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Decrease in liver cancer incidence rates in Bamako,Mali over 28 years of population-based cancer registration(1987-2015)

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World Journal of Hepatology 2022年第9期14卷 1767-1777页

作者： Amina Amadou Dominique Sighoko Bourama Coulibaly Cheick Traoré Bakarou Kamaté Brahima S Mallé Maëlle de Seze Francine N Kemayou Yoghoum Sandrine Biyogo Bi Eyang Denis Bourgeois Maria Paula Curado sinébayo Emmanuelle Gormally Pierre Hainaut Institute for Advanced Biosciences Grenoble 38700France Department of Prevention Cancer Environment Centre Léon BérardLyon 69008France Department of Medicine University of ChicagoChicagoIL 60611United States Department of Pathological Anatomy and Cytology University Hospital of Point GBamako BP333Mali UniversitéParis 1 Panthéon-Sorbonne Paris 75005France Health SystemicProcessUR 4129 Research UnitUniversitéClaude Bernard Lyon 1Villeurbanne 69100France Epidemiology and Statistics Nucleus ACCamargo Cancer CenterSao Paulo 01508-010Brazil Sciences and Humanities Confluence Research Center UniversitéCatholique de LyonLyon 69288France Institut pour l’Avancée des Biosciences Grenoble 38700France

BACKGROUND Primary liver cancer is common in West Africa due to endemic risk ***,epidemiological studies of the global burden and trends of liver cancer are *** report changes in trends of the incidence of liver cancer over a period of 28 years using the population-based cancer registry of Bamako,*** assess the trends and patterns of liver cancer by gender and age groups by analyzing the cancer registration data accumulated over 28 years(1987-2015)of activity of the population-based registry of the Bamako *** Data obtained since the inception of the registry in 1987 through 2015 were stratified into three periods(1987-1996,1997-2006,and 2007-2015).Age-standardized rates were estimated by direct standardization using the world *** rate ratios and the corresponding 95%confidence intervals(CI)were estimated using the early period as the reference(1987-1996).Joinpoint regression models were used to assess the annual percentage change and highlight trends over the entire period(from 1987 to 2015).RESULTS Among males,the age-standardized incidence rates significantly decreased from 19.41(1987-1996)to 13.12(1997-2006)to 8.15(2007-2015)per 105 *** incidence rate ratio over 28 years was 0.42(95%CI:0.34-0.50),and the annual percentage change was-4.59[95%CI:(-6.4)-(-2.7)].Among females,rates dropped continuously from 7.02(1987-1996)to 2.57(2007-2015)per 105 person-years,with an incidence rate ratio of 0.37(95%CI:0.28-0.45)and an annual percentage change of-5.63[95%CI:(-8.9)-(-2.3)].CONCLUSION The population-based registration showed that the incidence of primary liver cancer has steadily decreased in the Bamako district over 28 *** trend does not appear to result from biases or changes in registration *** is the first report of such a decrease in an area of high incidence of liver cancer in *** decrease may be explained by the changes and diversity of diet that could reduce exposure to

关键词： Hepatocellular carcinoma Hepatitis B infection Aflatoxin West Africa Cancer registration Annual percentage change

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Challenges and Opportunities in the Practice of Chinese Medicine in singapore

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Chinese Journal of Integrative Medicine 2024年第6期30卷 483-488页

作者： CHEW sin Yee National University Hospital Singapore119074Singapore

According to the World Health Oranization(WHO)Traditional Medicine Strategy 2014-2023,traditional medicine is defined as"the sum total of the knowledge,skill and practices based on the theories,beliefs,and experiences indigenous to different cultures,whether explicable or not,used in the maintenance of health as well as in the prevention,diagnosis,improvement or treatment of physical and mental illness.

关键词： theories prevention diagnosis

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Emerging roles and therapeutic potentials of sphingolipids in pathophysiology:emphasis on fatty acyl heterogeneity

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Journal of Genetics and Genomics 2024年第3期51卷 268-278页

作者： Jinming Mu sin Man Lam Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Lipidall Technologies Company Limited ChangzhouJiangsu 213000China

Sphingolipids not only exert structural roles in cellular membranes,but also act as signaling molecules in various physiological and pathological processes.A myriad of studies have shown that abnormal levels of sphingolipids and their metabolic enzymes are associated with a variety of human ***,blood sphingolipids can also be used as biomarkers for disease *** review summarizes the biosynthesis,metabolism,and pathological roles of sphingolipids,with emphasis on the biosynthesis of ceramide,the precursor for the biosynthesis of complex sphingolipids with different fatty acyl *** possibility of using sphingolipids for disease prediction,diagnosis,and treatment is also *** endogenous ceramides and complex sphingolipids along with their specific fatty acyl chain to promote future drug development will also be discussed.

关键词： Sphingolipids Ceramide Therapeutic targets Microdomain Biomarker

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Fabrication of La,Ce co-doped ZnO nanorods for improving photodegradation of methylene blue

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Journal of Rare Earths 2024年第1期42卷 76-83,I0003页

作者： Erfan Hakim Azmal Zaid Jin-Chung sin Sze-Mun Lam Abdul Rahman Mohamed School of Chemical Engineering Universiti Sains Malaysia(USM)14300Nibong TebalPenangMalaysia College of Environmental Science and Engineering Guilin University of TechnologyGuilin541004China Guangxi Key Laboratory of Theory and Technology for Environmental Pollution Control Guilin University of TechnologyGuilin541004China Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area Guilin University of TechnologyGuilin541004China Faculty of Engineering and Green Technology Universiti Tunku Abdul RahmanJalan UniversitiBandar Barat31900KamparPerakMalaysia

La,Ce co-doped ZnO nanorods(ZnLC)were synthesized through a one-step solvothermal *** photocatalysts were characterized by X-ray diffraction,Raman spectroscopy,field-emission scanning electron microscopy,energy dispersive X-ray,transmission electron microscopy,UV-vis diffuse reflectance spectroscopy and photo luminescence *** La and Ce doping enhanced the visible light absorption ability of ZnLC and a red shift was detected for *** simulated solar light irradiation,the ZnO doped with 3 at%La and 1 at%Ce(ZnLC1)degrades methylene blue(MB)more effectively than those of pure ZnO,La-doped ZnO(ZnL)and commercially available *** improved photocatalytic performance of ZnLC1 can be attributed to the high charge separation efficiency as demonstrated by the photoluminescence ***,the photocatalytic experiments reveal that several parameters have their own impact on the MB *** a variety of radical scavengers,it is discovered that superoxide anion radical plays a crucial role in the degradation of *** ZnLC1 is also reused several times without noticeable decrease of photoactivity,indicating that it has a substantial potential for environmental remediation applications.

关键词： ZnO Lanthanum Cerium Co-doping Photodegradation Rare earths

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Quantitative discrimination of surface adsorbed NO_(x) species on CeO_(2) via spectrophotometry for SCR denitration investigation

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Journal of Rare Earths 2024年第6期42卷 1066-1072,I0003页

作者： Songil sin Jiawei Ji Lijun Cheng Zhiwen Gu Chong Tan Kwangchol Ri Changjin Tang School of Environment Nanjing Normal UniversityNanjing210023China Department of Mining Engineering Kim Chaek University of TechnologyPyongyang999093Democratic People's Republic of Korea Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical EngineeringNanjing UniversityNanjing20023China Institute of Chemical Engineering Hamhung University of Chemical EngineeringHamhungDemocratic People's Republic of Korea Jiangsu Province Engineering Research Center of Environmental Risk Prevention and Emergency Response Technology Nanjing210023China

CeO_(2)-based catalysts are widely investigated for selective catalytic reduction(SCR)of NO with *** of NO/O_(2) with CeO_(2) generally produces two surface species,i.e.,nitrates and ***,the explicit quantification of these two species is still ***,we reported that spectrophotometry characterization was effective in determining surface adsorbed NOx species on CeO_(2) by measuring the corresponding ions(NO_(2)-and NO_(3)^(-))dissolved in aqueous *** results show that both nitrate(-NO_(3))and nitrite(-NO_(2))species can be quantitatively evaluated and the accuracy is verified by calibrating with NOx-TPD *** transfer of adsorbed NOx from catalyst surface to aqueous solution is confirmed and the dissolution process can be accelerated by ultrasonic ***,useful information related to evolution of surface NOx species under various conditions(O_(2) treatment,different adsorption temperature and duration)and over different catalysts(Fe_(2)O_(3),MnO_(2) and MnOx—CeO_(2))are *** result of present study demonstrates the potential of spectrophotometry for quantitative discrimination of surface NOx species on CeO_(2) and other oxide-based materials,which is conducive to mechanism analysis of SCR reaction.

关键词： Quantitative evaluation Spectrophotometry analysis Nitrate species Nitrite species CeO_(2)catalyst NH_(3)-SCR

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Advances of machine learning in materials science: Ideas and techniques

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Frontiers of physics 2024年第1期19卷 155-194页

作者： Sue sin Chong Yi Sheng Ng Hui-Qiong Wang Jin-Cheng Zheng Department of New Energy Science and Engineering Xiamen University MalaysiaSepang 43900Malaysia Engineering Research Center of Micro-nano Optoelectronic Materials and Devices Ministry of EducationFujian Key Laboratory of Semiconductor Materials and ApplicationsCI Center for OSEDand Department of PhysicsXiamen UniversityXiamen 361005China

In this big data era, the use of large dataset in conjunction with machine learning (ML) has been increasingly popular in both industry and academia. In recent times, the field of materials science is also undergoing a big data revolution, with large database and repositories appearing everywhere. Traditionally, materials science is a trial-and-error field, in both the computational and experimental departments. With the advent of machine learning-based techniques, there has been a paradigm shift: materials can now be screened quickly using ML models and even generated based on materials with similar properties;ML has also quietly infiltrated many sub-disciplinary under materials science. However, ML remains relatively new to the field and is expanding its wing quickly. There are a plethora of readily-available big data architectures and abundance of ML models and software;The call to integrate all these elements in a comprehensive research procedure is becoming an important direction of material science research. In this review, we attempt to provide an introduction and reference of ML to materials scientists, covering as much as possible the commonly used methods and applications, and discussing the future possibilities.

关键词： machine learning materials science

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Proposal for valleytronic materials:Ferrovalley metal and valley gapless semiconductor

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Frontiers of physics 2024年第2期19卷 131-139页

作者： San-Dong Guo Yu-Ling Tao Guangzhao Wang Shaobo Chen Dong Huang Yee sin Ang School of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology of Chongqing School of Electronic Information EngineeringYangtze Normal UniversityChongqing 408100China College of Electronic and Information Engineering Anshun UniversityAnshun 561000China Science Mathematics and Technology(SMT)Singapore University of Technology and Design(SUTD)8 Somapah RoadSingapore 487372Singapore

Valleytronic materials can provide new degrees of freedom to future electronic *** this work,the concepts of the ferrovalley metal(FVM)and valley gapless semiconductor(VGS)are proposed,which can be achieved in valleytronic bilayer systems by electric field *** valleytronic bilayer systems,the interaction between out-of-plane ferroelectricity and A-type antiferromagnetism can induce layer-polarized anomalous valley Hall(LP-AVH)*** K and−K valleys of FVM are both metallic,and electron and hole carriers simultaneously *** the extreme case,the FVM can become VGS by analogizing spin gapless semiconductor(SGS).Moreover,it is proposed that the valley splitting enhancement and valley polarization reversal can be achieved by electric field engineering in valleytronic bilayer *** the bilayer RuBr_(2)as an example,our proposal is confirmed by the first-principle *** FVM and VGS can be achieved in bilayer RuBr_(2)by applying electric *** appropriate electric field range,increasing electric field can enhance valley splitting,and the valley polarization can be reversed by flipping electric field *** effectively tune valley properties by electric field in bilayer systems,the parent monolayer should possess out-of-plane magnetization,and have large valley *** results shed light on the possible role of electric field in tuning valleytronic bilayer systems,and provide a way to design the ferrovalley-related material by electric field.

关键词： valleytronics electric field bilayer

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On a Partially Non-Stationary Vector AR Model with Vector GARCH Noises:Estimation and Testing

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Communications in Mathematical Research 2024年第1期40卷 64-101页

作者： Chor-yiu sin Zichuan Mi Shiqing Ling Department of Economics National Tsing Hua UniversityHsinchu 30013TaiwanP.R.China School of Statistics Shanxi University of Finance and EconomicsTaiyuan 030006P.R.China Department of Mathematics The Hong Kong University of Science and TechnologyKowloonHong KongSARP.R.China

This paper studies a partially nonstationary vector autoregressive(VAR)model with vector GARCH *** study the full rank and the reduced rank quasi-maximum likelihood estimators(QMLE)of parameters in the *** is shown that both QMLE of long-run parameters asymptotically converge to a functional of two correlated vector Brownian *** these,the likelihood ratio(LR)test statistic for cointegration rank is shown to be a functional of the standard Brownian motion and normal vector,*** far as we know,our test is new in the *** critical values of the LR test are simulated via the Monte Carlo *** performance of this test in finite samples is examined through Monte Carlo *** apply our approach to an empirical example of three interest rates.

关键词： Vector AR model cointegration full rank estimation vector GARCH process partially nonstationary reduced rank estimation

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Accurate Diagnosis of SARS-CoV-2 JN.1 by Sanger Sequencing of Receptor-Binding Domain Is Needed for Clinical Evaluation of Its Immune Evasion

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Journal of Biosciences and Medicines 2024年第4期12卷 69-78页

作者： sin Hang Lee Milford Molecular Diagnostics Laboratory Milford CT USA

Background: Omicron JN.1 has become the dominant SARS-CoV-2 variant in recent months. JN.1 has the highest number of amino acid mutations in its receptor binding domain (RBD) and has acquired a hallmark L455S mutation. The immune evasion capability of JN.1 is a subject of scientific investigation. The US CDC used SGTF of TaqPath COVID-19 Combo Kit RT-qPCR as proxy indicator of JN.1 infections for evaluation of the effectiveness of updated monovalent XBB.1.5 COVID-19 vaccines against JN.1 and recommended that all persons aged ≥ 6 months should receive an updated COVID-19 vaccine dose. Objective: Recommend Sanger sequencing instead of proxy indicator to diagnose JN.1 infections to generate the data based on which guidelines are made to direct vaccination policies. Methods: The RNA in nasopharyngeal swab specimens from patients with clinical respiratory infection was subjected to nested RT-PCR, targeting a 398-base segment of the N-gene and a 445-base segment of the RBD of SARS-CoV-2 for amplification. The nested PCR amplicons were sequenced. The DNA sequences were analyzed for amino acid mutations. Results: The N-gene sequence showed R203K, G204R and Q229K, the 3 mutations associated with Omicron BA.2.86 (+JN.1). The RBD sequence showed 24 of the 26 known amino acid mutations, including the hallmark L455S mutation for JN.1 and the V483del for BA.2.86 lineage. Conclusions: Sanger sequencing of a 445-base segment of the SARS-CoV-2 RBD is useful for accurate determination of emerging variants. The CDC may consider using Sanger sequencing of the RBD to diagnose JN.1 infections for statistical analysis in making vaccination policies.

关键词： Omicron JN.1 SARS-CoV-2 Sanger Sequencing RBD L455S Mutation Immune Evasion Vaccination Policies CDC

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First Trimester Preeclampsia Screening and Prevention:Perspective in Chinese Mainland

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Maternal-Fetal Medicine 2024年第2期6卷 84-91页

作者： Jiao Liu Yunyu Chen sin Ting Tai Long Nguyen-Hoang Kunping Li Jing Lin Xiaohong Lu Liona C.Poon Department of Obstetrics and Gynecology The Chinese University of Hong KongShatinHong Kong 999077China

Preeclampsia(PE),a multisystem disorder in pregnancy,is one of the leading causes of perinatal morbidity and mortality that poses financial and physical burdens *** PE with delivery atsing Bayes theorem to combine maternal characteristics and medical history together with measurements of mean arterial pressure,uterine artery pulsatility index,and serum placental growth *** a quality control process for regular monitoring and to ensure data standardization,reliability,and accuracy is key to maintaining optimal screening *** rate of preterm PE can be reduced by 62%by using the FMF prediction model,followed by the administration of low-dose *** evidence has also demonstrated that metformin has the potential for preventing PE in patients at high-risk of the *** this article,we will summarize the existing literature on the different screening methods,different components of risk assessment,therapeutic interventions,and clinical implementation of the first trimester screening and prevention program for PE with specific considerations for Chinese mainland.

关键词： Preeclampsia Chinese population First trimester Screening Prevention

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