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Acta Mechanica Solida Sinica 2017年第1期30卷 87-97页

作者： Yu xiang Automotive and Transportation Engineering Collage Guangxi University of Science and Technology Liuzhou 545006 China Guangxi Key Laboratory of Automobile Components and Vehicle Technology Guangxi University of Science and Technology Liuzhou 545006 China

Based on the classical theory of thin plate and Biot theory, a precise model of the transverse vibrations of a thin rectangular porous plate is proposed. The first order differential equations of the porous plate are derived in the frequency domain. By considering the coupling effect between the solid phase and the fluid phase and without any hypothesis for the fluid displacement, the model presented here is rigorous and close to the real materials. Owing to the use of extended homogeneous capacity precision integration method and precise element method, the model can be applied in higher frequency range than pure numerical methods. This model also easily adapts to various boundary conditions. Numerical results are given for two different porous plates under different excitations and boundary conditions.

关键词： Thin rectangular porous plate Blot theory Vibration First order differential equations Extended homogeneous capacity high precision integration method

Tensile-WAXD Apparatus:An Improved and Accurate System for the In situ Study of Extension-induced Segmental Orientation in Highly Stretched Elastomer

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Chinese Journal of Polymer Science 2024年第12期42卷 2002-2010,I0011页

作者： xiang Shi Center for Advanced Material Diagnostic Technology Shenzhen Technology UniversityShenzhen518118China Laboratoire de Physique des Solides CNRSUniversitéParis-SudUniversitéParis-SaclayOrsay91400France

An improved X-ray apparatus that combines tensile testing and X-ray diffraction has been designed and constructed to conduct timeresolved experiments during uniaxial *** utilizing mortise-like clamping jaws and dogbone-shaped specimens,this setup allows for the simultaneous recording of high-quality mechanical responses and 2D diffraction patterns due to the minimization of experimental errors from sample slippage or premature ***,the local extension ratio can be accurately determined based on thickness variation,and the Hermans'orientation function was demonstrated to be a reliable method with high accuracy to calculate the segmental orientation parameter〈P_(2)〉in elastomeric samples under high degree of *** summary,this innovative tensile-WAXD instrument has proven to be a promising and powerful technique for investigating the“stress-deformation-segmental orientation”relationship in elastomers with high extensibilities.

关键词： X-ray apparatus Elongation calculation Segmental orientation In situ measurement

Digital signal processing for coherent multi-level modulation formats

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Chinese Optics Letters 2010年第9期8卷 863-870页

作者： xiang Zhou AT&T Labs-Research 200 Laurel Ave South Middletown NJ 07748 USA

This paper presents a review on the recent progress of digital signal processing （DSP） in the high-speed optical transmission system using single-carrier based multi-level modulation formats. The principle of several digital phase and polarization tracking algorithms recently proposed and demonstrated for future spectrally-efficient optical transmission system are discussed in detail. A novel DSP-based interference mitigation algorithm for the single-ended coherent receiver has been included. Recent technology advance on transmitter-side DSP such as digital pulse-shaping, pre-equalization and digital nonlinear compensation has also been discussed.

关键词： Coherent receivers Dense wavelength division multiplexing Optical signals Phase recovery Polarization division multiplexing Signal processing

Response of bacteria in the deep-sea sediments and the Antarctic soils to carbohydrates: Effects on ectoenzyme activity and bacterial community

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Journal of Environmental Sciences 2010年第11期22卷 1779-1785页

作者： xiang Zeng School of Life Sciences Xiamen University Xiamen 361005 China. Key Laboratory of Marine Biogenetic Resources Third Institute of Oceanography State Oceanic Administration Xiamen 361005 China School of Life Sciences and Biotechnology Shanghai Jiaotong University Shanghai 200240 China

The response of bacteria to various carbohydrates in the deep-sea sediments and the Antarctic soils was investigated using cellulose, chitin, and olive oil. It was found that the carbohydrates significantly increased the corresponding specific ectoenzyme activity （β- glucosidase, β-N-acetylglucosaminidase, lipase） in the samples from deep-sea sediments. In the case of Antarctic soil samples, the cellulose or olive oil amendments had minor or no effect on β-glucosidase or lipase activity, except the chitin which stimulated β- N-acetylglucosaminidase production. The responses of the bacteria in the deep-sea sediment sample WP02-3 and the Antarctic soil sample CC-TY2 towards the chitin amendment were further analyzed. Chitin amendments were shown to stimulate the ectoenzyme activity in all the tested sediments and the soils. The bacterial response before and after the carbohydrates amendments were compared by denaturing gradient gel electrophoresis and quantitative competitive polymerase chain reaction. Significant changes were found in the structure and density of the bacterial community in the deep sea sediments as compared to the Antarctic soil sample, where the effects were relatively lower. There was no change in the bacterial population in both studied samples in response to carbohydrates amendments. These data indicate that the bacterial communities in the oligotrophic deep-sea sediments are more dynamic than that in the Antarctic soils as they respond to the nutrient sources efficiently by regulation of ectoenzyme activity and/or changing community structure.

关键词： deep-sea sediments Antarctic soils amending cellulose chitin olive oil ectoenzyme activity

circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan Yi He Pan Chen Ming Zhou Bo xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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高性能YOLOv3-tiny嵌入式硬件加速器的混合优化设计

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半导体技术 2025年第1期50卷 55-63页

作者：谭会生肖鑫凯卿翔湖南工业大学轨道交通学院湖南株洲412000

为解决在嵌入式设备中部署神经网络受算法复杂度、执行速度和硬件资源约束的问题,基于Zynq异构平台,设计了一个高性能的YOLOv3-tiny网络硬件加速器。在算法优化方面,将卷积层和批归一化层融合,使用8 bit量化算法,简化了算法流程;在加速... 详细信息

为解决在嵌入式设备中部署神经网络受算法复杂度、执行速度和硬件资源约束的问题,基于Zynq异构平台,设计了一个高性能的YOLOv3-tiny网络硬件加速器。在算法优化方面,将卷积层和批归一化层融合,使用8 bit量化算法,简化了算法流程;在加速器架构设计方面,设计了可动态配置的层间流水线和高效的数据传输方案,缩短了推理时间,减小了存储资源消耗;在网络前向推理方面,针对卷积计算,基于循环展开策略,设计了8通道并行流水的卷积模块;针对池化计算,采用分步计算策略实现对连续数据流的高效处理;针对上采样计算,提出了基于数据复制的2倍上采样方法。实验结果表明,前向推理时间为232 ms,功耗仅为2.29 W,系统工作频率为200 MHz,达到了23.97 GOPS的实际算力。

关键词： YOLOv3-tiny网络异构平台硬件加速器动态配置架构硬件混合优化数据复制上采样

压应力激活SOST/Wnt/β-catenin 通路诱导软骨终板细胞退变

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中国组织工程研究 2025年第5期29卷 951-957页

作者：项攀车艳军罗宗平苏州大学附属第一医院骨科研究所江苏省苏州市215006 南京医科大学附属苏州医院骨科与运动医学中心江苏省苏州市215000

背景:在许多可以导致椎间盘退变的因素中(衰老、营养匮乏、机械因素等),力学负荷被认为是极其重要的因素,但其机制尚不清楚。目的:探讨硬骨素和Wnt/β-catenin信号通路在压应力诱导终板软骨退变中的作用。方法:提取4周龄雄性SD大鼠软骨... 详细信息

背景:在许多可以导致椎间盘退变的因素中(衰老、营养匮乏、机械因素等),力学负荷被认为是极其重要的因素,但其机制尚不清楚。目的:探讨硬骨素和Wnt/β-catenin信号通路在压应力诱导终板软骨退变中的作用。方法:提取4周龄雄性SD大鼠软骨终板细胞,体外利用力学加载仪器对终板软骨细胞施加压应力,于压缩细胞1,3,5,7 d,采用CCK-8法测定细胞活力;Western blot、RT-qPCR及细胞免疫荧光等检查终板软骨细胞内软骨标记物(聚集蛋白聚糖、Ⅱ型胶原)、钙化相关因子(Runx2、骨钙素)、细胞外基质降解酶及信号通路基因(硬骨素、β-catenin)等表达。结果与结论:①压应力作用下,终板软骨细胞活力会随着压应力时间、强度增加而降低;②终板软骨细胞的软骨标记物(聚集蛋白聚糖、Ⅱ型胶原)表达下降,而钙化相关因子(Runx2、骨钙素)表达上升;③压应力能促进终板软骨细胞的细胞外基质降解,基质金属蛋白酶3、基质金属蛋白酶13表达量增加;④细胞内Wnt/β-catenin信号通路表达出现异常,其特异性抑制因子硬骨素伴随着β-catenin的异常积累而表达下降。结果说明:在压应力作用下,终板软骨细胞内硬骨素的表达下降,导致Wnt/β-catenin信号通路激活,促进软骨终板的钙化、退变与细胞外基质的降解,进而促进椎间盘退变。

关键词：软骨终板软骨细胞 SOST Wnt/β-catenin 压应力椎间盘退变

Homological Dimensions of Skew Group Rings

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Algebra Colloquium 2020年第2期27卷 319-330页

作者： Yueming xiang School of Mathematics and Computational Science Huaihua University HuaihuaHunan 418000China

Let R be a ring and let H be *** of a finite group *** consider the weak global dimension,cotorsion dimension and weak Gorenstein global dimension of the skew group ring R^σ G and its coefficient ring *** the assumption that R^σ G is a,separable extension over R^σ H,it is shown that R^σ G and R^σ H share the same homological *** known results are then obtained as ***,we investigate the relationships between the homological dimensions of Ra G and the homological dimensions of a commutative ring R,using the trivial R^σ G-module.

关键词： skew group rings weak global dimensions cotorsion dimensions weak Gorenstein global dimensions separable extensions

Exact Solutions for String Cosmology

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Chinese Physics Letters 2003年第5期20卷 615-617页

作者： WANGXing-xiang DepartmentofPhysics AnhuiNormalUniversityWuhu241000

Some more general cosmological solutions of Bianchi types II, VIII, and IX for a cloud string are presented. The physical implications of the solutions are briefly discussed. Our solutions include some of the results ... 详细信息

关键词：宇宙论爱因斯坦方程拓扑代数星云

The Global Attractor of a Non-Local PDE Model with Delay for Population Dynamics in Rn

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Acta Mathematica Sinica,English Series 2011年第6期27卷 1121-1136页

作者： xiang LI Zhi xiang LI Department of Mathematics and Systems Science College of ScienceNational University of Defense Technology Changsha 410073 P. R. China

In this paper, we consider a non-local PDE model with delay for population dynamics in Rn. First, we prove the existence and uniqueness of weak solutions under some suitable decayed assumptions on non-local term at infinity. Then, we obtain the global attractor by proving w-limit compactness property of the solution operator semigroup.

关键词： Non-local PDE model w-limit compact global attractor