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Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression

Journal of Genetics and Genomics 2020年第2期47卷 69-83页

作者： Raoxu Wang Bowen Li sin Man Lam Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology.Chinese Acadmy of SciencesBeijing.100101China University of Chinese Academy of Sciences Beijing100101China Lipidall Technologies Company Limited Changzhou213000China

Mass spectrometry(MS)-based omics technologies are now widely used to profile small molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic *** metabolomes of cells,tissues,and organisms comprise a variety of molecules including lipids,amino acids,sugars,organic acids,and so *** mainly focus on the hydrophilic classes,while lipidomics has emerged as an independent omics owing to the complexities of the organismal *** potential roles of lipids and small metabolites in disease pathogenesis have been widely investigated in various human diseases,but system-level understanding is largely lacking,which could be partly attributed to the insufficiency in terms of metabolite coverage and quantitation accuracy in current analytical *** scientists are continuously striving to develop high-coverage omics approaches,integration of metabolomics and lipidomics is becoming an emerging approach to mechanistic *** of metabolome and lipidome offers a complete atlas of the metabolic landscape,enabling comprehensive network analysis to identify critical metabolic drivers in disease pathology,facilitating the study of interconnection between lipids and other metabolites in disease *** this review,we summarize omics-based findings on the roles of lipids and metabolites in the pathogenesis of selected major diseases threatening public *** also discuss the advantages of integrating lipidomics and metabolomics for in-depth understanding of molecular mechanism in disease pathogenesis.

关键词： Metabolomics Lipidomics Integration Disease progression

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On Product-Cordial Index Sets and Friendly Index Sets of 2-Regular Graphs and Generalized Wheels

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Acta Mathematica sinica,English Series 2012年第4期28卷 661-674页

作者： Harris KWONG sin Min LEE Ho Kuen NG Department of Mathematical Science SUNY Fredonia Department of Computer Science San Jose State University Department of Mathematics San Jose State University

A vertex labeling f ： V →Z2 of a simple graph G = （V, E） induces two edge labelings The friendly index set and the product-cordial index set of G are defined as the setsf is friendly}. In this paper we study and determine the connection between the friendly index sets and product-cordial index sets of 2-regular graphs and generalized wheel graphs.

关键词： Friendly index set product cordial index set 2-regular graphs generalized wheels

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Synergistic optimization framework for the process synthesis and design of biorefineries

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Frontiers of Chemical Science and Engineering 2022年第2期16卷 251-273页

作者： Nikolaus IVollmer Resul Al Krist V.Gernaey Gürkan sin Process and Systems Engineering(PROSYS)Research Center Department of Chemical and Biochemical EngineeringTechnical University of Denmark2800 Kgs.LyngbyDenmark Novo Nordisk A/S 2880 BagsværdDenmark

The conceptual process design of novel bioprocesses in biorefinery setups is an important task,which remains yet challenging due to several *** propose a novel framework incorporating superstructure optimization and simulation-based optimization *** this context,several approaches for superstructure optimization based on different surrogate models can be *** means of a case study,the framework is introduced and validated,and the different superstructure optimization approaches are *** results indicate that even though surrogate-based optimization approaches alleviate the underlying computational issues,there remains a potential issue regarding their *** development of appropriate surrogate models,comprising the selection of surrogate type,sampling type,and size for training and cross-validation sets,are essential *** this aspect,satisfactory validation metrics do not ensure a successful outcome from its embedded use in an optimization ***,the framework’s synergistic effects by sequentially performing superstructure optimization to determine candidate process topologies and simulationbased optimization to consolidate the process design under uncertainty offer an alternative and promising *** findings invite for a critical assessment of surrogatebased optimization approaches and point out the necessity of benchmarking to ensure consistency and quality of optimized solutions.

关键词： biotechnology surrogate modelling superstructure optimization simulation-based optimization process design

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Effect of pH on the photocatalytic removal of silver ions byβ-MnO2 particles

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International Journal of Minerals,Metallurgy and Materials 2021年第2期28卷 325-334页

作者： sin-Ling Chiam Anh Thi Le Swee-Yong Pung Fei-Yee Yeoh School of Materials and Mineral Resources Engineering Engineering CampusUniversiti Sains Malaysia14300 Nibong TebalPulau PinangMalaysia

The presence of silver ions(Ag(I))in wastewater has a detrimental effect on living *** of soluble silver,especially at low concentrations,is *** paper presents the use ofβ-MnO2 particles as a photocatalyst to remove Ag(I)ions selectively from aqueous solution at various pH *** coupled plasma mass spectrometry(ICP-MS),X-ray diffraction(XRD),field emission electron microscope(FESEM),transmission electron microscopy(TEM),and X-ray photoelectron microscopy(XPS)were employed to determine the removal efficiency and to characterize the deposition of silver onto the surface ofβ-MnO2 *** optimum pH for the removal of Ag(I)ions was at pH 4 with 99%removal efficiency under 1 h of visible light *** phenomenon can be attributed to the electrostatic attraction betweenβ-MnO2 particles and Ag(I)ions as well as the suppression of electron–hole recombination in the presence of H+ions.

关键词： manganese oxide(MnO2) silver metal ion removal photocatalyst

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Taking advantage of the potential of mesenchymal stromal cells in liver regeneration:Cells and extracellular vesicles as therapeutic strategies

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World Journal of Gastroenterology 2018年第23期24卷 2427-2440页

作者： Esteban Juan Fiore Luciana María Domínguez Juan bayo Mariana Gabriela García Guillermo Daniel Mazzolini Laboratory of Gene Therapy Instituto de Investigaciones en Medicina TraslacionalCONICET-Universidad Austral

Cell-based therapies for acute and chronic liver diseases are under continuous progress. Mesenchymal stem/stromal cells(MSCs) are multipotent cells able to migrate selectively to damaged tissue and contribute to its healing and regeneration. The MSC pro-regenerative effect occurs due to their immunomodulatory capacity and their ability to produce factors that promote cell protection and survival. Likewise,it has been observed that part of their paracrine effect is mediated by MSC-derived extracellular vesicles(EVs). EVs contain proteins,lipids and nucleic acids(DNA,m RNA,mi RNA,lnc RNA) from the cell of origin,allowing for intercellular communication. Recently,different studies have demonstrated that MSC-derived EVs could reproduce,at least in part,the biological effects obtained by MSCbased therapies. Moreover,due to EVs' stability for long periods of time and easy isolation methods they have become a therapeutic option to MSCs treatments. This review summarizes the latest results achieved in clinical trials using MSCs as cell therapy for liver regeneration,the role of EVs in liver physiopathology and the potential of MSC-derived EVs as intercellular mediators and therapeutic tools in liver diseases.

关键词： Mesenchymal stem cells Extracellular vesicles Cirrhosis Liver Acute damage Regeneration

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Endoscope-guided pneumatic dilation for treatment of esophageal achalasia

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World Journal of Gastroenterology 2010年第4期16卷 411-417页

作者： Seng-Kee Chuah Tsung-Hui Hu Chi-sin Changchien Gastrointestinal Motility Unit Division of HepatogastroenterologyChang Gang Memorial HospitalKaohsiung Medical CenterNo.123Ta-Pei RoadNiaosung HsiangKaohsiung 833TaiwanChina Chang Gung University College of Medicine No.123Ta-Pei RoadNiaosung HsiangKaohsiung 833TaiwanChina

Pneumatic dilation(PD) is considered to be the first line nonsurgical therapy for *** principle of the procedure is to weaken the lower esophageal sphincter by tearing its muscle fibers by generating radial *** endoscope-guided procedure is done without fluoroscopic *** usually use a lowcompliance balloon such as Rigiflex dilator to perform endoscope-guided PD for the treatment of esophageal *** has the advantage of determining mucosal injury during the dilation process,so that a repeat endoscopy is not needed to assess the mucosal *** studies have shown that endoscope-guided PD is an efficient and safe nonsurgical therapy with results that compare well with other treatment *** the results may be promising,long-term follow-up is required in the near future.

关键词： Esophagoscopy Dilatation Esophageal achalasia

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Linking stemness with colorectal cancer initiation, progression, and therapy

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World Journal of Stem Cells 2019年第8期11卷 519-534页

作者： Deepak Narayanan Iyer Wai-Yan sin Lui Ng Department of Surgery Li Ka Shing Faculty of Medicine The University of Hong Kong

The discovery of cancer stem cells caused a paradigm shift in the concepts of origin and development of colorectal cancer. Several unresolved questions remain in this field though. Are colorectal cancer stem cells the cause or an effect of the disease? How do cancer stem cells assist in colorectal tumor dissemination to distant organs? What are the molecular or environmental factors affecting the roles of these cells in colorectal cancer? Through this review, we investigate the key findings until now and attempt to elucidate the origins, physical properties, microenvironmental niches, as well as the molecular signaling network that support the existence, self-renewal, plasticity, quiescence, and the overall maintenance of cancer stem cells in colorectal cancer. Increasing data show that the cancer stem cells play a crucial role not only in the establishment of the primary colorectal tumor but also in the distant spread of the disease. Hence, we will also look at the mechanisms adopted by cancer stem cells to influence the development of metastasis and evade therapeutic targeting and its role in the overall disease prognosis. Finally, we will illustrate the importance of understanding the biology of these cells to develop improved clinical strategies to tackle colorectal cancer.

关键词： Cancer stem cell Colorectal cancer Tumor microenvironment Metastasis Extracellular matrix Tumor heterogeneity Resistance Stemness Quiescence Recurrence

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Effect of rheo-diecast process on the mechanical properties of A390 alloy by serpentine channel

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International Journal of Minerals,Metallurgy and Materials 2016年第10期23卷 1177-1186页

作者： Kunhyok Ri Wei-min Mao Zhi-kai Zheng Myongsik Kim Yongho sin School of Materials Science and Engineering University of Science and Technology Beijing School of Material Engineering Pyongyang Machinery University

In this paper, the effects of rheo-diecast process parameters and T6 heat treatment on the microstructure and mechanical properties of the rheo-diecasting（RDC） semi-solid A390 alloy prepared through pure copper serpentine channel were investigated. The results indicate that the mechanical properties of the RDC samples change with the pouring temperature and injection pressure. In this case, a lower pouring temperature results in better tensile strength and elongation of the RDC A390 alloy; however, the tensile strength and elongation decrease when the pouring temperature decreases to 660°C. Higher injection pressures result in the improved mechanical properties of the RDC A390 alloy. To some extent, T6 heat treatment improves the tensile strength and ductility of the RDC A390 alloy compared to those of the non-heat treated alloy. However, when the pouring temperature and injection pressure are greater than 670°C and 70 MPa, respectively, the mechanical properties are sharply diminished.

关键词： aluminum alloys diecasting rheo-casting microstructure mechanical properties

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Extensive spectral tuning of the proton transfer emission from green to red via a rational derivatization of salicylideneaniline

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Chinese Chemical Letters 2012年第11期23卷 1279-1282页

作者： Hsing Yang Tsai sin Kai Fang Kew Yu Chen Department of Chemical Engineering Feng Chia University

A series of salicylideneaniline derivatives 1a-lf were synthesized under mild condition in high yields, and characterized by ^1H NMR, HRMS, UV-vis and emission spectra. In solid and aprotic solvents 1a-1f exist mainly as E conformers that possess a sixmembered-ring hydrogen bond and undergo excited-state intramolecular proton transfer （ESIPT） reactions, resulting in a protontransfer tautomer emission. Depending on the electronic donor or acceptor strength of the substituent in either the HOMO or LUMO site, a broad tuning range of the emission from green （1c） to red （1a） has been achieved.

关键词： ESIPT Schiff bases Salicylideneaniline derivatives Db'T calculations

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Physics of electron emission and injection in two-dimensional materials: Theory and simulation

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InfoMat 2021年第5期3卷 502-535页

作者： Yee sin Ang Liemao Cao Lay Kee Ang Science Mathematics and Technology(SMT)Singapore University of Technology and Design(SUTD)SingaporeSingapore College of Physics and Electronic Engineering Hengyang Normal UniversityHengyangChina

Electrically contacting two-dimensional(2D)materials is an inevitable process in the fabrication of devices for both the study of fundamental nanoscale charge transport physics and the design of high-performance novel electronic and optoelectronic *** physics of electrical contact formation and interfacial charge injection critically underlies the performance,energyefficiency and the functionality of 2D-material-based devices,thus representing one of the key factors in determining whether 2D materials can be successfully implemented as a new material basis for the development of nextgeneration beyond-silicon solid-state device *** this review,the recent developments in the theory and the computational simulation of electron emission,interfacial charge injection and electrical contact formation in 2D material interfaces,heterostructures,and devices are *** on thermionic charge injection phenomena which are omnipresent in 2Dmaterials-based metal/semiconductor Schottky contacts,we summarize various transport models and scaling laws recently developed for 2D *** progress on the first-principle density functional theory simulation of 2D-material-based electrical contacts are also *** review aims to provide a crystalized summary on the physics of charge injection in the 2D Flatlands for bridging the theoretical and the experimental research communities of 2D material device physics and technology.

关键词： 2D material interfaces charge injection contact engineering heterostructures theory and simulations

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