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Evaluation of wound healing and antimicrobial potentials of Ixora coccinea root extract

Asian Pacific Journal of Tropical Medicine 2011年第12期4卷 959-963页

作者： Nagaraj Selvaraj Baskar Lakshmanan Papiya Mitra Mazumder Muthukumar Karuppasamy simon santosh jena Ashok Kumar Pattnaik Department of Pharmaceutical Sciences Birla Institute of TechnologyMesraRanchiJharkhand-835215India

Objective:To evaluate the wound healing and antimicrobial activity of root extracts of Ixora coccinea(***).Methods:To investigate the wound healing efficacy of root extract of *** Linn,five groups of animals were divided each containing six *** wound models including incision and excision wound models were used in this *** parameters studied were tensile strength on incision wound model and in terms of wound contraction for excision wound model were compared with standard Nitrofurazone(NFZ) ointment(0.2%w/w). Six extracts(***,petroleum ether,benzene,chloroform and ethyl acetate ) of I. coccinea were screened for in vitro growth inhibiting activity against different bacterial strains riz. Staphylococcia *** pumilius,Enterococcus *** coli,Salmonella typhi and Pseudomonas aeruginosa and fungi Candida albicans and Aspergillus niger were compared with the standard drugs ciprofloxacin and chloramphenicol for antibacterial and griscofulvin for antifungal *** serial dilution and cup(or) well plate methods were used for the antimicrobial study and MIC was ***:The ethanolic extract showed significant (P<0.001) wound healing activity when compared to standard drug NFZ with respect to normal control *** *** extract showed highly significant antibacterial activity against all bacterial strains used in this study when compared to *** aqueous extract showed moderate significant inhibition against all bacterial strains when compared to standard. All the extracts were shown negligible activity against the fungal strains used in this study. Conclusions:The ethanolic root extract of *** showed pronounced wound healing and antibacterial *** probable reason to heal the wound was that the external application of the extract prevented the microbes to invade through the wound thus the protection of wound occurs against the infection of the various or

关键词： Ixora coccinea Wound contraction Tensile strength Antimicrobial activity Ethanolic extract

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Upstream-downstream linkages of hydrological processes in the Himalayan region

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Ecological Processes 2014年第1期3卷 51-66页

作者： santosh Nepal Wolfgang-Albert Flugel Arun Bhakta Shrestha International Centre for Integrated Mountain Development(ICIMOD) KathmanduNepal Department of Geoinformatics Hydrology and ModellingFriedrich Schiller UniversityJena(FSU-Jena)Germany

Understanding the upstream-downstream linkages in hydrological processes is essential for water resources planning in river *** there are many studies of individual aspects of these processes in the Himalayan region,studies along the length of the basins are *** study summarizes the present state of knowledge about linkages in hydrological processes between upstream and downstream areas of river basins in the Himalayan region based on a literature *** paper studies the linkages between the changes in the physical environment of upstream areas(land use,snow storage,and soil erosion)and of climate change on the downstream water availability,flood and dry season flow,and erosion and *** is argued that these linkages are complex due to the extreme altitudinal range associated with the young and fragile geology,extreme seasonal and spatial variation in rainfall,and diversity of anthropogenic *** on the findings,the paper concludes that integrated systems analysis is required to understand the holistic complexity of upstream-downstream linkages of hydrological processes in the river basin *** integrated land and water resources management(ILWRM)approach can be instrumental in developing adaptive solutions to problems and can also enable stakeholders of upstream and downstream areas with various interests and needs to work together for the better utilization and management of land and water *** a part of this,the specific circumstances of the upstream communities,who live in fragile and inaccessible mountain areas with limited resource opportunities,should be taken into account so that incentive mechanisms can be established to encourage and acknowledge their contribution.

关键词： Integrated land and water resources management Himalayan region Integrated systems analysis Geoinformatics Physical linkages Value of environmental services

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CuZr-based bulk metallic glass and glass matrix composites fabricated by selective laser melting

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Journal of Materials Science & Technology 2021年第22期81卷 139-150页

作者： Liang Deng Long Zhang Konrad Kosiba RenéLimbach Lothar Wondraczek Gang Wang Dongdong Gu Uta Kühn simon Pauly Leibniz IFW Dresden Institute for Complex MaterialsHelmholtzstraße 20D-01069DresdenGermany Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Otto Schott Institute of Materials Research University of JenaFraunhoferstraße 6D-07743 JenaGermany Laboratory for Microstructure Institute of MaterialsShanghai UniversityShanghai200444China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China University of Applied Sciences Aschaffenburg Würzburger Straße 45D-63743AschaffenburgGermany

Monolithic bulk metallic glass and glass matrix composites with a relative density above 98%were produced by processing Cu_(46)Zr_(46)Al_(8)(at.%)via selective laser melting(SLM).Their microstructures and mechanical properties were systematically examined.B2 CuZr nanocrystals(30-100 nm in diameter)are uniformly dispersed in the glassy matrix when SLM is conducted at an intermediate energy *** B2 CuZr nanocrystals nucleate the oxygen-stabilized big cube phase during a remelting *** presence of these nanocrystals increases the structural heterogeneity as indirectly revealed by mircrohardness and nanoindentation *** corresponding maps in combination with calorimetric data indicate that the glassy phase is altered by the processing *** the formation of crystals and a high overall free volume content,all additively manufactured samples fail at lower stress than the as-cast glass and without any plastic *** inherent brittleness is attributed to the presence of relatively large pores and the increased oxygen content after selective laser melting.

关键词： Selective laser melting CuZr-based glass Bulk metallic glass matrix composites Phase formation Mechanical properties

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Reactivation of the Archean lower crust:Implications for zircon geochronology,elemental and Sr-Nd-Hf isotopic geochemistry of late Mesozoic granitoids from northwestern Jiaodong Terrane,the North China Craton

Reactivation of the Archean lower crust:Implications for zir...

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中国科学院地质与地球物理研究所2012年度（第12届）学术年会

作者： Kui-Feng Yang Hong-Rui Fan M.santosh Fang-Fang Hu simon A.Wilde Ting-Guang Lan Li-Na Lu Yong-Sheng Liu Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Sciences Division of Interdisciplinary Science Faculty of ScienceKochi UniversityKochi 780-8520Japan Geoscience Frontiers China University of Geosciences State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences

The late Mesozoic granitoids widely distributed in the nortliwestern Jiaodong Terrane are important markers of cratonic destruction and lithospheric thinning of the eastern North China Craton(NCC).Here we investigate the Late Jurassic Linglong and Luanjiahe granites and report zircon U-Pb emplacement ages of 157- 159 *** rocks also contain abundant late Archean,Paleoproterozoic,Neoproterozoic,early Paleozoic and Triassic inherited zircons,suggesting the involvement of continental crustal materials from both the NCC and Yangtze Craton in magma *** rocks investigated in this study show high NaO + KO and low MgO and are peraluminous,with enrichment in LREEs and LILEs(Rb,Ba,U,and Sr) and depletion in HFSEs(Nb,Ta,P,and Ti).They also display lowε(t) values and high Sr/Y ratios,comparable to adakitic rocks,suggesting that the Linglong and Luanjiahe granitoids formed under relatively high pressure conditions and were likely derived from the partial melting of the thickened lower crust of the *** Guojialing granodiorites were emplaced in the early Cretaceous(129 Ma),and also contain abundant late Archean and Paleoproterozoic inherited *** rocks possess high CaO,TFeO and MgO,and are metalumrnous,with enrichment in LREEs and LILEs and depletion in *** are also characterized by high Sr/Y ratios,and have higherε(t) andε(t) values than the Late Jurassic granitoids,suggesting the involvement of mantle components in the magmatic *** correlate the magma tectonics with the processes accompanying the subduction of the Pacific Plate beneath the NCC and the associated asthenospheric upwelling.

关键词： Geochemistry Zircon geochronology Late Mesozoic granitoids Northwestern Jiaodong Terrane North China Craton

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Ultraviolet Laser Based Gas Phase Fluorination of Polystyrene

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Journal of Surface Engineered Materials and Advanced Technology 2014年第5期4卷 309-317页

作者： simon Kibben Klaus Vogelsang BIAS—Bremer Institut für angewandte Strahltechnik GmbH Bremen Germany INNOVENT e.V. Jena Germany

A novel hybrid process for surface fluorination of polymers is being introduced. The process is based on ultra violet (UV) laser radiation, which on the one hand forms radicals out of an atmosphere of a partially fluorinated benzene, and on the other hand activates a polymer surface in the areas where the UV radiation hits the surface. The radicals can react with the polymer surface, hence altering the surface energy. With this process, a fluorine content of over 30% on the surface of bulk polystyrene can be achieved, while the smallest possible structure size was smaller than 1 mm.

关键词： UV-Laser Polymer Modification Local Fluorination

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Sex differences in injury rates in team-sport athletes:A systematic review and meta-regression analysis

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Journal of Sport and Health Science 2022年第1期11卷 104-114页

作者： Astrid Zech Karsten Hollander Astrid Junge simon Steib Andreas Groll Jonas Heiner Florian Nowak Daniel P.feiffer Anna Lina Rahlf Department of Human Movement Science and Exercise Physiology Friedrich Schiller University JenaJena 07749Germany MSH Medical School Hamburg Hamburg 20457Germany Swiss Concussion Center Schulthess KlinikZürich 8008Switzerland Department of Human Movement Training and Active AgingHeidelberg UniversityHeidelberg 69117Germany Department of Statistics Technical University of DortmundDortmund 44227Germany Department of Sports and Exercise Medicine Institute of Human Movement ScienceUniversity of HamburgHamburg 20146Germany

Background:Team-sport players have a particularly high injury *** female sex is considered a risk factor,it is still unknown whether female and male team-sport players,in fact,differ in their injury *** aimed to compare injury rates between female and male players by systematically reviewing and meta-analyzing injury surveillance studies of both sexes in order to evaluate sex-specific differences in team-sport ***:Studies that prospectively collected injury data for high-level female and male players(age≥16 years)in basketball,field hockey,football(soccer),handball,rugby(union and sevens),and volleyball were *** reviewers(AZ and ALR)independently assessed study quality and extracted data for overall,match,training,and severe injuries(>28 days’time loss)as well as data regarding injury locations and *** rate ratios(IRRs)were pooled in a meta-analysis,and meta-regression analysis was performed when 10 or more studies were ***:Of 20 studies,9 studies reported injury data from football,3 studies from rugby,3 studies from handball,1 study from basketball,1 study from field hockey,2 studies from volleyball,and 1 study from basketball and field *** overall injuries,the pooled IRR=0.86(95%confidence interval(95%CI):0.76-0.98)indicated significantly more injuries in male than in female *** injury location,the pooled IRR showed higher injury rates in male athletes than in female athletes for upper extremity,hip/groin,thigh,ande foot *** players had a significantly higher rate of anterior cruciate ligament injuries(IRR=2.15,95%CI:1.27-3.62)than male *** significant sex-specific differences in IRR were found for match,training,severe injuries,concussions,or ankle ***:Our meta-analysis provides evidence for sex-specific differences in the injury rates in team *** epidemiological studies including both sexes in sports other than football are needed in order t

关键词： Athletes Female Injuries Male Team sports

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A concept for multiterawatt fibre lasers based on coherent pulse stacking in passive cavities

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Light(Science & Applications) 2014年第1期3卷 62-68页

作者： Sven Breitkopf Tino Eidam Arno Klenke Lorenz von Grafenstein Henning Carstens simon Holzberger Ernst Fill Thomas Schreiber Ferenc Krausz Andreas Tunnermann Ioachim Pupeza Jens Limpert Institute of Applied Physics Abbe Center of PhotonicsFriedrich-Schiller-Universitat Jena07745 JenaGermany Helmholtz Institute jena 07743 JenaGermany Max Planck Institute of Quantum Optics 85748 GarchingGermany Ludwig Maximilians University Munchen Department of Physics85748 GarchingGermany Fraunhofer Institute for Applied Optics and Precision Engineering 07745 JenaGermany

Since the advent of femtosecond lasers,performance improvements have constantly impacted on existing applications and enabled novel ***,one performance feature bearing the potential of a quantum leap for high-field applications is still not available:the simultaneous emission of extremely high peak and average *** applications such as laser particle acceleration require exactly this performance regime and,therefore,challenge laser technology at *** the one hand,canonical bulk systems can provide pulse peak powers in the multi-terawatt to petawatt range,while on the other hand,advanced solid-state-laser concepts such as the thin disk,slab or fibre are well known for their high efficiency and their ability to emit high average powers in the kilowatt range with excellent beam *** this contribution,a compact laser system capable of simultaneously providing high peak and average powers with high wall-plug efficiency is proposed and *** concept is based on the temporal coherent combination(pulse stacking)of a pulse train emitted from a high-repetition-rate femtosecond laser system in a passive enhancement ***,the pulse energy is increased at the cost of the repetition rate while almost preserving the average *** concept relies on a fast switching element for dumping the enhanced pulse out of the *** switch constitutes the key challenge of our *** this challenge could,for the first time,allow the highly efficient dumping of joule-class pulses at megawatt average power levels and lead to unprecedented laser parameters.

关键词： cavity dumping cavity enhancement coherent pulse addition high average power and high peak power ultrafast lasers

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<i>In</i>-<i>Situ</i>XAFS Characterization of PtPd Nanoparticles Synthesized by Galvanic Replacement

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Advances in Nanoparticles 2017年第2期6卷 75-91页

作者： simon Tymen Andreas C. Scheinost Christian Friebe Ulrich S. Schubert Institute of Organic and Macromolecular Chemistry (IOMC) Friedrich-Schiller University Jena Germany The Rossendorf Beamline at the European Synchroton European Synchrotron Radiation Facility (ESRF) Grenoble France and Molecular Structure Division Institute of Radiochemistry Forschungszentrum Dresden-Rossendorf (FZD) Dresden Germany Center for Energy and Environmental Chemistry jena (CEEC jena) Friedrich-Schiller University Jena Germany jena Center for Soft Matter (JCSM) Friedrich-Schiller University Jena Germany

Platinum-palladium nanoparticles are synthesized and characterized with regard to their application in fuel cells due to their high (electro) catalytic activity. Different preparation times are applied leading to different structures, from Pd cubic to core-shell PtPd concave, and different chemical compositions. The resulting particles are studied via Transmission Electron Microscopy (TEM) and in-situ X-ray absorption fine structure (XAFS) measurements. The latter allows the investigation of the oxygen reduction reaction following the variations with varying applied potentials by analysis using the Iterative Transformation Factor Analysis (ITFA) and the creation of a two-component system that consists of metallic Pt-Pd and the related oxide. With the used model, the different concentrations of the oxide are linked to the consecutive chemical steps of the oxygen reduction reaction. Finally, the catalytic activity of the particles is determined via linear scanning voltammetry and reveals a dependence on the shape and the composition of the particles.

关键词： Platinum Palladium Nanoparticles Oxygen Reduction Reaction In-Situ XAFS ITFA

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Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity

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Bioactive Materials 2021年第12期6卷 4342-4359页

作者： Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.simon Vera Hintze Sandra Franz Department of Dermatology Venerology und AllergologyLeipzig University04103LeipzigGermany Institute of Materials Science Max Bergmann Center for BiomaterialsTechnische Universitǎt Dresden01069DresdenGermany Biomaterials Department INNOVENT e.V.JenaGermany

Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic *** of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic *** we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound *** sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in *** further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo *** a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the *** is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation *** in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one *** immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound *** sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure.

关键词： 4-6):sulfated hyaluronan Macrophages Immunomodulation Chronic wounds Hydrogel Skin inflammation

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How the laser beam size conditions the temporal contrast in pulse stretchers of chirped-pulse amplification lasers

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High Power Laser Science and Engineering 2022年第6期10卷 1-7页

作者： simon Roeder Yannik Zobus Christian Brabetz Vincent Bagnoud GSI Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany Technische Universität Darmstadt DarmstadtGermany Helmholtz-Institut jena JenaGermany

In this work,we propose and verify experimentally a model that describes the concomitant influence of the beam size and optical roughness on the temporal contrast of optical pulses passing through a pulse stretcher in chirped-pulse amplification laser *** develop an analytical model that is capable of predicting the rising edge caused by the reflection from an optical element in a pulse stretcher,based on the power spectral density of the surface and the spatial beam profile on the *** an experimental campaign,we characterize the temporal contrast of a laser pulse that passed through either a folded or an unfolded stretcher design and compare these results with the analytical *** varying the beam size for both setups,we verify that optical elements in the near-and the far-field act opposed to each with respect to the temporal contrast and that the rising edge caused by a surface benefits from a larger spatial beam size on that surface.

关键词： chirped-pulse amplification laser stretcher temporal contrast

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