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Journal of Electromagnetic Analysis and Applications 2016年第1期8卷 1-7页

作者： silverio soto alvarez Lidia Flor E. Huerta Alma Verónica Vargas Jaime López Jesus Gabriel Silva César A. González Universidad del Ejército y FAM/EMGS Laboratorio Multidisciplinario de Investigación Mexico D.F. Mexico Instituto Politécnico Nacional Escuela Superior de Medicina SEPI Mexico D.F. Mexico

The effectiveness of breast cancer ablation by radiofrequency (RF) has been associated to the capacity of concentrating the electromagnetic energy in the tumor region, our group has proposed that this condition could be modulated by appropriate RF exposure cycle times as well as modification of tissue electrical conductivity. The aim of this work was to evaluate analytical and experimental optimal exposure cycle times to induce tissue ablation by RF assisted with magnetic nanoparticles. The study was conducted both analytically by multiphysics simulation of the induced currents in cancer tissue given a magnetron source and experimentally by the observation of hyperthermic effects induced in agar phantoms by a magnetron device by the use of RF assisted with magnetic nanoparticles. The temperature showed significant increases in short periods of time, and was clearly higher under the condition with nanoparticles. Appropriate RF exposure cycle times as well as modification of tissue electrical conductivity by magnetic nanoparticles seems suitable factors to modulate the electromagnetic energy in tumoral regions.

关键词： Breast Cancer Radiofrequency Ablation Multiphysics Simulation Magnetic Nanoparticles

A Differential Evolution Approach for Protein Folding Using a Lattice Model

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Journal of Computer Science & Technology 2007年第6期22卷 904-908页

作者： Heitor silverio Lopes Reginaldo Bitello Bioinformatics Laboratory Federal University of Technology-ParanáAv.7 de setembro3165 80230-901 CuritibaBrazil

Protein folding is a relevant computational problem in Bioinformatics, for which many heuristic algorithms have been proposed. This work presents a methodology for the application of differential evolution （DE） to the problem of protein folding, using the bi-dimensional hydrophobic-polar model. DE is a relatively recent evolutionary algorithm, and has been used successfully in several engineering optimization problems, usually with continuous variables. We introduce the concept of genotype-phenotype mapping in DE in order to provide a mapping between the real-valued vector and an actual folding. The methodology is detailed and several experiments with benchmarks are done. We compared the results with other similar implementations. The proposed DE has shown to be competitive, statistically consistent and very promising.

关键词： bioinformatics differential evolution evolutionary computation protein folding

Influence of Beliefs and Representations of the Psyche in the Post-Breast Cancer Period

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Psycho-Oncologie 2024年第4期18卷 349-357页

作者： Virginie Di silverio Susann Heenen-Wolff Jochem Willemsen Patrick Derleyn Institut de recherche en sciences psychologiques Universitécatholique de LouvainLouvain-la-Neuve1348Belgique Service d’oncologie-hématologie Grand Hôpital de CharleroiCharleroi6000Belgique Centre d’études pathoanalytiques Bruxelles BelgiqueConsultant pour l’analyse du Szondi auprès deséquipes du service psycho-social du ministère de la JusticeBruxelles1000Belgique

For some,the announcement of a cancerous illness awakens or reinforces representations linked to the presumed power of the psyche over the *** psychosomatic theories underline the importance of a specific psychic functioning as the guarantor of good somatic *** our view,confusion in the understanding of such concepts has effects on the aftermath for women with breast *** study was carried out by six women with breast cancer and focused on the influence of beliefs and representations of breast cancer on how they experienced the acute post-treatment phase of an oncology care *** identify a possible link between beliefs and representations held by the patient,his or her family,and/or caregivers,and the possible reinforcement of defensive psychic movement we call“Transient Secondary Obsessional Movement”(TSOM).Longitudinal qualitative research using a combined approach involving non-directive clinical interviews and a projective test,the Szondi.A study focusing on two specific phases of the oncology care pathway:treatment(T1)and acute post-treatment(T2).An individual and cross-sectional analysis of the twelve Szondi protocols and a thematic analysis of non-directive clinical interviews were carried *** results corroborate the identification of specific psychic movements for these six *** T1,we observe a major need to cling,a psychic lability favoring the fixation of reassuring discourse and repression of *** T1 and T2,we identify a decathexis of the Ego and the presence of obsessional traits independent of the women’s psychic *** T2,there is a lifting of repression,a heightened sense of injustice,and a gradual new psychic *** psychic movement that takes place at T2 is the transition from the desire to“stay as before”(T1)to“I thought I’d go back to being as before”.The post-cancer period often reflects a dissonance between psychic time and medical time:an announced“healing”of breast cancer does not necessar

关键词： Power of the psyché psychic healing post-cancer breast cancer

Current approach in the treatment of hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2010年第9期2卷 348-359页

作者： Luigi Rossi Federica Zoratto Anselmo Papa Francesca Iodice Marina Minozzi Luigi Frati silverio Tomao Department of Experimental Medicine University of Rome "Sapienza" Department of Anaesthesiology Bambino Gesù Hospital

Hepatocellular carcinoma (HCC) is the most common malignant hepatobiliary disease; it is responsible for about 1 million deaths per year. Risk factors include hepatitis B and C, hepatic cirrhosis, including alcohol related hepatitis, metabolic and nutritional hepatic damage. The main modality of diffusion is intrahepatic in the natural course of the disease. There are two leading types of treatment: local and systemic. Surgical resection and liver transplantation constitute the most appropriate local treatments and are considered the only real possibility for recovery. Other local approaches include: radiofrequency ablation, percutaneous ethanol ablation, hepatic endoarterial chemoembolization and intrahepatic radiotherapy (SIRT: selective internal radiation therapy). These last treatments are used to control the disease when surgery or transplantation is not achievable; in some cases they are able to prolong survival while theyconstitute mainly a palliative treatment. Systemic treatments include: chemotherapy, immunological and hormonal therapies and, more recently, the introduction of new specific molecular target drugs. At the moment, in this group, the only drug that has given positive results during phase trials (SHARP study) is *** represents the only primary systemic therapy that has demonstrated, unlike the other treatments previously described, an increase in survival rate in patients affected with advanced HCC. Currently, other studies are taking place that are further developing the potential of this drug. These studies, including phase trials, aredirected in order to test the activity and safety of new emerging drugs with targeted activity. Examples of these new agents are: Sunitinib, Gef itinib, Cetuximab, Bevacizumab and Erlotinib.

关键词： Systemic treatments Hepatocarcinogenesis Targeted therapy Sorafenib Hepatocarcinoma Local treatments

Development of endemicity and conservation importance indices for tropical forests and the floral diversity assessment of *** in Benguet,Philippines

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Journal of Mountain Science 2024年第3期21卷 786-804页

作者： Johndale Rein T.BULLONG Jim P.silverio Joanna I.ALAFAG Maricel A.GURON Jones T.NAPALDET Department of Environmental Science Benguet State UniversityLa Trinidad 2601Philippines Department of Biology Benguet State UniversityLa Trinidad 2601Philippines

The scientific community faces the challenge of measuring progress toward biodiversity targets and indices have been traditionally ***,recent inventories in secondary tropical mountain forests using traditional biodiversity indices have yielded results that are indistinct with primary *** shows the need to develop complementary indices that goes beyond species count but integrates the distribution and conservation status of the *** study developed endemicity and conservation importance index for tropical forest that incorporated the distribution and conservation status of the *** indices were applied to ***,a remnant primary mossy forest in Buguias,Benguet,Philippines,that resulted to endemicity index of 81.07 and conservation importance index of *** these with secondary forest sites with comparable Shannon-Wiener,Simpson,Evenness and Margalef’s indices,our endemicity and conservation indices clearly differentiates primary forest(our study site)with higher values from secondary forests with much lower ***,we are proposing these indices for a direct but scientifically-informed identification of specific sites for conservation and protection in tropical ***,our study documented a total of 168 vascular plant species(79 endemic and 12 locally threatened species)in *** are of tropical elements for both generic and species levels with some temperate elements that could be attributed to the site's high elevation and semi-temperate *** are important baseline information for conservation plans and monitoring of tropical mossy forests.

关键词： Endemicity index Conservation importance index Cordillera Central Range Floristic element Jaccard Index of Similarity

Helicobacter pylori and functional dyspepsia: An unsolved issue?

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World Journal of Gastroenterology 2014年第27期20卷 8957-8963页

作者： Angelo Zullo Cesare Hassan Vincenzo De Francesco Alessro Repici Raffaele Manta silverio Tomao Bruno Annibale Dino Vaira Gastroenterology and Digestive Endoscopy "Nuovo Regina Margherita" Hospital Gastroenterology Unit "Riuniti" Hospital Digestive Endoscopy Unit "IRCCS Istituto Clinico Humanitas" 20089 Milan Italy Gastroenterology and Endoscopy Unit "Nuovo S Agostino" Hospital Oncology Unit "SM Goretti" Hospital Latina "Sapienza" University Department of Digestive and Liver Diseases "Sant’Andrea" Hospital "Sapienza" University Department of Internal Medicine and Gastroenterology University of Bologna

Patients with Helicobacter pylori (H. pylori) infection may complain of dyspeptic symptoms without presence of macroscopic lesions on gastroduodenal mucosa. Such a condition is usually recognized as functional dyspepsia, and different pathogenetic mechanisms are involved. The role of H. pylori in these patients is controversial. Several trials assessed the potential role of H. pylori eradication in improving dyspeptic symptoms, and data of some meta-analyses demonstrated that cure of infection is associated with a small (10%), but significant therapeutic gain as compared to placebo. The reason for which dyspeptic symptoms regress in some patients following bacterial eradication, but persist in others remains unclear. Regrettably, trials included in the meta-analyses are somewhat different for study design, definition of symptoms, assessment of symptoms changes, and some may be flawed by potential pitfalls. Consequently, the information could be not consistent. We critically reviewed the main available trials, attempting to address future research in this field

关键词： Helicobacter pylori Dyspepsia Symptoms Therapy Pathogenesis

Degradation Process and Durability of Polymeric Materials for Architectural Applications

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Journal of Architectural Research and Development 2018年第2期2卷 22-32页

作者： silverio Hernández-Moreno Mexico

This review paper discusses the polymeric materials most commonly used in construction industry,where the main considerations and design recommendations for durability are ***,it aims to provide useful insights and information to professionals and researchers in areas related to construction and architectural materials to help them to make decisions when selecting materials from sustainable and durable *** methodology was based on a review of scientific literature,where the main properties of polymeric materials were identified in the main considerations for the durable design of each polymeric *** conclude that these materials consume large amounts of resources and energy in their process of manufacture,so,their use should be ***,at the same time,they are durable and recyclable building materials with good operation and service life,especially serve as sealants,insulation,paints,pipes,window frames and exterior finishes.

关键词： polymers durability service life durable design building materials

Colorectal cancer metastatic to the breast:A case report

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 1073-1079页

作者： Silvia Taccogna Elisa Gozzi Luigi Rossi Davide Caruso Davide Conte Patrizia Trenta Valentina Leoni silverio Tomao Lucrezia Raimondi Francesco Angelini Department of Pathology Regina ApostolorumAlbano 00041RomeItaly UOC of Oncology Sapienza University of RomeAprilia 04011RomeItaly Medical Oncology Unit Regina Apostolorum HospitalAlbano 00041RomeItaly Division of Medical Oncology A Sapienza University of RomeAlbano 00161RomeItaly

BACKGROUND Breast metastases from colorectal cancer(CRC)are very *** is no unanimous consensus regarding the best treatment for this rare condition,and management is,especially in elderly patients,limited to diagnosis and palliative ***,an oral fluoropyrimidine derivative,might be helpful in controlling the disease and may be a treatment option for patients unable to receive more aggressive *** SUMMARY We report a case of synchronous massive breast metastasis from CRC in an 85 year old patient who came to the hospital presenting a huge mass originating from the axillary extension of the right breast.A whole body computed tomography also showed a mass in the right *** patient underwent a simple right mastectomy along with right *** resected breast showed massive metastasis from CRC with intense and homogeneous nuclear CDX2 staining,while the colon specimen revealed poorly differentiated adenocarcinoma stage pT4a pN0 pM1(breast)(Tumor Node Metastasis 2017).Three months later she developed a subcutaneous mass at the site of the previous *** ultrasound guided biopsy was carried out again and revealed a metastasis from *** patient then started treatment with capecitabine plus bevacizumab,obtaining stable disease(RECIST criteria)and a clinical benefit after 3 mo of *** In our experience,capecitabine and bevacizumab may be a useful treatment option for breast metastases from primary CRC in elderly patients.

关键词： Breast metastases Colorectal cancer Elderly patient Capecitabine Bevacizumab Case report

Follow-up of intestinal metaplasia in the stomach: When, how and why

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World Journal of Gastrointestinal Oncology 2012年第3期4卷 30-36页

作者： Angelo Zullo Cesare Hassan Adriana Romiti Michela Giusto Carmine Guerriero Roberto Lorenzetti Salvatore MA Campo silverio Tomao Gastroenterology and Digestive Endoscopy Nuovo Regina Margherita Hospital Oncology Sant'Andrea Hospital Oncology Department of Experimental Medicine University of Rome "Sapienza"

Gastric cancer remains the second most frequent cause of cancer-related mortality in the world. Screening programs in some Asian countries are impractical in the majority of other countries worldwide. Therefore, follow-up of precancerous lesions is advisable for secondary gastric cancer prevention. Intestinal metaplasia (IM) is recognized as a precancerous lesion for gastric cancer, increasing the risk by 6-fold. IM is highly prevalent in the general population, being detected in nearly 1 of every 4 patients undergoing upper endoscopy. The IM prevalence rate is significantly higher in patients with Helicobacter pylori (H. pylori) infection, in first-degree relatives of gastric cancer patients, in smokers and it increases with patient age. IM is the "breaking point" in the gastric carcinogenesis cascade and does not appear to regress following H. pylori eradication, although the cure of infection may slow its progression. Gastric cancer risk is higher in patients with incomplete-type IM, in those with both antral and gastric body involvement, and the risk significantly increases with IM extension over 20% of the gastric mucosa. Scheduled endoscopic control could be cost-effective in IM patients, depending on the yearly incidence of gastric cancer in IM patients, the stage of gastric cancer at diagnosis discovered at surveillance, and the cost of endoscopy. As a pragmatic behavior, yearly endoscopic control would appear justified in all IM patients with at least one of these conditions: (1) IM extension > 20%; (2) the presence of incomplete type IM; (3) first-degree relative of gastric cancer patients; and (4) smokers. In the remaining IM patients, a less intensive (2-3 years) could be proposed.

关键词： Intestinal metaplasia Gastric cancer Follow-up Prevention Risk factors

King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da Silva Athanasio Antonio Marcio de Faria Andrade Vivian Vasconcelos Costa Juliano Felix Castro silverio Leonardo Macedo Garcia Mauro Martins Teixeira Daniele da Gloria Souza Paula Vieira Teixeira Vidigal Cristiano Xavier Lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-Villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-Villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-Vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-Villejuif criteria