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Intensified intensity-modulated radiotherapy in anal cancer with prevalent HPV p16 positivity

World Journal of Gastroenterology 2015年第37期21卷 10688-10696页

作者： Liliana Belgioia Stefano Vagge Dario Agnese Stefania Garelli Roberto Murialdo Giuseppe Fornarini silvana chiara Fabio Gallo Almalina Bacigalupo Renzo Corvò Department of Radiation Oncology AOU IRCCS San Martino - IST National Cancer Research Institute and University Department of Medical Physics AOU IRCCS San Martino - IST National Cancer Research Institute and University Department of Internal Medicine University of Genoa Department of Medical Oncology AOU IRCCS San Martino - IST National Cancer Research Institute and University Section of Biostatistics Department of Health Sciences University of Genoa

AIM: To investigate the toxicity and response of intensity-modulated radiotherapy schedule intensified with a simultaneous integrated boost in anal canal ***: From March 2009 to March 2014, we retrospectively analyzed 41 consecutive patients treated with intensity-modulated radiotherapy(IMRT) and concurrent chemotherapy for anal canal squamous cell carcinoma at our center. Radiotherapy was delivered via simultaneous integrated boost(SIB) technique by helical tomotherapy, and doses were adapted to two clinical target volumes according to the tumor-nodemetastasis(TNM) stage: 50.6 Gy and 41.4 Gy in 23 fractions in T1N0, 52.8 Gy and 43.2 Gy in 24 fractionsin T2N0, and 55 Gy and 45 Gy in 25 fractions in all patients with N positive and/or ≥ T3, respectively, to planning target volumes 1 and 2. The most common chemotherapy regimen was 5-fluorouracil and mitomycin-based. Human papilloma virus(HPV) p16 expression was performed by immunohistochemistry and evaluated in the majority of patients. Acute and late toxicity was scored according to CTCAe v 3.0 and RTOG ***: The median follow-up was 30 mo(range:12-71). Median age was 63 years(range 32-84). The stage of disease was: stage Ⅰ in 2 patients, stage Ⅱin 13 patients, stage ⅢA in 12 patients, and stage ⅢB in 14 patients, respectively. Two patients were known to be HIV positive(4.9%). HPV p16 expression status was positive in 29/34(85.3%) patients. The 4-year progression-free survival and overall survival in HPVpositive patients were 78% and 92%, *** grade 3 skin and gastrointestinal toxicities were reported in 5% and 7.3% of patients, respectively;patients' compliance to the treatment was good due to a low occurrence of severe acute toxicity, although treatment interruptions due to toxicity were required in 7.3% of patients. At 6 mo from end of treatment,36/40(90%) patients obtained complete response;during follow-up, 5(13.8%) patients presented with disease progression(local or systemic)

关键词： Anal canal cancer Intensity-modulated radiotherapy

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Autoimmune hepatitis in genetic syndromes:A literature review

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World Journal of Hepatology 2021年第10期13卷 1328-1340页

作者： Anna Paola Capra Emanuele chiara silvana Briuglia Department of Biomedical DentalMorphological and Functional Imaging SciencesUniversity of MessinaMessina 98100Italy Department of Clinical Pathology University of MessinaMessina 98100Italy

Genetic syndromes represent relevant and rare *** conditions include a large amount of epidemiological,pathogenetic and clinical ***,a systematic approach to genetic syndromes is often prevented by the rareness of these ***,although clinical features are usually precisely defined,nowadays more uncommon associations between genetic syndromes and internal medicine related diseases have been insufficiently *** hepatitis(AIH)is a chronic liver disease caused by loss of tolerance to hepatocyte-specific ***,a better knowledge about specific genetic syndromes in which AIH is more frequent could be important in the clinical management of patients,both for an early diagnosis and for a prompt ***,a systematic approach could explain if onset,clinical course,and response to treatment of AIH are typical for specific genetic *** took in consideration all the scientific articles reported in PubMed in the last 10 years,from 2010 to *** purpose of this review is to explore the prevalence of AIH in genetic syndrome,but also to suggest new classification,that could be useful for pathogenetic hypothesis and clinical approach to genetic *** the 139 publications selected using keywords“autoimmune hepatitis”and“genetic syndrome”,30 papers(21.6%)respected the chosen inclusion criteria,reporting the association between AIH in patients with a genetic *** have collected in all 47 patients with AIH and genetic syndrome,and with median age of *** suggest that when a patient presents a clinical picture of cryptogenic chronic hepatitis,that is unexplained,it is useful to explore differential diagnosis of AIH associated with genetic *** the clinical relevance of this topic,further reports are needed to demonstrate our hypothesis and collect new evidence in this field.

关键词： Autoimmunity Hepatitis Gene Syndrome Liver Disease Immunity

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Palm oil biodiesel:An assessment of PAH emissions,oxidative potential and ecotoxicity of particulate matter

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Journal of Environmental Sciences 2021年第3期33卷 326-338页

作者： silvana Arias Francisco Molina John R.Agudelo Grupo de Investigación en Gestión y Modelación Ambiental-GAIA Escuela AmbientalFacultad de IngenieríaUniversidad de Antioquia UdeACalle 70 No.52-21MedellínColombia Departamento de Ingeniería Mecánica Universidad de Antioquia UdeA

This work assessed the impact of fuelling an automotive engine with palm biodiesel(pure,and two blends of 10%and 20%with diesel,B100,B10 and B20,respectively)operating under representative urban driving conditions on 17 priority polycyclic aromatic hydrocarbon(PAH)compounds,oxidative potential of ascorbic acid(OP^(AA)),and ecotoxicity through D aphnia pulex mortality *** diluted with filtered fresh air(WD)gathered in a minitunel,and particulate matter(PM)collected directly from the exhaust gas stream(W/oD)were used for *** showed that PM collecting method significantly impact PAH *** all PAH appeared in both,WD and W/oD,higher concentrations were obtained in the last *** biodiesel concentration in the fuel blend decreased all PAH compounds,and those with 3 and 5 aromatic rings were the most *** biodiesel affected both OP^(AA)and *** B10 and B20 exhibited the same rate of ascorbic acid(AA)depletion,B100 showed significant faster oxidation rate during the first four minutes and oxidized 10%more AA at the end of the test.B100 and B20 were significantly more ecotoxic than *** lethal concentration LC50 for B10 was 6.13 mg/*** was concluded that palm biodiesel decreased PAH compounds,but increased the oxidative potential and ecotoxicity.

关键词： Biodiesel Particulate matter P emissions Oxidative stress Ecotoxicity Daphnia pulex

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Dose escalation of adalimumab as a strategy to overcome anti-drug antibodies:A case report of infantile-onset inflammatory bowel disease

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World Journal of Gastroenterology 2023年第38期29卷 5428-5434页

作者： silvana Ancona Sara Signa chiara Longo Giuliana Cangemi Roberta Carfora Enrico Drago Alessandro La Rosa Marco Crocco Andrea Chiaro Paolo Gandullia Serena Arrigo Dipartimento di Neuroscienze RiabilitazioneOftalmologiaGenetica e Scienze Materno-Infantili(DINOGMI)Universitàdegli Studi di GenovaGenova 16126Italy Pediatric Gastroenterology and Endoscopy Unit IRCCS Istituto Giannina GasliniGenova 16147Italy Chromatography and Mass Spectrometry Section Central Laboratory of AnalysisIRCCS Istituto Giannina GasliniGenova 16147Italy

BACKGROUND Treatment of infantile-onset inflammatory bowel disease(IO-IBD)is often challenging due to its aggressive disease course and failure of standard therapies with a need for *** loss of response is frequently caused by the production of anti-drug antibodies,a well-known problem in IBD patients on biologic *** present a case of IO-IBD treated with therapeutic drug monitoring(TDM)-guided high-dose anti-tumor necrosis factor therapy,in which dose escalation monitoring was used as a strategy to overcome anti-drug *** SUMMARY A 5-mo-old boy presented with a history of persistent hematochezia from the 10th d of life,as well as relapsing perianal abscess and growth ***,anemia,and elevated inflammatory markers were also *** assessment revealed skip lesions with deep colic ulcerations,inflammatory anal sub-stenosis,and deep fissures with persistent abscess.A diagnosis of IO-IBD Crohn-like was *** patient was initially treated with oral steroids and *** the perianal abscess healed,adalimumab(ADA)was administered with concomitant gradual tapering of *** and biochemical steroid-free remission was achieved with good trough *** 3 mo,antibodies to ADA(ATA)were found with undetectable trough levels;therefore,we optimized the therapy schedule,first administering 10 mg weekly and subsequently up to 20 mg weekly(2.8 mg/kg/dose).After 2 mo of high-dose treatment,ATA disappeared,with concomitant high trough levels and stable clinical and biochemical remission of the *** TDM-guided high-dose ADA treatment as a monotherapy overcame ATA *** strategy could be a good alternative to combination therapy,especially in very young patients.

关键词： Infantile-onset inflammatory bowel disease Adalimumab Loss of response Dose escalation Anti-drug antibodies Case report

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New neuroprotective perspectives in fighting oxidative stress and improving cellular energy metabolism by oleocanthal

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Neural Regeneration Research 2019年第7期14卷 1217-1218页

作者： Cristina Angeloni Laura Giusti silvana Hrelia School of Pharmacy University of Camerino Department of Clinical and Experimental Medicine University of Pisa Department for Life Quality Studies Alma Mater Studiorum-University of Bologna

Neurodegenerative diseases are a heterogeneous group of disorders characterized by a progressive dysfunction and death of neural cells which lead to compromised motor or cognitive ***,the loss of neuron is associated with both gliosis and,frequently,with abnormal accumulation of extracellular and intracellular filamentous deposit in specific cell *** a rapidly increasing aging population,these diseases are becoming a primary health problem(Albers and Beal,2000).

关键词： New neuroprotective fighting oxidative

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Anti Inflammatory Property of PDRN—An <i>in Vitro</i>Study on Cultured Macrophages

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Advances in Bioscience and Biotechnology 2017年第1期8卷 13-26页

作者： chiara Castellini silvana Belletti Paolo Govoni Stefano Guizzardi Department of Biomedical Biotechnological and Translational Sciences—Section of Histology University of Parma Parma Italy

Skin aging and most age-related diseases are associated with a low-grade chronic inflammation. The nucleoside adenosine, a potent endogenous anti-inflammatory agent, is deeply involved in inflammatory diseases and, by interaction with the adenosine A2 receptor (A2AR) it immediately promotes a mechanism of defence against the inflammatory damage. The aim of our study was to investigate whether polydeoxyribonucleotide (PDRN), a mixture of deoxyribonucleotides polymers of different lengths that like adenosine, binds the A2A receptor, can reduce the inflammatory state in the macrophage cell line. RAW264.7, murine macrophage cells, were incubated with PDRN in the presence and in the absence of lipopolysaccaride (LPS), which was the major component of the outer membrane of gram-negative bacteria and which acted as a strong macrophage activator. We assessed the production of nitric oxide and the secretion of inflammatory mediators (i.e., TNF-α, IL-10, IL-12 and VEGF-A). Our data showed that PDRN produced a significant decrease of inflammation in macrophages pre-stimulated with LPS, assessed in terms of the nitric oxide content (p 2A receptor, contributed to a great extent towards reducing inflammation.

关键词： Cell Culture Macrophages RAW264.7 Inflammation Skin Aging

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Predicting stable crystalline compounds using chemical similarity

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npj Computational Materials 2021年第1期7卷 99-107页

作者： Hai-Chen Wang silvana Botti Miguel A.L.Marques Institut für Physik Martin-Luther-Universität Halle-Wittenberg06120 Halle(Saale)Germany Institut für Festkörpertheorie und-Optik Friedrich-Schiller-Universität Jena and European Theoretical Spectroscopy FacilityMax-Wien-Platz 107743 JenaGermany

We propose an efficient high-throughput scheme for the discovery of stable crystalline *** approach is based on the transmutation of known compounds,through the substitution of atoms in the crystal structure with chemically similar *** concept of similarity is defined quantitatively using a measure of chemical replaceability,extracted by data-mining experimental *** this way we build 189,981 possible crystal phases,including 18,479 that are on the convex hull of *** resulting success rate of 9.72%is at least one order of magnitude better than the usual success rate of systematic high-throughput calculations for a specific family of materials,and comparable with speed-up factors of machine learning filtering *** a characterization of the set of 18,479 stable compounds,we calculate their electronic band gaps,magnetic moments,and *** approach,that can be used as a filter on top of any high-throughput scheme,enables us to efficiently extract stable compounds from tremendously large initial sets,without any initial assumption on their crystal structures or chemical compositions.

关键词： stability similarity crystalline

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Synthesis of Water-soluble, Polyester-based Dendrimer Prodrugs for Exploiting Therapeutic Properties of Two Triterpenoid Acids

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Chinese Journal of Polymer Science 2018年第9期36卷 999-999,1000-1010页

作者： silvana Alfei Gaby Brice Taptue Silvia Catena Angela Bisio Dipartimento di Farmacia Sezione di Chimica e Tecnologie Farmaceutiche e Alimentari Università di Genova

Dendrimers are macromolecules characterized by high controlled size, shape and architecture, presence of inner cavities able to accommodate small molecules and many peripheral functional groups to bind target entities. They are of eminent interest for biomedical applications, including gene transfection, tissue engineering, imaging, and drug delivery. The well-known pharmacological activities of ursolic and oleanolic acids are limited by their small water solubility, non-specific cell distribution, low bioavailability, poor pharmacokinetics, and their direct administration could result in the release of thrombi. To overcome such problems, in this paper we described their physical incorporation inside amino acids-modified polyester-based dendrimers which made them highly water-soluble. IR, NMR, zeta potential, mean size of particles, buffer capacity and drug release profiles of prepared materials were reported. The achieved water-soluble complexes harmonize a polycationic character and a buffer capacity which presuppose efficient cell penetration and increased residence time with a biodegradable cell respectful scaffold, thus appearing as a promising team of not toxic prodrugs for safe administration of ursolic and oleanolic acids.

关键词： Polyester-based amino acids-modified dendrimers Physical encapsulation Water-soluble dendriplexes Buffer capacity NMR investigations

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Biosolid Application to Agricultural Land a Contribution to Global Phosphorus Recycle： A Review

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Pedosphere 2017年第1期27卷 1-16页

作者： silvana Irene TORRI Rodrigo Studart CORRt Giancarlo RENELLA Department of Natural Resources and Environment School of Agriculture University of Buenos Aires Avenue San Martin 4453 Buenos Aires 1417 DSE (Argentina) University of Brasilia-UnB/PPGCA Campus Darcy Ribeiro Caixa Postal 04401 70910-970 DF (Brazil) Department of Agrifood Production and Environmental Sciences University of Florence Piazzale delle Caseine 18 Florence 50144 (Italy)

Phosphorus(P) is an essential nutrient required for plant *** population growth and rising global demand for food are expected to increase the demand for phosphate ***,high-quality phosphate rock reserves are progressively becoming *** of the increased pressure on P resources could be alleviated by recycling P present in ***,it is crucial to understand the dynamics of P in biosolid-amended soils,the effects of residual biosolid-borne P in soils,the way in which microorganisms may control P dynamics in biosolid-amended soils and the environmental implications of the use of biosolids as a source of *** research is needed to maximize biosolid-borne P uptake by crops and minimize its loss from biosolid-amended *** analysis of the microbiological control of P dynamics in biosolid-amended soils indicates interactions of biosolid P with other nutrients such as carbon(C) and nitrogen(N),suggesting that harmonization of the current regulation on the use of biosolids in agriculture,mainly based on total N and pollutant contents,is needed to better recycle P in agriculture.

关键词： anthropogenic P phosphate P availability P biogeocycle P uptake runoff P

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Antiglycative activity of sulforaphane: a new avenue to counteract neurodegeneration?

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Neural Regeneration Research 2015年第11期10卷 1750-1751页

作者： Cristina Angeloni Marco Malaguti silvana Hrelia Department for Life Quality Studies Alma Mater StudiorumUniversity of Bologna

Neurodegeneration is a key aspect of a large number of diseases that come under the umbrella of＂neurodegenerative diseases＂with the most notable being Parkinson＇s,Alzheimer＇s,and Huntington＇s diseases（AD,PD,HD）.They are all incurable and debilitating conditions that result in progressive degeneration and/or death of neurons and are the leading cause of disability in the elderly. The incidence of these diseases is on the rise and yet there is a paucity of effective therapies to treat them.

关键词： Antiglycative activity of sulforaphane

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