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Differential retention of lymph-borne CD8 memory T cell subsets in the subcapsular sinus of resting and inflamed lymph nodes

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Cellular & Molecular Immunology 2021年第5期18卷 1317-1319页

作者： Ginka Nikolova siegfried weiss Berislav Bosnjak Reinhold Förster Institute of Immunology Hannover Medical School30625HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical School30625HannoverGermany

Immunological memory represents the ability of specific immune cells to recall an encounter with a cognate *** results in an immediate response upon a second exposure to the same infectious ***,conventional memory T cells are generated after encountering specific foreign *** contrast,a group of innate memory T cells develops without initial exposure to foreign antigen that specifically binds to a cognate T cell receptor.1 These naturally occurring memory-like T cells,also known as“virtual”memory T cells,are generated under steady-state *** accumulate during aging in both humans and mice.2 By comparing the TCR repertoire of young and old mice,an early study identified age-dependent clonal expansion and age-related changes in CD8^(+) but not CD4^(+) T cells.3 Interestingly,more than 50%of CD62L^(hi)CD44^(hi) central memory T cells in the peripheral blood of aged naive mice have been suggested to represent virtual memory T cells based on their lower expression levels of CD49d.4 Infection studies in mice employing Listeria monocytogenes showed that both virtual memory T cells and conventional antigen-specific memory T cells were able to provide protection.5 However,in contrast to virtual memory T cells,conventional memory T cells produced fivefold higher levels of IFN-γupon short-term in vitro TCR stimulation.

关键词： lymph retention exposure

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Occult celiac disease prevents penetrance of hemochromatosis

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World Journal of Gastroenterology 2005年第21期11卷 3323-3326页

作者： Andreas Geier Carsten Gartung Igor Theurl Guenter weiss Frank Lammert Christoph G.Dietrich Ralf Weiskirchen Heinz Zoller Benita Hermanns siegfried Matern Department of Internal Medicine Ⅲ Aachen University (RWTH) AachenGermany Department of Internal Medicine University of Innsbruck InnsbruckAustria Department of Clinical Chemistry and Pathobiochemistry Aachen University(RWTH) AachenGermany Department of Pathology Aachen University (RWTH) AachenGermany Department of Internal Medicine Ⅲ Aachen University(RWTH) Aachen Germany

AIM: To report a patient with C282Y homozygocity, depleted body iron and intestinal atrophy caused by celiac disease (CD) who experienced resolution of the enteropathy with subsequent normalization of iron metabolism upon glutenfree ***: To obtain information on the tissue distribution and quantitative expression of proteins involved in duodenal iron trafficking, we determined the expression of divalent-metal transporter 1 (DMT1), ferroportin 1 (FP1) and transferrin receptor (TfR1) by means of immunohistochemistry and real-time PCR in duodenal biopsies of this ***: Whereas in hereditary hemochromatosis patients without CD, DMT1 expression was up-regulated leading to excessive uptake of iron, we identified a significant reduction in protein and mRNA expression of DMT1 as acompensatory mechanism in this patient with HH and ***: Occult CD may compensate tot increased DMT1 expression in a specific subset of individuals withhomozygous C282Y mutations in the hemochromatosis(HFE) gene, thus contributing to the low penetrance of HH.

关键词：腹腔疾病血色沉着病外显率疾病预防 C282Y 肠萎缩

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男性包皮环切术预防男性的HIV异性感染

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生殖与避孕 2007年第8期27卷 553-556页

作者： Charles Morrison Robert Salata siegfried N Muller M Volmink J Deeks J Egger M Low N weiss H Walker S Williamson P 单位不详

现有观察性研究表明,男性包皮环切术与HIV预防有高度相关性,高危人群尤为如此。然而,由于观察性研究的固有局限性,仅凭这些发现尚不能下结论。极有必要开展评估男子包皮环切术对HIV-1传播干预效果的随机对照试验。

关键词： HIV-1传播包皮环切术男性预防感染异性随机对照试验高危人群

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