检索结果-南通市图书馆

Impact of exercise on markers of B cell-related immunity:A systematic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第3期13卷 339-352,I0002页

作者： David Walzik Sergen Belen Karen Wilisch Marie Kupjetz silvana Kirschke Tobias Esser Niklas Joisten Alexander Schenk Sebastian Proschinger Philipp Zimmer Division of Performance and Health(Sports Medicine) Institute for Sport and Sport ScienceTU Dortmund UniversityDortmund 44227Germany

Background:B cells represent a crucial component of adaptive immunity that ensures long-term protection from infection by generating pathogen-specific *** alters B cell counts and immunoglobulin levels,but evidence-based conclusions on potential benefits for adaptive immunity are *** systematic review assessed current literatures on the impact of acute exercise and exercise training on B cells,immunoglobulins,and markers of secretory immunity in human ***:According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,MEDLINE,Web of Science,and Embase were searched on March 8,***-randomized controlled trials and crossover trials investigating the impact of acute exercise or exercise training on B cell counts and proportions,immunoglobulin levels,salivary flow rate,or secretory immunoglobulin A secretion rate were *** and reporting of exercise training studies were assessed using the Tool for the Assessment of Study Quality and reporting in *** characteristics,outcome measures,and statistically significant changes were summarized ***:Of the 67 eligible studies,22 applied acute exercise and 45 applied exercise *** included outcomes revealed significant alterations over time in acute exercise and exercise training context,but only a few investigations showed significant differences compared to control *** and plasma immunoglobulin A levels were most consistently increased in response to exercise ***:B cell-related outcomes are altered by acute exercise and exercise training,but evidence-based conclusions cannot be drawn with high confidence due to the large heterogeneity in populations and exercise ***-designed trials with large sample sizes are needed to clarify how exercise shapes B cell-related immunity.

关键词： Antibody B-lymphocyte Exercise Humoral immunity Immune system

Bee venom acupuncture reduces neuroinflammation modulating microglia/macrophage phenotype polarization in spinal cord injury compression model

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neuroimmunology and Neuroinflammation 2019年第11期6卷 1-13页

作者： Raquel do Nascimento de Souza Júlia Miccolis Azevedo Lopes Lívia da Rocha Natalino Monteiro Raiana Andrade Quintanilha Barbosa Gabriela Hollmann silvana allodi Luis Carlos Reis MagdaAlves de Medeiros Department of Physiological Sciences Institute of Biology and Health SciencesFederal Rural University of Rio de JaneiroSeropedica 23897-000RJBrazil Carlos Chagas Filho Institute of Biophysics Federal University of Rio de JaneiroRio de Janeiro 21941-902RJBrazil.

Aim: The present study aimed to examine whether apipuncture (stimulation of acupuncture points with bee venom)at ST36 and GV3 acupoints promotes neuroprotection and reduces neuroinflammation by modulating M1 and M2 phenotype ***: Wistar rats were treated with bee venom (BV) (0.08 mg/kg) injection at acupoints ST36 and GV3 [BV (ST36 + GV3)-spinal cord injury (SCI)] or BV injection at non-acupoints [BV (NP)-SCI] or no treatment (CTL-SCI)after SCI by compression. The spinal cord mRNA expression of iNOS, Arg-1 and TGF-β was measured by real time PCR and the levels of IBA-1;BCL-2;NeuN e CNPase was measured by western blotting. Locomotor performance was measured by Basso, Beattie, and Bresnahan (BBB) and grid-walking ***: Apipuncture treatment was able to (1) ameliorate locomotor performance;(2) reduce inflammatory markers (Cox-2 levels) and activation of microglia and macrophages;(3) reduce the polarization of the M1 phenotype marker (iNOS) and increase M2 (Arg-1 and TGF-β) phenotypic markers;(4) promote neuroprotection by reducing the death of neurons and oligodendrocytes;and (5) increase the expression of the anti-apoptotic factor ***: Apipuncture treatment induces locomotor recovery and neuroprotection after the compression model of spinal cord injury. Further, it reduces neuroinflammation by decreasing M1 polarization and increasing M2 phenotype.

关键词： Acupuncture bee venom spinal cord injury compression microglia macrophage neuroinflammation

Superior rectus/levator complex in acquired anophthalmic socket repaired with spheric implant—a computed tomography scan and topographic study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第8期17卷 1483-1488页

作者： Shaikha Al Eid Hamad M AlSulaiman Sahar M Elkhamary Osama Al Sheikh Alicia Ferrero-Galindo Rajiv Kandekhar silvana A Schellini Oculoplastic Division King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia Radiology Division King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia Department of Diagnostic Radiology Mansoura Faculty of MedicineMansoura 35511Egypt University Hospital Rio Hortega Valladolid 47012Spain Research Department King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia Ophthalmology Department Medical SchoolState University of Sao PauloBotucatu 18618-687Brazil

AIM:To determine whether the levator palpebrae superioris(LPS)/superior rectus(SR)muscle complex,can influence the position of the upper lid and fornix in acquired anophthalmic ***:This comparative non-randomized and non-interventional study included retrospective data of 21 patients with unilateral acquired anophthalmic sockets repaired with spheric ***-resolution computed tomography(CT)measurements of the LPM/SR muscle complex and clinical topographic position of the upper lid,superior and inferior fornix depth in primary gaze position were *** data were presented as frequency and percentage proportions and quantitative variables comparing the socket measurements with the normal contralateral orbit was statistically analyzed using non-parametric tests considering P0.05,all comparisons).The superior fornix depth was similar in the anophthalmic socket and the contralateral normal orbit(P=0.192)as well the inferior fornix depth(P=0.351).CONCLUSION:Acquired anophthalmic sockets repaired with spheric implants have shorter LPS,thicker SR,and more lagophthalmos than normal *** relationship of the LPS and SR with other orbital structures,associated with passive or active forces acting in the final position of the lids and external ocular prosthesis should be further investigated.

关键词： anophthalmic socket spheric implant levator palpebrae superioris superior rectus lagophthalmos fornix depth

Unusual Case of Unilateral Neonatal Eyeball Luxation: A Case Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Ophthalmology 2024年第1期14卷 69-75页

作者： Abdullah S. Alghamdi Muhammed S. Alrajeh Ahmad S. Alsalem silvana Schellini Azzah Maktabi Amal Alhumaidan Diego Strianese Prince Sultan Military Medical City Riyadh Saudi Arabia King Abdulaziz Medical City Riyadh Saudi Arabia King Khalid Eye Specialist Hospital Riyadh Saudi Arabia University of Naples Federico II Naples Italy

The newborn infant presented with severe proptosis. Data on clinical history, presentation, photos, radiological imaging, and laboratory results were presented. A literature review was conducted for the case and relevant treatment modalities. The surgical technique and the outcome were also discussed. The mass was present since birth in a full term neonate, causing complete globe dislocation of the left eye. Imaging showed a large cystic retro-bulbar mass completely occupying the orbital cavity and causing anterior dislocation of the left globe. Surgical excision of the tumor was carried out with globe preservation and Histopathology examination confirmed the diagnosis of optic nerve glioma. This was an atypical presentation of an optic nerve glioma causing globe dislocation in a neonate. The resection of such a large orbital tumor made globe preservation possible and resulted in an excellent cosmetic outcome. .

关键词： Neonatal Proptosis Optic Nerve Glioma Globe Dislocation Globe Preservation Cosmetic Surgery

基于氯化胆碱的低共熔体系在Au上电沉积无枝晶Zn

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2024年第7期34卷 2367-2380页

作者： Vesna S.CVETKOVIĆ Nebojša D.NIKOLIĆ Tanja S.BARUDŽIJA silvana B.DIMITRIJEVIĆ Jovan N.JOVIĆEVIĆ Department of Electrochemistry Institute of ChemistryTechnology and MetallurgyUniversity of BelgradeNjegoševa 1211000 BelgradeSerbia Institute for Nuclear Sciences Vinča University of BelgradeP.O.Box 52211001 BelgradeSerbia Mining and Metallurgy Institute Zeleni bulevar 3519210 BorSerbia

以氯化胆碱和乙二醇混合液为低共熔溶剂,不使用其他添加剂,电化学沉积无枝晶Zn/Au合金。在不同的Zn(Ⅱ)浓度下,采用恒电位电沉积法在相对较低的Zn电沉积过电位下进行电沉积。通过循环伏安法(CV)和计时安培法(CA)揭示Zn电沉积的电化学机... 详细信息

以氯化胆碱和乙二醇混合液为低共熔溶剂,不使用其他添加剂,电化学沉积无枝晶Zn/Au合金。在不同的Zn(Ⅱ)浓度下,采用恒电位电沉积法在相对较低的Zn电沉积过电位下进行电沉积。通过循环伏安法(CV)和计时安培法(CA)揭示Zn电沉积的电化学机理。采用扫描电子显微镜和X射线衍射分析(XRD)对沉积层的形貌和结构进行表征,并用能谱仪对沉积层进行元素分析。CV结果表明,Zn的电沉积始于Zn欠电位沉积区,并一直持续到Zn过电位沉积(OPD)区。随着Zn(Ⅱ)浓度的增加,Zn/Zn(Ⅱ)电偶的沉积电位向更高的正值偏移。CA分析表明,在Zn的OPD区开始三维渐进形核,随后形成三维生长。形貌分析表明,电沉积始于致密Zn岛的形成,随后形成无枝晶Zn/Au合金。XRD分析表明,其物相为金属Zn、立方AuZn3和Au Zn金属间化合物。

关键词：锌电沉积低共熔溶剂锌金合金形貌结构

Computational screening of materials with extreme gap deformation potentials

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 1482-1491页

作者： Pedro Borlido Jonathan Schmidt Hai-Chen Wang silvana Botti Miguel A.L.Marques Institut für Festkörpertheorie und-optik Friedrich-Schiller-Universität Jena and European Theoretical Spectroscopy FacilityMax-Wien-Platz 107743JenaGermany CFisUC Department of PhysicsUniversity of CoimbraRua Larga3004-516CoimbraPortugal Institut für Physik Martin-Luther-Universität Halle-WittenbergD-06099HalleGermany

In this work,we present a large-scale study of gap deformation potentials based on density-functional theory calculations for over 5000 *** expected,in most cases the band gap decreases for increasing volume with deformation potentials that can reach values of almost−15 *** find,however,also a sizeable number of materials with positive deformation *** members of this group are halide perovskites,known for their applications in *** then focus on understanding the physical reasons for so different values of the deformation potentials by investigating the correlations between this property and a large number of other material and compositional *** also train explainable machine learning models as well as graph convolutional networks to predict deformation potentials and establish simple rules to understand predicted ***,we analyze in more detail a series of materials that have record positive and negative deformation potentials.

关键词： deformation properties. extreme

c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第2期18卷 237-243页

作者： Daniela A.Gutiérrez América Chandía-Cristi María JoséYáñez silvana Zanlungo Alejandra R.Alvarez Cell Signaling Laboratory Department of Cellular and Molecular BiologyCenter for Aging and Regeneration(CARE)Millennium Institute on Immunology and ImmunotherapyBiological Sciences FacultyPontificia Universidad Católica de ChileSantiagoChile School of Medical Technology Health Sciences FacultyUniversidad San SebastianSede Los LeonesSantiagoChile Department of Gastroenterology Faculty of MedicinePontificia Universidad Católica de ChileSantiagoChile

Our ability to learn and remember depends on the active formation,remodeling,and elimination of ***,the development and growth of synapses as well as their weakening and elimination are essential for neuronal *** structural reorganization of synaptic complexes,changes in actin cytos keleton and organelle dynamics,as well as modulation of gene expression,determine synaptic *** has been proposed that dys regulation of these key synaptic homeostatic processes underlies the synaptic dysfunction observed in many neurodegenerative *** is known about downstream signaling of activated N-methyl-D-aspartate andα-amino-3-hydroxy-5-methyl-4-isoazolepro pionate receptors;howeve r,other signaling pathways can also contribute to synaptic plasticity and long-lasting changes in learning and *** non-receptor tyrosine kinase c-Abl(ABL1)is a key signal transducer of intra and extracellular signals,and it shuttles between the cyto plasm and the *** review focuses on c-Abl and its synaptic and neuronal ***,we discuss the evidence showing that the activation of c-Abl can be detrimental to neurons,promoting the development of neurodegenerative ***,c-Abl activity seems to be in a pivotal balance between healthy synaptic plasticity,regulating dendritic spines remodeling and gene expression after cognitive training,and synaptic dysfunction and loss in neurodegenerative ***,c-Abl genetic ablation not only improves learning and memory and modulates the brain genetic program of trained mice,but its absence provides dendritic spines resiliency against *** re,the present review has been designed to elu cidate the common links between c-Abl regulation of structural changes that involve the actin cytos keleton and organelles dynamics,and the transc riptional program activated during synaptic *** summarizing the recent discove ries on c-Abl functions,we aim to provide an overview of how

关键词： actin cytoskeleton activity-dependent plasticity Alzheimer's disease c-Abl dendritic spines learning synapse synaptic plasticity transcription tyrosine kinase

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

博洛尼亚Bonfiglioli总部大楼

现代装饰 2024年第3期 24-31页

作者： Peter Pichler(设计) silvana Ordinas(设计) Niklas Knap(设计) Simona Alu(设计) Ugo Licciardi(设计) Cem Ozbasaran(设计) Filippo Ogliani(设计) Giovanni Paterlini(设计) Domenico Calabrese(设计) Nathalia Rotelli(设计) Angela Ferrari(设计) Alessandro Cardellini(设计) Simone Valbusa(设计) Gustav Willeit(摄影) 范嘉苑(编译) 不详

Peter Pichler Architecture近期落成的Bonfiglioli总部大楼现已揭幕,该项目位于意大利博洛尼亚的Calderara di Reno地区。新总部设计旨在打造一座高效且功能齐全的办公建筑,以此展现出这家意大利企业的专业性、创新性以及引以为傲的历... 详细信息

Peter Pichler Architecture近期落成的Bonfiglioli总部大楼现已揭幕,该项目位于意大利博洛尼亚的Calderara di Reno地区。新总部设计旨在打造一座高效且功能齐全的办公建筑,以此展现出这家意大利企业的专业性、创新性以及引以为傲的历史。创立于1956年,Bonfiglioli公司是一家拥有领先地位的制造商以及供应商,产品门类涵盖齿轮电动机、驱动系统、减速齿轮箱和变频器等。Bonfiglioli的产品解决方案在全球范围内的自动化、移动机械和可再生能源领域都具有强有力的推动作用。

关键词：产品门类减速齿轮箱移动机械可再生能源博洛尼亚总部大楼办公建筑产品解决方案

Effective Finite-Difference Techniques for Estimating Sensitivities for Stochastic Biochemical Systems

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics 2022年第11期13卷 878-895页

作者： Fauzia Jabeen silvana Ilie Department of Mathematics Ryerson University Toronto Canada

Cellular environments are in essence stochastic, owing to the random character of the biochemical reaction events in a single cell. Stochastic fluctuations may substantially contribute to the dynamics of systems with small copy numbers of some biochemical species. Then, stochastic models are indispensable for properly portraying the behaviour of the system. Sensitivity analysis is one of the central tools for studying stochastic models of cellular dynamics. Here, we propose some finite-difference strategies for estimating parametric sensitivities of higher-order moments of the system state for stochastic discrete biochemical kinetic models. To reduce the variance of the sensitivity estimator, we employ various coupling techniques. The advantages of the proposed methods are illustrated in several models of biochemical systems of practical relevance.

关键词： Stochastic Simulation Algorithm Stochastic Biochemical Kinetics Sensitivity Analysis