Avian hepatitis B viruses： Molecular and cellular biology, phylogenesis, and host tropism

作     者：Anneke Funk Mouna Mhamdi Hans Will Hüseyin Sirma 

作者机构：Department of General Virology Heinrich-Pette-lnstitut Fttr expe-rimentelle Virologic und Immunologic an der Universitaet Ham-burg Hamburg Germany 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2007年第13卷第1期

页      面：91-103页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：Supported by the Freie und Hansestadt Hamburg and the Bundesministcrium für Gesundheit und Soziale Sicherung grants from DFG and by the German Competence Network for Viral Hepatitis (Hop-Net), funded by the German Ministry of Education and Research (BMBF), Grant No. TFI3. IWe apologize to those authors whose work we could not cite directly due to space limitations. The authors are indebted to Claudia Franke (Heinrich-Pette-Institute, Hamburg, Germany) for providing the picture of core protein phosphorylation 

主　　题：Hepadnavirus Pararetroviruses Evolution Host range Genome Structure, Virions Subviral particles In vitro and in v/vo infection Transport Fusion Endocytosis Hepatocellular differentiation cccDNA Gene expression Horphogenesis and secretion 

摘      要：The human hepatitis B virus （HBV） and the duck hepatitis B virus （DHBV） share several fundamental features. Both viruses have a partially double-stranded DNA genome that is replicated via a RNA intermediate and the coding open reading frames （ORFs） overlap extensively. In addition, the genomic and structural organization, as well as replication and biological characteristics, are very similar in both viruses. Host of the key features of hepadnaviral infection were first discovered in the DHBV model system and subsequently confirmed for HBV. There are, however, several differences between human HBV and DHBV. This review will focus on the molecular and cellular biology, evolution, and host adaptation of the avian hepatitis B viruses with particular emphasis on DHBV as a model system.