新生儿囊性纤维化筛查与治疗强度减低有关
Newborn screening for cystic fibrosis is associated with reduced treatment intensity作者机构：Division of Maternal and Child Health Sciences Ninewells Hospital and Medical School University of Dundee Dundee DD1 9SY United Kingdom
出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)
年 卷 期：2006年第2卷第2期
页 面：24-25页
学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100202[医学-儿科学] 100215[医学-康复医学与理疗学] 10[医学]
主 题：新生儿筛查 治疗强度 囊性纤维化 绿脓杆菌感染 临床诊断 胎粪性肠梗阻 NBS 观察性研究 年龄组 抗生素治疗
摘 要：Objectives: To determine whether the improved clinical status after newborn screening (NBS) for cystic fibrosis (CF) segregates with increased therapeutic intervention compared with presentation by clinical diagnosis (CD). Study design: In 2002, two populations (1 to 9 years of age) who presented (excluding meconium ileus) by NBS ≤ 3 months of age or by CD were compared in an observational, cross-sectional design. NBS and CD populations (184 and 950 patients, respectively) were divided into 3-year age groups (1 to 3, 4 to 6, and 7 to 9 years)-. Therapies of duration 3 months were compared together with Pseudomonas aeruginosa infection status. Results: NBS patients≤ 6 years of age received significantly fewer and less demanding therapies not explained by age, genotype, geography, or social deprivation. In 7-to 9-year-olds, significantly fewer NBS patients received intravenous antibiotics. NBS patients without P aeruginosa infection received significantly fewer therapies, but no differences were found between intermittently or chronically infected NBS and CD populations. Comparable results were found in Δ F508/Δ F508 subpopulations. Conclusions: CF populations diagnosed by NBS are associated with reduced treatment compared with age and genotype-matched CD control subjects.
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