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Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor simone prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

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Clustering of voltage-gated ion channels as an evolutionary trigger of myelin formation

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Neural Regeneration Research 2024年第8期19卷 1631-1632页

作者： Henrike Ohm simone Rey Christian Klambt Institut fur Neuro-und Verhaltensbiologie MunsterGermany

Neurons carry apical dendrites that perceive information and a basal axon that transmits the computed information towards its to *** axon originates at the axon hillock which is followed by the axon initial ***,action potentials are initiated that are based on millisecond long openings of specific voltagegated sodium and potassium channels that are conserved in all parahoxozoa(Placozoa,Cnidaria,Bilateria)(Li et al.,2015).

关键词： initiated carry potassium

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Statistical analysis of physico-mechanical parameters of sandstones occurring in orogenic settings

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Journal of Mountain Science 2024年第4期21卷 1388-1402页

作者： PAPPALARDO Giovanna CARBONE Serafina MONACO Carmelo ZOCCO Giordana MINEO simone Dipartimento Di Scienze Biologiche Geologiche E AmbientaliUniversitàDegli Studi Di CataniaCorso Italia 5795129 CataniaItaly

In northeastern Sicily(Italy),sandstone rock masses widely crop out as cover deposits over crystalline terrains belonging to the orogenic *** being part of the same geological formation,these sandstones are characterized by highly different features in terms of texture and physico-mechanical *** poses a scientific question on the possibility of tracing these rocks to a single statistical model,which could be representative of their main engineering geological ***,it is worth investigating on the possible reasons of such differences,that should be searched either in the current geographical sandstone distribution or in the rock *** this study,sandstone samples were collected from different sites and were analyzed at both the hand and thin section *** sandstone types were recognized,characterized by a different ***,the laboratory characterization allowed estimating their main physico-mechanical and ultrasonic properties,such as porosity,density,mechanical strength,deformability,and ultrasonic *** rock mechanical strength proved linked to the rock compactness and to the presence of lithic fragments,while pores and a pseudo-matrix between grains represent weakening *** data were also statistically analyzed by grouping the specimens according to a geographical criterion,with respect to their sampling area,but no link was found between location and rock ***,with the aim of achieving mathematical laws that could be used to predict some rock properties from others,useful for practical purposes when dealing with such a high property variability,single and multiple regression analyses were carried *** show that the Uniaxial Compressive Strength,porosity,and P-wave velocity are the best predictors for a quick,indirect estimation of the main physico-mechanical *** methodological approach developed for this research can be taken as reference to study other world

关键词： Sandstone Laboratory test Uniaxial Compressive Strength Porosity Rocks

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High-speed tracked vehicle model order reduction for static and dynamic simulations

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Defence Technology（防务技术） 2024年第8期38卷 89-110页

作者： Luca Dimauro simone Venturini Antonio Tota Enrico Galvagno Mauro Velardocchia Department of Mechanical and Aerospace Engineering Politecnico di TorinoCorso Duca degli Abruzzi2410129TorinoItaly

In this paper, a model order reduction strategy is adopted for the static and dynamic behaviour simulation of a high-speed tracked vehicle. The total number of degree of freedom of the structure is condensed through a selection of interface degrees of freedom and significant global mode shapes, for an approximated description of vehicle dynamic behaviour. The methodology is implemented in a customised open-source software to reduce the computational efforts. The modelled tracked vehicle includes the sprung mass, the unsprung masses, connected by means of torsional bars, and all the track assemblies, composing the track chain. The proposed research activity presents a comprehensive investigation of the influence of the track chain, combined with longitudinal vehicle speed, on statics and vehicle dynamics, focusing on vertical dynamics. The vehicle response has been investigated both in frequency and time domain. In this last case road-wheel displacements are assumed as inputs for the model, under different working conditions, hence considering several road profiles with different amplitudes and characteristic excitation frequencies. Simulation results have proven a high fidelity in model order reduction approach and a significant contribution of the track chain in the global dynamic behaviour of the tracked vehicle.

关键词： Tracked vehicle dynamics Rubber characteristics Component mode synthesis Modal analysis Open-source

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Are we close to using Alzheimer blood biomarkers in clinical practice?

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Neural Regeneration Research 2024年第12期19卷 2583-2585页

作者： Bruno P.Imbimbo simone Lista Camillo Imbimbo Robert Nisticò Department of Research&Development Chiesi FarmaceuticiParmaItaly i+HeALTH Strategic Research Group Department of Health SciencesMiguel de Cervantes European University(UEMC)ValladolidSpain Department of Brain and Behavioral Sciences University of PaviaPaviaItaly School of Pharmacy University of Rome“Tor Vergata”RomeItaly Laboratory of Pharmacology of Synaptic Plasticity EBRI Rita Levi-Montalcini FoundationRomeItaly

Alzheimer's disease(AD) is a progressive neurodegenerative disease histologically characterized by the presence of extraneuronal plaques,mainly formed by the 42-aminoacid isoform of amyloid-(Aβ_(1-42)),and by intraneuronal neurofibrillary to ngles,mainly formed by the tau protein and its hyperphosphorylated isoforms(p-tau).AD is the most common cause of dementia,with an estimated lifetime risk of about 1 in 10 for men and 1 in 5 for women.

关键词： Alzheimer tau Aβ

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Cavity-enhanced photoacoustic dual-comb spectroscopy

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Light(Science & Applications) 2024年第4期13卷 610-618页

作者： Zhen Wang Qinxue Nie Haojia Sun Qiang Wang simone Borri Paolo De Natale Wei Ren Department of Mechanical and Automation Engineering The Chinese University of Hong KongNew TerritoriesHong Kong SARChina. State Key Laboratory of Applied Optics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of Sciences130033 ChangchunChina. CNRINO-Istituto Nazionale di Ottica and LENS-European Laboratory for Nonlinear Spectroscopy50019 Sesto FiorentinoItaly

Photoacoustic dual-comb spectroscopy(DCS),converting spectral information in the optical frequency domain to the audio frequency domain via multi-heterodyne beating,enables background-free spectral measurements with high resolution and broad ***,the detection sensitivity remains limited due to the low power of individual comb lines and the lack of broadband acoustic ***,we develop cavity-enhanced photoacoustic DCS,which overcomes these limitations by using a high-finesse optical cavity for the power amplification of dual-frequency combs and a broadband acoustic resonator with a flat-top frequency *** demonstrate high-resolution spectroscopic measurements of trace amounts of C2H2,NH3 and CO in the entire telecommunications *** method shows a minimum detection limit of 0.6 ppb C2H2 at the measurement time of 100 s,corresponding to the noise equivalent absorption coefficient of 7×10−10 cm−*** proposed cavityenhanced photoacoustic DCS may open new avenues for ultrasensitive,high-resolution,and multi-species gas detection with widespread applications.

关键词： individual cavity spectroscopy

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ZrB_(2)-SiC ceramics toughened with oriented paper-derived graphite for a sustainable approach

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Journal of Advanced Ceramics 2024年第2期13卷 207-219页

作者： Luca Zoli Francesca Servadei simone Failla Matteo Mor Antonio Vinci Pietro Galizia Diletta Sciti CNR-ISSMC Institute of ScienceTechnology and Sustainability for CeramicsFaenza I-48018Italy

Carbon fibre-reinforced ultra-high temperature ceramics(UHTCs)are considered a class of promising materials for several applications,the most appealing ones being in the aerospace *** is necessary to overcome the brittleness and low thermal shock resistance of ceramics and is often provided through the addition of carbon fibres or other carbon-based phases,such as nanotubes,graphene,and *** present work is focused on the toughening of UHTCs through incorporation of 30-50 vol% thin,ordered graphite layers from conventional filter paper followed by hot pressing *** filter paper was selected because it undergoes thermolysis with no melting stage forming a strong carbonaceous residue that can be used as *** and mechanical properties of toughened composites were compared to those of other materials reinforced with short carbon fibres and the effect of different distribution of graphite was *** of graphite allowed toughness to be increased from 3−4 MPa·m^(1/2)(for unreinforced materials)to 5.1−5.5 MPa·m^(1/2),similar to results obtained with short fibre *** high-temperature properties,such as strength and toughness as well as oxidation resistance at 1500℃,were also examined.

关键词： borides paper-derived graphite microstructure toughness sustainability

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The initial stages of Li_(2)O_(2) formation during oxygen reduction reaction in Li-O_(2) batteries:The significance of Li_(2)O_(2) in charge-transfer reactions within devices

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Journal of Energy Chemistry 2024年第1期88卷 223-231,I0006页

作者： Daniela M.Josepetti Bianca P.Sousa simone A.J.Rodrigues Renato G.Freitas Gustavo Doubek Advanced Energy Storage Division LABCenter for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasAv Albert Einstein 50013083-852CampinasSPBrazil Institute of Physics&Department of Chemistry Laboratory of Computational MaterialsFederal University of Mato Grosso78060-900CuiabáMTBrazil

Lithium-oxygen batteries are a promising technology because they can greatly surpass the energy density of lithium-ion ***,this theoretical characteristic has not yet been converted into a real device with high *** with air contamination,metallic lithium reactivity,and complex discharge and charge reactions are the main issues for this technology.A fast and reversible oxygen reduction reaction(ORR)is crucial for good performance of secondary batteries',but the partial knowledge of its mechanisms,especially when devices are concerned,hinders further *** this perspective,the present work uses operando Raman experiments and electrochemical impedance spectroscopy(EIS)to assess the first stages of the discharge processes in porous carbon electrodes,following their changes cycle by cycle at initial operation.A growth kinetic formation of the discharge product signal(Li_(2)O_(2))was observed with operando Raman,indicating a first-order reaction and enabling an analysis by a microkinetic *** solution mechanism in the evaluated system was ascribed for an equivalent circuit with three time *** the time constant for the anode interface reveals to remain relatively constant after the first discharge,its surface seemed to be more *** model indicated that the reaction occurs at the Li_(2)O_(2) surface,decreasing the associated resistance during the initial discharge ***,the growth of Li_(2)O_(2) forms a hetero-phase between Li_(2)O_(2)/electrolyte,while creating a more compact and homogeneous on the Li_(2)O_(2)/cathode *** methodology here described thus offers a way of directly probing changes in surface chemistry evolution during cycling from a device through EIS analysis.

关键词： Li-O_(2)battery Operando Raman analysis Equivalent circuit modeling Time-constant distribution

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Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health

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Journal of Animal Science and Biotechnology 2024年第2期15卷 645-658页

作者： Christina Larsen simone Margaard Offersen Anders Brunse Mattia Pirolo Soumya Kanti Kar Luca Guadabassi Thomas Thymann Department of Veterinary and Animal Science University of CopenhagenDyrlagevej 681870 Frederiksberg CDenmark Animal Nutrition Wageningen Livestock ResearchWageningen University&Research1 De Elst6708 WageningenThe Netherlands

Background Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig *** and gut dysbiosis may in part be prevented via improved early postnatal microbial colonization of the *** secure better postnatal gut colonization,we hypothesized that transplantation of colonic or gastric content from healthy donors to newborn recipients would prevent diarrhea in the recipients in the post-weaning *** objective was to examine the impact of transplanting colonic or gastric content on health and growth parameters and paraclinical parameters in recipient single-housed piglets exposed to a weaning transition and challenged with enterotoxigenic Escherichia coli(ETEC).Methods Seventy-two 1-day-old piglets were randomized to four groups:colonic microbiota transplantation(CMT,n=18),colonic content filtrate transplantation(CcFT,n=18),gastric microbiota transplantation(GMT,n=18),or saline(CON,n=18).Inoculations were given on d 2 and 3 of life,and all piglets were milk-fed until weaning(d 20)and shortly after challenged with ETEC(d 24).We assessed growth,diarrhea prevalence,ETEC concentration,organ weight,blood parameters,small intestinal morphology and histology,gut mucosal function,and microbiota composition and *** Episodes of diarrhea were seen in all groups during both the milk-and the solid-feeding phase,possibly due to stress associated with single ***,CcFT showed lower diarrhea prevalence on d 27,28,and 29 compared to CON(all Pprevalence on d 27(Pprotective effect was marginal,suggesting that higher doses,more effective modalities of administration

关键词： Colonic content filtrate transplantation Colonic microbiota transplantation Gastric microbiota transplantation Gut microbiota Mucosa Neonatal Post-weaning diarrhea

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Solid pseudopapillary tumor of the pancreas:A systematic review of clinical,surgical and oncological characteristics of 1384 patients underwent pancreatic surgery

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 331-338页

作者： Gennaro Mazzarella Edoardo Maria Muttillo Diego Coletta Biagio Picardi Stefano Rossi simone Rossi Del Monte Vito Gomes Irnerio Angelo Muttillo Division of General and Emergency Surgery San Filippo Neri Hospital00136 RomeItaly Department of Surgery“Pietro Valdoni” Sapienza University of RomeViale del Policlinico 15500161 RomeItaly Surgical and Medical Department of Translational Medicine Sant’Andrea HospitalSapienza University of Rome00185 RomeItaly Department of Surgical Sciences Umberto I University HospitalSapienza University of Rome00136 RomeItaly Department of General Surgery Ospedali Riuniti Marche Nord61121 PesaroItaly Department of Pathology San Filippo Neri Hospital00136 RomeItaly

Background:Pancreatic solid pseudopapillary tumors(SPTs)are rare clinical entity,with low malignancy and still unclear *** account for less than 2%of exocrine pancreatic *** study aimed to perform a systematic review of the main clinical,surgical and oncological characteristics of pancreatic *** sources:MEDLINE/PubMed,Web of Science and Scopus databases were systematically searched for the main clinical,surgical and oncological characteristics of pancreatic SPTs up to April 2021,in accordance with the preferred reporting items for systematic reviews and meta-analyses(prISMA)*** endpoints were to analyze treatments and oncological ***:A total of 823 studies were recorded,86 studies underwent full-text reviews and 28 met inclusion ***,1384 patients underwent pancreatic *** age was 30 years and 1181 patients(85.3%)were *** most common clinical presentation was non-specific abdominal pain(52.6%of cases).Mean overall survival was 98.1%.Mean recurrence rate was 2.8%.Mean follow-up was 4.2 ***:Pancreatic SPTs are rare,and predominantly affect young women with unclear *** resection is the gold standard of treatment achieving good oncological impact and a favorable prognosis in a yearly life-long follow-up.

关键词： Frantz’s tumor Pancreas Pancreatic neoplasms Pancreatic surgery Solid pseudopapillary tumor

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