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Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

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Infectious Diseases of Poverty 2018年第1期7卷 1270-1283页

作者： Kazeem Akano Godwin Ntadom Chimere Agomo Christian T.Happi Onikepe A.Folarin Grace O.Gbotosho Olugbenga Mokuolu Finomo Finomo Joy C.Ebenebe Nma Jiya Jose Ambe Robinson Wammanda George Emechebe Oluwabunmi K.Basorun Olubunmi A.Wewe sikiru amoo Nnenna Ezeigwe Stephen Oguche Bayo Fatunmbi Akintunde Sowunmi Department of Pharmacology and Therapeutics University of IbadanIbadanNigeria Antimalarial Therapeutic Efficacy Monitoring Group National Malaria Elimination ProgrammeThe Federal Ministry of HealthAbujaNigeria Department of Medical Laboratory Science University of LagosLagosNigeria Department of Biological Sciences and African Centre of Excellence for Genomics of Infectious Diseases(ACEGID) Redeemer UniversityEdeNigeria Institute for Medical Research and Training University of IbadanIbadanNigeria Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of IbadanIbadanNigeria Department of Paediatrics University of IlorinIlorinNigeria Department of Paediatrics Federal Medical CentreYenagoaNigeria Department of Paediatrics Nnamdi Azikiwe UniversityAwkaNigeria Department of Paediatrics Uthman Dan Fodio UniversitySokotoNigeria Department of Paediatrics University of MaiduguriMaiduguriNigeria Department of Paediatrics Ahmadu Bello UniversityZariaNigeria Department of Paediatrics Imo State University Teaching HospitalOrluNigeria Department of Paediatrics University of JosJosNigeria World Health Organization Country OfficeKampalaUganda

Background:In acute falciparum malaria,asexual parasite reduction ratio two days post-treatment initiation(PRRD2)≥10000 per cycle has been used as a measure of the rapid clearance of parasitaemia and efficacy of artemisinin ***,there is little evaluation of alternative measures;for example,parasite reduction ratio one day after treatment initiation(PRRD1)and its relationship with parasite clearance time(PCT)or *** study evaluated the use of PRRD1 as a measure of responsiveness to antimalarial ***:In acutely malarious children treated with artesunate-amodiaquine(AA),artemether-lumefantrine(AL)or dihydroartemisinin-piperaquine(DHP),the relationships between PRRD1 or PRRD2 and PCT,and between PRRD1 and PRRD2 were evaluated using linear *** between estimates of PCT using PRRD1 and PRRD2 linear regression equations was evaluated using the Bland-Altman *** of PRRD1>5000 per half cycle and PRRD2≥10000 per cycle were evaluated using stepwise multiple logistic regression *** the linear regression equation of the relationship between PRRD1 and PCT previously generated in half of the DHP-treated children during the early study phase,PCT estimates were compared in a prospective blinded manner with PCTs determined by microscopy during the later study phase in the remaining ***:In 919 malarious children,PRRD1 was significantly higher in DHP-and AA-treated compared with AL-treated children(P15months,parasitaemia>10000/μl and DHP treatment independently predicted PRRD1>5000 per half cycle,while age>30months,haematocrit≥31%,body temperature>37.4°C,parasi

关键词： Falciparum malaria Artemisinin-based combination therapies Parasite clearance Children Nigeria

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Declining responsiveness of childhood Plasmodium falciparum infections to artemisinin-based combination treatments ten years following deployment as first-line antimalarials in Nigeria

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Infectious Diseases of Poverty 2019年第4期8卷 96-97页

作者： Akintunde Sowunmi Godwin Ntadom Kazeem Akano Folasade O.Ibironke Adejumoke I.Ayede Chimere Agomo Onikepe A.Folarin Grace O.Gbotosho Christian Happi Stephen Oguche Henrietta U.Okafor Martin Meremikwu Philip Agomo William Ogala Ismaila Watila Olugbenga Mokuolu Finomo Finomo Joy C.Ebenebe Nma Jiya Jose Ambe Robinson Wammanda George Emechebe Wellington Oyibo Francis Useh Temitope Aderoyeje Titilope M.Dokunmu Omobolaji T.Alebiosu sikiru amoo Oluwabunmi K.Basorun Olubunmi A.Wewe Chukwuebuka Okafor Odafe Akpoborie Bayo Fatunmbi Elsie O.Adewoye Nnenna M.Ezeigwe Ayoade Oduola Antimalarial Therapeutic Efficacy Monitoring Group National Malaria Elimination ProgrammeThe Federal Ministry of HealthAbujaNigeria Department of Pharmacology and Therapeutics University of IbadanIbadanNigeria 不详

Background:The development and spread of artemisinin-resistant Plasmodium falciparum malaria in Greater Mekong Subregion has created impetus for continuing global monitoring of efficacy of artemisinin-based combination therapies(ACTs). This post analyses is aimed to evaluate changes in early treatment response markers 10 years after the adoption of ACTs as first-line treatments of uncomplicated falciparum malaria in ***: At 14 sentinel sites in six geographical areas of Nigeria, we evaluated treatment responses in 1341 children under 5 years and in additional 360 children under 16 years with uncomplicated malaria enrolled in randomized trials of artemether-lumefantrine versus artesunate-amodiaquine at 5-year interval in 2009-2010 and 2014-2015 and at 2-year interval in 2009-2010 and 2012-2015, respectively after deployment in ***: Asexual parasite positivity 1 day after treatment initiation (APPD1) rose from 54 to 62% and 2 days after treatment initiation from 5 to 26% in 2009-2010 to 2014-2015(P=0.002 and P 75 000 μl^-1, haematocrit > 27% 1 day post-treatment initiatiortreatment with artemether-lumefantrine and enrolment in 2014-2015 independently predicted APPD1. In paralle , Kaplan-Meier estimated risk of recurrent infections by day 28 rose from 8 to 14% (P=0005) and from 9 to 15%(P=0.02) with artemether-lumefantrine and artesunate-amodiaquine, respectively. Mean asexual parasitaemia half-life increased significantly from 1.1 h to 1.3h within 2 years (P<0.0001).Conclusions:These data indicate declining parasitological responses through time to the two ACTs may be due to emergence of parasites with r

关键词： Declining responsiveness Falciparum malaria Children Artemisinin-based combination treatment Nigeria

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Development of a composite catalyst from anthill and eggshell:an optimization study on biodiesel production from virgin and waste vegetable oils

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Waste Disposal and Sustainable Energy 2019年第4期1卷 279-288页

作者： Adeyinka sikiru Yusuff Department of Chemical and Petroleum Engineering College of EngineeringAfe Babalola UniversityAdo-EkitiEkiti StateNigeria

The primary goal of this study is to develop a composite material from the anthill and chicken eggshell and to use it as a catalyst for the synthesis of biodiesel from virgin and waste vegetable *** anthill-eggshell composite(AEC)catalyst was prepared using an incipient wetness impregnation *** composite design(CCD)was applied to investigate the effects of catalyst preparation parameters(calcination temperature,calcination time,and anthill proportion in the AEC)on the yields of biodiesel from the two *** on the CCD,two quadratic models were developed to correlate the AEC preparation parameters to the two *** of variance(ANOVA)was performed to verify the reliability of the models and also,identify the factor that mostly affects the experimental design *** results showed that the predicted values of biodiesel yield from the models for the two oils agreed reasonably well with the experimental *** optimum conditions for the preparation of AEC catalyst for the transesterification process were calcination temperature of 1000℃,calcination time of 4 h,and anthill proportion of 20% to achieve 97.13%yield of biodiesel from virgin vegetable *** the same optimum parameters,the yield of biodiesel from waste vegetable oil was found to be 70.92%.

关键词： Anthill Chicken eggshell Conversion of vegetable oil to biodiesel Heterogeneous catalyst Central composite design

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Comparisons of corrosion behaviour for X65 and low Cr steels in high pressure CO2-saturated brine

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Journal of Materials Science & Technology 2020年第6期41卷 21-32页

作者： Yong Hua sikiru Mohammed Richard Barker Anne Neville Institute of Functional Surfaces School of Mechanical Engineering University of Leeds Leeds LS2 9JT United Kingdom

Appropriate materials for injection pipelines and tubing for carbon dioxide geologic storage is fundamental to ensure asset integrity and save *** paper evaluates the corrosion behaviour of X65,1Cr,3Cr and 5Cr,which have the potential to be injection pipeline/tubing *** influence of steel Cr content on the general and localised corrosion behaviour was investigated at time periods from 6 to 192 h at 60℃and 100 *** evolution,morphology and chemistry of corrosion products on the surface of each material were evaluated using a combination of scanning electron microscopy,energy dispersive X-ray spectroscopy and X-ray diffraction and related to their overall corrosion *** indicate that prior to the formation of protective films on the steel surfaces,the resistance of the materials to corrosion increase with increasing Cr content(Corrosion resistance:X651Cr>3Cr>5Cr).In terms of the corrosion products on X65,both inner amorphous and outer crystalline corrosion layers consist of *** the Cr-containing steels,the outer layer also comprises FeCO3,but the inner layer is enriched with Cr,and is predominantly amorphous Cr(OH)*** extent of localised corrosion(determined using surface profilometry)is noticeably less for X65 compared to the Cr-containing *** paper raises questions about the benefits that low Cr steels offer towards extending component design life compared to carbon steel under the test conditions considered here.

关键词： Carbon dioxide Corrosion X65 Low-Cr steels Iron carbonate Chromium hydroxide

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Aperiodic tidal data resource assessment and LCOE analysis of selected areas in Nigeria

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Clean Energy 2018年第1期2卷 45-57页

作者： L.M.amoo Stevens Institute of Technology HobokenNew Jersey 07030USA

Renewable energy is plentiful;we need only develop the technology to harness and distribute it efficiently and *** conversion of energy to electricity continues to be an area of interest for engineers and *** energy has been classified as one of five energy innovations that could transform our world-the others being fuel cells,lithium-air batteries,the smart grid,and space-based solar power(http://***/Alternative-Energy/Renewable-Energy/***).Resource engineering assessment constitutes the first step to the effective utilization of any *** are various candidate sites for tidal stream energy in *** objective of this research is to examine the tidal stream resource potential of seven coastal sites using the modified continuous wavelet transform(CWT)method with a levelized cost of energy(LCOE)***’s method is newly applied to the aperiodic tidal series *** results indicate that meaningful power is viable and could be economically extracted at each respective site,with peak mean approximate velocities at each site of~10 m/s,and the LCOE estimate was found to be lower than that of the International Renewable Energy Agency(IRENA).This work represents the culmination of a series of papers exploring tidal energy resources in tropical Nigeria.

关键词： tidal energy renewable energy continuous wavelet transform(CWT) LCOE Nigeria

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Evaluation of the wind energy potential of two south west sites in Nigeria

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Frontiers in Energy 2012年第3期6卷 237-246页

作者： Olaleye M.amoo Aeromechanics-Fan Blades Cold Section Engineering(CSE)United Technologies Corporation(UTC)-Pratt&WhimeyEast HartfordCT06108USA

Wind resource assessment is a crucial first step in gauging the potential of a site to produce energy from wind turbines. In this paper, the wind energy potential of Abeokuta （07°03＇N, 03°19＇E） and Ijebu-Ode （06°47＇N, 03°58＇E）, two south west sites in Nigeria were examined. Twenty years （1990-2010） of monthly mean wind data from a 10m height were subjected to two-parameter Weibull analysis and other statistical analyses. The results show that the average annual mean wind speed variation for Abeokuta ranges from 2.2 to 5.0 m/s. For Ijebu-Ode, it ranges from 2.0 to 5.0m/s. The wind power density variation based on the Weibull analysis ranges from 4.26 to 24.51 W/m2 for Abeokuta and from 8.54 to 76.46 W/m2 for Ijebu-Ode. Ijebu-Ode was found to be the better of the two sites in terms of annual variation of mean wind speed.

关键词： wind potential wind speed wind power density wind gust turbulence intensity Nigeria

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Boosting CO_(2) hydrogenation to high-value olefins with highly stable performance over Ba and Na co-modified Fe catalyst

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Journal of Energy Chemistry 2023年第5期80卷 614-624,I0014页

作者： Joshua Iseoluwa Orege Na Liu Cederick Cyril amoo Jian Wei Qingjie Ge Jian Sun Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

CO_(2)hydrogenation has been considered to be a highly promising route for the production of high-value olefins(HVOs)while also mitigating CO_(2)***,it is challenging to achieve high selectivity and maintain stable performance for HVOs(ethylene,propylene,and linear a-olefins)over a prolonged reaction time due to the difficulty in precise control of carbon coupling and rapid catalyst ***,we present a selective Ba and Na co-modified Fe catalyst enriched with Fe_(5)C_(2)and Fe_(3)C active sites that can boost HVO synthesis with up to 66.1%selectivity at an average CO_(2)conversion of 38%for over 500 *** to traditional NaFe catalyst,the combined effect of Ba and Na additives in the NaBaFe-0.5 catalyst suppressed excess oxidation of FeCxsites by H_(2)*** absence of Fe3O4phase in the spent NaBaFe-0.5 catalyst reflects the stabilization effect of the co-modifiers on the *** study provides a strategy to design Fe-based catalysts that can be scaled up for the stable synthesis of HVOs from CO_(2)hydrogenation.

关键词： CO_(2)hydrogenation High-value olefins Barium additive Iron carbide Catalytic stability

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Sputtering FeCu nanoalloys as active sites for alkane formation in CO_(2) hydrogenation

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Journal of Energy Chemistry 2022年第7期31卷 162-173,I0005页

作者： Zhiyan Si Cederick Cyril amoo Yu Han Jian Wei Jiafeng Yu Qingjie Ge Jian Sun Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

Catalytic conversion of CO_(2) to high-value products is a crucial method to achieve targets of carbon dioxide emissions peak and carbon ***,realizing a controllable product distribution in a single CO_(2) hydrogenation process is of great ***,we prepared the CuFe nanoalloy catalyst that directly transforms CO_(2) to alkanes using physical sputtering method in mild *** characteristic results show that the proximity between Cu and Fe is the crucial factor to tunable products among the different *** formation of unique coordination of FeCu4 nanoalloys from high-energy sputtering process provides close interaction between Cu and Fe,which is favorable to formation of low carbon paraffin,however,a distant proximity and weak interaction will increase the selectivity of olefins and *** work provides a general strategy for tuning target chemicals and enriches the viewpoints in CO_(2) hydrogenation.

关键词： CO_(2)hydrogenation Physical sputtering FeCu nanoalloys Proximity Paraffin

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Characterization of Novel Lignocellulosic Spinifex littoreus Fibers and Their Composites

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Journal of Bionic Engineering 2020年第2期17卷 393-404页

作者： Milan Soosai Christopher Thankian Winowlin Jappes Jebas Thangiah Rajini Nagarajan Mayandi Kalimuthu sikiru Oluwarotimi Ismail Faruq Mohammad Department of Mechanical Engineering Cape Institute of TechnologyLevengipuramTirunelveli 627114Tamil NaduIndia Department of Mechatronics Engineering Kamaraj College of Engineering&Technology VellakulamMadurai dist-622701Tamil NaduIndia Centre for Composite Materials Department of Mechanical EngineeringKalasalingam UniversityKrishnankoilVirudhunagar 626126Tamil NaduIndia Centre for Engineering Research Department of EngineeringSchool of Engineering and Computer ScienceUniversity of HertfordshireHatfieldHertfordshire AL109ABUK Surfactants Research Chair Department of ChemistryCollege of ScienceKing Saud UniversityRiyadh 11451Kingdom of Saudi Arabia

This innovative work presents mechanical,physical and chemical characterization and analysis of newly extracted fiber from naturally resourced plant stem,named Spinifex littoreus fibers(SLF).This is a novel natural,biodegradable and sustainable reinforcement for an improved ***,the chemical constituents of SLF,such as cellulose,lignin,moisture and wax content were *** raw SLF surfaces were modified by chemical treatment with sodium hydroxide(NaOH),calcium hydroxide(Ca(OH)2)and silane.A polyester matrix was reinforced with all the treated SLF,before the mechanical properties(tensile strengths)of the composites were *** all the surface chemically treated SLF/polyester composite samples,the Ca(OH)2 treated sample exhibited the highest tensile *** microscopic examination was carried out to validate this ***,this analysis established the mechanism of failure of the tensile fractured composite samples,using Scanning Electron Microscope(SEM),among other techniques.

关键词： cellulosic fiber Spinifex littoreus fibers XRD FTIR SEM tensile strength

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Benchmark assessment of performance indices of a selection of hybrid nanofluids in a hybrid photovoltaic/thermal system

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Clean Energy 2022年第2期6卷 247-270页

作者： O.M.amoo R.O.Fagbenle M.O.Oyewola Department of Mechanical Engineering University of IbadanIbadanOyo StateNigeria School of Mechanical Engineering Fiji National UniversityFiji

This research is a study assessing the performance of hybrid nanofluids in hybrid photovoltaic(PV)-thermal *** study addresses 10 hybrid nanofluids applied to hybrid PV-thermal *** transition to carbon-free energy can mitigate the worst effects of climate change,ensuring that global sustainability is *** energy is now responsible for one-third of the global capacity,of which 20%is attributed to solar *** continue to be economically viable,with declining costs driving *** study aims to compare the yearly performances of a model hybrid PV-thermal system using 10 different hybrid *** nanofluids constitute two or more dissimilar materials stably suspended in a base fluid(***).MATLAB and COMSOL Multiphysics®computational fluid dynamics software are employed together for the benchmarking assessment with good agreement *** fluid inlet temperatures(Tin∈[300,360]K),nanofluid volume concentrations(φ∈[0,4]%)and storage-tank volumes(V∈[50,300]L)were *** meteorological data applied were those for Lagos,Nigeria(6°27’55.5192”N,3°24’23.2128”E).The assessment based on analytical-numerical solutions reveals that the thermal enhancement by hybrid nanofluids ranges from 6.7%(graphene oxide[GO]-multiwalled carbon nanotube[MWCNT]/water)to 7%(ZnO-Mn-ZnFe2O4/water)forφ=2%and V=300 *** yearly exergy efficiency ranges from 2.8%(ZnO-Mn-ZnFe2O4/water)to 2.9%(GO-MWCNT/water),also forφ=2%and V=300 *** findings have implications for a vast range of industrial processes,expanding the knowledge that is critical to a sustainable future.

关键词： energy transformation hybrid photovoltaic-thermal(PV/T)system hybrid nanofluids COMSOL Multiphysics® MATLAB enhancements

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