检索结果-南通市图书馆

CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij J.P.Welters Tom de Wit Ellen Schrama hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos Charlotte L.Zuur Noel F.C.C.de Miranda heinz Jacobs sj.erd h.van der burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IFNβvia the STING pathway,which promotes MhC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer *** cooperation with CD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CTL response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Disturbance increases high tide travel distance of a roosting shorebird but only marginally affects daily energy expenditure

引用

Avian Research 2019年第3期10卷 294-304页

作者： hans Linssen Martijn van de Pol Andrew M.Allen Mitzi Jans Bruno J.Ens Karen L.Krijgsveld Magali Frauendorf henk-Jan van der Kolk Department of Animal Ecology Netherlands Institute of Ecology6708PB WageningenThe Netherlands Resource Ecology Group Wageningen University & Research6708PB WageningenThe Netherlands Centre for Avian Population Studies Droevendaalsesteeg 106708PB WageningenThe Netherlands Department of Animal Ecology and Physiology Radboud University6500GL NijmegenThe Netherlands Sovon-Texel Sovon Dutch Centre for Field Ornithology1790AB Den BurgThe Netherlands Nature Bureau Royal Netherlands Air Force4820BB BredaThe Netherlands

Background:Anthropogenic disturbance can negatively affect an animal's energy budget by evoking movement *** research focuses mainly on immediate displacement as a disturbance effect,since this can be easily observed in the field. however, effects on movement over longer timescales are poorly examined and it is largely unknown if and to what extent they reflect immediate ***-term responses could for example be larger than immediate responses if birds, after disturbance, return to the original location and thereby travel twice the immediate disturbed distance. Methods:We combined GPS tracking data with observational data to quantify the effects of anthropogenic (air force and walkers) and non-anthropogenic disturbances on distances travelled by roosting Eurasian Oystercatchers (haematopus ostralegus) during the non-breeding season. We compared immediate displacement after a disturbance with distance travelled during the entire high tide period (longer-term response), while accounting for environmental ***,we calculated energy expenditure due to disturbance based on observed disturbance ***:Disturbance resulted in an immediate displacement response of ~200 m (median).Air force disturbances tended to yield larger immediate responses than walker and,especially,than non-anthropogenic ***-term responses and immediate responses were approximately similar,suggesting that,over longer timescales,spatial disturbance effects in the study area remain confined to immediate ***,disturbances were infrequent (0.17 disturbances per bird per hour) and most disturbances were of natural origin (62%).Consequently, anthropogenic disturbance of roosting oystercatchers in the study area on average costs 0.08% of the daily energy expenditure. Conclusions:Our results suggest that immediate spatial responses to disturbance can be a useful proxy for spatial responses over longer *** the non-exha

关键词： Biologging Disturbance haematopus ostralegus high tide roost Movement ecology Shorebird

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Colour-ring wear and loss effects in citizen science mark-resighting studies

引用

Avian Research 2019年第2期10卷 148-162页

作者： Andrew M.Allen Bruno J.Ens Martijn van de Pol henk van der Jeugd Magali Frauendorf henk-Jan van der Kolk Kees Oosterbeek Jeroen Nienhuis Eelke Jongejans Department of Animal Ecology and Physiology Radboud University6500 GL NijmegenThe Netherlands Sovon Dutch Centre for Field Ornithology 6503 GANijmegen and Sovon-Texel1790 AB Den BurgThe Netherlands Department of Animal Ecology Netherlands Institute of Ecology NIOOKNAW6708 PB WageningenThe Netherlands Dutch Centre for Avian Migration and Demography 6700 AB WageningenThe Netherlands Centre for Avian Population Studies WageningenThe Netherlands

Background: Ring wear and loss may have important consequences for mark-recapture studies that aim to estimate survival trends. Our study quantifies the rates of wear and loss from a long-running colour-ringing project of the Eurasian Oystercatcher (haematopus ostralegus) in the Netherlands. Methods: Our analysis included 8909 colour-ringed oystercatchers with 118,071 resightings, predominantly ringed and observed by citizen scientists. We quantified how ring wear and loss may vary with ring colour and age, and how this may impact resighting probabilities. We then determined how ring loss may impact survival estimates and resighting probabilities of mark-recapture models by simulating four scenarios of how citizen scientists may resight and report birds with lost colour rings. Results: Annual rates of colour ring loss averaged 2.5% compared with 1% for ring wear, but lost rings also had a higher reporting probability (31.2%) than worn rings (10.3%). Lost rings may not directly impact survival estimates since 50% of oystercatchers with lost rings could still be uniquely identified. Ring wear and loss rapidly increased between 10 and 15 years after ringing. Rates of ring loss were comparable amongst ring colours, but the wear rate appeared higher for red and white rings compared to other colours. Rates of ring wear and loss varied significantly amongst different regions in our study, which were characterised as having different habitat features. Differential rates of ring wear may have important implications for studies conducted over large geographical scales or of multiple species. Conclusions: Based on simulations of ring loss in our population, estimates of apparent survival may be 0.3–1.2% lower whilst the impact of ring wear was deemed even lower. We developed a table of recommendations containing advice for ring fitting, data collection, study design, and mark-recapture analyses, so that future colour-ringing studies can benefit from our experiences in collecti

关键词： Bias Bird migration Citizen science Colour-ring Mark-recapture Shorebirds Survival

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Expression of cyclin-dependent kinase inhibitor genes induces apoptosis in human hepatoma cell line

引用

Chinese Science Bulletin 1997年第23期42卷 2000-2005页

作者： Ren, CC Tian, PK Qu, SM Teng, QS Jiang, hQ Zheng, Yh Ren, sj Gu, JR Shanghai Canc Inst Natl Lab Oncogenes & Related Genes Shanghai 200032 Peoples R China

APOPTOSIS is an active, inherently programmed cell death, which has typical morphologicaland biochemical characteristics. Cell death during embryonic development, shaping of the Tand B lymphocyte and tissue dystrophy related to endocrine is designated a physiological apop-tosis by which cell numbers can be effectively controlled. As a process opposite to cell division,there is a balance between apoptosis and cell proliferation. A tumor will develop once the bal-ance is disturbed and the cell division is more rapid than the cell death. Also, apoptosis is un-der the control of multiple molecular components, while cell division is under the control of thecell cycle engine. The precise control of cell proliferation and differentiation is essential for

关键词： apoptosis cyclin-dependent kinase inhibitor hepatoma.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The SPLASh Action Group—Towards standardized sampling strategies in permafrost science

引用

Advances in Polar Science 2020年第3期31卷 153-155页

作者： Frederic BOUChARD Yannick AGNAN Lisa BROder Julien FOUChE Catherine hIRST Ylva sjOBERG Geosciences Paris Sud(GEOPS) UniversiteParis SaclayOrsayFrance Centre d’etudes nordiques(CEN) UniversiteLavalQuebecCanada Earth and Life Institute Universitecatholique de LouvainLouvain-la-NeuveBelgium Department of Earth Sciences Swiss Federal Institute of Technology(ETH)ZurichSwitzerland Department of Earth Sciences Vrije Universiteit AmsterdamAmsterdamthe Netherlands LISAh Univ MontpellierINRAEIRDInstitut AgroMontpellierFrance Department of Geosciences and Natural Resource Management CENPERMUniversity of CopenhagenCopenhagenDenmark

The Action Group called‘Standardized methods across Permafrost Landscapes:from Arctic Soils to hydrosystems’(SPLASh)is a community-driven effort aiming to provide a suite of standardized field strategies for sampling mineral and organic components in soils,sediments,and water across permafrost *** unified approach will allow data from different landscape interfaces,field locations and seasons to be shared and compared,thus improving our understanding of the processes occurring during lateral transport in circumpolar Arctic watersheds.

关键词： biogeochemistry soils organic matter minerals lateral transport aquatic systems

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

β-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas:role in the regulation of response to somatostatin analogue treatment in patients with acromegaly

引用

中国神经肿瘤杂志 2013年第4期11卷 235-235页

作者： Gatto F Feelders R van der Pas R Kros JM Dogan F van Koetsveld PM van der Lelij AJ Neggers sj Minuto F de herder W Lamberts SW Ferone D hofland LJ Erasmus Medical Center Room Ee 530bDoctor Molewaterplein 503015 GE Rotterdam

Recent in vitro studies highlighted G protein-coupled receptor kinase(GRK)2 andβ-arrestins as important players in driving somatostatin receptor(SSTR)desensitization and *** aim was to characterize GRK2 andβ-arrestins expression in different pituitary adenomas and to investigate their potential role in the response to somatostatin analog(SSA)treatment in Ghsecreting adenomas(Ghomas).We evaluated mRNA expression of multiple SSTRs,GRK2,β-arrestin 1,andβ-arrestin 2 in 41pituitary adenomas(31 Ghomas,6 nonfunctioning[NFPAs],and 4 prolactinomas[PRLomas]).Within the Ghomas group,mRNA data were correlated with the in vivo response to an acute octreotide test and with the Gh-lowering effect of SSA in cultured primary cells.β-Arrestin 1 expression was low in all 3 adenoma ***,its expression was significantly lower in Ghomas

关键词： G蛋白偶联受体激酶生长抑素受体垂体腺瘤治疗作用类似物调节作用患者肥大

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

皮肤自发荧光、戊糖素与主动脉僵硬度相关:Maastricht研究

引用

中华高血压杂志 2016年第9期24卷 899-899页

作者： van Eupen MG Schram MT van Sloten TT Scheijen J Sep sj van der Kallen CJ Dagnelie PC Koster A Schaper N henry RM Kroon AA Smit AJ Stehouwer CD Schalkwijk CG 刘莉叶鹏

以颈股动脉脉搏波传导速度（carotid-femoralpulse-wavevelocity，cfPWV）或脉压增加为特征的动脉硬化可增加心血管病发生风险，尤其是在2型糖尿病的个体。

关键词： Maastricht 主动脉僵硬度自发荧光脉搏波传导速度皮肤糖素 2型糖尿病发生风险

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

奴卡菌感染：临床文献复习

引用

世界医学杂志 2000年第2期4卷 15-19页

作者： burg.,sj 马小军

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Avian hepatitis B viruses： Molecular and cellular biology, phylogenesis, and host tropism

引用

World Journal of Gastroenterology 2007年第1期13卷 91-103页

作者： Anneke Funk Mouna Mhamdi hans Will hüseyin Sirma Department of General Virology Heinrich-Pette-lnstitut Fttr expe-rimentelle Virologic und Immunologic an der Universitaet Ham-burg Hamburg Germany

The human hepatitis B virus （hBV） and the duck hepatitis B virus （DhBV） share several fundamental features. Both viruses have a partially double-stranded DNA genome that is replicated via a RNA intermediate and the coding open reading frames （ORFs） overlap extensively. In addition, the genomic and structural organization, as well as replication and biological characteristics, are very similar in both viruses. host of the key features of hepadnaviral infection were first discovered in the DhBV model system and subsequently confirmed for hBV. There are, however, several differences between human hBV and DhBV. This review will focus on the molecular and cellular biology, evolution, and host adaptation of the avian hepatitis B viruses with particular emphasis on DhBV as a model system.

关键词： hepadnavirus Pararetroviruses Evolution host range Genome Structure, Virions Subviral particles In vitro and in v/vo infection Transport Fusion Endocytosis hepatocellular differentiation cccDNA Gene expression horphogenesis and secretion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

动脉僵硬度和皮肤微血管功能的相关性

引用

中华高血压杂志 2015年第11期23卷 1098-1098页

作者：练桂丽叶鹏 van Sloten TT Czernichow S houben AJ Protogerou AD henry RM Muris DM Schram MT Sep sj Dagnelie PC van der Kallen CJ Schaper NC Blacher J hercberg S Levy BI Stehouwer CD

已有假设认为,动脉僵硬度导致广泛微血管功能障碍,2型糖尿病（type 2diabetes,T2DM）患者对动脉僵硬度的有害作用更为敏感。然而,缺乏动脉僵硬度与微血管功能障碍标志物的相关性证据。

关键词：动脉僵硬度血管功能障碍脉搏波传导速度反应性充血 carotid 静脉淤血毛细血管密度马斯特里赫特 femoral 抗氧化剂

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：