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Comparison of ocular biometry in Chinese patients using two swept-source optical coherence tomography devices

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Annals of Eye Science 2023年第3期8卷 59-69页

作者： Vivian Wing-Man Ho hong Chau Nguyen siu-hong wong Anita Lai-Wah Li Kenneth Kai Wang Li Department of Ophthalmology United Christian HospitalKwun TongHong Kong SARChina Department of Ophthalmology Tseung Kwan O HospitalHong Kong SARChina Department of Ophthalmology School of Clinical MedicineLKS Faculty of MedicineThe University of Hong KongHong Kong SARChina

Background:To compare two swept-source optical coherence tomography(SS-OCT)biometers,IOLMaster 700 and ***:This is a retrospective *** measurements of cataract patients performed between March and July 2021 in the Department of Ophthalmology,United Christian Hospital,hong Kong,were *** scheduled for cataract surgery were measured with both SS-OCT devices on the same *** following biometry parameters were compared:keratometry(K),total keratometry(TK),axial length(AL),central corneal thickness(CCT),anterior chamber depth(ACD),lens thickness(LT),white-to-white(WTW)and the predicted intraocular lens(IOL)power to achieve *** assess the agreement between the devices,Bland-Altman analysis with 95%limits of agreement(LoA)were ***:In total,92 eyes of 47 subjects were measured with both *** were statistically significant differences between the two biometers for most measurements(P<0.05)except for flat K,AL and IOL power when using the right eyes for *** the left eyes,there were statistically significant differences in the measurements from the two biometers in all parameters except for flat and steep *** ANTERION did not obtain ACD,AL and LT in 2(2.17%),1(1.09%)and 5 cases(5.43%)***:The two biometers showed a clinically acceptable agreement in most *** showed significant differences in most parameters but not clinically relevant except for the TK and WTW,and these two parameters should not be used interchangeably between the devices.

关键词： Ocular biometry cataract swept-source optical coherence ANTERION IOLMaster 700

An AIEgen/graphene oxide nanocomposite(AIEgen@GO)-based two-stage“turn-on”nucleic acid biosensor for rapid detection of SARS-CoV-2 viral sequence

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Aggregate 2023年第1期4卷 219-230页

作者： Qin Zhang Bohan Yin Jianhua Hao Linjie Ma Yingying Huang Xueying Shao Chuanqi Li Zhiqin Chu Changqing Yi siu hong Dexter wong Mo Yang Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina Department of Electrical and Electronic Engineering Joint Appointment with School of Biomedical SciencesThe University of Hong KongHong KongChina Key Laboratory of Sensing Technology and Biomedical Instruments(Guangdong Province) School of Biomedical EngineeringSun Yat-Sen UniversityGuangzhouPR China

The ongoing outbreak of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)pandemic has posed significant challenges in early viral ***,it is urgently desirable to develop a rapid,inexpensive,and sensitive method to aid point-of-care SARS-CoV-2 *** this work,we report a highly sequence-specific biosensor based on nanocomposites with aggregationinduced emission luminogens(AIEgen)-labeled oligonucleotide probes on graphene oxide nanosheets(AIEgen@GO)for one step-detection of SARS-CoV-2-specific nucleic acid sequences(Orf1ab or N genes).A dual“turn-on”mechanism based on AIEgen@GO was established for viral nucleic acids ***,the first-stage fluorescence recovery was due to dissociation of the AIEgen from GO surface in the presence of target viral nucleic acid,and the second-stage enhancement of AIEbased fluorescent signal was due to the formation of a nucleic acid duplex to restrict the intramolecular rotation of the ***,the feasibility of our platform for diagnostic application was demonstrated by detecting SARS-CoV-2 virus plasmids containing both Orf1ab and N genes with rapid detection around 1 h and good sensitivity at pM level without *** platform shows great promise in assisting the initial rapid detection of the SARS-CoV-2 nucleic acid sequence before utilizing quantitative reverse transcription-polymerase chain reaction for second confirmation.

关键词： aggregation-induced emission(AIE)luminogen graphene oxide SARS-CoV-2 detection

A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer’s disease therapy

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Bioactive Materials 2024年第12期42卷 165-177页

作者： Qin Zhang Chuanqi Li Bohan Yin Jiaxiang Yan Yutian Gu Yingying Huang Jiareng Chen Xinyue Lao Jianhua Hao Changqing Yi Yi Zhou James Chung Wai Cheung siu hong Dexter wong Mo Yang School of Medicine and Pharmacy Ocean University of ChinaQingdao266003ChinaLaboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology CenterQingdao266237China Department of Biomedical Engineering The Hong Kong Polytechnic University999077Hong KongChina The hong Kong Polytechnic University Shenzhen Research Institute Shenzhen518000China Research Center for Nanoscience and Nanotechnology The Hong Kong Polytechnic UniversityKowloon999077Hong KongChina Joint Research Center of Biosensing and Precision Theranostics The Hong Kong Polytechnic UniversityKowloon999077Hong KongChina Department of Applied Physics The Hong Kong Polytechnic University999077Hong KongChina Key Laboratory of Sensing Technology and Biomedical Instruments(Guangdong Province) School of Biomedical EngineeringSun Yat-Sen UniversityGuangzhou510000China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou510080China

Abnormal hyperphosphorylation of tau protein is a principal pathological hallmark in the onset of neurodegenerative disorders,such as Alzheimer’s disease(AD),which can be induced by an excess of reactive oxygen species(ROS).As an antioxidant,hydrogen gas(H_(2))has the potential to mitigate AD by scavenging highly harmful ROS such as·***,conventional administration methods of H_(2) face significant challenges in controlling H_(2) release on demand and fail to achieve effective accumulation at lesion ***,we report artificial nanoreactors that mimic natural photosynthesis to realize near-infrared(NIR)light-driven photocatalytic H_(2) evolution in *** nanoreactors are constructed by biocompatible crosslinked vesicles(CVs)encapsulating ascorbic acid and two photosensitizers,chlorophyll a(Chla)and indoline dye(Ind).In addition,platinum nanoparticles(Pt NPs)serve as photocatalysts and upconversion nanoparticles(UCNP)act as light-harvesting antennas in the nanoreacting system,and both attach to the surface of *** NIR irradiation,the nanoreactors release H_(2) in situ to scavenge local excess ROS and attenuate tau hyperphosphorylation in the AD mice *** NIR-triggered nanoreactors provide a proof-of-concept design for the great potential of hydrogen therapy against AD.

关键词： Artificial photosynthesis Hydrogen therapy Oxidative stress Tau hyperphosphorylation Alzheimer’s disease

Recent advances in optical techniques for dynamically probing cellular mechanobiology

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Biomedical Engineering Communications 2024年第3期3卷 3-11页

作者： Fengqi Wang Qin Zhang Mo Yang Bohan Yin siu hong Dexter wong School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology CenterQingdao 266237China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China.

Cellular mechanotransduction characterized by the transformation of mechanical stimuli into biochemical signals,represents a pivotal and complex process underpinning a multitude of cellular *** process is integral to diverse biological phenomena,including embryonic development,cell migration,tissue regeneration,and disease pathology,particularly in the context of cancer metastasis and cardiovascular *** the profound biological and clinical significance of mechanotransduction,our understanding of this complex process remains *** recent development of advanced optical techniques enables in-situ force measurement and subcellular manipulation from the outer cell membrane to the organelles inside a *** this review,we delved into the current state-of-the-art techniques utilized to probe cellular mechanobiology,their principles,applications,and *** mainly examined optical methodologies to quantitatively measure the mechanical properties of cells during intracellular transport,cell adhesion,and *** provided an introductory overview of various conventional and optical-based techniques for probing cellular *** techniques have provided into the dynamics of mechanobiology,their potential to unravel mechanistic intricacies and implications for therapeutic intervention.

关键词： mechanobiology cell adhesion optical techniques live cell imaging cell fates

Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana Ching-On wong Department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo Yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

Nanoimprint lithography-assisted block copolymer self-assembly for hyperfine fabrication of magnetic patterns based on L10-FePt nanoparticles

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Science China Chemistry 2025年

作者： Jie Zhang Yi Chen Guijun Li Zelin Sun Zhengong Meng Wai-Yeung wong Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic University The hong Kong Polytechnic University Shenzhen Research Institute Division of Integrative Systems and Design and Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology School of Flexible Electronics (Future Technology) and Institute of Advanced Materials (IAM) Nanjing Tech University

L10-FePt-type bit-patterned media has provided a promising alternative for ultrahigh-density magnetic recording systems in the current digital era, but rapid fabrication of magnetic patterns with hyperfine bit islands is still challenging, especially with the target for miniaturization and scalable production simultaneously. Herein, Fe,Pt-containing block copolymers were utilized as single-source precursors for solution-processable patterning and subsequent generation of the demanding magnetic FePt dots by in situ pyrolysis. High-throughput nanoimprint lithography was initially employed to fabricate the predefined bit cells precisely,and then the intrinsic self-assembly of phase-separated block copolymers further drove the formation of accurate bit *** from the synergistic effect of top-down lithographic approach and bottom-up self-assembly, the customizable patterns could be achieved for large-scale mass production in targeted areas, but high-density isolated dots could also be accurately aligned along the patterned features after subsequent self-assembly. This reliable strategy would provide a good avenue to precisely construct ultrahigh-density magnetic data storage devices.

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An overview on the chemistry, pharmacology and anticancer properties of tetrandrine and fangchinoline(alkaloids) from Stephania tetrandra roots

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Journal of Integrative Medicine 2021年第4期19卷 311-316页

作者： Eric Wei Chiang Chan siu Kuin wong Hung Tuck Chan Faculty of Applied Sciences UCSI UniversityKuala Lumpur 56000Malaysia School of Foundation Studies Xiamen University MalaysiaSelangor 43900Malaysia Secretariat of the International Society for Mangrove Ecosystems(ISME) Faculty of AgricultureUniversity of the RyukyusOkinawa 903-0129Japan

Tetrandrine(TET) and fangchinoline(FAN) are dominant bisbenzylisoquinoline(BBIQ) alkaloids from the roots of Stephania tetrandra of the family Menispermaceae. BBIQ alkaloids comprise two benzylisoquinoline units linked by oxygen bridges. The molecular structures of TET and FAN are exactly the same, except that TET has a methoxy(-OCH3) group, while FAN has a hydroxyl(-OH) group at C7. In this overview,the current knowledge on the chemistry, pharmacology and anticancer properties of TET and FAN have been updated. The focus is on colon and breast cancer cells, because they are most susceptible to TET and FAN, respectively. Against colon cancer cells, TET inhibits cell proliferation and tumor growth by inducing apoptosis and G1 cell cycle arrest, and suppresses adhesion, migration and invasion of *** breast cancer cells, FAN inhibits cell proliferation by inducing apoptosis, G1-phase cell cycle arrest and inhibits cell migration. The processes involve various molecular mechanisms and signaling pathways. Some insights on the ability of TET and FAN to reverse multi-drug resistance in cancer cells and suggestions for future research are provided.

关键词： Tetrandrine Fangchinoline Alkaloids Pharmacology Anticancer Multi-drug resistance

Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties

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Journal of Integrative Medicine 2018年第3期16卷 147-152页

作者： Eric Wei Chiang Chan siu Kuin wong Hung Tuck Chan Faculty of Applied Sciences UCSI University School of Science Monash University Secretariat of International Society for Mangrove Ecosystems Faculty of Agriculture University of the Ryukyus

This short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond,two hydroxyl groups and four methoxyl groups. Casticin has been isolated from various tissues of plants in the Vitex genus： fruits and leaves of V. trifolia, aerial parts and seeds of V. agnus-castus and leaves of ***. Studies have reported the antiproliferative and apoptotic activities of casticin from Vitex *** compound is effective against many cancer cell lines via different molecular mechanisms. Studies have also affirmed the anti-inflammatory properties of casticin, with several molecular mechanisms identified. Other pharmacological properties include anti-asthmatic, tracheospasmolytic, analgesic, antihyperprolactinemia, immunomodulatory, opioidergic, oestrogenic, anti-angiogenic, antiglioma, lung injury protection, rheumatoid arthritis amelioration and liver fibrosis attenuation activities. Clinical trials and commercial use of the casticin-rich fruit extract of V. agnus-castus among women with premenstrual syndrome were briefly discussed.

关键词： Vitexicarpin Polymethylflavone Apoptosis Molecular mechanisms