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Plant Communications 2024年第8期5卷 100-103页

作者： Lingling Yun Chuyi Zhang Tongtong Liang Yu Tian Guoxu Ma Vincent Courdavault sijie sun Baiping Ma Ziqin Li Rucan Li Feng Cao Xiaofeng Shen Jianhe Wei Ying Li Baolin Guo Chao sun Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Biomole cules et Biotechnologies Ve ge tales EA2106Universite de Tours37200 ToursFrance Beijing Institute of Radiation Medicine Beijing 100850China Present address:National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China

Dear Editor,Gynostemma pentaphyllum(Thunb.)Makino,a perennial climbing vine in the Cucurbitaceae family,has been widely used in traditional medicine for over 600 years(Blumert and Liu,1999).It serves as a valuable natural source of over 200 dammaranetype saponins with notable bioactive properties,including anti-cancer,cardioprotective,hepatoprotective,neuroprotective,and anti-diabetic activities(Li et al.,2016;Nguyen et al.,2021).

关键词： protective Gynostemma saponins

On-Chip Fabrication of Carbon Nanoparticle–Chitosan Composite Membrane

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Journal of Materials Science & Technology 2015年第11期31卷 1087-1093页

作者： Weiping Ding Cheng Liang sijie sun Liqun He Dayong Gao Center for Biomedical Engineering University of Science and Technology of China Department of Electronic Science and Technology University of Science and Technology of China Department of Laboratory Medicine University of Washington Department of Thermal Science and Energy Engineering University of Science and Technology of China Department of Mechanical Engineering University of Washington

The on-chip fabrication of a carbon nanoparticle-chitosan composite membrane （i.e. a sorbent membrane or a mixed matrix membrane） using laminar flow-based interfacial deprotonation technology was presented in this paper. In addition, the effects of carbon nanoparticles and reactant flow rates on membrane formation were investigated. Finally, the permeability and adsorption capacities of the membrane were discussed. During fabrication, an acidic chitosan solution and a basic buffer solution that contained carbon nanoparticles were introduced into a microchannel. At the flow interface, a freestanding composite membrane with embedded carbon nanoparticles was formed due to the deprotonation of the chitosan molecules. The membrane growth gradually stopped with time from upstream to downstream and the thickness of the membrane increased rapidly and then slowly along the reactant flow direction. The formation of the membrane was divided into two stages. The average growth rate in the first stage was significantly larger than the average growth rate in the second stage. Carbon nanoparticles in the basic solution acted as nucleating agents and made the membrane formation much easier. As the flow rate of the chitosan solution increased, the averaged membrane thickness and the membrane hydraulic permeability initially increased and then decreased. Because of the addition of carbon nanoparticles, the formed membrane had adsorption abilities. The carbon nanoparticle-chitosan composite membrane that was fabricated in this study could be employed for simultaneous adsorption and dialysis in microdevices in the future.

关键词： On-chip fabrication Composite membrane Carbon nanoparticle Chitosan Interracial deprotonation Mixed matrix membrane

大脑皮层下肢运动区联合小脑皮质区iTBS对脑卒中后偏瘫患者下肢运动功能的影响

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贵州医科大学学报 2024年第8期49卷 1170-1175,1197页

作者：孙思杰邓罗义王先斌潘晓张静吴霜贵州医科大学附属医院康复医学科贵州贵阳550004 贵州医科大学临床医学院康复医学与理疗学教研室贵州贵阳550004 贵州医科大学

目的探讨大脑皮层下肢运动区及健侧小脑皮质区间歇性Theta爆发性刺激(iTBS)对脑卒中偏瘫患者下肢运动功能的影响。方法63例脑卒中后偏瘫患者随机均分为对照组(常规康复治疗+假刺激)、iTBS单靶点组(常规康复治疗+大脑皮质区iTBS)及iTBS... 详细信息

目的探讨大脑皮层下肢运动区及健侧小脑皮质区间歇性Theta爆发性刺激(iTBS)对脑卒中偏瘫患者下肢运动功能的影响。方法63例脑卒中后偏瘫患者随机均分为对照组(常规康复治疗+假刺激)、iTBS单靶点组(常规康复治疗+大脑皮质区iTBS)及iTBS双靶点组(常规康复治疗+大脑皮层下肢运动区iTBS+健侧小脑皮质区iTBS),1次/d、21 d,收集3组患者的一般资料[年龄、性别、卒中类型(脑梗死、脑出血)、病程时间、偏瘫侧及布氏分期等基线指标];与治疗前及治疗第21天,采用改良Barthel指数评定量表(MBI)、Fugl-Meyer下肢运动功能评定量表(FMA)及Berg平衡评定量表(BBS)评定3组患者的日常生活能力、下肢运动功能及下肢平衡功能,采用表面肌电系统评估患者下肢双侧胫前肌、股直肌、股二头肌及腓肠肌的肌电信号的均方根平均值(RMS)及平均功率频率(MPF)。结果各组患者治疗后临床评分均较治疗前升高(P<0.01);与对照组比较,单靶点组患者MBI、FMA、BBS评分及股直肌RMS升高(P<0.05),双靶点组患者临床评分、胫前肌RMS、股直肌RMS提高(P<0.01);与单靶点组比较,双靶点组患者FMA、BBS评分、胫前肌RMS提高(P<0.05)。结论与单靶点相比,双靶点iTBS治疗对脑卒中后偏瘫患者下肢行走能力的恢复效果更优。

关键词：卒中偏瘫下肢运动功能间歇性Theta爆发性刺激表面肌电双靶点刺激

ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish

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Journal of Genetics and Genomics 2024年第9期51卷 934-946页

作者： Pengcheng Wang Wenxiang Shi sijie Liu Yunjing Shi Xuechao Jiang Fen Li sun Chen Kun sun Rang Xu Department of Pediatric Cardiology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Department of Cardiovascular Medicine Heart Failure CenterRuijin HospitalRuijin Hospital Lu Wan BranchShanghai Jiao Tong University School of MedicineShanghai 200025China Scientific Research Center Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Department of Pediatric Cardiology Shanghai Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China

Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo *** in the process can result in severe organ ***-coil domain containing 141(CCDC141)has been previously known as a centrosome-related gene,but its role in left-right(LR)asymmetry has not been *** this study,we utilize the zebrafish model and human exome analysis to elucidate the function of ccdc141 in laterality *** knockdown of ccdc141 in zebrafish disrupts early LR signaling pathways,cilia function,and Kupffer's vesicle *** ccdc141-knockdown embryos exhibiting aberrant LR patterns,ccdc141-null mutants show no apparent abnormality,suggesting a genetic compensation response *** parallel,we observe a marked reduction inα-tubulin acetylation levels in the ccdc141 *** treatment with histone deacetylase(HDAC)inhibitors,particularly the HDAC6 inhibitor,rescues the ccdc141 crispant ***,exome analysis of 70 patients with laterality defects reveals an increased burden of CCDC141 mutations,with in-vivo studies verifying the pathogenicity of the patient mutation *** findings highlight the critical role of ccdc141 in ciliogenesis and demonstrate that CCDC141 mutations lead to abnormal LR patterns,identifying it as a candidate gene for laterality defects.

关键词： Left-right axis Cilia WES Laterality defects Zebrafish CCDC141

High strength mullite-bond SiC porous ceramics fabricated by digital light processing

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Journal of Advanced Ceramics 2024年第1期13卷 53-62页

作者： Jian sun Jingde Zhang Xu Zhang Zihe Li Jianzhang Li sijie Wei Weibin Zhang Weili Wang Guifang Han Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China Key Laboratory of Special Functional Aggregated Materials Ministry of EducationShandong UniversityJinan 250100China Materials and Structures Research Centre Department of Mechanical EngineeringUniversity of BathBath BA27AYUK National Engineering Research Centre of Ceramic Matrix Composite Manufacture Technology Xi’an Golden Mountain Ceramic Composites Co.Ltd.Xi’an 710118China School of Physics and Materials Science Changji UniversityChangji 831100China

Fabricating SiC ceramics via the digital light processing(DLP)technology is of great challenge due to strong light absorption and high refractive index of deep-colored SiC powders,which highly differ from those of resin,and thus significantly affect the curing performance of the photosensitive SiC *** this paper,a thin silicon oxide(SiO_(2))layer was in-situ formed on the surface of SiC powders by pre-oxidation *** method was proven to effectively improve the curing ability of SiC *** SiC photosensitive slurry was fabricated with solid content of 55 vol%and viscosity of 7.77 Pa·s(shear rate of 30 s^(−1)).The curing thickness was 50μm with exposure time of only 5 ***,a well-designed sintering additive was added to completely convert low-strength SiO_(2) into mullite reinforcement during *** mullite-bond SiC ceramics were successfully *** flexural strength of SiC ceramics sintered at 1550℃in air reached 97.6 MPa with porosity of 39.2 vol%,as high as those prepared by spark plasma sintering(SPS)techniques.

关键词： digital light processing(DLP) SiC ceramics pre-oxidation mullite-bond SiC mechanical properties

Quantum vector DC magnetometry via selective phase accumulation

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 12-22页

作者： Min Zhuang sijie Chen Jiahao Huang Chaohong Lee Institute of Quantum Precision Measurement State Key Laboratory of Radio Frequency Heterogeneous IntegrationCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen 518045China Laboratory of Quantum Engineering and Quantum Metrology School of Physics and AstronomySun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

Precision measurement of magnetic fields is a crucial issue in both fundamental scientific research and practical sensing *** sensitive detection of a vector magnetic field poses a significant challenge in quantum magnetometry,particularly in estimating a vector DC magnetic field with high ***,we propose a comprehensive protocol for quantum vector DC magnetometry,utilizing selective phase accumulation in both non-entangled and entangled quantum *** upon the principles of Ramsey interferometry,our protocol enables the selective accumulation of phase for a specific magnetic field component by incorporating a meticulously designed pulse *** the individual measurement scheme,we employ three individual quantum interferometries to independently estimate each of the three magnetic field ***,in the simultaneous measurement scheme,the application of a pulse sequence along different directions enables the simultaneous estimation of all three magnetic field components using only one quantum ***,by employing an entangled state(such as the Greenberger-Horne-Zeilinger state)as the input state,the measurement precisions of all three components may reach the Heisenberg *** study not only establishes a general protocol for measuring vector magnetic fields using quantum probes,but also presents a viable pathway for achieving entanglement-enhanced multi-parameter estimation.

关键词： magnetometry quantum interferometry entanglement-enhanced quantum metrology

一流本科教育视域下大学“金课”课堂的建设路径

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豫章师范学院学报 2021年第3期36卷 75-79页

作者：孙思捷云南师范大学教育学部云南昆明650500

课堂教学是大学教学活动的关键环节,其质量高低对高等教育质量有着重要影响。教育部明确提出“淘汰‘水课’、打造‘金课’”的行动目标,以期提高大学本科课堂教学质量和人才培养质量。“金课”这一命题的提出正是基于对大学本科课堂教... 详细信息

课堂教学是大学教学活动的关键环节,其质量高低对高等教育质量有着重要影响。教育部明确提出“淘汰‘水课’、打造‘金课’”的行动目标,以期提高大学本科课堂教学质量和人才培养质量。“金课”这一命题的提出正是基于对大学本科课堂教学现状的客观审视与精确判断,对今后大学本科教育发展和一流本科建设具有重要作用。

关键词：大学本科金课课堂教学建设路径

On-chip ultrafast stackable dielectric laser positron accelerator

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Chinese Physics B 2024年第3期33卷 350-354页

作者：孙斌何阳帆潘晨浩樊思劼王度王少义赵宗清 Department of Plasma Physics and Fusion Engineering School of Nuclear Science and TechnologyUniversity of Science and Technology of ChinaHefei 230026China National Key Laboratory of Plasma Physics Research Center of Laser FusionChina Academy of Engineering PhysicsMianyang 621900China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of High Field Laser Physics and Chinese Academy of Sciences Center for Excellence in Ultra-Intense Laser Science Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Department of Engineering Physics Tsinghua UniversityBeijing 100084China The Institute of Technological Sciences Wuhan UniversityWuhan 430072China

We present a first on-chip positron accelerator based on dielectric laser *** innovative approach significantly reduces the physical dimensions of the positron acceleration apparatus,enhancing its feasibility for diverse *** utilizing a stacked acceleration structure and far-infrared laser technology,we are able to achieve a seven-stage acceleration structure that surpasses the distance and energy gain of using the previous dielectric laser acceleration ***,we are able to compress the positron beam to an ultrafast sub-femtosecond scale during the acceleration process,compared with the traditional methods,the positron beam is compressed to a greater *** also demonstrate the robustness of the stacked acceleration structure through the successful acceleration of the positron beam.

关键词： dielectric laser accelerator positron accelerator high gradient accelerator inverse Cherenkov effect

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套圈端面产生划痕的原因分析及解决方法

哈尔滨轴承 2022年第3期43卷 21-24页

作者：孙思婕白雪瓦房店轴承集团精密传动轴承有限公司辽宁瓦房店116300

本文主要讨论了磨削套圈端面时产生端面划伤的原因及解决方案。通过对砂轮结构及护板形状等的一系列改进,可有效地防止砂轮脱落颗粒造成的套圈端面有深度的划痕,从而改善端面的外观质量;最重要的是可保证后工序加工及检测的精度和准确性... 详细信息

本文主要讨论了磨削套圈端面时产生端面划伤的原因及解决方案。通过对砂轮结构及护板形状等的一系列改进,可有效地防止砂轮脱落颗粒造成的套圈端面有深度的划痕,从而改善端面的外观质量;最重要的是可保证后工序加工及检测的精度和准确性,进而提升整套轴承的精度等级。

关键词：端面划痕砂轮结构定位基准砂轮脱落颗粒

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高校学术领导力的三个范畴研究及未来展望

高教发展与评估 2023年第5期39卷 32-46,I0003页

作者：黄小宾钟云华孙思捷湖南师范大学教育科学学院湖南长沙410081 云南师范大学教育学部云南昆明650500

高校学术领导力是推动高等教育治理体系与治理能力现代化的重要抓手。高校学术领导力的内涵要素、功能发挥等方面的研究总体上处于初步探索阶段,高校学术领导力的主体、空间与时间三个范畴的研究须进一步归纳与凝练。高校学术领导力三... 详细信息

高校学术领导力是推动高等教育治理体系与治理能力现代化的重要抓手。高校学术领导力的内涵要素、功能发挥等方面的研究总体上处于初步探索阶段,高校学术领导力的主体、空间与时间三个范畴的研究须进一步归纳与凝练。高校学术领导力三个范畴研究的系统梳理,既是全面研究高校学术领导力的应有之义,又是推进高等教育深化改革的实践需要。随着系统科学发展的深入,高校学术领导力研究不仅要在已有三个范畴上加以思考,而且还要立足于线性与非线性、有序与无序、渐变与突变等新的研究维度,以期实现高校学术领导力研究从静态封闭走向动态开放。

关键词：高校学术领导力高等教育治理体系高校学术组织