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Stereoselective metabolic disruption of cypermethrin by remolding gut homeostasis in rat

Journal of Environmental Sciences 2023年第4期126卷 761-771页

作者： Quan Zhang Sijia Gu YanWang Shitao Hu siqing yue Cui Wang Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province College of EnvironmentZhejiang University of TechnologyHangzhou 310032China School of Life Science Zhejiang Chinese Medical UniversityHangzhou 310053China

Cypermethrin(CYP), a prototypical synthetic pyrethroid, reportedly causes metabolic disruption, while its stereoselective impact remains elusive. This study initially revealed that only α-CYP caused significant weight loss at 8.5 mg/(kg·day) in rats. All three CYP isomers caused the accumulation of hepatic glycogen, and hyperlipemia phenotype as the increment of total triglyceride. Rats treated with α-CYP had markedly high blood glucose levels and homeostasis model assessment of insulin resistance index. The systematic inflammation of θ-CYP group rats was evidenced by high lipopolysaccharide-binding protein levels and abnormalities of leukocytes indices. By examining the gut microbiome, we found thatα-CYP-treated rats had low contents of Firmicutes and high levels of Verrucomicrobia while Elusimicrobia was enriched in the β-CYP group. The increasing alpha diversity in the θ-CYP group may be due to the dominance of pathogenic bacteria and the increase of probiotics to counteract adverse effects. Exclusively, the α-CYP group enriched total short-chain fatty acids(SCFAs), whereas most SCFAs depleted in the θ-CYP group. The correlation analysis further found Firmicutes, an energy storage modulator, was positive to body weight(BW),while SCFAs exerted the opposite, confirming the low BW in α-CYP. Blood glucose that correlated well with SCFAs and Verrucomicrobia can be accounted for the discrepancy betweenα-CYP and θ-CYP. Overall, the three isomers exerted stereoselective glycolipid disruption in rats, and gut homeostasis acted as vital indicators.

关键词： Cypermethrin Stereoisomeric selectivity Gut microbiota Short-chain fatty acids Glycolipid metabolism

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Polyhalogenated carbazoles induce hepatic metabolic disorders in mice via alteration in gut microbiota

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Journal of Environmental Sciences 2023年第5期127卷 603-614页

作者： Chenyang Ji Yunkai Luo Jiawen Yang Yaoyao Dai Jiahui Miao siqing yue Meirong Zhao Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province Interdisciplinary Research AcademyZhejiang Shuren UniversityHangzhou 310015China Department of Ultrasound in Medicine The Fourth Affiliated Hospital of Zhejiang University School of MedicalYiwu 322000China Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province College of EnvironmentZhejiang University of TechnologyHangzhou 310014China

Polyhalogenated carbazoles(PHCZs)have been widely accepted as emerging pollutants,whereas their ecological and health risks remain ***,female and male Sprague-Dawley(SD)mice were treated with four typical PHCZs to investigate their negative consequences,along with alternations in gutmicrobiota to indicate *** female mice,the relative liver weight ratio increased after four PHCZs exposure;2-bromocarbazole(2-BCZ)increased urine glucose level;3-bromocarbazole(3-BCZ)decreased the glucose and total cholesterol levels;3,6-dichlorocarbazole(3,6-DCCZ)decreased glucose *** only disturbed biochemical index in male mice was the promoted alkaline phosphatase(ALP)level by 3,*** also found that the differential blood biochemical indices were correlated with gut microbiota.3-BCZ and 3,6-DCCZ altered Bacteroidetes and Proteobacteria phyla in female and male mice,which were correlated with metabolic *** findings demonstrated the correlation between PHCZs induced potential hepatotoxicity andmetabolic disordersmay be due to their dioxin-like potentials and endocrine disrupting activities,and the gender differences might result from their estrogenic ***,data presented here can help to evaluate the ecological and health risks of PHCZs and reveal the underlying mechanisms.

关键词： Polyhalogenated carbazoles Liver Metabolic disorders Gut microbiota

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基于多组学技术的农药致毒机制研究进展

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农药学学报 2019年第5期21卷 823-830页

作者：毛曼菲岳思青赵美蓉浙江工业大学环境学院

中国作为农业大国,国家的安宁稳定与粮食生产及安全密不可分。农药使用在保障农作物高产稳产的同时,其与环境安全和食品安全的矛盾也越来越突出,因而对农药风险评估与管理的研究正日益受到研究者的关注。多组学技术已在生命科学及医药... 详细信息

中国作为农业大国,国家的安宁稳定与粮食生产及安全密不可分。农药使用在保障农作物高产稳产的同时,其与环境安全和食品安全的矛盾也越来越突出,因而对农药风险评估与管理的研究正日益受到研究者的关注。多组学技术已在生命科学及医药学等领域得到迅猛发展,但其在农药风险评估和致毒机制研究中的应用尚处于起步阶段,未来发展空间较大。文章重点比较分析了基因组学、蛋白质组学、代谢组学及表观遗传学等组学方法在农药致毒分子机制研究方面的进展及优劣,根据研究发现的各种关键性生物标志物及其重要调控信号路径,综合探讨了基于多组学技术的农药对非靶标生物的毒性作用机制,以及多组学技术在农药风险管理中的应用。

关键词：多组学基因组学蛋白质组学代谢组学表观遗传学致毒机制研究进展

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抑霉唑的毛细管电泳手性拆分及其在线富集

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农药学学报 2019年第3期21卷 309-314页

作者：虞婕许杭杰赵美蓉岳思青浙江工业大学环境学院

采用毛细管电泳法对抑霉唑进行手性拆分,研究了手性选择剂β-环糊精(β-CD)、有机添加剂、NaH2PO4、NH4H2PO4和分离电压对手性拆分的影响;同时,采用堆积法对抑霉唑进行在线富集,研究了进样压力和进样时间对在线富集的影响。结果表明:在... 详细信息

采用毛细管电泳法对抑霉唑进行手性拆分,研究了手性选择剂β-环糊精(β-CD)、有机添加剂、NaH2PO4、NH4H2PO4和分离电压对手性拆分的影响;同时,采用堆积法对抑霉唑进行在线富集,研究了进样压力和进样时间对在线富集的影响。结果表明:在分离电压为20 kV、β-CD浓度为5 mmol/L及缓冲体系为2.5%异丙醇+75 mmol/L NaH2PO4+5 mmol/L NH4H2PO4时,抑霉唑获得最佳分离度,分离度可达3.0;在分离电压为20 kV、β-CD浓度为5 mmol/L、缓冲体系为75 mmol/L NaH2PO4+5 mmol/L NH4H2PO4+50 mmol/L H3PO4及进样条件为13.8 kPa×99.9 s时获得最高富集倍数,富集倍数达91~92倍。

关键词：抑霉唑毛细管电泳手性拆分堆积法在线富集

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Partial inhibition of CDK4 gene expression leads to the extension of G1 phase of V79-8 cells

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Chinese Science Bulletin 1999年第2期44卷 149-153页

作者： Weiqun Xiao siqing Zhang Yongchao Wang yue Wang Beijing Normal Univ Key Lab Cell Proliferat & Regulat Biol Beijing 100875 Peoples R China Natl Univ Singapore Inst Mol & Cell Biol Singapore 117609 Singapore

V79-8 is an abnormal cell line which does not have detectable G1 and G2 phases in its cell *** cell line is derived from V79 cell line which has G1 phase but lacks G2 phase. By using an anti-sense approach, CDK4 gene expression was partially inhibited to find whether CDK4 might contribute to the lack of G1 phase in V79-8 cells. Anti-CDK4 anti-sense plasmid was constructed and used to transfect V79-8 cells. Clones of transfected cells (V79-8-asCDK4) were examined, in comparison with V79-8 cells, to determine its growth curve, cell doubling-time (GT), the level of CDK4 gene expression and the levels of expression of some other growth related genes. V79-8-asCDK4 cells showed a slower growth rate with a doubling time 2.5-h longer than that of V79-8 cells. A flow cytometry (FCM) analysis demonstrated that the 2.5 h increase of the doubling time of V79-8-asCDK4 cells was mainly due to the appearance of G1 phase because its G2+M phase was not significantly different from that of V79-8 cells. The

关键词： CDK4 V79-8 cell line anti-sense and cell doubling time.

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IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells

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Cellular & Molecular Immunology 2019年第7期16卷 644-651页

作者： Ning Liu Yuxue Jiang Jintong Chen He Nan Yinghua Zhao Xiao Chu Alison Wang Dongjiao Wang Tianxue Qin Sujun Gao Ying yue siqing Wang Department of Gynecological Oncology The First Hospital of Jilin UniversityChangchun 130061China Department of Cancer Immunology The First Hospital of Jilin UniversityChangchun 130061China Department of Rheumatology and Immunology China-Japan Union Hospital of Jilin UniversityChangchun 130033China Department of Hematology The First Hospital of Jilin UniversityChangchun 130061China and 5 Department of Cancer BiologyLerner Research InstituteCleveland ClinicClevelandOH 44195USA

Dendritic cell(DC)tumor vaccines exert their antitumor effects through the induction of effector T *** recently identified Tc9 cells as a new potent antitumor effector T cell ***,approaches to direct DCs to preferably prime antitumor Tc9 cells should be further ***,we demonstrate that the addition of interleukin(IL)-33 potently promotes the induction of Tc9 cells by DCs in vitro and in ***-33 treatment also drives the cytotoxic activities of DC-induced Tc9 ***,IL-33 treatment enhances cell survival and proliferation of DC-primed CD8+T *** importantly,the addition of IL-33 during in vitro priming of tumor-specific Tc9 cells by DCs increases the antitumor capability of Tc9 *** studies demonstrated that IL-33 treatment inhibits exhaustive CD8+T cell differentiation by inhibiting PD-1 and 2B4 expression and increasing IL-2 and CD127(IL-7 receptor-α,IL-7Rα)expression in CD8+T ***,the addition of IL-33 further promotes the therapeutic efficacy of DC-based tumor vaccines in the OT-I mouse *** study demonstrates the important role of IL-33 in DC-induced Tc9 cell differentiation and antitumor immunity and may have important clinical implications.

关键词： Interleukin-33 Dendritic cells Tc9 Cancer immunology

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SUPERPOSITION OF STRESSES AND COMBINED STRUCTURE

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Science in China,Ser.B 1987年第8期30卷 875-887页

作者：乐光禹杜思清 Department of Geology Chengdu College of Geology

There are two kinds of superposition in the tectonic deformation of the crust, compound superposition and combined superposition. According to the principle of superposition of elastic theory, the tectonic stress field caused by two or more systems of external forces, acting on a block at the same time, equals superposition of the individual tectonic stress-field produced by the action of the forces applied individually. A group of formulas of stress superposition are given, and the superposition of homogeneous and inhomogeneous stress-fields are analysed. The geometric property and features of deformation of combined structures are explained in this paper.

关键词： SUPERPOSITION OF STRESSES AND COMBINED STRUCTURE

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基于改进SEGNET模型的图像语义分割

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计算机工程 2021年第4期47卷 256-261页

作者：罗嗣卿张志超岳琪东北林业大学信息与计算机工程学院哈尔滨150040

使用原始SEGNET模型对图像进行语义分割时,未对图像中相邻像素点间的关系进行考虑,导致同一目标中像素点类别预测结果不一致。通过在SEGNET结构中加入一条自上而下的通道,使得SEGNET包含的多尺度语义信息更加丰富,从而提升对每个像素点... 详细信息

使用原始SEGNET模型对图像进行语义分割时,未对图像中相邻像素点间的关系进行考虑,导致同一目标中像素点类别预测结果不一致。通过在SEGNET结构中加入一条自上而下的通道,使得SEGNET包含的多尺度语义信息更加丰富,从而提升对每个像素点的类别预测精度,在模型中加入生成对抗网络以充分考虑空间中相邻像素点间关系。实验结果表明,该模型的语义分割效果相比原始SEGNET模型显著提升,且可有效解决SEGNET测试中出现的分类错误问题。

关键词： SEGNET模型生成对抗网络多尺度语义信息相邻像素类别关系特征融合

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掺入催化裂化油浆对减压渣油性质的影响

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石油炼制与化工 2016年第6期47卷 47-51页

作者：杨月沈健程丽华陈思青辽宁石油化工大学辽宁抚顺113001 广东石油化工学院

以中国茂名分公司减压渣油和催化裂化油浆为丙烷脱沥青的原料,对二者在不同掺入比下的组成和性质进行分析,运用数学回归得出其变化规律,并采用质量分数电导率法以及四组分组成法考察了调合油品胶体稳定性的变化。结果表明:调合油品黏度... 详细信息

以中国茂名分公司减压渣油和催化裂化油浆为丙烷脱沥青的原料,对二者在不同掺入比下的组成和性质进行分析,运用数学回归得出其变化规律,并采用质量分数电导率法以及四组分组成法考察了调合油品胶体稳定性的变化。结果表明:调合油品黏度的变化符合指数函数特性;密度、残炭、元素含量和族组成的变化符合一次函数特性;调合油品胶体体系的稳定性下降。综合调合油品的性质与稳定性等情况,催化裂化油浆掺入比控制在30%以下比较合适。

关键词：减压渣油催化裂化油浆调合胶体稳定性

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三级甲等医院护士管理关怀感知的潜在剖面分析

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中国实用护理杂志 2021年第36期37卷 2864-2871页

作者：张斯清王玉玲彭胜张越孙雨晴天津中医药大学研究生院 301617 天津市南开医院临床学院 300100

目的通过分析天津市三级甲等医院护士管理关怀感知的分类特点及不同类别间人口学特征的差异,为护理管理者提供针对性的关怀干预方案提供参考借鉴。方法于2020年5—7月,采用便利抽样法选取天津市6所三级甲等医院456名护士,通过网络问卷... 详细信息

目的通过分析天津市三级甲等医院护士管理关怀感知的分类特点及不同类别间人口学特征的差异,为护理管理者提供针对性的关怀干预方案提供参考借鉴。方法于2020年5—7月,采用便利抽样法选取天津市6所三级甲等医院456名护士,通过网络问卷星平台进行问卷调查。调查内容包括一般资料和中文版管理关怀感知量表。结果456名护士根据护士管理关怀感知构建4个潜在类别,分别为低决策尊重低关怀组(C1组)占20.5%(94/456)、中度决策尊重高关怀组(C2组)占35.6%(162/456)、偏高决策尊重低关怀组(C3组)占18.9%(85/456)、高决策尊重高关怀组(C4组)占25.0%(115/456)。单因素分析显示,不同类别护士在科室、工作年限、科室氛围和家庭支持的分布差异有统计学意义(χ^(2)值为19.119~55.947,均P<0.01)。多项Logistic回归分析显示,科室、工作年限、科室氛围可影响护士管理关怀感知水平(P<0.05或0.01),其中内科、妇产科、重症监护室护士更倾向于C2组(OR值为2.435、5.224、22.291,P<0.05或0.01);外科护士更倾向于C4组(OR值为4.146,P<0.01);工作年限≤5年的护士更倾向于C1、C2组(OR值为0.326、3.811,P<0.05或0.01);科室氛围感知一般的护士更倾向于C1组(OR值为0.057,P<0.01)。结论护士管理关怀感知处于中等偏上水平,可分4个类别。外科、高年资护士、科室氛围感知很融洽及家庭很支持的护士管理关怀感知水平较好;而内科、妇产、重症监护室、科室氛围感知一般及低年资护士的管理关怀感知水平一般,亟待提升。护理管理者可根据不同类别的护士特征制订针对性的关怀管理措施。

关键词：护士管理关怀潜在剖面分析

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