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即使采用现代疗法,新生儿囊性纤维化筛查依然大有裨益

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世界核心医学期刊文摘（儿科学分册） 2006年第A3期2卷 59-60页

作者： sims E.j. Mc Cormick j. Mehta G. Mehta A. 贺文龙 Division of Maternal and Child Health Sciences Ninewells Hospital and Medical School University of Dundee Dundee DD1 9SY United Kingdom

Objectives: To determine whether early identification of babies with cystic fibrosis (CF) improves outcome in the current environment of new improved treatments, considering the criticism that there may be only marginal benefit gained by CF newborn screening (NBS). Study design: We tested whether CF NBS in the setting of modern CF center care still afforded benefit using the UK CF Database (UKCFD; ***) to compare clinical outcomes in infants who underwent NBS and control subjects who were clinically diagnosed (CD). With Mann-Whitney rank tests, 184 patients who underwent NBS aged 1 to 9 years in 2002 (excluding meconium ileus) were compared with matched patients who were CD in 3-year age groups (950 control subjects). Results: Patients as old as 6 years who underwent NBS had significantly greater median height z-scores, less severe Northern chest radiography scores, better Shwachman-Kulczycki scores, and lower rates of chronic Pseudomonas aeruginosa infection. No difference was found for weight z-score or % predicted forced expiratory value in 1 second or forced volume capacity. Nutritional benefit was demonstrated in patients who underwent NBS and were homozygous for the Δ F508 mutation. Conclusions: NBS segregates with better outcomes in patients as old as 6 years compared with age and gene-matched control subjects who are CD. This cross-sec-tional study shows that infants who undergo screening derive nutritional benefit in improved median height and reduced morbidity.

关键词：囊性纤维化胎粪性肠梗阻用力呼气量营养状况临床诊断纯合子横断面研究年龄组试验设计肺容

Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer

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Cancer Biology & Medicine 2018年第4期15卷 375-388页

作者： Maria Bonello ANDrew Harvey sims Simon Peter Langdon Cancer Research UK Edinburgh Center and Division of Pathology Laboratory MRC Institute of Genetics and Molecular Medicine University of Edinburgh

Ovarian cancer is the second most lethal gynecological cancer worldwide and while most patients respond to initial therapy, they often relapse with resistant disease. Human epidermal growth factor receptors(especially HER1/EGFR and HER2/ERBB2) are involved in disease progression; hence, strategies to inhibit their action could prove advantageous in ovarian cancer patients,especially in patients resistant to first line therapy. Monoclonal antibodies and tyrosine kinase inhibitors are two classes of drugs that act on these receptors. They have demonstrated valuable antitumor activity in multiple cancers and their possible use in ovarian cancer continues to be studied. In this review, we discuss the human epidermal growth factor receptor family; review emerging clinical studies on monoclonal antibodies and tyrosine kinase inhibitors targeting these receptors in ovarian cancer patients; and propose future research possibilities in this area.

关键词： Tyrosine kinase monoclonal antibodies ovarian cancer inhibitors HER receptors

Does orthotics use improve comfort,speed and injury rate during running?Preliminary analysis of a randomised control trial

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World journal of Orthopedics 2022年第7期13卷 652-661页

作者： Alice E Fortune jonathan M G sims Samantha j Rhodes George Ampat School of Medicine University of LiverpoolLiverpool L693GEUnited Kingdom Research Unit Talita Cumi LtdSouthport PR83NSUnited Kingdom

BACKGROUND Evidence regarding the effectiveness of using orthotics in improving comfort,increasing running speed and helping to reduce injury rate during running is limited and *** the increasing popularity of running is the increasing rate of running-related injuries(RRIs).Further research into whether orthotics could be used to help reduce RRIs would be highly beneficial for those ***,there is a need to clarify whether orthotics use increases comfort during running and helps improve running *** To investigate whether running with Aetrex Orthotics improves comfort and performance and reduces injury whilst *** Runners were recruited on a voluntary basis if they were 18 or older with no serious health conditions,ongoing foot pain or deformity,previous foot surgery in their lifetime or any surgery in the past 6 *** were randomly assigned to either an intervention group or a control *** participants were asked to complete runs and provide quantitative data regarding comfort during running,running time and distance,and any RRIs over an 8-wk study *** in the intervention group ran with Aetrex L700 Speed Orthotics,whilst participants in the control group ran without *** than the addition of orthotics for participants in the intervention group,all participants were asked to run as they usually *** report presents preliminary data from the first 47 participants recruited for this *** speed was calculated from running distance and time and given in miles per *** each outcome variable,the mean for each group,effect size and 95%confidence interval were calculated,and a t-test was performed to determine if between-group differences were statistically *** Data for all three primary outcomes was provided from a total of 254 runs by the 23 participants in the intervention group and a total of 289 runs by the 24 participants in the control ***

关键词： Running Foot orthoses Running related injuries Pain Patient comfort Athletic performance

Risk factors for hamstring injuries in Australian male professional cricket players

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journal of Sport and Health Science 2017年第3期6卷 271-274页

作者： john W.Orchard Alex Kountouris Kevin sims School of Public Health The University of SydneySydneyNSW 2006Australia Cricket Australia MelbourneVIC 3002Australia

Background:Injuries to the hamstring are relatively common in professional cricketers(as they are in many team sports) and have increased in incidence in the "T20 era"(introduction of 20-over matches) of cricket since ***:This study analyzed incidence of hamstring injury in the various elite male match types over a 20-year period(1995–1996 to 2014–2015seasons).Risk factors for hamstring strain were assessed using a multivariate logistic regression analysis ***:There were 276 match time-loss hamstring injuries recorded over a 20-year period at the Australian state or national player level,of which170 occurred in one of 40,145 player match *** overall rate of match onset rate was 22.5 hamstring injuries per 1000 team *** bowling onset injuries were the highest subcategory at a rate of 10.9 injuries per 1000 team days,although batting onset injuries were particularly common in 50-over(one day) international *** risk factors in logistic regression analysis,in addition to hamstring injury history,were being a fast bowler relative risk(RR) 2.5(95% confidence interval(CI):1.3–4.5) and playing a match in Australia RR 2.3(95%CI:1.3–3.9).Conclusion:Fast bowlers suffer more hamstring injuries than other playing roles in cricket,particularly in First Class(multi-day) *** are more likely to get injured in 50-over(one day) *** in Australia(compared to overseas venues) leads to increased risk of hamstring injury.

关键词： Cricket Fast bowling Fielding Hamstring strains Muscle strains Sprinting

INTERNATIONAL COLLABORATION TO CONTROL ALKALI-AGGREGATE REACTION:THE SUCCESSFUL PROGRESS OF RILEM TC 106 AND TC 191-ARP.

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INTERNATIONAL COLLABORATION TO CONTROL ALKALI-AGGREGATE REAC...

促进2型糖尿病患者行为的可持续性改变：澳大利亚美好生活俱乐部的自我健康管理计划的评价

第十二届国际混凝土碱集料反应会议

作者： Ian sims Philip j Nixon Anne-Marie Marion STATS Limited St AlbansAL3 6PQUnited Kingdom Building Research Establishment GarstonWatfordWD25 9XXUnited Kingdom CRIC BrusselsB-1050Belgium

＜正＞ Since 1988, RILEM has been seeking to establish universally applicable test methods for assessing the alkali-reactivity potential of aggregates. Technical committee TC 106 （1988-2000） published two expansion tests （AAR-2 ＆ AAR-3）, following international trials, and started to develop two further procedures, for petrographic examination （AAR-1） and an ultra-accelerated concrete method （AAR-4）, together with an integrated assessment scheme （AAR-0）. Successor committee TC 191-ARP （formed in 2000）, comprising members from all parts of the world, has now finalised and published procedures AAR-0 and AAR-1 and has carried out international trials on AAR-4 and a method for assessing carbonate aggregates （AAR-5）. It also has a widened scope to seek international consistency in approaches to diagnosis （AAR-6） and specification （AAR-7） and in the assessment of alkali release from aggregates （AAR-8）. This paper reviews the overall progress of TC 191-ARP;three other papers presented at the conference describe the detailed progress on particular aspects of the work.. The authors are respectively Secretary and Chairman of TC 191-ARP （and previously of TC 106） and the leader of the TC 191-ARP team developing AAR-4.

关键词： RILEM International Tests Diagnosis Specification Alkali-aggregate Reaction Carbonates Releasable Alkalis.

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中国全科医学 2009年第23期12卷 2099-2104页

作者： Colette Browning Shane Thomas jane sims Lindner Helen Kelly j 3168 澳大利亚Monash大学初级卫生保健学院澳大利亚心理学会澳大利亚墨尔本东区全科医学网络

本文分析了澳大利亚美好生活俱乐部18个月的监测数据。美好生活俱乐部是澳大利亚联邦政府资助的"分担卫生服务项目"的一个研究项目,旨在促进50岁及以上糖尿病患者的慢性病自我管理。该项目的干预措施是跨理论行为改变模型和通过电话的... 详细信息

本文分析了澳大利亚美好生活俱乐部18个月的监测数据。美好生活俱乐部是澳大利亚联邦政府资助的"分担卫生服务项目"的一个研究项目,旨在促进50岁及以上糖尿病患者的慢性病自我管理。该项目的干预措施是跨理论行为改变模型和通过电话的动机谈话技术。在患者参加项目的基线、第6个月、第18个月收集数据。数据包括人口学信息、慢性病种类、健康行为、对健康的认识、锻炼程度、功能状态、自我效能、情绪状态、服务利用,以及9个目标行为的改变阶段。本文报告了150名接受18个月监测的患者数据。结果表明,在8个自我评价的症状中,有6个症状明显改善,差异有统计学意义。接受干预的患者对自我健康管理的信心在短期内明显增强。患者的卫生服务利用呈现减少趋势,但无统计学差异。卫生服务利用没有减少的原因,归因于参加者之间卫生服务利用方式的差异较大。参加项目第6个月时,患者行走的活动量增加,但第18个月时回到基线水平。这些发现表明,动机谈话技术能够在行为改变的最初阶段发挥作用,不过如果要长期地维持行为改变,则需要确定个体化和结构性的策略。

关键词：糖尿病,2型自我管理行为改变

Evolution of heart transplant donor characteristics in the 21st century: A United States single center’s experience

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World journal of Transplantation 2024年第3期14卷 22-29页

作者： Alexander M Spring Christiana Gjelaj Shivank Madan Snehal R Patel Omar Saeed Sandhya Murthy Yogita Rochlani Daniel B sims Sasha Vukelic Stephen j Forest jamil F Borgi Daniel j Goldstein Ulrich P jorde Montefiore-Einstein Center for Heart and Vascular Care Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10467United States Division of Cardiothoracic Surgery Tulane UniversityNew OrleansLA 70112United States

Despite a record setting number of heart transplants performed annually,the national donor shortage continues to plague transplant teams across the United *** we describe the barriers to adaptation of numerous“non-traditional”orthotopic heart transplant donor characteristics including donors with hepatitis C virus,those meeting criteria for donation after cardiac death,donors with coronavirus disease 19 infection,donors with the human immunodeficiency virus,and grafts with left ventricular systolic *** center’s objective was to increase our transplant volume by expanding our donor pool from“traditional”donors to these“non-traditional”*** detail how medical advances such as certain laboratory studies,pharmacologic interventions,and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.

关键词： Orthotopic heart transplantation Hepatitis C virus COVID-19 Left ventricular systolic dysfunction Human immunodeficiency virus Donation after cardiac death

Assessment of the Effects of Poultry Litter on Surface Runoff Water Quality from Agricultural Lands

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journal of Water Resource and Protection 2010年第5期2卷 413-423页

作者： Sudarshan K. Dutta Shreeram P. Inamdar j. Tom sims Alyssa Collins 不详

The use of pelletized poultry litter (PPL) as a substitute for inorganic fertilizers is increasingly being en-couraged in states like Delaware which have a considerable surplus of poultry litter. However, we know very little about the impacts of PPL on runoff water quality and whether it is an environmentally-sound and sus-tainable alternative to inorganic fertilizer. To address these questions we compared the exports of nutrients (NH4-N, NO3-N and PO4-P) and trace elements (As, Cu, and Zn) in surface runoff from agricultural plots receiving PPL, raw poultry litter (RPL), urea and no-fertilizer (control) treatments. The study was conducted on agricultural land located in Middletown, Delaware with corn as the cover crop. The experimental plots were 5 m wide and 12 m long with reduced tillage and no-tillage management practices. Sampling was con-ducted for six natural rainfall events from April through August 2008. Nutrient (NH4-N, NO3-N and PO4-P) exports from plots receiving PPL were less than those with urea or raw litter applications. While exports of trace elements from the PPL treatment exceeded those from urea, they were much lower than the corre-sponding exports from the RPL treatments. Mass exports of nutrients and trace elements were correlated with event size (rainfall amount) but were not correlated with timing of event (days since litter application). Results from this study suggest that the use of PPL in combination with no-tillage may provide an environ-mentally safe alternative to synthetic fertilizers.

关键词： Poultry Litter Surface Runoff Water Quality Tillage Best Management Practices Nutrients Trace Elements

术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除（英文）

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中华神经外科疾病研究杂志 2016年第5期15卷 465-465页

作者： Neira jA Ung TH sims j Malone HR Chow DS Samanamud jL Zanazzi Gj Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce jN Department of Neurological Surgery Columbia University Medical Center Department of Neuroradiology Columbia University Medical Center Department of Pathology and Cell Biology Columbia University Medical Center Department of Radiology Columbia University Medical Center

Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 *** localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of *** Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the u

关键词：神经外科学疾病研究医学研究临床分析