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Suspension electrospinning of decellularized extracellular matrix: A new method to preserve bioactivity

Bioactive Materials 2024年第11期41卷 640-656页

作者： Sarah Jones Sabrina VandenHeuvel Andres Luengo Martinez Ruchi Birur Eric Burgeson Isabelle Gilbert Aaron Baker Matthew Wolf Shreya A.Raghavan simon rogers Elizabeth Cosgriff-Hernandez Department of Biomedical Engineering The University of Texas at AustinAustinTX78712USA Department of Biomedical Engineering Texas A&M UniversityCollege StationTX77843USA Department of Chemical and Biomolecular Engineering University of Illinois Urbana-ChampaignChampaignIL61820USA Cancer Biomaterials Engineering Section Cancer Innovation LaboratoryCenter for Cancer ResearchNational Cancer InstituteFrederickMD21702USA

Decellularized extracellular matrices (dECM) have strong regenerative potential as tissue engineering scaffolds;however, current clinical options for dECM scaffolds are limited to freeze-drying its native form into sheets. Electrospinning is a versatile scaffold fabrication technique that allows control of macro- and microarchitecture. It remains challenging to electrospin dECM, which has led researchers to either blend it with synthetic materials or use enzymatic digestion to fully solubilize the dECM. Both strategies reduce the innate bioactivity of dECM and limit its regenerative potential. Herein, we developed a new suspension electrospinning method to fabricate a pure dECM fibrous mesh that retains its innate bioactivity. Systematic investigation of suspension parameters was used to identify critical rheological properties required to instill “spinnability,” including homogenization, concentration, and particle size. Homogenization enhanced particle interaction to impart the requisite elastic behavior to withstand electrostatic drawing without breaking. A direct correlation between concentration and viscosity was observed that altered fiber morphology;whereas, particle size had minimal impact on suspension properties and fiber morphology. The versatility of this new method was demonstrated by electrospinning dECM with three common decellularization techniques (Abraham, Badylak, Luo) and tissue sources (intestinal submucosa, heart, skin). Bioactivity retention after electrospinning was confirmed using cell proliferation, angiogenesis, and macrophage polarization assays. Collectively, these findings provide a framework for researchers to electrospin dECM for diverse tissue engineering applications.

关键词： Electrospinning Extracellular matrix Biological scaffolds

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机器学习基础教程

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作者： (英)simon rogers (英)Mark Girolami

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Identifying pain-related concerns in routine follow-up clinics following oral and oropharyngeal cancer

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World Journal of Clinical Oncology 2012年第8期3卷 116-125页

作者： simon N rogers Alexander J Cleator Derek Lowe Naseem Ghazali Regional Maxillofacial Unit University Hospital Aintree Liverpool L97LN United Kingdom Evidence-Based Practice Research Centre Faculty of Health Edge Hill University St Helens Road Ormskirk L39 4QP United Kingdom Faculty of Medicine University of Liverpool Duncan Building Daulby Street Liverpool L69 3GA United Kingdom

AIM:To describe clinical characteristics of head and neck cancer(HNC)patients with pain and those wishing to discuss pain concerns during ***:Cross-sectional,questionnaire study using University of Washington Quality of Life,version 4(UWQOL)and the Patients Concerns Inventory(PCI)in disease-free,post-treatment HNC *** pain on UW-QOL and indicating"Pain in head and neck"and"Pain elsewhere"on ***:One hundred and seventy-seven patientscompleted UW-QOL and *** prevalence of selfreported pain issues was 38%(67/177)comprising25%(44/177)with significant problems despite medications and 13%(23/177)with lesser or no problems but wishing to discuss *** aged under 65years and patients having treatment involving radiotherapy were more likely to have pain *** over half,55%(24/44)of patients with significant pain did not express a need to discuss *** with significant pain or others wanting to discuss pain in clinic had greater problems in physical and social-emotional functioning,reported suboptimal QOL,and also had more additional PCI items to discuss in clinic compared to those without significant pain and not wishing to discuss ***:Significant HNC-related pain is prevalent in the disease-free,posttreatment *** referral to a specialist pain team may be *** UW-QOL and PCI package is a valuable tool that may routinely screen for significant pain in outpatient clinics.

关键词： Pain Health related quality of life Patient Concerns Inventory Head and neck cancer Mouth neoplasm Quality of life Questionnaire

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数据新闻大趋势

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作者： (英)西蒙·罗杰斯(simon rogers)

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Theoretical and Experimental Studies of Schottky Diodes that Use Aligned Arrays of Single-Walled Carbon Nanotubes

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Nano Research 2010年第6期3卷 444-451页

作者： Xinning Ho Lina Ye Slava V.Rotkin Xu Xie Frank Du simon Dunham Jana Zaumseil John A.rogers Department of Materials Science and Engineering Beckman Instituteand Frederick Seitz Materials Research LaboratoryUniversity of Illinois at Urbana-Champaign1304 West Green StreetUrbanaIllinois 61801USA Department of Chemistry University of Science and Technology of ChinaHefei 230026China Department of Physics Lehigh UniversityBethlehemPennsylvania 18015 and Centre for Advanced Materials and NanotechnologyLehigh UniversityBethlehemPennsylvania 18015USA Center for Nanoscale Materials Argonne National LaboratoryArgonneIllinois 60439USA Department of Chemistry University of Illinois at Urbana-ChampaignUrbanaIllinois 61801USA Department of Electrical and Computer Engineering Mechanical Science and EngineeringUniversity of Illinois at Urbana-ChampaignUrbanaIllinois 61801USA

We present theoretical and experimental studies of Schottky diodes that use aligned arrays of single-walled carbon nanotubes. A simple physical model, taking into account the basic physics of current rectification, can adequately describe the single-tube and array devices. We show that for as-grown array diodes, the rectification ratio, defined by the maximum-to-minimum-current-ratio, is low due to the presence of metallic-single-walled nanotube (SWNT) shunts. These tubes can be eliminated in a single voltage sweep resulting in a high rectification array device. Further analysis also shows that the channel resistance, and not the intrinsic nanotube diode properties, limits the rectification in devices with channel length up to 10 μm.

关键词： Schottky diodes aligned arrays single-walled carbon nanotubes

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