Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

作     者：Kazeem Akano Godwin Ntadom Chimere Agomo Christian T.Happi Onikepe A.Folarin Grace O.Gbotosho Olugbenga Mokuolu Finomo Finomo Joy C.Ebenebe Nma Jiya Jose Ambe Robinson Wammanda George Emechebe Oluwabunmi K.Basorun Olubunmi A.Wewe Sikiru Amoo Nnenna Ezeigwe Stephen Oguche Bayo Fatunmbi Akintunde Sowunmi 

作者机构：Department of Pharmacology and TherapeuticsUniversity of IbadanIbadanNigeria Antimalarial Therapeutic Efficacy Monitoring GroupNational Malaria Elimination ProgrammeThe Federal Ministry of HealthAbujaNigeria Department of Medical Laboratory ScienceUniversity of LagosLagosNigeria Department of Biological Sciences and African Centre of Excellence for Genomics of Infectious Diseases(ACEGID)Redeemer UniversityEdeNigeria Institute for Medical Research and TrainingUniversity of IbadanIbadanNigeria Department of Pharmacology and ToxicologyFaculty of PharmacyUniversity of IbadanIbadanNigeria Department of PaediatricsUniversity of IlorinIlorinNigeria Department of PaediatricsFederal Medical CentreYenagoaNigeria Department of PaediatricsNnamdi Azikiwe UniversityAwkaNigeria Department of PaediatricsUthman Dan Fodio UniversitySokotoNigeria Department of PaediatricsUniversity of MaiduguriMaiduguriNigeria Department of PaediatricsAhmadu Bello UniversityZariaNigeria Department of PaediatricsImo State University Teaching HospitalOrluNigeria Department of PaediatricsUniversity of JosJosNigeria World Health OrganizationCountry OfficeKampalaUganda 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2018年第7卷第1期

页      面：1270-1283页

核心收录：

学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学] 

基　　金：The efficacy study from which the data were derived received financial support from The Global Fund to Fights AIDS,Tuberculosis and Malaria the United States President’s Malaria Initiative(PMI) Malaria Consortium Grants to The Federal Ministry of Health,Abuja,through Drug Therapeutic Efficacy Testing in Nigeria.Logistic support was provided by the governments of the study states 

主　　题：Falciparum malaria Artemisinin-based combination therapies Parasite clearance Children Nigeria 

摘      要：Background:In acute falciparum malaria,asexual parasite reduction ratio two days post-treatment initiation(PRRD2)≥10000 per cycle has been used as a measure of the rapid clearance of parasitaemia and efficacy of artemisinin ***,there is little evaluation of alternative measures;for example,parasite reduction ratio one day after treatment initiation(PRRD1)and its relationship with parasite clearance time(PCT)or *** study evaluated the use of PRRD1 as a measure of responsiveness to antimalarial ***:In acutely malarious children treated with artesunate-amodiaquine(AA),artemether-lumefantrine(AL)or dihydroartemisinin-piperaquine(DHP),the relationships between PRRD1 or PRRD2 and PCT,and between PRRD1 and PRRD2 were evaluated using linear *** between estimates of PCT using PRRD1 and PRRD2 linear regression equations was evaluated using the Bland-Altman *** of PRRD15000 per half cycle and PRRD2≥10000 per cycle were evaluated using stepwise multiple logistic regression *** the linear regression equation of the relationship between PRRD1 and PCT previously generated in half of the DHP-treated children during the early study phase,PCT estimates were compared in a prospective blinded manner with PCTs determined by microscopy during the later study phase in the remaining ***:In 919 malarious children,PRRD1 was significantly higher in DHP-and AA-treated compared with AL-treated children(P15months,parasitaemia10000/μl and DHP treatment independently predicted PRRD15000 per half cycle,while age30months,haematocrit≥31%,body temperature37.4°C,parasi