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Amine-rich carbon nitride nanoparticles:Synthesis,covalent functionalization with proteins and application in a fluorescence quenching assay

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Nano Research 2019年第8期12卷 1862-1870页

作者： Gabriele Capilli simone Cavalera Laura Anfossi Cristina Giovannoli Marco Minella Claudio Baggiani Claudio Minero Department of Chemistry and NIS Center of Excellence University of Torino10125 TorinoItaly

Carbon nitride nanoparticles (CNNPs) have been employed as fluorescent sensing tools owing to their unique features, e.g. low cost production, high stability in water and high photoluminescence quantum yield. Here, an easy and versatile synthetic approach was exploited to design fluorescent nanoparticles with surface functionalities suitable for covalent binding to bioligands. High hydrophilic, brightly fluorescent CNNPs, rich of superficial amines, were obtained from the thermal condensation of urea and lysine (CNNP^Lys) and by tuning the precursor ratio and the heating time. Structure and size of the functionalized nanoparticles were characterized through infrared (IR) spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering (DLS). Their optical properties were studied by ultraviolet-visible (UV-Vis) and fluorescence spectroscopy. The superficial primary amino groups, furnished by the lysine co-precursor, enabled for covalently linking CNNP^Lys to model proteins. The CNNP^Lys-protein conjugates excited under UV irradiation emit in the 400-450 nm visible range (quantum yield 24%). The applicability of CNNP^Lys as novel fluorescent probes was demonstrated by a fluorescence quenching assay, in which gold nanoparticles (GNPs) were attached to Staphylococcal protein A and employed to quench the CNNP^Lys fluorescence by Forster resonant energy transfer (FRET). The quenching occurred upon formation of the specific binding between the GNP-linked protein A and CNNP^Lys-tagged immunoglobulins, while the inhibition of the binding resulted in the recovery of CNNP^Lys luminescence. The synthetic strategy, based on combining a "conjugated polymer"-forming unit (urea) and a co-precursor able to provide the desired functional group (lysine), allows designing innovative materials for the development of new generation fluorescence biosensors in which easily functionalized fluorophores are needed.

关键词： fluorescent probe carbon nitride nanoparticles quenching assay fluorescent materials g-C3N4 Forster resonant energy transfer (FRET)

Current highlights on solid pseudopapillary neoplasm of the pancreas

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World Journal of Hepatology 2022年第1期14卷 300-303页

作者： simone Sibio Sara Di Carlo Department of Surgery Pietro Valdoni Sapienza University of RomeUmberto I HospitalRome 00161Italy Minimally Invasive Surgery Unit Tor Vergata HospitalTor Vergata University of RomeRome 00133Italy

Solid pseudopapillary neoplasm of the pancreas is a low-grade malignant tumor that predominantly affects young women in their third and fourth *** and risk factors are *** symptoms are aspecific and most commonly due to mass *** is made by computed tomography scan or magnetic resonance imaging and histological characterization is obtained by endoscopic ultrasound-guided fine needle ***,these lesions are composed by both solid and pseudopapillary structures with necrotic and hemorrhagic ***,the biological behavior is aggressive with tumor recurrence and distant ***,curative R0 surgical resection is the best option able to provide long term survival even in advanced *** disease is the main predictor of poor *** and radiotherapy regimens are not well ***,they could be effective in reducing tumor size as neoadjuvant treatment or disease control in palliative *** complete surgical resection provides a cure rate of>95%,considering young age of the patients and morbidity associated to pancreatic surgery,further studies are needed to better investigate risk factors and responsiveness to hormones in order to allow early diagnosis and follow up strategies that could avoid unnecessary surgery in less aggressive disease.

关键词： Pseudopapillary neoplasm Pancreatic tumor Pancreaticoduodenectomy Distal pancreatectomy Pancreas Surgery

Credit, funding, margin, and capital valuation adjustments for bilateral portfolios

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Probability, Uncertainty and Quantitative Risk 2017年第1期2卷 145-170页

作者： Claudio Albanese simone Caenazzo Stephane´Crepey IMEX LondonUK CASS School of Business LondonUK LaMME Univ EvryCNRSUniversite Paris-Saclay91037EvryFrance

We apply to the concrete setup of a bank engaged into bilateral trade portfolios the XVA theoretical framework of Albanese and Crepey(2017),whereby´so-called contra-liabilities and cost of capital are charged by the bank to its clients,on top of the fair valuation of counterparty risk,in order to account for the incompleteness of this *** transfer of the residual reserve credit capital from shareholders to creditors at bank default results in a unilateral CVA,consistent with the regulatory requirement that capital should not diminish as an effect of the sole deterioration of the bank credit *** funding cost for variation margin(FVA)is defined asymmetrically since there is no benefit in holding excess capital in the *** is fungible as a source of funding for variation margin,causing a material FVA *** introduce a specialist initial margin lending scheme that drastically reduces the funding cost for initial margin(MVA).Our capital valuation adjustment(KVA)is defined as a risk premium,*** cost of remunerating shareholder capital at risk at some hurdle rate.

关键词： Counterparty risk Credit valuation adjustment(CVA) Cost of funding variation margin(FVA) Cost of funding initial margin(MVA) Cost of capital(KVA)

Molecular methods for colorectal cancer screening:Progress with next-generation sequencing evolution

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World Journal of Gastrointestinal Oncology 2023年第3期15卷 425-442页

作者： Salma Abbes simone Baldi Hayet Sellami Amedeo Amedei Leila Keskes Laboratory of Parasitic and Fungal Molecular Biology University of SfaxSfax 3029Tunisia Department of Experimental and Clinical Medicine University of FlorenceFlorence 50134Italy Drosophila Research Unit-Parasitology and Mycologie Laboratory University of SfaxSfax 3029Tunisia SOD of Interdisciplinary Internal Medicine Careggi University HospitalFlorence 50134Italy Laboratory of Human Molecular Genetic University of SfaxSfax 3029Tunisia

Currently,colorectal cancer(CRC)represents the third most common malignancy and the second most deadly cancer worldwide,with a higher incidence in developed *** other solid tumors,CRC is a heterogeneous genomic disease in which various alterations,such as point mutations,genomic rearrangements,gene fusions or chromosomal copy number alterations,can contribute to the disease ***,because of its orderly natural history,easily accessible onset location and high lifetime incidence,CRC is ideally suited for preventive intervention,but the many screening efforts of the last decades have been compromised by performance limitations and low penetrance of the standard screening *** advent of next-generation sequencing(NGS)has both facilitated the identification of previously unrecognized CRC features such as its relationship with gut microbial pathogens and revolutionized the speed and throughput of cataloguing CRC-related genomic ***,in this review,we summarized the several diagnostic tools used for CRC screening in the past and the present,focusing on recent NGS approaches and their revolutionary role in the identification of novel genomic CRC characteristics,the advancement of understanding the CRC carcinogenesis and the screening of clinically actionable targets for personalized medicine.

关键词： Colorectal cancer Gut microbiota Colorectal cancer screening Next-generation sequencing

An integrative Tai Chi program for patients with breast cancer undergoing cancer therapy:study protocol for a randomized controlled feasibility study

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Journal of Integrative Medicine 2018年第2期16卷 99-105页

作者： Lizhou Liu simone Petrich Blair McLaren Lyndell Kelly G.David Baxter Centre for Health Activity and Rehabilitation ResearchSchool of PhysiotherapyUniversity of Otago Department of Surgical Sciences Southern District Health Board Oncology Department Southern District Health Board

Background： Breast cancer patients experience various side effects during cancer therapy, often resulting in reduced quality of life and poor adherence to treatment. A limited range of proven interventions has been developed to target such side effects. While Tai Chi offers benefits for the health and well-being of breast cancer survivors, the effectiveness of Tai Chi across the treatment continuum has not been evalu- ated. Improved patient education and support has been suggested as a priority for breast cancer care. This pilot study assesses the feasibility of a randomized controlled trial （RCT） to evaluate the effectiveness of ＂an integrative Tai Chi＂（ANITA） program for breast cancer patients undergoing cancer therapy. Methods/design： This is a single-centre, two-arm feasibility RCT. Twenty-four patients with breast cancer who have undergone surgical treatment will be recruited from the Dunedin Hospital （New Zealand） over a 12-month period （from August 2017 to July 2018）. Subject to informed consent, patients will be ran- domized to receive standard cancer treatment alone or standard cancer treatment plus the ANITA pro- gram, consisting of peer support, health education, and Tai Chi Ruler exercise. The program runs alongside the patient＇s adjuvant cancer therapy, which may include chemotherapy, radiation therapy, antibody treatment, and/or antihormonal therapy. Analysis in this study will focus on process evaluation of participant recruitment, retention, treatment fidelity, acceptability of the program, and occurrence of adverse events. Clinical outcomes （i.e., fatigue, sleep quality, anxiety and depression and quality of life） will be assessed at baseline, and at 12 weeks and 24 weeks post-randomization. Discussion： Outcomes from this study will inform the feasibility and methodology for a future fully- powered RCT.

关键词： Tai Chi Breast cancer Feasibility study Randomized controlled trial Peer support Health education

Levant Drought Occurrence, Lebanon Case

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Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer

Atmospheric and Climate Sciences（大气和气候科学） 2024年第1期

作者： Ihab Jomaa Mariam Choker Nisrine El Haj Marie Therese Abi Saab Matteo Funaro simone Mereu

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World Journal of Gastroenterology 2016年第8期22卷 2441-2459页

作者： simone Polvani Mirko Tarocchi Sara Tempesti Lapo Bencini Andrea Galli Department of Experimental and Clinical Biomedical Sciences "Mario Serio" University of Florence Chirurgia Generale Oncologica Azienda Ospedaliero Universitaria Careggi

Pancreatic ductal adenocarcinoma (PDAC) is the fourth cause of cancer death with an overall survival of 5% at five years. The development of PDAC is characteristically associated to the accumulation of distinctive genetic mutations and is preceded by the exposure to several risk factors. Epidemiology has demonstrated that PDAC risk factors may be non-modifiable risks (sex, age, presence of genetic mutations, ethnicity) and modifiable and co-morbidity factors related to the specific habits and lifestyle. Recently it has become evident that obesity and diabetes are two important modifiable risk factors for PDAC. Obesity and diabetes are complex systemic and intertwined diseases and, over the years, experimental evidence indicate that insulin-resistance, alteration of adipokines, especially leptin and adiponectin, oxidative stress and inflammation may play a role in PDAC. Peroxisome proliferator activated receptor-γ (PPARγ) is a nuclear receptor transcription factor that is implicated in the regulation of metabolism, differentiation and inflammation. PPARγ is a key regulator of adipocytes differentiation, regulates insulin and adipokines production and secretion, may modulate inflammation, and it is implicated in PDAC. PPARγ agonists are used in the treatment of diabetes and oxidative stress-associated diseases and have been evaluated for the treatment of PDAC. PPARγ is at the cross-road of diabetes, obesity, and PDAC and it is an interesting target to pharmacologically prevent PDAC in obese and diabetic patients.

关键词： Insulin Pancreatic cancer Adipose tissue Metformin Nuclear receptor Leptin Adiponectin Inflammation Thiazolidinediones

Geospatial web services pave new ways for server-based on-demand access and processing of Big Earth Data

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International Journal of Digital Earth 2018年第1期11卷 7-25页

作者： Julia Wagemann Oliver Clements Ramiro Marco Figuera Angelo Pio Rossi simone Mantovani Forecast Department European Centre for Medium-Range Weather ForecastsReadingUK Remote Sensing Group Plymouth Marine LaboratoryPlymouthUK Department of Physics and Earth Sciences Jacobs UniversityBremenGermany MEEO S.r.l. FerraraItaly

Big Earth Data has experienced a considerable increase in volume in recent years due to improved sensing technologies and improvement of numerical-weather prediction *** traditional geospatial data analysis workflow hinders the use of large volumes of geospatial data due to limited disc space and computing *** web service technologies bring new opportunities to access large volumes of Big Earth Data via the Internet and to process them at *** practical examples are presented from the marine,climate,planetary and earth observation science communities to show how the standard interface Web Coverage Service and its processing extension can be integrated into the traditional geospatial data *** service technologies offer a time-and cost-effective way to access multidimensional data in a user-tailored format and allow for rapid application development or time-series *** transport is minimised and enhanced processing capabilities are *** research is required to investigate web service implementations in an operational mode and large data centres have to become more progressive towards the adoption of geo-data standard *** the same time,data users have to become aware of the advantages of web services and be trained how to benefit from them most.

关键词： Geospatial web services interoperability Big Earth Data open data Open Geospatial Consortium(OGC)

Multiscale Hemodynamics Using GPU Clusters

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Communications in Computational Physics 2012年第1期11卷 48-64页

作者： Mauro Bisson Massimo Bernaschi simone Melchionna Sauro Succi Efthimios Kaxiras Department of Computer Science University of Rome“Sapienza”Italy Istituto Applicazioni Calcolo Consiglio Nazionale delle RicercheRomeItaly Istituto Processi Chimico-Fisici Consiglio Nazionale delle RicercheRomeItaly Institute of Material Sciences and Engineering ´Ecole Polytechnique F´ed´erale de LausanneSwitzerland Freiburg Institute for Advanced Studies School of Soft Matter ResearchAlbertstr.1979104 FreiburgGermany Department of Physics and School of Engineering and Applied Sciences Harvard UniversityCambridgeMAUSA

The parallel implementation of MUPHY,a concurrent multiscale code for large-scale hemodynamic simulations in anatomically realistic geometries,for multi-GPU platforms is *** tests show excellent results,with a nearly linear parallel speed-up on up to 32GPUs and a more than tenfold GPU/CPU acceleration,all across the range of *** basic MUPHY scheme combines a hydrokinetic(Lattice Boltzmann)representation of the blood plasma,with a Particle Dynamics treatment of suspended biological bodies,such as red blood *** the best of our knowledge,this represents the first effort in the direction of laying down general design principles for multiscale/physics parallel Particle Dynamics applications in non-ideal *** configures the present multi-GPU version of MUPHY as one of the first examples of a high-performance parallel code for multiscale/physics biofluidic applications in realistically complex geometries.

关键词： Multi-GPU computing hemodynamics molecular dynamics irregular domain