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疱疹早期应用度洛西汀预防带状疱疹后神经痛的疗效:一项随机对照研究

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中国疼痛医学杂志 2025年第1期31卷 13-14页

作者： Zhao c Zhang T Zhu Q 赵春美(译) 不详首都医科大学附属北京天坛医院疼痛科

经典抗焦虑抑郁药物-度洛西汀为带状疱疹后神经痛(postherpetic neuralgia,PHN)的一线治疗药物。本研究首次提出在带状疱疹出疱急性期预防性口服度洛西汀有望预防PHN的发生,纳入疼痛VAS评分≥4、带状疱疹出疱72 h内的750例病人,随机分... 详细信息

经典抗焦虑抑郁药物-度洛西汀为带状疱疹后神经痛(postherpetic neuralgia,PHN)的一线治疗药物。本研究首次提出在带状疱疹出疱急性期预防性口服度洛西汀有望预防PHN的发生,纳入疼痛VAS评分≥4、带状疱疹出疱72 h内的750例病人,随机分为对照组和度洛西汀组。对照组接受常规临床治疗,度洛西汀组在常规治疗基础上口服度洛西汀。主要结局指标为12周时PHN的发生率。次要结局指标包括3、4、8周VAS评分>0的人数,以及4、8、12周VAS评分≥3的人数、生活质量评分、病人总体变化评分、睡眠质量评分等。结果表明,度洛西汀组的PHN发生率与对照组相比无显著差异,度洛西汀组第3、4、8周VAS评分>0的人数,以及4、8和12周VAS评分≥3的人数显著少于对照组。度洛西汀组病人的生活质量评分、病人总体变化评分、睡眠质量评分均显著优于对照组。虽然本研究为阴性结果,但预防性口服度洛西汀仍可以避免5.9%的带状疱疹病人发展成为PHN,因此具有一定的临床意义。

关键词：带状疱疹后神经痛度洛西汀结局指标阴性结果一线治疗药物早期应用随机对照研究带状疱疹病

Polyethylene glycol fusion repair of severed sciatic nerves accelerates recovery of nociceptive sensory perceptions in male and female rats of different strains

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Neural regeneration research 2025年第9期20卷 2667-2681页

作者： Liwen Zhou Karthik Venkudusamy Emily A.Hibbard Yessenia Montoya Alexa Olivarez cathy Z.Yang Adelaide Leung Varun Gokhale Guhan Periyasamy Zeal Pathak Dale r.Sengelaub George D.Bittner Department of Neuroscience University of TexasAustinTXUSA Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Molecular Biosciences University of TexasAustinTXUSA

Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Wallerian Degeneration and maintain their myelin sheaths;(3)promote primarily motor,voluntary behavioral recoveries as assessed by the Sciatic Functional Index;and,(4)rapidly produce correct and incorrect connections in many possible combinations that produce rapid and extensive recovery of functional peripheral nervous system/central nervous system connections and reflex(e.g.,toe twitch)or voluntary *** preceding companion paper describes sensory terminal field reo rganization following PEG-fusion repair of sciatic nerve transections or ablations;howeve r,sensory behavioral recovery has not been explicitly explored following PEG-fusion *** the current study,we confirmed the success of PEG-fusion surgeries according to criteria(1-3)above and more extensively investigated whether PEG-fusion enhanced mechanical nociceptive recovery following sciatic transection in male and female outbred Sprague-Dawley and inbred Lewis *** nociceptive responses were assessed by measuring withdrawal thresholds using von Frey filaments on the dorsal and midplantar regions of the *** von Frey filament tests were a more reliable method than plantar von Frey filament tests to assess mechanical nociceptive sensitivity following sciatic nerve *** withdrawal thresholds of the sciatic-mediated lateral dorsal region differed significantly across strain but not *** thresholds did not change significantly from baseline in chronic Unoperated and Sham-operated *** sciatic transection,all rats exhibited severe hyposensitivity to stimuli at the lateral dorsal region of the hindpaw ipsilateral to the ***,PEG-fused rats exhibited significantly earlier return to baseline withdrawal thresholds than Negative

关键词： autophagia axotomy collateral sprouting neuropathic pain peripheral nerve repair polyethylene glycol fusion(PEG-fusion) saphenous nerve sensory neurons sex and strain Wallerian degeneration

Vortex quasi-crystals in mesoscopic superconducting samples

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chinese Physics B 2016年第8期25卷 361-368页

作者：王璟琨张威 Sde Melo c A r Department of Physics Renmin University of China Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Renmin University of China School of Physics Georgia Institute of Technology

There seems to be a one to one correspondence between the phases of atomic and molecular matter（AMOM） and vortex matter（VM） in superfluids and superconductors. crystals, liquids, and glasses have been experimentally observed in both AMOM and VM. Here, we propose a vortex quasi-crystal state which can be stabilized due to boundary and surface energy effects for samples of special shapes and sizes. For finite sized pentagonal samples, it is proposed that a phase transition between a vortex crystal and a vortex quasi-crystal occurs as a function of magnetic field and temperature as the sample size is reduced.

关键词： vortex matter quasi-crystal mesoscopic superconductor

A simple and distinguished nebulizer approach to prepare cdS thin films

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Journal of Energy chemistry 2017年第3期26卷 398-405页

作者： M.Girish r.Sivakumar c.Sanjeeviraja r.Gopalakrishnan Department of Physics Alagappa UniversityKaraikudi 630003India Department of Physics Alagappa Chettiar College of Engineering and TechnologyKaraikudi 630003India Department of Physics Anna UniversityChennai 600025India

In this paper, we report the substrate temperature induced change in structural, optical, morphological,luminescence and photoelectrochemical properties of cdS films deposited by a simple and facile approach called nebulized spray pyrolysis technique. X-ray diffraction study confirmed the deposited cdS films belong to hexagonal wurtzite structure, with preferential orientation along c-axis,(002) direction perpendicular to the substrate plane. The crack free, uniform, and homogeneously distributed spherical particles are witnessed from AFM image. Various optical parameters like energy band gap, optical conductivity,refractive index, extinction coefficient, dielectric constants, and dispersion energy parameters of the films were evaluated. The strong band edge emission observed in the PL study may be attributed to the recombination of excitations and/or shallowly trapped electron-hole pairs. The first and second overtone of LO modes of cdS at 302 and 600 cm-1are observed in the raman study. The photoelectrochemical properties of the films were also tested.

关键词： Semiconductors chemical synthesis Optical properties X-ray diffraction

Growth response of three plantation species of the tropics exposed to elevated cO_2 levels

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Journal of Forestry research 2013年第3期24卷 449-456页

作者： rekha r. Warrier c. Buvaneswaran P. Priyadharshini r.S.c. Jayaraj Institute of Forest Genetics and Tree Breeding Forest CampusR. S. Puram Coimbatore 641002 India

The response of forest trees, the largest carbon sinks on the earth, to continuing rise in atmospheric carbon levels is unknown. re- ports state that increasing levels of atmospheric cO2 will stimulate pho- tosynthesis and productivity in most ecosystems. However, the duration and magnitude of this stimulation, particularly in the tropics, remains a question. To investigate the effects of cO2 fertilization on plant growth, seedlings of three common plantation species, casuarina equisetifolia, Ailanthus excelsa and Tectona grandis were grown in closed chambers enriched with cO2. After 180 days of treatment, morphological traits of seedling height, biomass of root and shoot and root-shoot allometric co-efficient were measured. The activity of carbonic anhydrase and con- tents of chlorophylls, total carbohydrates and soluble proteins were de- termined. In Tectona grandis, significant effects of cO2 supply were found on chlorophylls, root-shoot allometric ratio and seedling quality index. Ailanthus excelsa showed significant effect on only the shoot characteristics on exposure to elevated cO2 but the root characteristics and concentrations of chlorophylls were not significantly different. ca- suarina equisetifolia also showed significant effects on exposure to ele- vated cO2 in terms of shoot characteristics and concentrations of chlo- rophylls. Total sugars, the major photosynthates, did not show any sig- nificant variation to elevated cO2 in any of the three species. carbonic anhydrase, the key enzyme responsible for transfer of cO2 into the tis- sues significantly increased in all three species. Overall, all the variables responded to elevated cO2, reflecting the positive effects of one parame- ter of climate change conditions on seedling quality. A positive response of these three plantation species to elevated cO2 content is a good indi- cation for their future existence in potentially changed climatic eonditions.

关键词： Plantation Elevated cO2 Tropical trees India carbonicanhydrase

OH and O radicals production in atmospheric pressure air/Ar/H_2O gliding arc discharge plasma jet

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Plasma Science and Technology 2017年第12期19卷 71-80页

作者： N c rOY M r TALUKDEr A N cHOWDHUrY Plasma Science and Technology Laboratory Department of Applied Physics and Electronic EngineeringUniversity of RajshahiRajshahi 6205Bangladesh Bangladesh council of Scientific and Industrial research Laboratory rajshahi Rajshahi 6206Bangladesh

Atmospheric pressure air/Ar/H_2O gliding arc discharge plasma is produced by a pulsed dc power supply. An optical emission spectroscopic（OES） diagnostic technique is used for the characterization of plasmas and for identifications of OH and O radicals along with other species in the plasmas. The OES diagnostic technique reveals the excitation Tx？≈？5550–9000 K, rotational Tr？≈？1350–2700 K and gas Tg？≈？850–1600 K temperatures, and electron density n？（1.1-1.9） ′101 4 cm^（-3） e under different experimental conditions. The production and destruction of OH and O radicals are investigated as functions of applied voltage and air flow rate. relative intensities of OH and O radicals indicate that their production rates are increased with increasing Ar content in the gas mixture and applied voltage. nereveals that the higher densities of OH and O radicals are produced in the discharge due to more effective electron impact dissociation of H_2O and O_2 molecules caused by higher kinetic energies as gained by electrons from the enhanced electric field as well as by enhanced n *** productions of OH and O are decreasing with increasing air flow rate due to removal of Joule heat from the discharge region but enhanced air flow rate significantly modifies discharge maintenance properties. Besides, Tgsignificantly reduces with the enhanced air flow rate. This investigation reveals that Ar plays a significant role in the production of OH and O radicals.

关键词： reactive oxygen species(rOS) optical emission spectroscopy(OES) gliding arc discharge plasma kinetics broadening mechanism

Dynamic response of composite Materials with 2D reduced Micromorphic Model

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Acta Mechanica Solida Sinica 2022年第4期35卷 603-615页

作者： A.r.El Dhaba c.W.Lim Department of Mathematics Faculty of ScienceDamanhour UniversityDamanhourEgypt Department of Architecture and civil Engineering City University of Hong KongKowloonHong Kong SARChina

In this article,we introduce a complete set of constitutive relations and field equations for the linear reduced micromorphic *** further investigate the internal variables and their relationship in the case of two-dimensional(2D)wave *** dynamic response is investigated for composite materials,which is due to an external wave in two dimensions applied at the boundary of the considered *** solutions for the model are unavailable at this stage due to dependency of the field equations on spatial and time variables in a complicated manner.A finite element approach is adopted to derive approximate solutions for the field equations,and numerical finite element solutions for the internal fields are presented in detail and discussed.

关键词： composite materials Finite element method(FEM) reduced micromorphic model Wave propagation

Simple shear extrusion versus equal channel angular pressing:A comparative study on the microstructure and mechanical properties of an Mg alloy

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Journal of Magnesium and Alloys 2023年第5期11卷 1769-1790页

作者： A.rezaei r.Mahmudi c.cayron r.E.Logé School of Metallurgical and Materials Engineering College of EngineeringUniversity of TehranNorth Kargar StreetTehran 14395-515Iran Laboratory of Thermomechanical Metallurgy-PX Group chair Ecole Polytechnique Fédérale de Lausanne(EPFL)Neuchâtel CH-2002Switzerland

Two severe plastic deformation(SPD)techniques of simple shear extrusion(SSE)and equal channel angular pressing(EcAP)were employed to process an extruded Mg-6Gd-3Y-1.5Ag(wt%)alloy at 553 K for 1,2,4 and 6 *** microstructural evolutions were studied by electron back scattered diffraction(EBSD)analysis and transmission electron microscopy(TEM).The initial grain size of 7.5μm in the extruded alloy was reduced to about 1.3μm after 6 SPD *** dynamic recrystallization was suggested to be operative in both SSE and EcAP,with also a potential contribution of continuous dynamic recrystallization at the early stages of *** difference in the shear strain paths of the two SPD techniques caused different progression rate of dynamic recrystallization(DrX),so that the alloys processed by EcAP exhibited higher fractions of recrystallization and high angle grain boundaries(HAGBs).It was revealed that crystallographic texture was also significantly influenced by the difference in the strain paths of the two SPD methods,where dissimilar basal plane texture components were *** compression tests,performed along extrusion direction(ED),indicated that the compressive yield stress(cYS)and ultimate compressive strength(UcS)of the alloys after both SEE and EcAP augmented continuously by increasing the number of ***-processed alloys had lower values of cYS and UcS compared to their counterparts processed by *** difference in the mechanical responses was attributed to the different configurations of basal planes with respect to the loading direction(ED)of each SPD technique.

关键词： Mg-Gd-Y alloys Severe plastic deformation Simple shear extrusion Equal channel angular pressing Dynamic recrystallization Mechanical properties

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory