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Design of a large-scale model for wind tunnel test of a multiadaptive flap concept

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Chinese Journal of Aeronautics 2024年第2期37卷 58-80页

作者： Mürüvvet sinem SICIM DEMIRCI Rosario PECORA Metin Orhan KAYA Aeronautical Engineering Department Istanbul Technical UniversityIstanbulTurkey Industrial Engineering Department University of Naples Federico IINapoliItaly

The design and application of morphing systems are ongoing issues compelling the aviation *** Clean Sky-program represents the most significant aeronautical research ever launched in Europe on advanced technologies for greening next-generation *** primary purpose of the program is to develop new concepts aimed at decreasing the effects of aviation on the environment,increasing reliability,and promoting eco-friendly *** ambitions are pursued through research on enabling technologies fostering noise and gas emissions reduction,mainly by improving aircraft aerodynamic *** the Clean Sky framework,a multimodal morphing flap device was designed based on tight industrial requirements and tailored for large civil aircraft *** flap is deployed in one unique setting,and its cross section is morphed differently in take-off and landing to get the necessary extra lift for the specific flight ***,during the cruise,the tip of the flap is deflected for load control and induced drag *** manufacturing the first flap prototype,a high-speed(Ma=0.3),large-scale test campaign(geometric scale factor 1:3)was deemed necessary to validate the performance improvements brought by this novel system at the aircraft *** the other hand,the geometrical scaling of the flap prototype was considered impracticable due to the unscalability of the embedded mechanisms and actuators for shape ***,a new architecture was conceived for the flap model to comply with the scaled dimensions requirements,withstand the relevant loads expected during the wind tunnel tests and emulate the shape transition capabilities of the true-scale *** strategies were developed to effectively morph the model during wind tunnel tests while ensuring the robustness of each morphed configuration and maintaining adequate stiffness levels to prevent undesirable deviations from the intended aerodynamic ***,

关键词： Morphing structures Smart aircraft Morphing flap Adaptive systems Finger-like ribs Wind tunnel tests Large-scale morphing archi-tectures Variable camber airfoil

Effects of obstructive sleep apnea on retinal microvasculature

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国际眼科杂志:英文版 2023年第10期16卷 1670-1675页

作者： Müjdat Karabulut Semai Bek sinem Karabulut Aylin Karalezli Gülnihal Kutlu Ophthalmology Department Mugla Sitki Kocman University Training and Research HospitalMugla 48300Türkiye Neurology Department Mugla Sitki Kocman University Faculty of MedicineMugla 48300Türkiye Ophthalmology Department Mugla Sitki Kocman University Faculty of MedicineMugla 48300Türkiye

AIM:To detect retinal microvascular variations in obstructive sleep apnea syndrome ***:This prospective,observational case-control study included healthy controls and patients with mild,moderate,and severe obstructive sleep apnea *** parameters,foveal avascular area,and flow areas in macula-centered,6.00×6.00 mm2 scan size optical coherence tomography angiography images were ***:The control group had the highest whole image,parafoveal,and perifoveal vessel density among the groups in both superficial and the deep capillary plexus(all P<0.05).Rapid eye movement sleep apnoea-hypopnoea index was reversely correlated with whole(Rho=-0.195,P=0.034),parafoveal(Rho=-0.242,P=0.008),perifoveal(Rho=-0.187,P=0.045)vessel density in the superficial capillary plexus,and whole(Rho=-0.186,P=0.046),parafoveal(Rho=-0.260,P=0.004),perifoveal(Rho=-0.189,P=0.043)vessel density in the deep capillary plexus,though the mean and non-rapid eye movement sleep apnoeahypopnoea index related with only parafoveal vessel density in the superficial capillary plexus(Rho=-0.213,P=0.020;Rho=-0.191,P=0.038)and the deep capillary plexus(Rho=-0.254,P=0.005;Rho=-0.194,P=0.035).CONCLUSION:This study shows decreased vessel density and its reverse correlation with the apnoea-hypopnoea index in patients with obstructive sleep apnea syndrome.

关键词： apnoea-hypopnoea index deep capillary plexus obstructive sleep apnea superficial capillary plexus vessel density retinal microvasculature

On the Gauss-Weierstrass Summability of Multiple Trigonometric Series at μ-smoothness Points

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Acta Mathematica Sinica,English Series 2011年第4期27卷 741-746页

作者： sinem SEZER Ilham A. ALIEV Department of Mathematics Akdeniz University 07058 Antalya Turkey

The notion of μ-smoothness points of periodic functions of several variables is introduced and the rate of convergence of the Gauss-Weierstrass means of relevant Fourier series at these points is investigated.

关键词： Multiple Fourier series Fourier transform Gauss-Weierstrass summability modulus ofcontinuity

Solifenacin- induced acute psychosis: a case report

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General Psychiatry 2021年第5期34卷 42-44页

作者： Betul Kirsavoglu Ozan odabasi Ibrahim Erkut Avci Psychiatry Istanbul Erenkoy Mental and Nervous Diseases Training and Research HospitalIstanbulTurkey Urology Kocaeli UniversitySchool of MedicineKocaeliTurkey

Solifenacin is a muscarinic receptor antagonist that has been used to treat overactive bladder since *** has a great affinity for the detrusor M3 receptor,which must be stimulated for bladder muscle contraction,and demonstrates the most selective profile to the bladder of the muscarinic receptor *** is thought that urinary antimuscarinic agents,due to their passage to the central nervous system and lipophilic properties,may cause central nervous system symptoms in some rare cases.A case report of a 42-year old male patient who had an acute psychotic attack as a result of solifenacin treatment for overactive bladder is presented in this article.

关键词： bladder acute urinary

Melatonin ameliorates docetaxel-induced mitochondrial oxidative toxicity and cytokine generation in the laryngo-tracheal epithelial cell

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BIOCELL 2021年第1期45卷 177-188页

作者： sinem GÖKÇE KÜTÜK MUSTAFA NAZIROĞLU Department of Otorhinolaryngology Aydın State HospitalAydın09100Turkey Department of Biophysics Faculty of MedicineSuleyman Demirel UniversityIsparta32000Turkey Drug Discovery Unit BSN Health AnalysesInnovationConsultancyOrganization Agriculture Ltd.Göller Bölgesi TeknokentiIsparta32260Turkey

A protective action of melatonin(MELAT)on docetaxel(DCT)-induced inflammation,apoptosis,and reactive free oxygen radical(fROS)generation values via blocking of TRPM2 calcium-permeable channel was investigated in different cells except for laryngo-tracheal epithelial(LT-Epi)***,the protective action ofMELAT on DCT-induced oxidative toxicity and inflammation in LT-Epi tissue and cells of mice were investigated in the current *** treatment ameliorated DCTinduced mitochondrial ROS in the LT-Epi cells by reducing the generation of fROS(cytosolic and mitochondrial),lipid peroxidation,and depolarization of the mitochondrial membrane,while increasing reduced glutathione(GSH),GSH peroxidase,and total antioxidant *** addition,DCT-induced increases of cytokine(IL-1β,IL-6,and TNF-α)generations were also diminished in the LT-Epi tissue by MELAT ***,MELAT treatment increased viability and count of the cells followed by decreasing levels of cell death,caspase-3,*** TRPM2 activity was also reduced by MELAT and TRPM2 channel blocker(ACA)*** conclusion,MELAT modulated the increase of DCT-induced LT-Epi cell death by inhibiting mitochondrial oxidative stress and TRPM2 channel ***,DCTcaused side cell death,oxidant,and inflammatory actions in the LT-Epi were diminished via the treatment of MELAT.

关键词： Docetaxel Melatonin Laryngo-tracheal epithelial cell Oxidative cytotoxicity TRPM2 channel

Heusler合金Li_(2)AlX(X=Ga,In)的晶格动力学和电子特性

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Chinese Journal of Chemical Physics 2021年第2期34卷 173-178,I0001页

作者： Emel Kilit Dogan sinem Erden Gulebaglan 土耳其Van Yuzuncu Yil大学物理系凡城65080 土耳其Van Yuzuncu Yil大学凡城职业学校电力与能源系凡城65080

本文计算了Heusler合金Li_(2)AlGa和Li_(2)AlIn的晶格参数、体积模量、体积模量的一阶导数、电子能带结构、声子色散曲线和声子态密度,并与密度泛函理论中的广义梯度近似计算结果进行比较.计算的晶格参数与文献有很好的一致性.两个Heus... 详细信息

本文计算了Heusler合金Li_(2)AlGa和Li_(2)AlIn的晶格参数、体积模量、体积模量的一阶导数、电子能带结构、声子色散曲线和声子态密度,并与密度泛函理论中的广义梯度近似计算结果进行比较.计算的晶格参数与文献有很好的一致性.两个Heusler合金的电子能带结构表明它们是半金属结构.并利用声子色散曲线和声子密度图研究Heusler合金晶格动力学.Li_(2)AlGa和Li_(2)AlIn Heusler合金在基态呈现动力学稳定.

关键词： Li_(2)AlGa Li_(2)AlIn Heusler合金电子特性动力学性质

Sertraline-induced reproductive toxicity in male rats： evaluation of possible underlying mechanisms

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Asian Journal of Andrology 2017年第6期19卷 672-679页

作者： Ozlem Atli Merve Baysal Gozde Aydogan-Kilic Volkan Kilic Seyda Ucarcan Burak Karaduman sinem Ilgin Department of Pharmaceutical Toxicology Faculty of Pharmacy Anadolu University Eskisehir 26470 Turkey Department of Biology Faculty of Science Anadolu University Eskisehir 26470 Turkey

This study was conducted to clarify the toxic effects of sertraline （SRT） on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg kg-1 for 28 consecutive days. At the end of the treatment period, sperm concentration, sperm motility, and sperm morphology were investigated by computer-assisted sperm analysis system whereas sperm DNA damage was detected by comet assay. The oxidative status of the testes was investigated, and a histopathological examination was conducted. Serum testosterone, follicle-stimulating hormone （FSH）, and luteinizing hormone （LH） levels were measured to determine the effects of SRT on the spermatogenesis process. One-way ANOVA, post-hoc Dunnett＇s T3 test for the sperm comet assay, and post-hoc Tukey＇s test for the others were performed for statistical analysis. The results showed that SRT caused an increase in sperm DNA damage and induced histopathological lesions in all groups treated with SRT. There was abnormal sperm morphology and increased malondialdehyde （MDA） in the 10 mg kg-1 treatment group. More dramatic changes were observed in the 20 mg kg-1 treatment group. Decreased sperm count was accompanied by a significant increase in abnormal sperm morphology, DNA damage, and degeneration in cellular-tubular structures. Serum LH and testosterone levels were elevated in the 20 mg kg-~ treatment group. Decreased glutathione （GSH） and increased MDA were signs of enhanced oxidative stress （OS）. In conclusion, SRT induced testicular toxicity in a dose-dependent manner and OS is suggested as a crucial mechanism.

关键词： DNA damage oxidative stress reproductive toxicity sertraline

Cytotoxic, apoptotic and cell migration inhibitory effects of atranorin on SPC212 mesothelioma cells

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Asian Pacific Journal of Tropical Biomedicine 2019年第7期9卷 299-306页

作者： Erhan Sahin sinem Dabagoglu Psav Ilker Avan Mehmet Candan Varol Sahinturk Ayse Tansu Koparal Histology and Embryology Department Medicine SchoolEskisehir Osmangazi UniversityEskisehirTurkey Biology Department Faculty of ScienceEskisehir Technical UniversityEskisehirTurkey Chemistry Department Faculty of ScienceEskisehir Technical UniversityEskisehirTurkey

Objective: To investigate the effects of atranorin, a lichen secondary metabolite, on SPC212 malignant mesothelioma cells in vitro. Methods: SPC212 malignant mesothelioma cell line was used. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to evaluate cytotoxic effects of atranorin and cisplatin at 24, 48 and 72 h. Hematoxylin-eosin staining and 4’,6-diamidino-2-phenylindole, dihydrochloride staining were used for determining cell and nucleus morphology, respectively. Wound healing assay was used for investigating cell migration. The xCELLigence real-time cell analysis system was used for determining cell ***: Atranorin at 5-450 μM decreased cell viability at 24, 48 and 72 h. IC50 values of atranorin were 300.94, 292.6 and 278.02 μM at 24, 48 and 72 h, respectively;meanwhile, the IC50 values of cisplatin were 128.00, 34.37 and 17.05 μM at 24, 48 and 72 h, respectively. Furthermore, atranorin disrupted cell and nuclear morphology with increasing concentrations. Atranorin significantly reduced cell migration by 38%, 37% and 35% at 300, 250 and 200 μM, respectively(P<0.000). Atranorin at 160-450 μM decreased cell proliferation at 72 h(P<0.000).Conclusions: Atranorin has cytotoxic, antiproliferative, apoptotic and cell migration inhibitory effects on SPC212 malignant mesothelioma cancer cells.

关键词： Atranorin Malignant mesothelioma SPC212 cell line

Saudi Foreign Policy Towards China in the Post-Arab Uprisings Era:A Neo-classical Realist Approach

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Asian Journal of Middle Eastern and Islamic Studies 2020年第1期14卷 51-67页

作者： sinem Cengiz Area Studies Program Middle East Technical UniversityAnkaraTurkey Arab News RiyadhSaudi Arabia

In light of the unprecedented developments in the Middle East since the Arab uprisings that started at the end of 2010,Saudi Arabia’s international and regional role began to *** a clear emphasis on its East Asia policy,this Gulf country has improved its relations with Asian powers,particularly China,across a wide range of the interests on its *** are the motivating factors that led the Saudi leadership to closer relations with Beijing?As this year marks the 30th anniversary of the establishment of diplomatic relations between two countries,it is worth examining the growing pace of Sino-Saudi *** paper draws on the‘neoclassical realist approach’to explore the evolving nature of Saudi foreign policy towards China since the Arab uprisings to the present with a particular focus on the Crown Prince Mohammed bin Salman *** examining the main determinants that could have had an impact on Saudi foreign policy strategy towards China,this review found that Riyadh’s growing attention to Beijing is mainly influenced by a variety of both internal and external factors related to Saudi leadership,regional patterns as well as the international *** the combination of these factors pushes Saudi Arabia and China towards cooperation,this paper argues that there are other factors that can act as limiting forces on the Sino-Saudi relationship.

关键词： China Saudi Arabia neo-classical realism Arab uprisings the Gulf