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NIR-II live imaging study on the degradation pattern of collagen in the mouse model

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Regenerative Biomaterials 2023年第1期10卷 271-279页

作者： Huizhu Li Xinxian Meng Huaixuan Sheng sijia feng Yuzhou Chen Dandan Sheng Liman Sai Yueming Wang Mo Chen Yan Wo Shaoqing feng Hossein Baharvand Yanglai Gao Yunxia Li Jun Chen Department of Sports Medicine Sports Medicine Institute of Fudan UniversityHuashan HospitalFudan UniversityShanghai 200040China Department of Plastic and Reconstructive Surgery School of MedicineShanghai Jiao Tong UniversityShanghai Ninth People’s HospitalShanghai 200011China Department of Physics Shanghai Normal UniversityShanghai 200234China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Stem Cells and Developmental Biology Cell Science Research CenterRoyan Institute for Stem Cell Biology and TechnologyACECRTehran ***Iran Department of Developmental Biology School of Basic Sciences and Advanced Technologies in BiologyUniversity of Science and CultureTehran ***Iran Hexi College ZhangyeGansu 73400China

The degradation of collagen in different body parts is a critical point for designing collagen-based biomedical ***,three kinds of collagens labeled by second near-infrared(NIR-II)quantum dots(QDs),including collagen with low crosslinking degree(LC),middle crosslinking degree(MC)and high crosslinking degree(HC),were injected into the subcutaneous tissue,muscle and joints of the mouse model,respectively,in order to investigate the in vivo degradation pattern of collagen by NIR-II live *** results of NIR-II imaging indicated that all tested collagens could be fully degraded after 35 days in the subcutaneous tissue,muscle and joints of the mouse ***,the average degradation rate of subcutaneous tissue(k=0.13)and muscle(k=0.23)was slower than that of the joints(shoulder:k=0.42,knee:k=0.55).Specifically,the degradation rate of HC(k=0.13)was slower than LC(k=0.30)in muscle,while HC showed the fastest degradation rate in the shoulder and knee *** summary,NIR-II imaging could precisely identify the in vivo degradation rate of ***,the degradation rate of collagen was more closely related to the implanted body parts rather than the crosslinking degree of collagen,which was slower in the subcutaneous tissue and muscle compared to the joints in the mouse model.

关键词： collagen degradation rate NIR-II live imaging in vivo crosslinking degree

Current Status and Analysis of Machine Learning in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1184-1191页

作者： sijia feng Jianhua Wang Liheng Wang Qixuan Qiu Dongdong Chen Huo Su Xiaoli Li Yao Xiao Chiayen Lin General Surgery Central South University Xiangya HospitalChangshaHunanChina

Hepatocellular carcinoma(HCC)is a common *** the diagnosis and treatment of HCC have made great progress,the overall prognosis remains *** the core component of artificial intelligence,machine learning(ML)has developed rapidly in the past *** particular,ML has become widely used in the medical field,and it has helped in the diagnosis and treatment of *** algorithms of ML have different roles in diagnosis,treatment,and *** article reviews recent research,explains the application of different ML models in HCC,and provides suggestions for follow-up research.

关键词： Machine learning Hepatocellular carcinoma Artificial intelligence Prognosis

SWIR FluorescenceImaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal Muscle Regeneration

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Engineering 2024年第2期33卷 283-294页

作者： Mo Chen Yuzhou Chen sijia feng Shixian Dong Luyi Sun Huizhu Li Fuchun Chen Nguyen Thi Kim Thanh Yunxia Li Shiyi Chen You Wang Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Key Laboratory of Infrared System Detection&Imaging Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK Healthcare Biomagnetic and Nanomaterials Laboratories University College LondonLondon W1S 4BSUK

Skeletal muscle has a robust regeneration ability that is impaired by severe injury,disease,and *** in a decline in skeletal muscle ***,improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related *** to their significant role in tissue regeneration,implantation of M2 macrophages(M2MФ)has great potential for improving skeletal muscle ***,we present a short-wave infrared(SWIR)fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2MФ*** fluorescence imaging was employed to track implanted M2MФin the injured skeletal muscle of mouse *** is found that the implanted M2MФaccumulated at the injury site for two ***,SWIR fluorescence imaging of blood vessels showed that M2MФimplantation could improve the relative perfusion ratio on day 5(1.09±0.09 vs 0.85±0.05;p=0.01)and day 9(1.38±0.16 vs 0.95±0.03;p=0.01)post-injury,as well as augment the degree of skeletal muscle regencration on day 13 ***,multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle *** results provide more in vivo details about M2MФin skeletal muscle regeneration and confirm that M2MФcould promote angiogenesis and improve the degree of skeletal muscle repair,which will guide the research and development of M2MФimplantation to improve skeletal muscle regeneration.

关键词： In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration

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Burgers方程的最优同伦渐近方法研究

高等学校计算数学学报 2019年第1期41卷 45-53页

作者：单丽冯思佳辽宁工程技术大学理学院

1引言Burgers方程是由Bateman在1915年提出的.求解该方程对于空气动力学、湍流、热传导、交通流、半导体模拟以及地下水污染等领域具有重要意义.求解Burgers方程的数值方法很多,例如有限差分法、LDG有限元方法、拟小波配点法、直线法等.

关键词： Burgers equation Optimal Homotopy Asymptotic Method Homotopy Analysis Method

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肩关节不稳与SLAP损伤联系的研究进展

中国修复重建外科杂志 2022年第2期36卷 135-142页

作者：冯思嘉陈俊张健陈世益复旦大学运动医学研究所上海200040 复旦大学附属华山医院运动医学科上海200040

目的总结肩关节不稳与上盂唇自前向后(superior labrum anterior posterior,SLAP)损伤的联系。方法通过查阅国内外相关研究文献,分析肩关节不稳与SLAP损伤的特点,归纳并探讨两者在发病机制、临床症状及生物力学上的关联。结果肩关节不稳... 详细信息

目的总结肩关节不稳与上盂唇自前向后(superior labrum anterior posterior,SLAP)损伤的联系。方法通过查阅国内外相关研究文献,分析肩关节不稳与SLAP损伤的特点,归纳并探讨两者在发病机制、临床症状及生物力学上的关联。结果肩关节不稳和SLAP损伤既可同时存在,也可单独发生。SLAP损伤由于破坏了上盂唇的完整性和肱二头肌长头腱(long head of biceps tendon,LHBT)止点,可引起肱骨头相对关节盂过度移位,导致肩关节不稳。而慢性反复性或急性高能量创伤导致的肩关节不稳也会加重SLAP损伤,造成原有损伤范围扩大及撕裂程度加重。结论 SLAP损伤会破坏肩关节稳定机制,肩关节不稳会引起上盂唇和LHBT撕裂,两者间存在一定联系。然而,现有研究结果仅能证明肩关节不稳和SLAP损伤之间具有互相诱发和促进发展的关系,而非互为充分必要条件,因此两者间具体因果关系还需进一步深入研究。

关键词：肩关节不稳 SLAP损伤关节盂唇肱二头肌长头腱

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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou Chen Mo Chen Chengxuan Yu Huizhu Li Liman Sai Nguyen T.K.Thanh Yueming Wang Yan Wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei V.Zvyagin Hao De Min Tang Shiyi Chen Yunxia Li Yuefeng Hao sijia feng Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)*** Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

基于霍尔三维结构的图书馆红色资源数据库建设研究

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山东图书馆学刊 2024年第6期 51-58页

作者：冯思佳中共武汉市委党校图书馆湖北武汉430024

随着信息技术的发展,建立红色资源数据库,推进红色资源信息开放共享,是图书馆推动红色资源科学保护利用的重要途径之一。文章基于霍尔三维结构模型的系统工程学优势,结合红色资源数据库建设的实践要素,从逻辑维、时间维和知识维等3个维... 详细信息

随着信息技术的发展,建立红色资源数据库,推进红色资源信息开放共享,是图书馆推动红色资源科学保护利用的重要途径之一。文章基于霍尔三维结构模型的系统工程学优势,结合红色资源数据库建设的实践要素,从逻辑维、时间维和知识维等3个维度构建了红色资源数据库建设三维结构模型,深入分析各维度实施要点,并以二维活动矩阵具体阐释了该模型在实践中的可行性和适用性。

关键词：红色资源霍尔三维结构模型数据库项目建设

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可编织柔性纤维状水伏纳米发电机

中国科学：技术科学 2022年第11期52卷 1659-1668页

作者：冯思佳李连辉刘梦愿郭昀张珽上海大学材料科学与工程学院上海200444 中国科学院苏州纳米技术与纳米仿生研究所苏州215123 材料科学姑苏实验室苏州215123

可穿戴设备在医疗健康、物联网和机器人等领域具有广泛需求,其发展具有小型化、轻量化、柔性化的趋势,然而便携式、持续稳定的能源供给方式是限制其应用的瓶颈问题.基于水伏效应的新型环境能源捕获技术为解决可穿戴设备的持续能源供给... 详细信息

可穿戴设备在医疗健康、物联网和机器人等领域具有广泛需求,其发展具有小型化、轻量化、柔性化的趋势,然而便携式、持续稳定的能源供给方式是限制其应用的瓶颈问题.基于水伏效应的新型环境能源捕获技术为解决可穿戴设备的持续能源供给问题提供了新的机遇.相关研究表明,碳纳米材料在对水能的转换与利用中展现了独特的优势.本文以导电炭黑为水伏材料,通过简易的浸涂法及材料表面浸润性调控,制备了水伏效应和原电池反应产能机制协同作用的可编织柔性纤维状水伏纳米发电机.其在纯水及多种盐溶液中均能实现持续稳定的产电,突破了目前水伏发电机对于水源中极低离子浓度要求的限制.值得一提的是,该水伏纳米发电机可以利用人体汗液直接发电,有望作为柔性可穿戴设备稳定的能源供给方式,解决柔性电子器件的持续能源供给问题.

关键词：水伏纳米发电机环境能源捕获柔性可穿戴电子汗液可编织

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