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高血压和增加的内皮机械牵张促进单核细胞分化和激活: StAt3,白细胞介素6和过氧化氢的作用

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中华高血压杂志 2019年第1期27卷 15-15页

作者：刘莉叶鹏 Loperena R Van Beusecum JP Itani HA Engel N Laroumanie F Xiao L Elijovich F Laffer CL Gnecco JS Noonan J Maffia P Jasiewicz-Honkisz B Czesnikiewicz-Guzik M Mikolajczyk t sliwa t Dikalov S Weyand CM Guzik tJ Harrison DG

单核细胞在高血压中起重要作用。人体中循环的单核细胞以经典、中间和非经典形式存在。单核细胞的分化受到内皮的影响,而内皮又通过机械拉伸在高血压中被激活。为了检查增加的内皮牵张和高血压对单核细胞表型及功能的作用,Loperena等将... 详细信息

单核细胞在高血压中起重要作用。人体中循环的单核细胞以经典、中间和非经典形式存在。单核细胞的分化受到内皮的影响,而内皮又通过机械拉伸在高血压中被激活。为了检查增加的内皮牵张和高血压对单核细胞表型及功能的作用,Loperena等将人单核细胞与汇合的人主动脉内皮细胞一起培养,进行5%或10%的周期性拉伸;还在正常血压和高血压人群中验证循环单核细胞。

关键词：高血压内皮细胞主动脉单核细胞 StAt3 白细胞介素过氧化氢

An Analysis of the Numerical Model Influence on the Ground temperatureProfile Determination

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Journal of thermal Science 2017年第1期26卷 82-88页

作者： Marek Jaszczur Inga Polepszyc Aneta Sapinska-sliwa Andrzej Gonet Faculty of Energy and Fuels Department of Fundamental Research in Energy Engineering Faculty of Drilling Oil and Gas ale Department of Drilling and Geoengineering AGH University of Science and Technology al. Mickiewicza 30 30-059 Krak6w Poland

the estimation of the ground temperature profile with respect to the depth and time is the key issue in many engineering applications which use the ground as a source of thermal energy. In the present work, the influence of the model components on the calculated ground temperature distribution has been analysed in order to develop an accurate and robust model for the prediction of the ground temperature profile. the presented mathematical model takes into account all the key phenomena occurring in the soil and on its top surface. the impact of individual model elements on the temperature of the soil has been analysed. It has been found that the simplest models and the most complex model result in a similar temperature variation over the simulation period, but only at a low depth. A detailed analysis shows that a larger depth requires more complex models and the calculation with the use of simple models results in an incorrect temperature and a theoretical COP estimation.

关键词： heat transfer ground heat transport ground temperature profile ground source heat pump

A Perspective on Data Processing in Super-resolution Fluorescence Microscopy Imaging

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Journal of Analysis and testing 2018年第3期2卷 193-209页

作者： S.Hugelier M.sliwa C.Ruckebusch Universitéde Lille LASIR CNRS59655 Villeneuve d’Ascq CedexFrance

With super-resolution microscopy,we attempt to visualize(biological)structures and processes at the sub-cellular level(i.e.,nanoscale).to obtain this information,the samples are labeled with fluorophores that have a stochastic on/off switching of their emissions,which help to overcome the optical diffraction limit of around 250 nm,related to the use of optical ***,nowadays,research focuses on the imaging of live cells and thicker *** investigations require a high amount of simultaneously active fluorophores(i.e.,high-density imaging)and are challenging due to the collapse of the single-molecule localization techniques and the increased background in the ***,recent efforts have shifted towards the development of new ways to process the *** publication gives an introduction to wide-field super-resolution fluorescence microscopy,explaining the concepts of the technique,and then gives an overview of the recently developed methods to provide super-resolution images for high-density data of live cells and ways to overcome the issues related to the imaging of these samples.

关键词： Super-resolution Fluorescence microscopy Nanoscopy Imaging

Chemometric analysis of femtosecond transient absorption spectroscopy data:Study of the photochromism of anils

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Science China(Physics,Mechanics & Astronomy) 2010年第6期53卷 1024-1035页

作者： Cyril RUCKEBUSCH Nicolas MOUtON thomas GLADYtZ Anika RENDELMANN Guy BUNtINX Michel sliwa LASIR CNRS UMR 8516Université de Lille1 Sciences et Technologiesbat C559655 Villeneuve d'Ascq cedexFrance

Chemometric methods are applied for the purpose of extracting relevant information from transient absorption spectroscopy data probing the photochromism of molecules from the family of salicylidene aniline. the process consists of an ultrafast excited state intramolecular proton transfer occurring from an enol form which is then followed by a cis-trans isomerization to finally reach a trans-keto photo-product. this work focuses on the potential of combining multivariate curve resolution for modeling pure profiles and two dimensional correlation spectroscopy data analysis for providing information on the dynamics of spectral features. the results obtained for one derivative of salicylidene aniline provide information regarding the number of species created after the proton transfer and characterization of their absorption spectra and their kinetics in the picosecond time scale. the spectral resolution of two cis-keto* forms is proposed for the first time. It is also found that both cis-keto* species are involved in the formation of the trans-keto photo-product. the main precursor of the trans-keto photo-product is the cis-keto* form which has the shortest characteristic time.

关键词： multivariate curve resolution two dimensional correlation spectroscopy femtosecond absorption proton transfer anils photochromism

Moisture-Induced Non-Equilibrium Phase Segregation in triple Cation Mixed Halide Perovskite Monitored by In Situ Characterization techniques and Solid-State NMR

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Energy & Environmental Materials 2023年第2期6卷 185-194页

作者： Mohammad Ali Akhavan Kazemi Nicolas Folastre Parth Raval Michel sliwa Jean Marie Vianney Nsanzimana Sema Golonu Arnaud Demortiere Jean Rousset Olivier Lafon Laurent Delevoye G.N.Manjunatha Reddy Frédéric Sauvage Laboratoire de Réactivité et Chimie des Solides(LRCS) UMR CNRS 7314-Institut de Chimie de Picardie FR 3085Université de Picardie Jules Verne33 rue Saint LeuAmiens Cedex FR-80039France CNRS Centrale LilleUMR 8181UCCSUnitéde Catalyse et Chimie du SolideUniversité de LilleUniversitéd’ArtoisLille F-59000France UMR 8516-LASIRE-Laboratoire de Spectroscopie pour les Interactions la Réactivité et l’EnvironnementCNRSUniversitéde LilleLille F-59000France EDF R&D EDF LabBoulevard Gaspard MongePalaiseau 91120France

Environmental stability is a major bottleneck of perovskite solar *** a handful of studies are investigating the effect of moisture on the structural degradation of the *** mostly rely on ex situ experiments and on completely degraded samples,which restrict the assessment on initial and final *** combining in situ X-ray diffraction under controlled 85%relative humidity,and live observations of the water-induced degradation using liquid-cell transmission electron microscopy,we reveal two competitive degradation paths leading on one hand to the decomposition of state-of-theart mixed cation/anion(Cs_(0.05)(MA_(0.17)FA_(0.83))_(0.95)Pb(Br_(0.17)I_(0.83))_(3)(CsMAFA)into PbI_(2) through a dissolution/recrystallization mechanism and,on the other hand,to a non-equilibrium phase segregation leading to CsPb_(2)Br_(5) and a Cesium-poor/iodide-rich Cs_(0.05)-x(MA_(0.17)FA_(0.83))_(0.95)Pb(Br_(0.17-2y)I_(0.83)+2y)_(3) *** degradation mechanism is corroborated at atomic-scale resolution through solid-state ^(1)H and ^(133)Cs NMR *** to moisture leads to a film containing important heterogeneities in terms of morphology,photoluminescence intensities,and *** results provide new insights and consensus that complex perovskite compositions,though very performant as champion devices,are comparatively metastable,a trait that limits the chances to achieve long-term stability.

关键词： liquid-cell transmission electron microscopy moisture degradation perovskite stability phase segregation solid-state NMR

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关于水准标石稳定性的若干问题

测绘译丛 1989年第3期 25-30页

作者： sliwa,L. 梁振英

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赞比亚祖母绿矿床的地质背景

华北地质 1985年第1期 85-93页

作者： A.S.sliwa C.A.Nguluwe 卢祥生

引言赞比亚的祖母绿矿床位于世界闻名的铜带西南附近。该矿床靠近卡富布(Kafubu)河(卡富埃河的支流),常称之为卡富布祖母绿矿田。这是世界上最近发现的祖母绿矿田,尽管产量已达值得注意的比例,但其开发仍处于极初步阶段。目前,矿山开采... 详细信息

引言赞比亚的祖母绿矿床位于世界闻名的铜带西南附近。该矿床靠近卡富布(Kafubu)河(卡富埃河的支流),常称之为卡富布祖母绿矿田。这是世界上最近发现的祖母绿矿田,尽管产量已达值得注意的比例,但其开发仍处于极初步阶段。目前,矿山开采全部限于小而分散的巷道和少量矿井。1928年在米库(Miku)首次发现了绿柱石,1931年经短期调查加以否定,四十～五十年代又作了一些工作,直至1974年以后陆续找到了卡马干加(Kamakanga)、比

关键词：片岩磁铁矿伟晶岩脉绿泥石变质岩尖晶石粘土矿物祖母绿矿床电气石宝石赞比亚地质背景

新近诊断的心衰患者中ACEI类药物治疗前给予卡维地洛对心功能的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 48-49页

作者： sliwa K. NortonG.R. Kone N. 尚福军

the purpose of this research was to evaluate the therapeutic value of initiati ng a beta-blocker before an angiotensin-converting enzyme inhibitor(ACEI) in t he treatment of heart failure. AlthoughACEI and carvedilol produce benefits in h eart failure, whether the order of initiation of therapy determines the impact o n left ventricular (LV) function and New York Heart Association functional class (NYHA FC) has not been determined. A single-center, prospective, randomized, op en-label study was performed. We eval uated whether initiation of therapy with carvedilol either before(n=38) or after (n=40) perindopril therapy in newly diagnosed patients in NYHA FC II to III hear t failure with idiopathic dilated cardiomyopathy, with the addition of the alter native agent after six months, determined subsequent changes in NYHA FC and LV f unction(echocardiography and radionuclide ventriculography). Study drugs were ti trated to maximum tolerable doses. there were no differences in baseline charact eristics between the study groups. After 12months 11 patients died (6 in the gro upwhere theACEI was initiated). At 12 months the group receiving carvedilol as i nitial therapy achieved a higher tolerable dose of carvedilol(43±17 mg vs. 33± 18 mg, p=0.03); a lower dose of furosemide (ptter improvements in symptoms (NYHA FC, p tion fraction (radionuclide: 15±16%vs. 6±13%, pterminal pro-brain natriuretic peptide concentrations (pto the conventional se quence of drug use in the treatment of heart failure, initiation of therapy with carvedilol before an ACEI results in higher tolerable doses of carvedilol and b etter improvements in FC and LV function.

关键词： ACEI类药物心功能药物治疗心脏协会 β-受体阻滞剂培多普利培哚普利脑钠素射血分数耐受剂量

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高危患者目标血压与心血管病预后

中华高血压杂志 2017年第6期25卷 586-588页

作者： B?hm M Schumacher H teo KK Lonn EM Mahfoud F Mann JF Mancia G Redon J Schmieder RE sliwa K Weber MA Williams BYusuf S 曲浥晨叶鹏 Institution unknown

指南推荐血压目标值应〈140/90 mmHg（1mmHg=0.133kPa）以减少心血管事件的发生。但与其他心血管病预后（如冠状动脉事件）相比,包括脑卒中及心力衰竭在内的心血管病预后与收缩压下降关系更密切。一些心血管事件（如冠状动脉事件）风险... 详细信息

指南推荐血压目标值应〈140/90 mmHg（1mmHg=0.133kPa）以减少心血管事件的发生。但与其他心血管病预后（如冠状动脉事件）相比,包括脑卒中及心力衰竭在内的心血管病预后与收缩压下降关系更密切。一些心血管事件（如冠状动脉事件）风险在收缩压低时亦增高,风险-收缩压关系呈J形曲线,而脑卒中与血压不是J形曲线关系。

关键词：心血管病目标血压预后高危患者冠状动脉事件心血管事件收缩压心力衰竭