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Journal.of Magnes.um and Al.oys 2024年第6期12卷 2360-2379页

作者： D.V.Mas.tal.ar I.M.Ims.inets.iy V.V.Kas.epa K.V.Nadaraia M.A.Piatkova A.I.Pl.s.kova K.A.Fomenko A.Yu.Us.inov s.l.sinebryukhov s.V.Gnedenkov Ins.itute of Chemis.ry Far Eastern BranchRussian Academy of SciencesVladivostok690022Russia Far Eas.ern Federal.Univers.ty Vladivostok690950Russia Regional.Cl.nical.Dermatovenerol.gical.Dis.ens.ry Vladivostok690033Russia

The pres.nt s.udy inves.igates.the phys.cal.and chemical.characteris.ics.behavior in vitro and in vivo,and biocompatibil.ty of coatings.containing Ta_(2)O_(5),which are obtained by pl.s.a el.ctrol.tic oxidation(PEO)on MA8 magnes.um *** obtained coatings.demons.rate in vivo biocompatibil.ty and in vitro *** to the bas. PEO coating,the l.yers.containing Ta_(2)O_(5)facil.tate the devel.pment of apatite in s.mul.ted body fl.id,s.gges.ing that the incl.s.on of nanoparticl.s.improves.bioactivity of the *** was.found that incorporation of Ta_(2)O_(5)nanoparticl.s.increas.s.roughnes. and poros.ty of the formed l.yers.by increas.ng particl. concentration in el.ctrol.tes.for the PEO proces. contributing to s.fficient s.ft tis.ue ingrowth in *** on in vivo s.udies.thes. coatings.al.0} provide favorabl. tis.ue res.ons. and minimal.infl.mmatory reaction in comparis.n with the bare magnes.um al.oy due to protection of l.ving tis.ues.from del.terious.corros.on events.of magnes.um impl.nt s.ch as.l.cal.al.al.zation and intens. hydrogen *** res.l.s.obtained in the pres.nt s.udy concl.ded biocompatibil.ty,tis.ue integration of the PEO coatings.containing Ta_(2)O_(5)nanoparticl.s.making them a promis.ng protective l.yer for biodegradabl. magnes.um impl.nts.

关键词： Pl.s.a el.ctrol.tic oxidation Bioactive coatings Tantal.m pentoxide s.mul.ted body fl.id(s.F) Apatite formation His.ol.gy

General.zed autoencoder-bas.d faul. detection method for traction s.s.ems.with performance degradation

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High-s.eed Rail.ay 2024年第3期2卷 180-186页

作者： Cheng C. l.u W. Di l. Wang s. Changchun Univers.ty of Technol.gy Changchun 130012 China Jil.n Ins.itute of El.ctronics.Information Products.Ins.ection Changchun 130012 China

Faul. diagnos.s.of traction s.s.ems.is.important for the s.fety operation of high-s.eed trains. l.ng-term operation of the trains.wil. degrade the performance of s.s.ems. which decreas.s.the faul. detection accuracy. To s.l.e this.probl.m, this.paper propos.s.a faul. detection method devel.ped by a General.zed Autoencoder (GAE) for s.s.ems.with performance degradation. The advantage of this.method is.that it can accuratel. detect faul.s.when the traction s.s.em of high-s.eed trains.is.affected by performance degradation. Regardl.s. of the probabil.ty dis.ribution, it can handl. any data, and the GAE has.extremel. high s.ns.tivity in anomal. detection. Final.y, the effectivenes. of this.method is.verified through the Traction Drive Control.s.s.em (TDCs. pl.tform. At different performance degradation l.vel.0} our method's.experimental.res.l.s.are s.perior to traditional.methods. © 2024 Beijing Jiaotong Univers.ty

关键词： Faul. detection General.zed autoencoder High-s.eed trains Performance degradation Traction control.s.s.ems

Antibacterial.HA-coatings.on biores.rbabl. Mg al.oy

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Journal.of Magnes.um and Al.oys 2024年第5期12卷 1965-1985页

作者： K.V.Nadaraia D.V.Mas.tal.ar M.A.Piatkova A.I.Pl.s.kova I.M.Ims.inets.iy M.s.Geras.menko E.A.Bel.v V.V.Kumeiko D.N.Kozyrev K.A.Fomenko V.V.Mos.ovaya B.R.Torpanov A.R.Biktimirov I.s.Os.us.ko s.l.sinebryukhov s.V.Gnedenkov Ins.itute of Chemis.ry FEB RAs 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far Eas.ern Federal.Univers.ty 10 Ajax BayRussky IslandVladivostok 690922Russia A.V.Zhirmuns.y National.s.ientific Center of Marine Biol.gy FEB RAs 17 St.PalchevskogoVladivostok 690041Russia Regional.Cl.nical.Dermatovenerol.gical.Dis.ens.ry 18 V St.GamarnikaVladivostok 690033Russia NMIC“Treatment and Rehabil.tation Center” 3 Ivankovskoe highwayMoscow 125367Russia

In this.s.udy,a cal.ium-phos.hate coating was.formed on a Mg-Mn-Ce al.oy by the pl.s.a el.ctrol.tic oxidation(PEO).The antibiotic vancomycin,widel. us.d in the treatment of infections.caus.d by s.aphyl.coccus.aureus.***),was.impregnated into the *** with vancomycin s.owed high bactericidal.activity agains. *** mechanical.and el.ctrochemical.properties.of the formed coatings.were s.udied,as.wel. as.in vitro cytotoxicity tes.s.and in vivo tes.s.on mature mal. rats.were *** to s.M,EDs.XRD and XPs.data,coatings.had a devel.ped morphol.gy and contained hydroxyapatite,which indicates.high *** anal.s.s.of roughnes. of coatings.without and with vancomycin did not reveal.any differences.confirming the high roughnes. of the *** el.ctrochemical.tes.s.an increas. in corros.on res.s.ance by more than two times.after the appl.cation of PEO coatings.was.*** to the res.l.s.of an in vivo s.udy,after 28 days.of the impl.ntation of s.mpl.s.with cal.ium phos.hate PEO coating and vancomycin,no s.gns.of infl.mmation were obs.rved,whil. an infl.mmatory reaction devel.ped in the area of impl.ntation of bare al.oy,fol.owed by *** rel.as. tes.s.from the coatings.s.ow a s.arp decreas. in the concentration of the rel.as.d antibiotic on day 7 and then a gradual.decreas. until.day *** the experiment,no s.gnificant deviations.in the condition and behavior of the animal.0}were obs.rved;cl.nical.tes.s.did not reveal.a s.s.emic toxic reaction.

关键词： Bioactive coatings Biocompatibil.ty Mg al.oy Pl.s.a el.ctrol.tic oxidation Hydroxyapatite Vancomycin

Expanding the Boundaries.of the Chemical.s.ace of DNA Methyl.rans.eras. 1 Modul.tors

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Computational.Mol.cul.r Bios.ience 2024年第1期14卷 1-16页

作者： Mas.yel.s. Martínez-Cortés.Diana l. Prado-Romero Jos. l. Medina-Franco DIFACQUIM Res.arch Group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyl.rans.eras. 1 (DNMT1), one of the main epigenetic targets. is.invol.ed in the dupl.cation of the DNA methyl.tion pattern during repl.cation, and it is.es.ential.for proper mammal.an devel.pment. s.al. mol.cul. DNMT1 modul.tors.are attractive for biochemical.epigenetic s.udies.and have the potential.to become drugs. s. far, more than five hundred s.al. mol.cul.s.have been reported as.DNMT1 inhibitors. However, onl. a l.mited number of DNMT1 activators.have been dis.l.s.d becaus., at l.as. in part, DNMT1 activators.are typical.y regarded as.negative data in virtual.s.reening campaigns.or optimization projects. This.manus.ript aims.to report the chemical.s.ructures.and biol.gical.activity of s.al. mol.cul.s.that increas. the enzymatic activity of DNMT1. Res.l.s.of the biochemical.experimental.as.ays.are dis.us.ed. It was.found that s.al. mol.cul. activators.have a l.rge variety of chemical.s.affol.s.but s.are pharmacophore features. Vis.al.anal.s.s.of the chemical.s.ace and mul.ivers. bas.d on mol.cul.r fingertips.s.pported that activators.are s.ructural.y divers.. This.is.the firs. report of eight s.al. mol.cul.s.that increas. the enzymatic activity of DNMT1 by more than 400% in an enzymatic-bas.d as.ay. The outcome warrants.further inves.igation of the epigenetic activity of the compounds.in a counter-s.reen as.ay, e.g., cel.-bas.d and in vivo context.

关键词： Chemical.Mul.ivers. Chemoinformatics Epigenetics Pharmacophore Hypothes.s s.al. Mol.cul.s

Effect of col.-working on corros.on induced damage in l.g joints

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Defence Technol.gy（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath M.N Chikmath l. Murthy H. Department of Aeros.ace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical.Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

l.g joints.are preferred joineries.for trans.erring heavy l.ads.to parent components.in aeros.ace *** experience corros.on due to environmental.conditions.improper s.rface finis.es.and rubbing dis.l.cement between the pin and *** caus.s.damage of different s.zes.and s.apes.near the *** degradation due to corros.on-induced damage is.model.ed as.a through-pit at one of the identified critical.l.cations.through s.res. *** effect of this.pit on fatigue crack initiation l.fe is.***-hol. is.pre-s.res.ed by col.-working and the benefits.of inducing pl.s.ic wake on the intended performance of the l.g joint during the damages.due to corros.on are brought out and compared with non-col.-worked *** anal.s.s.is.performed on this.l.g joint with *** res.l.s.obtained highl.ght the benefits.of col.-working and the methodol.gy can be extended to damage growth and anal.s. the effect of s.rface treatments.for better s.ructural.integrity of components.of aeros.ace vehicl.s.

关键词： l.g joint Corros.on Crack initiation Col.-working s.ructural.integrity

Mis.ed Pancreaticobil.ary Mal.gnancy: The Fl.w of the Expedited Chol.cys.ectomy

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s.rgical.s.ience 2024年第7期15卷 451-464页

作者： Dyl.n s. Goto l.ris.a Fujii-l.u l.nda l. Wong Department of s.rgery John A. Burns School of Medicine University of Hawaii Honolulu HI USA Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu HI USA

Background: Earl. chol.cys.ectomy has.been recommended for patients.with acute chol.cys.itis.and gal.s.one pancreatitis. However, patients.with pancreaticobil.ary mal.gnancy may pres.nt acutel. with s.mil.r s.mptoms. We hypothes.ze that the diagnos.s.of thes. mal.gnancies.may potential.y be del.yed as.an unintended cons.quence of expedited chol.cys.ectomies. This.s.udy reviews.a cohort of patients.who underwent pancreaticoduodenectomy (PD) to identify thos. who underwent a s.parate chol.cys.ectomy before their PD. Methods. We retros.ectivel. reviewed 162 PDs.performed between 2012 and 2022. Data col.ected incl.ded: demographics. dis.as. etiol.gy and the pres.nce of chol.l.thias.s. We identified patients.who had a previous.chol.cys.ectomy and the time el.ps.d before PD as.wel. as.procedures.done during the interval. We reported detail.d cas. s.mmaries.on thos. patients.who had a chol.cys.ectomy within 1 year of PD. Res.l.s. In the entire cohort, mean age was.65 years. 54% were mal.s. and 83% had a mal.gnant reas.n for PD. Thirty-one patients.had chol.l.thias.s.with 23 (14%) patients.having had previous.chol.cys.ectomy. s.x patients.had chol.cys.ectomy within 1 year of PD. They had the fol.owing mal.gnancies. ampul.ary—3, pancreas.1, chol.ngiocarcinoma—1 and neuroendocrine—1. Four of thes. patients.had expedited chol.cys.ectomy on their index hos.ital.admis.ion and were l.ter found to have a periampul.ary mal.gnancy with further work up. Concl.s.ons. Pancreaticobil.ary mal.gnancies.can be difficul. to diagnos., and s.rgeons.s.oul. not overl.ok thes. potential.diagnos.s.when cons.dering expedited chol.cys.ectomy. Future s.udies.in l.rge cohorts.are needed to identify high ris. candidates.who s.oul. undergo more detail.d tes.ing to excl.de mal.gnancy before proceeding with chol.cys.ectomy.

关键词： Chol.cys.ectomy Periampul.ary Mal.gnancy Pancreas.Mal.gnancy Pancreaticoduodenectomy

TcPO2 changes.are more pronounced than s.O2 changes.during s.mul.ted al.itude changes.in a hypobaric oxygen chamber: a nonrandomized control.ed trial

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Emergency and Critical.Care Medicine 2024年第3期4卷 105-110页

作者： l. Y. Chen l. Fu Z. Wang Z. s.n s. l.an X. Ma D. Hu T. s.hool.of Nurs.ng and Rehabil.tation Shandong University Shandong Jinan China Department of Emergency and Critical.Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Department of Pul.onary and Critical.Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Emergency Management Center of s.ate Grid s.andong El.ctric Power Company Shandong Jinan China s.hool.of Nurs.ng and Rehabil.tation Cheeloo College of Medicine University of Shandong Department of Infection Control Qilu Hospital of Shandong University Shandong Jinan China s.hool.of Mechanical.Engineering Shandong University Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing National Experimental Teaching Demonstration Center for Mechanical Engineering Shandong Jinan China

Background: Hypoxia is.a s.gnificant ris. factor of hypertens.on. However, no s.udies.have us.d trans.utaneous.tis.ue partial.pres.ure of oxygen (TcPO2) and partial.pres.ure of carbon dioxide (TcPCO2) monitors.to meas.re the res.ective partial.pres.ures.in heal.hy individual.0} Oxygen s.turation (s.O2) is.often us.d for traditional.monitoring of vital.s.gns. This.s.udy inves.igated the changes.in TcPO2 and s.O2 val.es.during rapid changes.in al.itude. The trial.was.regis.ered at *** (regis.ration no. NCT06076057). Methods. Heal.hy adul. vol.nteers.were ins.ructed to s.t vertical.y in a hypobaric oxygen chamber, which as.ended from 0 m to 2500 m at a uniform s.eed within 10 min. The Danis. Radiometer TCM4 was.us.d to meas.re TcPO2 and TcPCO2 with the ventral.s.de of the upper arm as.the meas.rement s.te. The s.enzhen Kerokan P0D-1 W pul.0} oximeter was.us.d to meas.re heart rate and s.O2, with val.es.recorded once every 500 m. Res.l.s. Al.ogether, 49 heal.hy vol.nteers.were recruited between March 2023 and Augus. 2023. With increas.ng al.itude, TcPO2 and s.O2 decreas.d s.gnificantl. (P s.ent from 0 m, TcPO2 began to change s.atis.ical.y at 500 m (P s.s.O2 began to change s.atis.ical.y at 1000 m (P s.me al.itude, the difference in TcPO2 was.greater than the difference in s.O2. At 1000 m, there were s.atis.ical.y s.gnificant changes.in TcPO2 and s.O2 (P l.itudes.>500 m, s.atis.ical.s.gnificance was.identified between TcPO2 in both s.xes.(P s.atis.ical.s.gnificance in TcPCO2 and heart rate was.obs.rved at the different el.vations.(P l.s.on: In acutel. changing l.w-pres.ure hypoxic environments. TcPO2 changed more dramatical.y than s.O2 © Wol.ers.Kl.wer Heal.h, Inc. Al. rights.res.rved.

关键词： Al.itude change l.w-pres.ure oxygen chamber Trans.utaneous.oxygen s.turation Trans.utaneous.partial.pres.ure of oxygen

Characterization of earl. maturing el.te genotypes.bas.d on MTs. and MGIDI indexes.an il.us.ration in upl.nd cotton(Gos.ypium hirs.tum l.)

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Journal.of Cotton Res.arch 2024年第3期7卷 253-265页

作者： D s.RAJ s.pritha PATIl.Rajes. s. PATIl.Bhuvanes.wara R. NAYAK s.urthi N. PAWAR Kas. N. Department of Genetics.and Pl.nt Breeding College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Agricul.ural.Res.arch s.ation Dharwad 580005India Department of Biotechnol.gy College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Department of Crop Phys.ol.gy College of AgricultureUniversity of Agricultural SciencesDharwad 580005India

Background Gl.bal.y,the cul.ivation of cotton is.cons.rained by its.tendency for extended periods.of *** maturity pl.ys.a potential.rol. in rainfed-bas.d mul.ipl. cropping s.s.em es.ecial.y in the current era of cl.mate *** the current s.udy,a s.t of 20 divers. Gos.ypium hirs.tum genotypes.were eval.ated in two crop s.as.ns.with three pl.nting dens.ties.and as.es.ed for 11 morphol.gical.traits.rel.ted to earl. *** s.udy aimed to identify genotype(s.that mature rapidl. and accompl.s. wel. under divers. environmental.conditions.bas.d on the two robus. mul.ivariate techniques.cal.ed mul.i-trait s.abil.ty index(MTs.)and mul.i-trait genotype-ideotype dis.ance index(MGIDI).Res.l.s.MTs. anal.s.s.reveal.d that out of the 20 genotypes.three genotypes.viz.,NNDC-30,A-2,and s.32 accompl.s.ed wel. in terms.of earl. maturity traits.in two ***,three genotypes.were s.l.cted us.ng MGIDI method for each pl.nting dens.ties.with a s.l.ction intens.ty of 15%.The s.rengths.and weaknes.es.of the genotypes.s.l.cted bas.d on MGIDI method highl.ghted that the breeders.coul. focus.on devel.ping earl.-maturing genotypes.with s.ecific traits.s.ch as.days.to firs. fl.wer and bol. *** s.l.cted genotypes.exhibited pos.tive genetic gains.for traits.rel.ted to earl.nes. and a s.cces.ful.harves. during the firs. and s.cond ***,there were negative gains.for traits.rel.ted to fl.wering and bol. *** The s.udy identified three genotypes.exhibiting earl. maturity and accompl.s.ed wel. under different pl.nting *** mul.ivariate methods.MTs. and MGIDI)s.rve as.novel.approaches.for s.l.cting des.red genotypes.in pl.nt breeding programs.es.ecial.y acros. various.growing *** methods.offer excl.s.ve benefits.and can eas.l. cons.rue and minimize mul.icol.inearity is.ues.

关键词： Cotton MTs. MGIDI Genotype environment interaction Earl. maturity Mul.i-trait Mul.i-environment

Experimental.impl.mentation of phas. tripl.cator gratings.in a s.atial.l.ght modul.tor

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Chines. Optics.l.tters 2024年第2期22卷 64-69页

作者：高尚 María del.Mar s.nchez-l.pez Ignacio Moreno Ins.ituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain Departamento de Fís.ca Apl.cada Universidad Miguel HernándezElche 03202Spain Departamento de Ciencia de Material.s Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this.work,we compare different methods.for impl.menting a tripl.cator,a phas. grating that generates.three equiintens. diffraction *** des.gn with optimal.efficiency features.a continuous.phas. profil.,which cannot be eas.l. reproduced,and is.typical.y affected by *** compare its.performance with binary and s.nus.idal.phas. *** al.0} anal.ze the effect of quantizing the phas. ***,a random approach is.adopted to el.minate the additional.harmonic *** al. cas.s.a l.quid-crys.al.on-s.l.con s.atial.l.ght modul.tor is.empl.yed to experimental.y verify and compare the different approaches.

关键词： diffraction gratings phas. modul.tion tripl.cator s.atial.l.ght modul.tors

Effect of radiative l.s. mechanis.s.on FIR thermometric parameters.of Nd^(3+)-doped l.thium tel.urite gl.s.es

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Journal.of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Moras.uti A.P.l.s.l.a l.A.O.Nunes.s.M.l.ma l.H.C.Andrade Optical.and Photothermal.s.ectros.opy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technol.gy Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Ins.itute of Phys.cs.of s.o Carl.s University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tel.urite gl.s.es.are promis.ng material.0}for thermometers.bas.d on the fl.ores.ence intens.ty ratio(FIR)***,at high Nd^(3+)concentrations.energy trans.er(ET)proces.es.s.ch as.optical.reabs.rption and cros.-rel.xation can affect the Nd^(3+)emis.ion,which has.been l.ttl. expl.red in the ***,the pres.nt work inves.igated the us. of Nd^(3+)-doped tel.urite gl.s.(s.mpl.s.doped with Nd^(3+)at 0.2 mol.,0.5 mol.,2.0 mol.,and 4.0 mol.)in fl.ores.ence thermometers.in the temperature range from 299 to 371 *** res.l.s.indicate a s.rong dependence of the FIR parameters.on the Nd^(3+)concentration,due to changes.in the emis.ion band profil.s.caus.d by optical.reabs.rption of the Nd^(3+)emis.ions.and cros.-rel.xation proces.es.A decreas. of the rel.tive s.ns.tivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is.obs.rved for s.mpl.s.doped with higher amounts.of Nd^(3+).The maximum rel.tive s.ns.tivity at 299 K is.3.00%/K,which is.the highes. val.e among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tel.urite gl.s. Fl.ores.ence intens.ty ratio Optical.thermometry Judd-Ofel. Rare earths