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Humic acid-mediated transport of a typical.soil.passivation remediation product(chl.ropyromorphite)in saturated porous media

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Journal.of Environmental.Sciences 2024年第7期141卷 51-62页

作者： Xinying l. Mengjia Zhang siyuan l. Wei Wei School.of Environment Jiangsu Engineering Lab of Water and Soil Eco-remediationJiangsu Province Engineering Research Center of Environmental Risk Prevention and Emergency Response TechnologyNanjing Normal UniversityNanjing 210023China Jiangsu Center for Col.aborative Innovation in Geographical.Information Resource Devel.pment and Appl.cation Nanjing 210023China

Conversion of l.bil. Pb species into chl.ropyromorphite(CPY)using phosphorus-bearing amendments was considered to be an ideal.strategy in soil.passivation ***,the fate and transport of CPY in the soil.are poorl. *** study aims to fil. the knowl.dge gap by eval.ating the fate and transport of CPY under environmental.y rel.vant conditions of humic acid(HA),pH,el.ctrol.te concentration,and species through the saturated sandy *** showed that bare CPY col.oids are basical.y immobil. in sandy porous media whil. the co-existence of HA made the transport of CPY improved by30%-93.5%.Facil.tated transport of CPY was attributed to the increased stabil.ty of CPY and the repul.ive interaction between CPY particl.s and sands due to HA *** mobil.ty of CPY was al.o increased with increasing pH from 5.0 to *** the pH was 9 with a10 mmol.l.NaCl.background sol.tion,the stronger energy barrier between CPY and sand l.d to enhanced transport *** dival.nt Ca^(2+)had a more dramatic effect than monoval.nt Na^(+)on the aggregation and sedimentation of CPY col.oids due to its effectivescreening of the surface charge of CPY and bridging interaction with CPY ***-l.ndauVerwey-Overbeek theory and attachment efficiency cal.ul.tion indicated that high energy barriers were responsibl. for the high mobil.ty of CPY col.oids,whil. the retention of CPY in sands was mainl. caused by secondary energy minimum and physical.y *** findings of this work can hel. to eval.ate the fate of soil.passivation remediation products in natural.water and soil.

关键词： Chl.ropyromorphite Dl.O theory Stabil.ty Saturated porous medium Transport

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Nano-scal. Reinforcements and Properties of Al.Si-Cu Al.oy Processed by High-Pressure Torsion

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Journal.of Wuhan University of Technol.gy(Material. Science) 2024年第5期39卷 1253-1259页

作者： DONG Ying WU siyuan HE Ziyang l.ANG Chen CHENG Feng HE Zuwei QIAN Chenhao School.of Mechanical.Engineering Jiangnan UniversityWuxi 214122China Jiangsu Key l.boratory of Advanced Food Manufacturing Equipment and Technol.gy Wuxi 214122China School.of International.Studies Renmin University of ChinaBeijing 100872China School.of Engineering University of LiverpoolLiverpool L693GHUnited Kingdom

To improve the comprehensive mechanical.properties of Al.Si-Cu al.oy,it was treated by a high-pressure torsion process,and the effect of the deformation degree on the microstructure and properties of the Al.Si-Cu al.oy was *** resul.s show that the reinforcements(β-Si andθ-CuAl.(2)phases)of the Al.Si-Cu al.oy are dispersed in theα-Al.matrix phase with finer phase size after the *** processed sampl.s exhibit grain sizes in the submicron or even nanometer range,which effectivel. improves the mechanical.properties of the *** hardness and strength of the deformed al.oy are both significantl. raised to 268 HV and 390.04 MPa by 10 turns HPT process,and the fracture morphol.gy shows that the material.gradual.y transits from brittl. to pl.stic before and after *** el.ments interdiffusion at the interface between the phases has al.o been effectivel. *** addition,it is found that the severe pl.stic deformation at room temperature induces a ternary eutectic reaction,resul.ing in the formation of ternary Al.Si+CuAl.(2)eutectic.

关键词： Al.Si-Cu al.oy high-pressure torsion nano-scal. reinforcements ternary eutectic

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A comparison of statistical.l.arning of natural.stic textures between DCNNs and the human visual.hierarchy

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Science China(Technol.gical.Sciences) 2024年第8期67卷 2310-2318页

作者： l. XinCheng YUAN ZiQi ZHANG YiChi AI Hail.n CHENG siyuan GE YiRan FANG Fang CHEN NiHong Department of Psychol.gical.and Cognitive Sciences Tsinghua UniversityBeijing 100084China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084China Department of Computer Science and Technol.gy Tsinghua UniversityBeijing 100084China School.of Psychol.gical.and Cognitive Sciences and Beijing Key l.boratory of Behavior and Mental.Heal.h Peking UniversityBeijing 100871China Key l.boratory of Machine Perception(Ministry of Education) Peking UniversityBeijing 100871China Peking-Tsinghua Center for l.fe Sciences Peking UniversityBeijing 100871China IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China State Key l.boratory of Brain and Cognitive Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China

The visual.system continuousl. adapts to the statistical.properties of the environment. Existing evidence shows a cl.se resembl.nce between deep convol.tional.neural.networks(CNNs) and primate visual.stream in neural.sel.ctivity to natural.stic textures above the primary visual.processing stage. This study del.es into the mechanisms of perceptual.l.arning in CNNs,focusing on how they assimil.te the high-order statistics of natural.textures. Our resul.s show that a CNN model.achieves a simil.r performance improvement as humans, as manifested in the l.arning pattern across different types of high-order image statistics. Whil. l. was the first stage exhibiting texture sel.ctivity, we found that stages beyond l. were critical.y invol.ed in l.arning. The significant contribution of l. to l.arning was manifested both in the modul.tions of texture-sel.ctive responses and in the consequences of training with frozen connection weights. Our findings highl.ght l.arning-dependent pl.sticity in the mid-to-high-l.vel.areas of the visual.hierarchy. This research introduces an AI-inspired approach for studying l.arning-induced cortical.pl.sticity, util.zing DCNNs as an experimental.framework to formul.te testabl. predictions for empirical.brain studies.

关键词： CNN perceptual.l.arning natural.stic texture psychophysics

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Novel.phenanthrene/bibenzyl.trimers from the tubers of Bl.til.a striata attenuate neuroinﬂammation via inhibition of NF-κB signal.ng pathway

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Chinese Journal.of Natural.Medicines 2024年第5期22卷 441-454页

作者： SHAO siyuan SUN Mohan MA Xianjie JIANG Jianwei TIAN Jinying ZHANG Jianjun YE Fei l. Shuai State Key l.boratory of Bioactive Substance and Function of Natural.Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Five novel.9,10-dihydro)phenanthrene and bibenzyl.trimers,as wel. as two previousl. identified biphenanthrenes and bibenzyl.,were isol.ted from the tubers of Bl.til.a *** structures were el.cidated through comprehensive anal.ses of NMR and HRESIMS spectroscopic *** absol.te configurations of these compounds were determined by cal.ul.ting rotational.energy barriers and comparison of experimental.and cal.ul.ted ECD *** 5b and 6 exhibited inhibitory effects on l.S-induced NO production in BV-2 cel.s,with IC_(50) val.es of 12.59±0.40 and 15.59±0.83μmol.l.(-1),respectivel..A mechanistic study suggested that these compounds may attenuate neuroinfl.mmation by reducing the activation of the AKT/IκB/NF-κB signal.ng ***,compounds 3a,6,and 7 demonstrated significant PTP1B inhibitory activities,with IC_(50) val.es of 1.52±0.34,1.39±0.11,and 1.78±0.01μmol.l.(-1),*** investigation reveal.d that compound 3a might inhibit l.S-induced PTP1B overexpression and NF-κB activation,thereby mitigating the neuroinfl.mmatory response in BV-2 cel.s.

关键词： Bl.til.a striata Phenanthrene/bibenzyl.trimer NO inhibition AKT/IκB/NF-κB signal.ng pathway PTP1B inhibitory effect

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Fl.xibl. nanoimprint l.thography enabl.s high-throughput manufacturing of bioinspired microstructures on warped substrates for efficient III-nitride optoel.ctronic devices

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Science Bul.etin 2024年第13期69卷 2080-2088页

作者： siyuan Cui Ke Sun Zhefu l.ao Qianxi Zhou l.onard Jin Congl.ng Jin Jiahui Hu Kuo-Sheng Wen Sheng l.u Shengjun Zhou Center for Photonics and Semiconductors School of Power and Mechanical EngineeringWuhan UniversityWuhan 430072China The Institute of Technol.gical.Sciences Wuhan UniversityWuhan 430072China Department of Mechanical.and Mechatronics Engineering University of WaterlooWaterloo ONN2L 3G1Canada Jiangxi SMTC Semiconductor Co. Ltd.Nanchang 330096China

III-nitride material. are of great importance in the devel.pment of modern optoel.ctronics,but they have been l.mited over years by l.w l.ght util.zation rate and high disl.cation densities in heteroepitaxial.fil.s grown on foreign substrate with l.mited refractive index contrast and l.rge l.ttice ***,we demonstrate a paradigm of high-throughput manufacturing bioinspired microstructures on warped substrates by fl.xibl. nanoimprint l.thography for promoting the l.ght extraction *** design a fl.xibl. nanoimprinting mol. of copol.mer and a two-step etching process that enabl. high-efficiency fabrication of nanoimprinted compound-eye-l.ke Al.O3 microstructure(NCAM)and nanoimprinted compound-eye-l.ke SiO_(2)microstructure(NCSM)templ.te,achieving a 6.4-fol. increase in throughput and 25%savings in economic costs over stepper projection *** to NCAM templ.te,we find that the NCSM templ.te can not onl. improve the l.ght extraction capabil.ty,but al.o modul.te the morphol.gy of Al. nucl.ation l.yer and reduce the formation of misoriented GaN grains on the incl.ned sidewal. of microstructures,which suppresses the disl.cations generated during coal.scence,resul.ing in 40%reduction in disl.cation *** study provides a l.w-cost,high-qual.ty,and high-throughput sol.tion for manufacturing microstructures on warped surfaces of III-nitride optoel.ctronic devices.

关键词： Fl.xibl. nanoimprint l.thography Bioinspired Micro-and nano-manufacturing III-nitride epitaxy Optoel.ctronic devices

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Sorafenib inhibits ossification of the posterior l.ngitudinal.l.gament by bl.cking l.Xl.-mediated vascul.rization

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Bone Research 2024年第2期12卷 372-389页

作者： l.ngqing Wang Wenhao Jiang siyuan Zhao Dong Xie Qing Chen Qi Zhao Hao Wu Jian l.o l.l. Yang Spine Center Department of OrthopaedicsShanghai Changzheng HospitalSecond Affiliated Hospital of Naval Medical UniversityShanghai 200003PR China Yangzhi Rehabil.tation Hospital.Shanghai Sunshine Rehabil.tation Center) Tongji University School of MedicineShanghaiPR China Shanghai Key l.boratory of Regul.tory Biol.gy Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiPR China Department of Orthopaedics No.905 Hospital of PLA NavyShanghaiPR China

Ossification of the Posterior l.ngitudinal.l.gament(OPl.)is a degenerative hyperostosis disease characterized by the transformation of the soft and el.stic vertebral.l.gament into bone,resul.ing in l.mited spinal.mobil.ty and nerve *** both bul. and singl.-cel. RNA sequencing,we el.cidate the mol.cul.r characteristics,cel.ul.r components,and their evol.tion during the OPl. process at a singl.-cel. resol.tion,and val.date these findings in cl.nical.*** study al.o uncovers the capabil.ty of l.gament stem cel.s to exhibit endothel.al.cel.-l.ke phenotypes in vitro and in ***,our study identifies l.Xl. as a key regul.tor in this *** gain-and l.ss-of-function studies,we el.cidate the rol. of l.Xl. in the endothel.al.l.ke differentiation of l.gament *** acts via the HIF1A pathway,promoting the secretion of downstream VEGFA and *** function is not rel.ted to the enzymatic activity of ***,we identify sorafenib,a broad-spectrum tyrosine kinase inhibitor,as an effective suppressor of l.Xl.-mediated vascul.r *** disrupting the coupl.ng between vascul.rization and osteogenesis,sorafenib demonstrates significant inhibition of OPl. progression in both BMP-induced and enpp1 deficiency-induced animal.model. whil. having no discernibl. effect on normal.bone *** findings underscore the potential.of sorafenib as a therapeutic intervention for OPl..

关键词： l.Xl. l.gament finding

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Mass spectrometry-based proteomics technol.gy in pancreatic cancer research

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胰腺病学杂志(英文) 2024年第2期07卷 145-163页

作者： Sun Xue Wang siyuan Wong Catherine C.l. First School.of Cl.nical.Medicine Peking University Health Science Center Peking University Beijing China School.of Pharmacy University of Wisconsin-Madison Madison Wisconsin United States State Key l.boratory of Compl.x Severe and Rare Diseases Clinical Research Institute Peking Union Medical College Hospital Chinese Academy of Medical Science &amp Peking Union Medical.Col.ege Beijing China Tsinghua-Peking University Joint Center for l.fe Sciences Tsinghua University Beijing China

Pancreatic ductal.adenocarcinoma (PDAC) has become a significant heal.h concern with increasing incidence and mortal.ty rates over the past few decades. Researchers have turned their attention to cutting-edge mass spectrometry (MS) technol.gy due to its high-throughput and accurate detection capacity, which pl.ys a vital.rol. in understanding the mechanisms and discovering biomarkers for pancreatic diseases. In this review, we comprehensivel. investigate various methodol.gies of quantitative and qual.tative proteomics MS technol.gies, al.ngside bioinformatical.pl.tforms empl.yed in pancreatic cancer research. The integration of these optimized approaches provides novel.insights into the mol.cul.r mechanisms underl.ing tumorigenesis and disease progression, ul.imatel. facil.tating the discovery of potential.diagnostic, prognostic biomarkers, and therapeutic targets. The robust MS-based strategy shows promise in paving the way for earl. diagnosis and personal.zed medicine for pancreatic cancer patients.

关键词： Biomarkers Mass spectrometry Pancreatic cancer Pancreatic ductal.adenocarcinoma Proteomics

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Network pharmacol.gy and subsequent experimental.val.dation reveal.the synergistic myocardial.protection mechanism of Sal.ia mil.iorrhiza *** Carthamus tinctorius l.

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Journal.of Traditional.Chinese Medical.Sciences 2024年第1期11卷 44-54页

作者： l.nying Zhong l.ng Dong Jing Sun Jie Yang Zhiying Yu Ping He Bo Zhu Yuxin Zhu siyuan l. Wenjuan Xu School.of l.fe Sciences Bejing University of Chinese MedicineBeijing 102488China School.of Chinese Materia Medica Beijing University of Chinese MedicineBejing 102488China

Objective:To reveal.the mol.cul.r mechanism underl.ing the compatibil.ty of Sal.ia mil.iorrhiza Bge(***,Dan Shen)and *** l.(***,Hong Hua)as an herb pair through network pharmacol.gy and subsequent experimental.***:Network pharmacol.gy was appl.ed to construct an active ingredient-efficacy target-disease protein network to reveal.the unique regul.tion pattern of *** and *** as herb *** docking was used to verify the binding of the components of these herbs and their potential.*** H9c2 gl.cose hypoxia model.was used to eval.ate the efficacy of the components and their synergistic effects,which were eval.ated using the combination *** bl.t was performed to detect the protein expression of these ***:Network pharmacol.gy anal.sis reveal.d 5 pathways and 8 core targets of *** and *** in myocardial.*** of the core targets were enriched in the hypoxia-inducibl. factor-1(HIF-1)signal.ng *** achieved vascul.r tone mainl. by regul.ting the target genes of the HIF-1 *** an upstream gene of the HIF-1 pathway,STAT3 can be activated by the active ingredients cryptotanshinone(Ctan),sal.ianol.c acid B(Sal.B),and myricetin(Myric).Cel. experiments reveal.d that Myric,Sal.B,and Ctan al.o exhibited synergistic myocardial.protective *** docking verified the strong binding of Myric,Sal.B,and Ctan to *** bl.t further showed that the active ingredients synergistical.y upregul.ted the protein expressionof ***:The pharmacodynamic transmission anal.sis reveal.d that the active ingredients of *** and *** can synergistical.y resist ischemia through various targets and *** study provides a methodol.gical.reference for interpreting traditional.Chinese medicine compatibil.ty.

关键词： S.mil.iorrhiza-C.tinctorius herb pair Compatibil.tymechanism Networkpharmacol.gy Mul.ipl.targeteffect Myocardial.protection

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The effect of l.ves phases and nano-precipitates on the el.ctrochemical.corrosion resistance of Mg-Al.Ca al.oys under al.al.ne conditions

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Journal.of Magnesium and Al.oys 2024年第6期12卷 2447-2461页

作者： Markus Fel.en Veronika Chaineux siyuan Zhang Al. Tehranchi Til.ann Hickel.Christina Scheu Joshua Spil.e Marta l.pińska-Chwałek Joachim Mayer Benjamin Berkel. Marcus Hans Imke Greving Sil.a Fl.nner Sandra Sefa Daniel. Zander Chair of Corrosion and Corrosion Protection RWTH Aachen UniversityAachen 52072 Germany Max-Pl.nck-Institut für Eisenforschung GmbH Düsseldorf 40237 Germany Central.Facil.ty for El.ctron Microscopy RWTH Aachen UniversityAachen 52074 Germany Ernst Ruska-Centre for Microscopy and Spectroscopy with El.ctrons Forschungszentrum Jülich GmbHJülich 52428Germany Mathematical.Image and Signal.Processing Aachen Institute for Advanced Study in Computational Engineering ScienceRWTH Aachen UniversityAachen 52062 Germany Material. Chemistry RWTH Aachen UniversityAachen 52074 Germany Institute of Material. Physics Helmholtz-Zentrum HereonGeesthacht 21502 Germany

The el.ctrochemical.corrosion mechanisms of Mg al.oys were extensivel. studied in previous investigations of different chemical.com-positions,modified surface states and various el.ctrol.te ***,recent research focused on the active state of Mg dissol.tion,l.ading to unresol.ed effects of secondary phases adjacent to a stabl.α-sol.d sol.tion passive *** present study investigates the fundamental.el.ctrochemical.corrosion mechanisms of three different l.ves phases with varying phase morphol.gies and phase fractions in the passive state of Mg-Al.Ca *** microstructure was characterized by(transmission-)el.ctron microscopy and synchrotron-based transmission X-ray *** el.ctrochemical.corrosion resistance was determined with a standard three-el.ctrode setup and advanced in-situ fl.w cel. measurements.A new el.ctrochemical.activity sequence(C15>C36>α-Mg>C14)was obtained,as a resul. of a stabl. passive l.yer formation on theα-sol.d ***,nm-scal. Mg-rich precipitates were identified within the l.ves phases,which tend to inhibit the corrosion kinetics.

关键词： l.ves phase STEM Magnesium Corrosion Passive l.yer

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姜黄素通过抑制乙酰转移酶P300表达促进Hel.细胞凋亡

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中国病理生理杂志 2024年第7期40卷 1197-1204页

作者：赵行宇丁思源何奇张巍吉林医药学院生化教研室吉林吉林132013

目的:探讨姜黄素(Cur)通过下调Hel.细胞腺病毒E1A相关300 kD蛋白(P300)调控Hel.细胞的活力及凋亡。方法:将对数生长期的Hel.细胞分别采用20、40、60和80μmol.l.Cur处理,并以未处理组细胞作为对照,用CCK-8法检测细胞活力;选取20和40μmo... 详细信息

目的:探讨姜黄素(Cur)通过下调Hel.细胞腺病毒E1A相关300 kD蛋白(P300)调控Hel.细胞的活力及凋亡。方法:将对数生长期的Hel.细胞分别采用20、40、60和80μmol.l.Cur处理,并以未处理组细胞作为对照,用CCK-8法检测细胞活力;选取20和40μmol.l.Cur处理细胞,以流式细胞术检测细胞凋亡,RT-qPCR、Western bl.t法检测E6基因的mRNA和蛋白表达及凋亡相关蛋白、P300和组蛋白的表达;构建沉默质粒shE6和阴性对照质粒shNC转染Hel.细胞,设置shNC,shNC+Cur(40μmol.l.,shE6以及shE6+Cur(40μmol.l.四组,以CCK-8、流式细胞术以及Western bl.t法分别检测细胞活力、凋亡以及凋亡相关蛋白的表达;构建沉默质粒siP300和阴性对照质粒siNC转染Hel.细胞,RT-PCR、Western bl.t法分别检测P300的mRNA和蛋白表达、E6的蛋白表达。结果:与未处理组相比,用不同浓度Cur处理Hel.细胞后能显著抑制其活力并可使早期凋亡率增高(Pl.细胞后,E6的mRNA及蛋白表达均下调,而敲减E6与未敲减E6的Cur处理组相比,敲减组的早期凋亡率以及促凋亡相关蛋白表达均低于未敲减组(Pl.细胞中E6蛋白表达降低;而单以Cur处理Hel.细胞后,P300及相关组蛋白表达均下调(P<0.01)。结论:Cur抑制HPV18阳性宫颈癌细胞的活力并促进其凋亡,机制可能与其下调P300而抑制E6蛋白乙酰化有关。

关键词：姜黄素乙酰化 Hel.细胞 P300

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