到病灶处的方法可以追溯到20世纪初,起源于镭的发现及其能够产生的生理作用。α核素在放射治疗应用于临床肿瘤学领域中备受关注。该综述的第一部分探讨了基本的放射化学、高细胞杀伤效力和α核素的可应用性,以及存在于放射性标记方法和子核再分布的阻碍。该综述的第二部分将概述α核素在临床前和临床研究中最有希望和最新的用途。

关键词：放射治疗 α核素放射化学临床试验

同方期刊数据库