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Thymoquinone enhances the antioxidant and anticancer activity of Lebanese propolis

World Journal of Clinical Oncology 2023年第5期14卷 203-214页

作者： sima aldreini Zaynab Fatfat Najwa Abou Ibrahim Maamoun Fatfat Hala Gali-Muhtasib Hala Khalife Rammal Rammal Laboratory(ATAC Group) Faculty of Sciences IHadath 1003Lebanon Department of Biology American University of BeirutBeirut 1107-2020Lebanon Applied Biochemistry Laboratory School of PharmacyCamerino UniversityCamerino 62032Italy

BACKGROUND Reactive oxygen species(ROS)are produced by multiple cellular processes and are maintained at optimal levels in normal cells by endogenous *** recent years,the search for potential exogenous antioxidants from dietary sources has gained considerable attention to eliminate excess ROS that is associated with oxidative stress related diseases including ***,a resinous honeybee product,has been shown to have protective effects against oxidative stress and anticancer effects against several types of *** To investigate the antioxidant and anticancer potential of Lebanese propolis when applied alone or in combination with the promising anticancer compound Thymoquinone(TQ)the main constituent of Nigella sativa essential *** Crude extracts of Lebanese propolis collected from two locations,Rashaya and Akkar-Danniyeh,were prepared in methanol and the total phenolic content was determined by Folin–Ciocalteu *** antioxidant activity was assessed by the ability to scavenge 2,2-diphenyl-1-picrylhydrazyl(DPPH)free radical and to inhibit H2O2-induced oxidative hemolysis of human *** anticancer activity was evaluated by[3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide]MTT assay against HCT-116 human colorectal cancer cells and MDAMB-231 human breast cancer *** The total phenolic content of propolis extract from Rashaya and Akkar-Danniyeh were 56.81μg and 83.503μg of gallic acid equivalent/mg of propolis,*** natural agents exhibited strong antioxidant activities as evidenced by their ability to scavenge DPPH free radical and to protect erythrocytes against H2O2-induced *** also dose-dependently decreased the viability of both cancer cell *** IC50 value of each of propolis extract from Rashaya and Akkar-Danniyeh or TQ was 22.3,61.7,40.44μg/mL for breast cancer cells at 72 h and 33.3,50.9,33.5μg/mL for colorectal cancer cells at the same time point,***

关键词： Lebanese propolis Thymoquinone Combination Antioxidant activity Anticancer activity Phenolic compounds

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DAMAGE DETECTION IN STRUCTURES USING MODIFIED BACK-PROPAGATION NEURAL NETWORKS

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Acta Mechanica Solida Sinica 2002年第4期15卷 358-370页

作者： sima Yuzhou School of Civil Engineering & Mechanics Huazhong University of Science & TechnologyWuhan 430074China

A nonparametric structural damage detection methodology based on neuralnetworks method is presented for health monitoring of structure-unknown systems. In this approachappropriate neural networks are trained by use of the modal test data from a 'healthy' *** trained networks which are subsequently fed with vibration measurements from the same structurein different stages have the capability of recognizing the location and the content of structuraldamage and thereby can monitor the health of the structure. A modified back-propagation neuralnetwork is proposed to solve the two practical problems encountered by the traditionalback-propagation method, i.e., slow learning progress and convergence to a false local *** training algorithms, types of the input layer and numbers of the nodes in the input layerare considered. Numerical example results from a 5-degree-of-freedom spring-mass structure andanalyses on the experimental data of an actual 5-storey-steel-frame demonstrate thatneural-networks-based method is a robust procedure and a practical tool for the detection ofstructural damage, and that the modified back-propagation algorithm could improve the computationalefficiency as well as the accuracy of detection.

关键词： neural network modified back-propagation damage detection modal testdata health monitoring

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New pseudo-dynamic analysis of two-layered cohesive-friction soil slope and its numerical validation

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Frontiers of Structural and Civil Engineering 2020年第6期14卷 1492-1508页

作者： Suman HAZARI sima GHOSH Richi Prasad SHARMA Department of Civil Engineering National Institute of TechnologyAgarala 799046India

Natural slopes consist of non-homlogeneous soil profiles with distinct characteristics from slopes made of homogeneous *** this study,the limit equilibrium modified pseudo-dynamic method is used to analyze the stability of two-layered c-φsoil slopes in which the failure surface is assumed to be a logarithmic *** zero-stress boundary condition at the ground surface under the seismic loading condition is *** formulations derived from an analytical method are proposed for the predicting the seismic response in two-layered soil.A detailed parametric study was performed in which various parameters(seismic accelerations,damping,cohesion,and angle of internal friction)were *** results of the present method were compared with those in the available *** present analytical analysis was also verified against the finite element analysis results.

关键词： layered soil limit equilibrium method seismic analysis damping PLAXIS

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Fluorescence Enhancement Ratio Dropdown at Low Fluences during Femtosecond Double Pulse Laser Ablation

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Chinese Physics Letters 2008年第7期25卷 2653-2656页

作者： sima SINGHA Robert J. GORDON 胡湛 Institute of Atomic and Molecular Physics Jilin University Changchun 130021 Department of Chemistry University of Illinois at Chicago Chicago Illinois 60607-7061 USA

In the study of double pulse ablation of materials （silicon and copper）, a dropdown of double pulse to single pulse fluorescence signal enhancement at low fluences is observed. The dropdown is analysed with a simple theoretical one-dimensional heat diffusion model and verified by fluorescence time constants change as a function of fluence. The dropdown is explained as a result of liquid-solid mixture layer at the liquid and solid boundary. The effect of the layer becomes important at low fluences.

关键词： the power-law exponents precipitation durative abrupt precipitation change

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A convenient synthesis of 2-aminocyclohex-1-ene-1-carboxylic esters by FeCl_3/SiO_2 nanoparticles as robust and efficient catalyst

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Chinese Chemical Letters 2015年第6期26卷 735-738页

作者： sima Kalhor Javad Safaei-Ghomi Department of Chemistry Qom BranchIslamic Azad University

A simple and green method has been developed for the synthesis of 2-aminocyclohex-l-ene-l- carboxylic esters through a one-pot three-component condensation reaction of primary amines, ethyl acetoacetate and chalcones using FeCI3/SiO2 nanoparticles in ethanol. This method has several advantages such as high to excellent product yields in short time, using an inexpensive and reusable catalyst and available starting material.

关键词： FeCl3/SiO2 nanoparticlesMulti-component reactionsOne-pot2-Aminocyclohex-l-ene-l-carboxylicestersChalcone

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Evaluating and modeling the spatiotemporal pattern of regional-scale salinized land expansion in highly sensitive shoreline landscape of southeastern Iran

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Journal of Arid Land 2018年第6期10卷 946-958页

作者： Mohammad SHAFIEZADEH Hossein MORADI sima FAKHERAN Department of Natural Resources Isfahan University of Technology

Taking an area of about 2.3×10~4 km~2 of southeastern Iran, this study aims to detect and predict regional-scale salt-affected lands. Three sets of Landsat images, each set containing 4 images for 1986, 2000, and 2015 were acquired as the main source of data. Radiometric, atmospheric and cutline blending methods were used to improve the quality of images and help better classify salinized land areas under the support vector machine method. A set of landscape metrics was also employed to detect the spatial pattern of salinized land expansion from 1986 to 2015. Four factors including distance to sea, distance to sea water channels, slope, and elevation were identified as the main contributing factors to land salinization. These factors were then integrated using the multi-criteria evaluation (MCE) procedure to generate land sensitivity map to salinization and also to calibrate the cellular-automata (CA) Markov chain (CA-Markov) model for simulation of salt-affected lands up to 2030, 2040 and 2050. The results of this study showed a dramatic dispersive expansion of salinized land from 7.7 % to 12.7% of the total study area from 1986 to 2015. The majority of areas prone to salinization and the highest sensitivity of land to salinization was found to be in the southeastern parts of the region. The result of the MCE-informed CA-Markov model revealed that 20.3% of the study area is likely to be converted to salinized lands by 2050. The findings of this research provided a view of the magnitude and direction of salinized land expansion in a past-to-future time period which should be considered in future land development strategies.

关键词： soil salinization remote sensing CA-Markov salt land expansion southeastern Iran

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DEARSENICATION FROM COBALT-ARSENIC CONCENTRATE BY VACUUM DISTILLATION

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中国有色金属学会会刊：英文版 1994年第2期4卷 4-9页

作者： Cao, Mingyan Dai, Yongnian sima, Zhongzhi Kunming Inst of Technology Kunminga China

ＤＥＡＲＳＥＮＩＣＡＴＩＯＮＦＲＯＭＣＯＢＡＬＴ－ＡＲＳＥＮＩＣＣＯＮＣＥＮＴＲＡＴＥＢＹＶＡＣＵＵＭＤＩＳＴＩＬＬＡＴＩＯＮＤＥＡＲＳＥＮＩＣＡＴＩＯＮＦＲＯＭＣＯＢＡＬＴ－ＡＲＳＥＮＩＣＣＯＮＣＥＮＴＲＡＴＥＢＹ... 详细信息

ＤＥＡＲＳＥＮＩＣＡＴＩＯＮＦＲＯＭＣＯＢＡＬＴ－ＡＲＳＥＮＩＣＣＯＮＣＥＮＴＲＡＴＥＢＹＶＡＣＵＵＭＤＩＳＴＩＬＬＡＴＩＯＮＤＥＡＲＳＥＮＩＣＡＴＩＯＮＦＲＯＭＣＯＢＡＬＴ－ＡＲＳＥＮＩＣＣＯＮＣＥＮＴＲＡＴＥＢＹＶＡＣＵＵＭＤＩＳＴＩＬＬＡＴＩＯ...

关键词： vacuum distillation cobalt-arsenic concentratc condensate residue redistillation

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sima Wensen: A Pioneer for China-France Cultural Exchange

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China & The World Cultural Exchange 2014年第4期80卷 36-39页

作者： sima Xiaoshen

January.27th,2014 marked a monumental date.50 years ago today,China and France issued a joint communiquéand declared the establishment of diplomatic *** June 6th,1964,China and France successfully established diploma... 详细信息

关键词：中国文化交流法国外交关系

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Singlet vector-like T quark production in association with Wb at the CLIC

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Communications in Theoretical Physics 2023年第3期75卷 62-69页

作者： Bingfang Yang Shiyu Wang Xiaoli sima Liangliang Shang School of Physics Henan Normal UniversityXinxiang 453007China

In a simplified model including an SU(2)singlet vector-like top quark T(VLT)with charge 2/3,we investigate the associated production of Wb with VLT at a Compact Linear Collider(CLIC).Focusing on the T→Wb decay channel,we discuss two decay models:e+e-→TW+b→(l-vb)(jjb)and e+e-→TW+b→(jjb)(l+νb).In this paper,we consider recent experimental limits including the electroweak precision observables,the width of the top quark,and the direct LHC *** a detailed detector simulation,we show the exclusion and discovery capability on the T at 3 TeV CLIC,where the initial state radiation effect has also been *** results show that it is promising to detect the VLT at future high-energy e+e-colliders.

关键词： VLQ CLIC simulation

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Efficient hydrolysis of cellulose to glucose catalyzed by lignin-derived mesoporous carbon solid acid in water

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Chinese Journal of Chemical Engineering 2020年第7期28卷 1866-1874页

作者： Shuai Wang Guobao sima Ying Cui Longjun Chang Linhuo Gan College of Chemical Engineering Huaqiao UniversityXiamen 361021China Key Laboratory of Pulp and Paper Science&Technology of Ministry of Education/Shandong Province Qilu University of Technology(Shandong Academy of Science)Jinan 250353China

Two kinds of mesoporous carbon solid acids(LDMCE-SO3H and LDMCS-SO3H)were successfully prepared using masson pine alkali lignin as carbon source by evaporation-induced self-assembly(EISA)and salt-induced selfassembly(SISA)followed by sulfonation,*** terms of preparation process,SISA(self-assembly in water and preparation time of 2 days)is greener and simpler than EISA(self-assembly in ethanol and preparation time of 7 days).The prepared LDMCE-SO3H and LDMCS-SO3H exhibit obvious differences in structural characteristics such as pore channel structure,specific surface area,mesopore volume and the density of-SO3H ***,the catalytic performances of LDMCE-SO3H and LDMCS-SO3H were investigated in the hydrolysis of microcrystalline cellulose in water,and the glucose yields of 48.99%and 54.42%were obtained under the corresponding optimal reaction *** importantly,the glucose yields still reached 28.85%and 30.35%after five runs,and restored to 39.02%and 45.98%through catalysts regeneration,respectively,demonstrating that LDMCE-SO3H and LDMCS-SO3H have excellent recyclability and regenerability.

关键词： Biomass Evaporation-induced self-assembly Salt-induced self-assembly Mesoporous carbon solid acid Catalysis Hydrolysis

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