检索结果-南通市图书馆

3D bioprinting:current status and trends-a guide to the literature and industrial practice

Bio-Design and Manufacturing 2022年第1期5卷 14-42页

作者： silvia santoni Simone G.Gugliandolo Mattia Sponchioni Davide Moscatelli Bianca M.Colosimo Department of Mechanical Engineering Politecnico di MilanoVia La Masa120156 MilanItaly Department of Chemistry Materials and Chemical Engineering“Giulio Natta”Politecnico di MilanoPiazza Leonardo da Vinci3220133 MilanItaly

The multidisciplinary research field of bioprinting combines additive manufacturing,biology and material sciences to cre-ate bioconstructs with three-dimensional architectures mimicking natural living *** high interest in the possibility of reproducing biological tissues and organs is further boosted by the ever-increasing need for personalized medicine,thus allowing bioprinting to establish itself in the field of biomedical research,and attracting extensive research efforts from companies,universities,and research institutes *** this context,this paper proposes a scientometric analysis and critical review of the current literature and the industrial landscape of bioprinting to provide a clear overview of its fast-changing and complex *** scientific literature and patenting results for 2000-2020 are reviewed and critically analyzed by retrieving 9314 scientific papers and 309 international patents in order to draw a picture of the scientific and industrial landscape in terms of top research countries,institutions,journals,authors and topics,and identifying the technology hubs *** review paper thus offers a guide to researchers interested in this field or to those who simply want to under-stand the emerging trends in additive manufacturing and 3D bioprinting.

关键词： Additive manufacturing 3D bioprinting Biofabrication Organ-on-a-chip Tissue engineering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10)

引用

Cellular & Molecular Immunology 2020年第1期17卷 95-107页

作者： Michela Comi Daniele Avancini Francesca santoni de Sio Matteo Villa Molly Javier Uyeda Matteo Floris Daniela Tomasoni Alessandro Bulfone Maria Grazia Roncarolo silvia Gregori San Raffaele Telethon Institute for Gene Therapy(SR-TIGET) San Raffaele Scientific Institute(IRCCS)MilanItaly PhD Program in Translational and Molecular Medicine(DIMET) University of Milan-BicoccaMilanItaly Division of Stem Cell Transplantation and Regenerative Medicine Department of PediatricsISCBRMStanford School of MedicineStanfordCAUSA CRS4 Technology Park PolarisPulaItaly

Tolerogenic dendritic cells(DCs)are key players in maintaining immunological homeostasis,dampening immune responses,and promoting ***-10,a tolerogenic population of human IL-10-producing DCs characterized by the expression of HLA-G and ILT4,play a pivotal role in promoting tolerance via T regulatory type 1(Tr1)*** far,the absence of markers that uniquely identify DC-10 has limited in vivo *** in vitro gene expression profiling of differentiated human DCs,we identified CD141 and CD163 as surface markers for *** coexpression of CD141 and CD163 in combination with CD14 and CD16 enables the ex vivo isolation of DC-10 from the peripheral ***14+CD16+CD141+CD163+cells isolated from the peripheral blood of healthy subjects(ex vivo DC-10)produced spontaneously and upon activation of IL-10 and limited levels of ***,in vitro stimulation of allogeneic naive CD4+T cells with ex vivo DC-10 induced the differentiation of alloantigen-specific CD49b+LAG-3+Tr1 ***,ex vivo DC-10 and in vitro generated DC-10 exhibited a similar transcriptional profile,which are characterized by an anti-inflammatory and pro-tolerogenic *** results provide new insights into the phenotype and molecular signature of DC-10 and highlight the tolerogenic properties of circulating *** findings open the opportunity to track DC-10 in vivo and to define their role in physiological and pathological settings.

关键词： Dendritic cells IL-10 T regulatory type 1(Tr1)cells Tolerance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Squamous cell carcinoma of the lung: clinical criteria for treatment strategy

引用

Journal of Cancer Metastasis and Treatment 2015年第1期1卷 90-93页

作者： Agnese Savini Rossana Berardi Paola Mazzanti Miriam Caramanti Matteo santoni Mariagrazia De Lisa Francesca Morgese silvia Rinaldi Mariangela Torniai Ilaria Fiordoliva Azzurra Onofri Stefano Cascinu Medical Oncology Unit UniversitàPolitecnica delle MarcheAzienda Ospedaliero-Universitaria Ospedali Riuniti60126 AnconaItaly.

Aim:Primary lung cancer is the leading cause of human cancer deaths worldwide,and squamous cell carcinoma(SCC)is one of the most frequent histologic *** aim of our study was to analyze clinical factors potentially affecting the overall outcome of advanced lung SCC ***:A series of 72 consecutive patients with advanced SCC undergoing chemotherapy at our institution between January 2007 and July 2013 were eligible for our ***:By univariate analysis,a better overall survival(OS)was related to response to first-line chemotherapy:median OS were 19.7 vs.7.17 months,respectively,for responders and nonresponders patients(P<0.0001).Eastern Cooperative Oncology Group performance status,gender,and surgery were other prognostic *** signifi cant relationship between OS and smoking status,age,body mass index,or type of treatment was *** the third-line setting,a better OS was associated with objective response to second-line treatment(P=0.015).Conclusion:Our results suggest that differences in OS seem strictly associated with clinical response to previous *** data should be considered in the therapeutic strategy and management of patients with SCC of the lung.

关键词： Non-small cell lung cancer prognostic factors squamous cell carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：