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Function and dysfunction of GEMIN5:understanding a novel neurodevelopmental disorder

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Neural Regeneration Research 2024年第11期19卷 2377-2386页

作者： Charles H.Nelson Udai B.pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Children’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

The recent identification of a neurodevelopmental disorder with cerebellar atrophy and motor dysfunction(NEDCAM)has resulted in an increased interest in GEMIN5,a multifunction RNA-binding protein.As the largest member of the survival motor neuron complex,GEMIN5 plays a key role in the biogenesis of small nuclear ribonucleoproteins while also exhibiting translational regulatory functions as an independent protein.Although many questions remain regarding both the pathogenesis and pathophysiology of this new disorder,considerable progress has been made in the brief time since its discovery.In this review,we examine GEMIN5 within the context of NEDCAM,focusing on the structure,function,and expression of the protein specifically in regard to the disorder itself.Additionally,we explore the current animal models of NEDCAM,as well as potential molecular pathways for treatment and future directions of study.This review provides a comprehensive overview of recent advances in our understanding of this unique member of the survival motor neuron complex.

关键词： cerebellar atrophy GEMIN5 neurodevelopmental disorder neurological disease SMN complex

Long COVID:From olfactory dysfunctions to viral Parkinsonism

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 137-147页

作者： Sanyukta pandey Vibha Bapat Jancy Nixon Abraham Nixon M.Abraham Department of Biology Laboratory of Neural Circuits and Behaviour(LNCB)Indian Institute of Science Education and Research(IISER)PuneMaharashtraIndia Department of Life Sciences Centre of Excellence in EpigeneticsShiv Nadar Institution of EminenceGautam Buddha NagarUttar PradeshIndia

Neurological and psychiatric complications continue to be a public health concern in long coronavirus disease 2019(COVID-19).This varies from olfactory dysfunctions such as parosmia to cognitive and emotional challenges.Historically,the surge of neurological disorders followed the viral pandemics,for example,the emergence of Encephalitis Lethargica after the outbreak of Spanish Influenza.During and after COVID-19 infection,the problems associated with the sense of smell and the reports of affected olfactory and limbic brain areas are leading to a growing concern about the similarity with the symptoms and the pattern of degeneration observed at the onset of Parkinson's disease and Alzheimer's disease.These reports reveal the essentiality of long-term studies of olfactory and cognitive functions in the post-COVID era and the experiments using animal models to dissect the neural basis of these complications.In this manuscript,we summarize the research reporting the potential correlation between neurological disorders and viral pandemic outbreaks with a historical perspective.Further,we discuss the studies providing evidence of neurodegeneration due to severe acute respiratory syndrome coronavirus 2 infection by focusing on viral Parkinsonism.

关键词： long COVID neurodegeneration neurotropism olfactory dysfunctions viral parkinsonism

Dynamics of a delay-induced prey-predator system with interaction between immature prey and predators

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International Journal of Biomathematics 2024年第2期17卷 139-176页

作者： Soumik pandey Abhijit Sarkar Debashis Das Sarbani Chakraborty Department of Mathematics West Bengal State University Barasat-7000126West BengalIndia Department of Basic Science&Humanities JIS College of Engineering Kalyani-741235West BengalIndia

In biological pest control systems,several pests(including insects,mites,weeds,etc.)are controlled by biocontrol agents that rely primarily on predation.Following this biocontrol management ecology,we have created a three-tier prey-predator model with prey phase structure and predator gestation delay.Several studies have demonstrated that predators with Holling type-II functional responses sometimes consume immature prey.A study of the well-posedness and local bifurcation(such as saddle-node and transcritical)near the trivial and planer equilibrium points is carried out.Without any time lag,the prey development coeficient has a stabilizing impact,while increasing attack rate accelerates instability.Energy transformation rate and handling time are shown to cause multiple stability switches in the system.Numerical results demonstrate time delay is the key destabilizer that destroys stability.Our model can replicate more realistic events by including time-dependent factors and exploring the dynamic behavior of nonautonomous systems.In the presence of time delay,sufficient conditions of permanence and global attractivity of the nonautonomous system are derived.Finally,MATLAB simulations are performed to validate the analytical findings.

关键词： Holling type-II functional response stage-structure bifurcation time delay seasonality

Investigating the Evolution of Amati Parameters with Redshift

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Research in Astronomy and Astrophysics 2024年第1期24卷 188-200页

作者： Meghendra Singh Darshan Singh Kanhaiya Lal pandey Dinkar Verma Shashikant Gupta Delhi Metro Rail Corporation Limited New Delhi 110001India GD Goenka University Gurugram 122103India Department of Physics Mata Raj Kaur Institute of Engineering and TechnologyRewari 123401India Department of Physics School of Advanced SciencesVellore Institute of TechnologyVellore 632014India

Gamma-ray bursts(GRBs) are among the brightest objects in the Universe and, hence, can be observed up to a very high redshift. Properly calibrated empirical correlations between intensity and spectral correlations of GRBs can be used to estimate the cosmological parameters. However, the possibility of the evolution of GRBs with redshift is a long-standing puzzle. In this work, we used 162 long-duration GRBs to determine whether GRBs below and above a certain redshift have different properties. The GRBs are split into two groups, and we fit the Amati relation for each group separately. Our findings demonstrate that estimations of the Amati parameters for the two groups are substantially dissimilar. We perform simulations to investigate whether the selection effects could cause the difference. Our analysis shows that the differences may be either intrinsic or due to systematic errors in the data, and the selection effects are not their true origin. However, in-depth analysis with a new data set comprised of 119 long GRBs shows that intrinsic scatter may partly be responsible for such effects.

关键词： Cosmology gamma rays:general (cosmology:)large-scale structure of universe galaxies:high-redshift

Influence of edaphic factors on distribution and condition of Himalayan silver birch(Betula utilis D.Don)communities in the northwestern Indian Himalayas

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Journal of Mountain Science 2024年第2期21卷 590-606页

作者： Khashti DASILA Renu RAWAL Tanay BARMAN Sher Singh SAMANT Anita pandey Veena PANDE G.B.Pant National Institute of Himalayan Environment Almora 263643India Centre of Excellence on Sustainable Land Management Indian Council of Forestry Research and EducationDehradun 248006India Uttarakhand State Council for Science&Technology Dehradun 248015India Department of Biotechnology Graphic Era(Deemed to be University)Dehradun 248002India Department of Biotechnology Kumaun UniversityNainital 263136India

The basic concept of phytosociology is crucial for the assessment of species composition and dynamic ecological succession of forests supporting ecological services,functions,disturbance,and resilience that lead to the development of integrated areas such as ecological niche modeling and contribute to identifying the valuable bio-indicators which can be used in framing conservation and management planning.B.utilis is one of the most dominant tree species of treeline ecotone in the Himalayan Region.The species is also considered as indicator species for monitoring the past and recent climate change impact.The current study was carried out in the natural populations of B.utilis from the sub-alpine zone of North-western Indian Himalaya.The birch dominated forest harbors a total of 305 plant species comprising Angiosperms(51 families,160 genera and 277 species),Gymnosperms(03 families,05 genera and 07 species)and Pteridophytes(07 families,11 genera and 21 species)with Asteraceae,Ranunculaceae and Rosaceae as dominant family.Birch forests are found dominant in shady moist habitat and North West aspect.Geographical characteristics,anthropogenic and developmental activities affect the population structure of B.utilis and associated species.However,the species has fair regeneration status in the study area.The acidic nature of soil pH and spatial variation in edaphic characteristics may be due to geographical differences,rooting patterns and litter accumulation of below and above-ground vegetation.Biomass estimation of a representative population of B.utilis from each site showed that TAGBD,TCD and TBD were found maximum in ST3(Hamta Pass II site).The CCA analysis determined that environmental variables such as altitude,organic matter,available phosphorous,organic carbon,available nitrogen,and electrical conductivity played a significant role in determining tree species composition and distribution in B.utilis dominated forests.

关键词： Species composition Indicator species Biomass North-western Indian Himalaya Regeneration Environmental variables

The circuitry landscape of perovskite solar cells:An in-depth analysis

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Journal of Energy Chemistry 2024年第7期94卷 393-413页

作者： Siddhi Vinayak pandey Daniel Prochowicz Apurba Mahapatra Saravanan Pandiaraj Abdullah Alodhayb Seckin Akin Pankaj Yadav Department of Solar Energy School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia Department of Physical Chemistry Polish Academy of SciencesKasprzaka 44/5201-224 WarsawPoland Department of Self-Development Skills King Saud UniversityRiyadh 11451Saudi Arabia Department of Physics and Astronomy College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Department of Metallurgical and Materials Engineering Necmettin Erbakan University42060 KonyaTurkey Department of Physics School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia

The extensive research and development in perovskite solar cells(PsCs)have rekindled the hopes of con-verting solar energy into electricity.An elusive understanding of underlying mechanisms is required for the development of effcient PsCs.Over the years,Impedance Spectroscopy(IS)characterization,along with complementary techniques,has proven to be an effective way to understand and analyze the charge transport and recombination at interface and bulk of PSCs.The IS of PSCs have been analyzed,interpreted,and improvised continuously,revealing intricate details about the work.However,there is a lack of cen-tralized source of these details,which make it tougher to account for the generalized approach to under-stand the device properties.The present work is focused on compiling the research done on various PsC device architectures via IS to construct a comprehensive foundation of information on impedance plots,equivalentcircuits,and associated processes.

关键词： Impedance Spectroscopy Perovskite solar cells Equivalent Circuits

Utility of trans-vaginal ultrasound in diagnosis and follow-up of non-pregnant sexually active females with lower ureteric calculi

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Asian Journal of Urology 2020年第1期7卷 45-50页

作者： siddharth pandey Tanica pandey Apul Goel Ajay Aggarwal Deepanshu Sharma Tushar pandey Satya sankhwar Gaurav Garg Department of Urology King George’s Medical UniversityLucknowIndia Department of Radiology Raghav Pathlabs and ImagingHaldwaniIndia Department of Pathology Post Graduate Institute of Medical Education and ResearchChandigarhIndia

objective:To assess the utility of trans-vaginal ultrasonography in evaluation of non-pregnant sexually active female patients with lower ureteric calculi.Methods:A prospective study was done from January 2015 to December 2017 including non-pregnant sexually active females with suspected ureteric calculus.Trans-abdominal ultrasound was initially done in all patients.In those patients in whom trans-abdominal ultrasound was inconclusive or there was indirect evidence of lower ureteric calculus in form of ureteral dila-tion but no calculus was evident,trans-vaginal ultrasound was done.The patients with ureteric calculi detected on trans-vaginal ultrasound and kept on conservative management were also followed up with trans-vaginal ultrasound.Non-contrast computed tomography was done in patients with inconclusive trans-vaginal ultrasound.Results:As per the study protocol,156 out of the total 468 patients evaluated by trans-abdominal ultrasound were eligible for trans-vaginal ultrasound.Trans-vaginal ultrasound was done in 149 patients,as seven patients did not give consent.Seventy-nine patients were detected with a lower ureteric calculus on trans-vaginal ultrasound and 27 patients had gyne-cologic or other cause for their symptoms.Forty-three patients had an inconclusive trans-vaginal ultrasound of which 36 underwent non-contrast computed tomography,among them only one patient had a lower ureteric calculus.Stone free status could be easily demonstrated on follow-up trans-vaginal ultrasound.

关键词： Trans-abdominal ultrasound Trans-vaginal ultrasound Lower ureteric calculus Ureteric colic Ureter

基于社区的气候变化适应方法与高海拔Garhwal喜马拉雅山脉Bhagirathi地区的生计安全

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Journal of Resources and Ecology 2024年第1期15卷 197-203页

作者： Shoryabh SRIVASTAVA Bindhy Wasini pandey Virender Singh NEGI 德里大学经济学院地理系印度德里110007 德里大学莎希德·巴加特·辛格学院地理系(E) 印度德里110017

位于Garhwal喜马拉雅山的Bhagirathi(HA-BV)谷地是一个生态和文化重要性极高的地区,但当地居民的生计容易受到气候变化的影响。基于社区的气候变化适应方法(CB-CCA)已成为一种增强地方社区的经济和社会福祉重要策略,并提高了社区发展的... 详细信息

位于Garhwal喜马拉雅山的Bhagirathi(HA-BV)谷地是一个生态和文化重要性极高的地区,但当地居民的生计容易受到气候变化的影响。基于社区的气候变化适应方法(CB-CCA)已成为一种增强地方社区的经济和社会福祉重要策略,并提高了社区发展的韧性。本文旨在研究HA-BV地区的CB-CCA和生计保障计划,关注应对气候变化所面临挑战的策略。研究认为优先考虑适应该地区崎岖的地形和恶劣的天气条件的可持续生计选择至关重要。例如,与山谷独特的土壤和气候动态相适应,推广温室种植和农林复合种植等替代农业,可能会带来较好的结果;此外,鼓励养蜂、手工艺和生态旅游等替代生计途径不仅可以创收,还能保护该地区的自然环境。为了鼓励当地居民实施这些环境友好的生计措施,政府和利益相关者需要进行战略性投资,基础设施的完善(包括道路建设和电力供应)可为经济增长创造良好的条件。研究结果可为喜马拉雅山地区的可持续发展做出贡献,为类似情境下未来构建气候韧性和保障生计的努力提供参考。

关键词： Bhagirathi谷基于社区的方法气候变化适应生计保障 Garhwal喜马拉雅山

Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

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Oncology Research 2024年第1期32卷 73-94页

作者： VIGNESH BALAJI E DIVYA RAMESH MANISHA CHUNGAN SHAJU AKSHARA KUMAR SAMYAK pandey RAKSHA NAYAK V.ALKA SRISHTI MUNJAL AMIR SALIMI K.SREEDHARA RANGANATH PAI SHANKAR M.BAKKANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human body.It is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological conditions.Also,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome source.Moreover,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological actions.There are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor cells.Once the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological response.Even though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic efficacy.So,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges