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Cr^6+、Pb^2+和Ni^2+对莱茵衣藻的毒性效应研究

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安全与环境工程 2020年第3期27卷 40-47页

作者：魏思洁马馨月张超柯檀张渝蕊陈兰洲武汉大学资源与环境科学学院湖北武汉430079

以莱茵衣藻为受试生物,利用快速叶绿素荧光诱导动力学分析和毒理测试方法,开展了3种典型重金属(Cr6+、Pb2+和Ni2+)对莱茵衣藻的单一毒性效应试验,分析不同种类和不同浓度的重金属对莱茵衣藻光合活性和抗氧化系统的影响。结果表明:不同... 详细信息

以莱茵衣藻为受试生物,利用快速叶绿素荧光诱导动力学分析和毒理测试方法,开展了3种典型重金属(Cr6+、Pb2+和Ni2+)对莱茵衣藻的单一毒性效应试验,分析不同种类和不同浓度的重金属对莱茵衣藻光合活性和抗氧化系统的影响。结果表明:不同浓度的3种重金属均能降低莱茵衣藻的叶绿素荧光产量和相应的光合参数(Fv/Fm、RC/CS0、ET0/TR0和ET0/ABS),抑制莱茵衣藻的光合活性,降低莱茵衣藻的SOD活性,并增加莱茵衣藻的MDA含量,对莱茵衣藻造成一定的氧化损伤,且随重金属浓度和处理时间的增加,对莱茵衣藻的抑制和损伤作用加剧;但莱茵衣藻对不同种类和不同浓度重金属的毒性效应响应程度存在一定的差异,Cr6+胁迫在其低浓度和短时间内即对莱茵衣藻表现出显著的抑制效果,而Ni2+胁迫随其浓度的增加对莱茵衣藻的ET0/TR0、ET0/ABS参数和MDA含量的抑制效果不明显;参数Fv/Fm是对重金属毒性效应响应最敏感的毒性评价指标,结合其半数效应浓度(EC50)值得出3种重金属对莱茵衣藻的毒性效应强度排序为Cr6+>Pb2+>Ni2+。该研究结果可为莱茵衣藻在重金属污染水体监测中的应用提供参考。

关键词： Cr^6+ Pb^2+ Ni^2+ 莱茵衣藻毒性效应快速叶绿素荧光诱导动力学分析毒理测试方法

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变应性鼻炎患病率及危险因素Meta分析

临床耳鼻咽喉头颈外科杂志 2017年第19期31卷 1485-1491页

作者：胡思洁魏萍寇巍武小芳刘萌雅陈成姚红兵重庆医科大学附属儿童医院耳鼻咽喉头颈外科重庆400014

目的:通过Meta分析,了解中国变应性鼻炎(AR)的患病率及探讨国内人群AR的主要危险因素,为AR的防治提供科学依据。方法:系统检索Pubmed、Embase、Web of science、Cochrane图书馆、中国期刊全文数据库、中文科技期刊全文数据库、万方数字... 详细信息

目的:通过Meta分析,了解中国变应性鼻炎(AR)的患病率及探讨国内人群AR的主要危险因素,为AR的防治提供科学依据。方法:系统检索Pubmed、Embase、Web of science、Cochrane图书馆、中国期刊全文数据库、中文科技期刊全文数据库、万方数字化期刊全文数据库、中国生物医学文献数据库等数据库查找关于中国AR患病率及危险因素相关文献,同时追索纳入文献的参考文献。采用R3.2.3软件对各研究结果进行Meta分析。结果:共纳入31篇文献,国内儿童AR患病率为15.79%(95%CI 15.13~16.45),华中地区患病率最高(17.20%),华东最低(13.94%)。成人AR患病率为13.26%(95%CI 12.05~14.47),华南地区患病率最高(15.45%),西南最低(10.93%)。各危险因素合并比值比(OR)分别为家族史(5.40)、粉尘接触史(2.04)、药物过敏史(2.83)、哮喘病史(4.45)、环境烟草烟雾(2.00)、水泛滥(1.50)、装修(1.41)、花粉过敏(17.18)、真菌(1.31)、饲养宠物(1.29)、蟑螂(1.69)。结论:中国AR的流行趋势研究发现,国内儿童AR患病率高于成人,不同地区患病率有差异,上述11种危险因素在AR的发病中起重要作用,在AR的防治过程中应针对这些危险因素进行早期干预。

关键词：鼻炎,变应性患病率危险因素 Meta分析

红球菌PB-1对高浓度苯酚及苯系物的降解研究

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安全与环境工程 2020年第2期27卷 85-91页

作者：马馨月魏思洁柯檀叶超然陶越陈兰洲武汉大学资源与环境科学学院湖北武汉430079

苯酚及一些苯系物是有机合成工业废水中常见的污染物,也是生物处理的难点。从某焦化厂污泥中分离得到一株苯酚高效降解菌,根据生理生化试验和16S rDNA测序,鉴定为红球菌,命名为PB-1,对其降解苯酚的条件进行优化以及该菌株降解底物广谱... 详细信息

苯酚及一些苯系物是有机合成工业废水中常见的污染物,也是生物处理的难点。从某焦化厂污泥中分离得到一株苯酚高效降解菌,根据生理生化试验和16S rDNA测序,鉴定为红球菌,命名为PB-1,对其降解苯酚的条件进行优化以及该菌株降解底物广谱性进行研究。结果表明:该菌株降解苯酚的最适温度为30~35℃,最适pH值为9.0;当菌体浓度OD600为0.3时,24 h可完全降解1000 mg/L的苯酚;该菌株可耐受2000 mg/L浓度的苯酚,对苯酚72 h的降解率为35.76%;此外,该菌株可适应300 mg/L浓度的喹啉,对1500 mg/L苯胺72 h的降解率达到68.06%;该菌株对苯酚和苯胺的降解均通过邻苯二酚1,2-双加氧酶催化的邻位途径,底物降解彻底,环境友好。红球菌PB-1可降解高浓度苯酚、苯胺,且耐受难降解喹啉类杂环芳香物质,在成分复杂的工业废水处理中具有十分广阔的应用前景。

关键词：红球菌PB-1 高浓度苯酚苯胺喹啉邻苯二酚1,2-双加氧酶微生物修复技术

Shape Memory Polymer Composite Booms with Applications in Reel-Type Solar Arrays

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Chinese Journal of Mechanical Engineering 2023年第3期36卷 326-338页

作者： Hong Xiao sijie Wu Dongdong Xie Hongwei Guo Li Ma Yuxuan wei Rongqiang Liu State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150006China Yinhe Hangtian Internet Technology Co. Ltd.Beijing 100192China China Academy of Space Technology Beijing 100098China

Solar arrays are the primary energy source for *** traditional rigid solar arrays improve power supply,the quality increases ***,it is difficult to satisfy the requirements of high-power and low-cost space *** this study,a shape-memory polymer composite(SMPC)boom was designed,fabricated,and characterized for flexible reel-type solar *** SMPC boom was fabricated from a smart material,a shape-memory polymer composite,whose mechanical properties were ***,a mathematical model of the bending stiffness of the SMPC boom was developed,and the bending and buckling behaviors of the boom were further analyzed using the ABAQUS *** SMPC boom was fabricated to demonstrate its shape memory characteristics,and the driving force of the booms with varying geometric parameters was *** also designed and manufactured a reel-type solar array based on an SMPC boom and verified its self-deployment *** results indicated that the SMPC boom can be used as a deployable unit to roll out flexible solar arrays.

关键词： Shape memory polymer composite Reel-type solar array Deployable boom Bending behavior

Experimental and numerical study of a gas cyclone with a central filter

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Particuology 2022年第4期20卷 47-59页

作者： Zihui Zhang sijie Dong Kejun Dong Li'an Hou Wenzheng Wang Yi wei Bo Wang Key Laboratory of Western China's Environmental Systems(Ministry of Education)and Engineering Research Center of Fine Particles Pollution Control Technology and Equipment of Gansu Province College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Centre for Infrastructure Engineering School of EngineeringWestern Sydney UniversityPenrithNSW 2751Australia Xi'an High-Tech Institute Xi'an 710025China Gansu Chemical Industry Research Institute Co. Ltd.Lanzhou 730000China

This paper studies a novel gas cyclone with a cylindrical fiter face installed in the center from the vortex finder to the bottom *** experimental results show that this composite cyclone has a higher collection fficiency and a lower pressure drop than the original *** mechanisms for the improvement are analyzed by both physical experiments and numerical *** measuring dust samples collected at different places it is revealed that the center filter can prevent fine particles from entering the inner vortex and escaping,which accounts for the increase of the collection *** addition,the flow field of the composite cyclone is simulated by computational fluid dynamics and compared with that of the original *** analysis shows that with the filter layer installed,the swirling flow disappears in the vortex finder,which decreases the kinetic energy dissipation and hence lowers the pressure drop.

关键词： Cyclone Filtration Porous media model Collection efficiency Pressure drop

nr0b1(DAX1) loss of function in zebrafish causes hypothalamic defects via abnormal progenitor proliferation and differentiation

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Journal of Genetics and Genomics 2022年第3期49卷 217-229页

作者： wei Zhang Yan Li sijie Chen Cuizhen Zhang Lili Chen Gang Peng State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceFudan UniversityShanghai 200032China Department of Endocrinology Huashan HospitalFudan UniversityShanghai 200040China

The nuclear receptor DAX-1, encoded by the NR0B1 gene, is presented in the hypothalamic tissues in humans and other vertebrates. Human patients with NR0B1 mutations often have hypothalamic-pituitary defects, but the involvement of NR0B1 in hypothalamic development and function is not well understood. Here, we report the disruption of the nr0b1 gene in zebrafish causes abnormal expression of gonadotropins, a reduction in fertilization rate, and an increase in postfasting food intake, which are indicators of abnormal hypothalamic functions. We find that loss of nr0b1 increases the number of prodynorphin(pdyn)-expressing neurons but decreases the number of pro-opiomelanocortin(pomcb)-expressing neurons in the zebrafish hypothalamic arcuate region(ARC). Further examination reveals that the proliferation of progenitor cells is reduced in the hypothalamus of nr0b1 mutant embryos accompanying the decreased expression of genes in the Notch signaling pathway. Additionally, the inhibition of Notch signaling in wildtype embryos increases the number of pdyn neurons, mimicking the nr0b1 mutant phenotype. In contrast,ectopic activation of Notch signaling in nr0b1 mutant embryos decreases the number of pdyn *** together, our results suggest that nr0b1 regulates neural progenitor proliferation and maintenance to ensure normal hypothalamic neuron development.

关键词： nr0b1 DAX-1 Hypogonadism Feeding Arcuate nucleus Neural progenitor

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广水河河流水质调查及健康评价

中南民族大学学报（自然科学版） 2019年第1期38卷 56-62页

作者：陈兰洲陶可赵剑吴新国张渝蕊魏思洁陶越武汉大学资源与环境科学学院湖北省环境修复技术研究中心武汉430072

在充分调研分析国内外河流健康研究的基础上,建立了由15个评价指标构成的广水河河流健康评价指标体系,确定了河流健康状况的评价标准,将其健康水平划分为"很健康、健康、亚健康、不健康、病态"5个等级,运用AHP-综合指数法对广水河健康... 详细信息

在充分调研分析国内外河流健康研究的基础上,建立了由15个评价指标构成的广水河河流健康评价指标体系,确定了河流健康状况的评价标准,将其健康水平划分为"很健康、健康、亚健康、不健康、病态"5个等级,运用AHP-综合指数法对广水河健康状况进行评价.结果表明:广水河健康综合指数为3.1963,健康状况总体处于亚健康水平.广水河的河流健康状况主要存在以下问题:水量和水资源承载力不足;部分河岸坍塌;水体污染,部分河段呈轻度富营养化状态;水土流失加剧而导致河床淤积;水生生物减少.根据评价结果及问题分析,提出了相应的保护及修复措施,为广水河流域的保护提供了可借鉴的决策依据,也对同类型的河流保护具有一定的指导意义.

关键词：广水河河流健康评价 AHP-综合指数法修复措施

Metal-organic framework-derived CoP_(2)@N-doped carbon hollow spheres for efficient oxygen evolution reaction

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Journal of Materials Science & Technology 2023年第33期164卷 240-245页

作者： wei Zhang Jiangshui Luo Xuan Zhang wei Guo Ning Han sijie Xie Zhenyu Zhou Zahid Anwer Zhenhong Xue Jan Fransaer Department of Materials Engineering KU LeuvenLeuven 3001Belgium Lab of Electrolytes and Phase Change Materials College of Materials Science and EngineeringSichuan UniversityChengdu 610065China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China

*** is considered as a viable alternative to fossil fuels[1,2].Large-scale hydrogen production by electrochemical water splitting is regarded as an important *** consists of two half-reactions:hydrogen evolution reaction(HER)at the cathode and oxygen evolution reaction(OER)at the anode[3].Compared to the HER,the OER has sluggish kinetic and large overpotentials,re-sulting from the complex oxidation pathway[4,5].Although RuO_(2) and IrO_(2) have excellent catalytic OER performance[6],their large-scale deployment is unfeasible due to the scarcity and high cost of these noble metal ***,cheap OER electrocatalysts have been actively investigated[7].

关键词： spheres splitting noble

Gabapentin inhibits central sensitization during migraine

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Neural Regeneration Research 2013年第32期8卷 3003-3012页

作者： Yanbo Zhang Guo Shao wei Zhang sijie Li Jingzhong Niu Dongmei Hu Mingfeng Yang Xunming Ji Institute of Hypoxia Medicine Xuanwu HospitalCapital Medical University Department of Neurology Affiliated Hospital of Taishan Medical University Biomedical Research Center Baotou Medical College Department of Gastroenterology Second Affiliated Hospital of Baotou Medical College

Peripheral and central sensitizations are phenomena that occur during migraine. The role of gabapentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was established by electrical stimulation of the trigeminal ganglion, and the animals were given intragastric gabapentin. Changes in amino acid content in the cerebrospinal fluid and protein kinase C membrane translocation in the spinal trigeminal nucleus were examined to clarify the mechanisms underlying the efficacy of gabapentin in the treatment of central sensiti- zation during migraine. Electrophysiology, liquid chromatography-mass spectrometry and western blot analysis results revealed that gabapentin reduces neuronal excitability in the spinal nucleus in the trigeminal nerve, decreases excitatory amino acid content and inhibits the activation of protein kinase C. This provides evidence that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine. Gabapentin inhibits mi- graine by reducing excitatory amino acid content in the cerebrospinal fluid and inhibiting protein kinase C activation.

关键词： neural regeneration migraine protein kinase C excitatory amino acid ionic excitatory amino acidreceptors neurons calcitonin gene-related peptide nitric oxide synthase nuclei of trigeminal nerve glutamic acid gamma-aminobutyric acid grants-supported paper neuroregeneration