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收缩压、舒张压和脉压与亚临床心肌损伤风险:特伦德拉格郡健康研究

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中华高血压杂志(中英文) 2024年第8期 762-762页

作者： Young J Lyngbakken MN Hveem K R?sj? H Omland T 袁源练桂丽

亚临床心肌损伤表现为肌钙蛋白浓度升高，可能代表高血压和心血管疾病风险的重要中间状态。该研究旨在评估收缩压、舒张压、脉压与亚临床心肌损伤的关联强度，以及血压变量随时间变化与亚临床心肌损伤的关联性。方法和结果：对第4波基...

亚临床心肌损伤表现为肌钙蛋白浓度升高，可能代表高血压和心血管疾病风险的重要中间状态。该研究旨在评估收缩压、舒张压、脉压与亚临床心肌损伤的关联强度，以及血压变量随时间变化与亚临床心肌损伤的关联性。方法和结果：对第4波基于人群的队列特伦德拉格郡健康研究(Tr?ndelag health study, HUNT)4中没有心血管疾病史的32 968例参与者进行心肌肌钙蛋白I(cardiac troponin I,cTnI)检测。

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Immune checkpoint inhibitors in breast cancer: development, mechanisms of resistance and potential management strategies

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Cancer Drug Resistance 2023年第4期6卷 768-787页

作者： Rachel sj Wong Rebecca JM Ong Joline sj Lim Department of Haematology-Oncology National University Cancer InstituteNational University HospitalSingapore 119228Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 119228Singapore

The use of immune checkpoint inhibitors(iCls)has increased exponentially in the past decade,although its progress specifically for breast cancer has been *** first *** and Drug Administration approval for ICl in breast cancer came in 2019,eight years after the first-ever approval of an *** present,current indications for ICls are relevant only to a subset of patients with triple-negative breast cancer,or those displaying high microsatellite instability or deficiency in the mismatch repair protein *** an increasing understanding of the limitations of using ICls,which stem from breast cancer being innately poorly immunogenic,as well as the presence of various intrinsic and acquired resistance pathways,ongoing trials are evaluating different combination therapies to overcome these *** this review,we aim to describe the development timeline of ICls and resistance mechanisms limiting their utility,and summarise the available approaches and ongoing trials relevant to overcoming each resistance mechanism.

关键词： Immunotherapy immune checkpoint inhibitors resistance mechanisms breast cancer

Construction of Conservative Numerical Fluxes for the Entropy Split Method

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Communications on Applied Mathematics and Computation 2023年第2期5卷 653-678页

作者： Björn sjögreen H.C.Yee Multid Analyses AB GothenburgSweden NASA Ames Research Center Moffett FieldCA 94035USA

The entropy split method is based on the physical entropies of the thermally perfect gas Euler *** Euler flux derivatives are approximated as a sum of a conservative portion and a non-conservative portion in conjunction with summation-by-parts(SBP)difference boundary closure of(Gerritsen and Olsson in J Comput Phys 129:245-262,1996;Olsson and Oliger in RIACS Tech Rep 94.01,1994;Yee et *** J Comp Phys 162:33-81,2000).sj?green and Yee(J Sci Comput)recently proved that the entropy split method is entropy conservative and ***-ard high-order spatial central differencing as well as high order central spatial dispersion relation preserving(DRP)spatial differencing is part of the entropy stable split methodol-ogy *** current work is our first attempt to derive a high order conservative numerical flux for the non-conservative portion of the entropy splitting of the Euler flux *** to the construction,this conservative numerical flux requires higher oper-ations count and is less stable than the original semi-conservative split ***,the Tadmor entropy conservative(EC)method(Tadmor in Acta Numerica 12:451-512,2003)of the same order requires more operations count than the new *** the entropy split method is a semi-conservative skew-symmetric splitting of the Euler flux derivative,a modified nonlinear filter approach of(Yee et *** J Comput Phys 150:199-238,1999,J Comp Phys 162:3381,2000;Yee and sj?green in J Comput Phys 225:910934,2007,High Order Filter Methods for Wide Range of Compressible flow *** of the ICOSAHOM09,June 22-26,Trondheim,Norway,2009)is proposed in conjunction with the entropy split method as the base method for problems containing shock ***-time integration of 2D and 3D test cases is included to show the com-parison of these new approaches.

关键词： Finite-difference method Entropy conservation Entropy splitting Shock capturing

Novel Architecture of OneM2M-Based Convergence Platform for Mixed Reality and IoT

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Computers, Materials & Continua 2022年第4期71卷 51-69页

作者： Seungwoon Lee Woogeun Kil Byeong-hee Roh sj Kim Jin-suk Kang Department of Computer Engineering and Department of AI Convergence Network Ajou UniversitySuwon16499Korea Howard R.Hughes College of Engineering University of NevadaLas VegasNV89154USA AST Co.Ltd. Suwon16681Korea

There have been numerous works proposed to merge augmented reality/mixed reality(AR/MR)and Internet of Things(IoT)in various ***,they have focused on their specific target applications and have limitations on interoperability or reusability when utilizing them to different domains or adding other devices to the *** paper proposes a novel architecture of a convergence platform for AR/MR and IoT systems and *** proposed architecture adopts the oneM2M IoT standard as the basic framework that converges AR/MR and IoT systems and enables the development of application services used in general-purpose environments without being subordinate to specific systems,domains,and device *** implement the proposed architecture utilizing the open-source oneM2M-based IoT server and device platforms released by the open alliance for IoT standards(OCEAN)and Microsoft HoloLens as an MR device *** also suggest and demonstrate the practical use cases and discuss the advantages of the proposed architecture.

关键词： Internet of things(IoT) augmented realty(AR) mixed reality(MR) microsoft HoloLens oneM2M convergence platform

State Transition Induced by Self-Steepening and Self Phase-Modulation

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Chinese Physics Letters 2014年第1期31卷 33-36页

作者： He Jing-Song Xu Shu-Wei M. S. Ruderman R. erdélyi Department of Mathematics Ningbo University Ningbo 315211 DAMTP University of Cambridge Cambridge CB3 0WA UK School of Mathematics University of Science and Technology of China Hefei 230026 Solar Physics and Space Plasma Research Centre University of Sheffield Sheffield S3 7RH UK

We present a rational solution for a mixed nonlinear Schr6dinger （MNLS） equation. This solution has two free parameters, a and b, representing the contributions of self-steepening and self phase-modulation （SPM） of an associated physical system, respectively. It describes five soliton states： a paired bright-bright soliton, a single soliton, a paired bright-grey soliton, a paired bright-black soliton, and a rogue wave state. We show that the transition among these live states is induced by self-steepening and SPM through tuning the values of a and b. This is a unique and potentially fundamentally important phenomenon in a physical system described by the MNLS eauation.

关键词： Solitons

The potential application of red mud and soil mixture as additive to the surface layer of a landfill cover system

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Journal of Environmental Sciences 2016年第6期28卷 189-196页

作者： Eva Ujaczki Viktória Feigl Mónika Molnár Emese Vaszita Nikolett Uzinger Attila erdélyi Katalin Gruiz Department of Applied Biotechnology and Food Science Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics H-1111 Budapest Muegyetem rkp. 3 Hungar Institute for Soil Sciences and Agricultural Chemistry Centre for Agricultural Research Hungarian Academy of Sciences H-1022 Budapest Herman Otto Street 15 Hungary A.S.A. Hungary Ltd. H-2360 Gydl Karosi Street 53 Hungary

Red mud, the by-product of aluminum production, has been regarded as a problematic residue all over the world. Its storage involves risks as evidenced by the Ajka red mud spill,an accident in Hungary where the slurry broke free, flooding the surrounding areas. As an immediate remediation measure more than 5 cm thick red mud layer was removed from the flooded soil surface. The removed red mud and soil mixture（RMSM） was transferred into the reservoirs for storage. In this paper the application of RMSM is evaluated in a field study aiming at re-utilizing waste, decreasing cost of waste disposal and providing a value-added product. The purpose was to investigate the applicability of RMSM as surface layer component of landfill cover systems. The field study was carried out in two steps： in lysimeters and in field plots. The RMSM was mixed at ratios ranging between 0 and 50% w/w with low quality subsoil（LQS） originally used as surface layer of an interim landfill cover. The characteristics of the LQS ＋ RMSM mixtures compared to the subsoil（LQS） and the RMSM were determined by physical–chemical, biological and ecotoxicological methods. The addition of RMSM to the subsoil（LQS） at up to 20% did not result any ecotoxic effect, but it increased the water holding capacity. In addition, the microbial substrate utilization became about triple of subsoil（LQS） after 10 months. According to our results the RMSM mixed into subsoil（LQS） at20% w/w dose may be applied as surface layer of landfill cover systems.

关键词： Red mud Soil amelioration Environmental toxicology Landfill cover constituent Field-study Lysimeter

Electrochemical reduction process of bilirubin in dimethylformamide

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Chinese Journal of Chemistry 1995年第4期13卷 289-298页

作者： NIU, JJ DONG, sj CHINESE ACAD SCI CHANGCHUN INST APPL CHEMELECTROANALYT CHEM LABCHANGCHUN 130022PEOPLES R CHINA

The electrochemical reduction behavior of bilirubin (BR) at platinum electrode in DMF was investigated by cyclic voltammetry, in situ electron spin resonance spectroscopy and in situ rapid scanning thin layer spectroelectrochemistry. Experimental results revealed that the reduction of BR firstly undergoes an ECE process: GRAPHICS The generated (BR)(2)(3-). can be re-oxidized to BR and then to purpurin (Pu) by a series of oxidation processes: GRAPHICS However, the re-reduction reactions of Pu are not the reverse processes. The different reduction mechanisms are discussed in detail.

关键词： BILIRUBIN BILIVerdIN PURPURIN SPECTROELECTROCHEMISTRY BIOELECTROCHEMISTRY

SYNTHESIS　OF　BLOCK　COPOLYMERS　OF　STYRENE　AND　N－（p－SUBSTITUTED　PHENYL）　MALEIMIDES　BY　ANIONIC　POLYMERIZATION

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Chinese Chemical Letters 1996年第4期7卷 367-370页

作者： Xu, sj Qiu, KY BEIJING UNIV COLL CHEM & MOL ENGNBEIJING 100871PEOPLES R CHINA

The block copolymers were synthesized by anionic pohymerization via two steps reaction. First, styrene was initiated by n-butyl lithium, then maleimides were added into the living styrene system to obtain block copolymers. 1H-NMR and FT-IR measurements indicated that block coplymers bad been formed From the esults of thermogravimetric, it could be concluded that the block copolymer had a much better thermal stability than random copolymers predared by radical polymerization. Also the surface hydrophilicities of the two kinds of copolymers were compared.

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Phase Structure Change of Mo-Si System duringMechanical Alloying

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Journal of Materials Science & Technology 1999年第5期15卷 423-426页

作者： Liu, sj Qu, XH Liu, ZJ Huang, BY Cent S Univ Technol State Key Powder Met Changsha 410083 Peoples R China

The structure of Mo-15.16 Si, Mo-30 Si and Mo-36.3 Si (wt pct) elemental powder mixture during mechanical alloying was studied using electron microscopy and X-ray diffraction. It had been found that, in all the systems under study, silicon disappeared initially during mechanical alloying (MA). In the Mo-Si systems all products were in form of amorphous state after long time milling, but there were different intermediate products. MoSi2 and Mo5Si3 intermetallic compounds in the Mo-30Si and Mo-36.3Si (wt pct) were directly synthesized from elements through inter-diffussion process. The high density of defects and interface of nano-crystal lines induced by ball milling would promote the reaction process. Only in the Mo-15.16Si (wt pct) system was Mo(Si) supersaturated solid solution formed as an intermediate product. Schematic free-energy diagram of Mo-Si system based on the thermodynamics was used to analyze the difference among the intermediate state products.

关键词： Molybdenum alloys