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The effect of cylindrospermopsin on the bacterioplankton community:a microcosm experiment on water from Dishui Lake,Shanghai,China

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Journal of Oceanology and Limnology 2022年第5期40卷 1829-1839页

作者： sicheng yin Ruohan HUANG Erik JEPPESEN Lijing CHEN Liqing WANG Xin FANG Wei ZHANG Engineering Research Center of Environmental DNA and Ecological Water Health Assessment Shanghai Ocean UniversityShanghai 201306China Department of Ecoscience Aarhus UniversitySilkeborg 8600Denmark Sino-Danish Centre for Education and Research(SDC) University of Chinese Academy of SciencesBeijing 100049China Limnology Laboratory and EKOSAM Department of Biological SciencesMiddle East Technical UniversityAnkara 06800Turkey Institute of Marine Sciences Middle East Technical UniversityMersin 33731Turkey School of Business Macao University of Science and TechnologyTaipaMacao 999078China

Eutrophication and climate warming have intensified the global expansion of invasive cyanobacteria such as Cylindrospermopsis *** Chrysosporum ***(CYN)produced by species of the latter two genera may harm phytoplankton,zooplankton,and ***,effects of CYN on the bacterioplankton community have not been *** on high-throughput sequencing,we explored the effect of CYN on the structure and function of the bacterioplankton community by adding pure CYN to in-situ water collected from a brackish coastal shallow lake:Dishui Lake,*** found that most bacterioplankton taxa had a certain tolerance potential to CYN,but that high concentrations of CYN(40μg/L)caused a significant decrease in microbial abundance and functional *** the dominant phyla,Actinobacteria had the strongest tolerance to *** analysis indicated that CYN caused shifts in the community structure of the bacterioplankton,reducing community stability and structural *** CYN concentrations also reduced the correlation between the different bacterioplankton groups,and the abundances of some bacterial taxa associated with the denitrification function and the process of carbon transfer in the microbial food web were *** study provide s new insight into the response of the bacterioplankton communities to harmful algal toxins produced by cyanobacteria.

关键词： cylindrospermopsin bacterioplankton denitrification function carbon cycles Dishui Lake

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经济增长的轨迹及启示:苏日经验与中国措施

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科技创业月刊 2023年第4期36卷 10-14页

作者：尹思成香港理工大学商学院中国香港999077

“中国是否会成为世界第一大经济体?”引发经济学界的广泛关注并成为一个热点话题。从历史观的角度和经济增长的3个维度出发,梳理了20世纪60年代苏联、日本开启的经济增长轨迹,及1978年以来中国采取的改革开放措施及取得的成效。受苏日... 详细信息

“中国是否会成为世界第一大经济体?”引发经济学界的广泛关注并成为一个热点话题。从历史观的角度和经济增长的3个维度出发,梳理了20世纪60年代苏联、日本开启的经济增长轨迹,及1978年以来中国采取的改革开放措施及取得的成效。受苏日经济增长的启示,考虑疫情冲击和国际竞争等因素,根据经济增长分析框架,提出了当前中国经济可以采取的措施:扩大内需;实现核心科技原始创新;对实体经济进行适当补贴并刺激消费;有效控制人口负增长,提高人口出生率;加快建设现代化经济体系。

关键词：经济增长现代化经济体系苏俄经济日本经济美国经济

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3种淡水微藻相互间化感作用的实验研究

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生态毒理学报 2020年第6期15卷 223-233页

作者：尹思成马逸驰王先云尚光霞王丽卿张玮上海海洋大学农业部鱼类营养与环境生态研究中心上海201306 上海城市水资源开发利用国家工程中心有限公司上海200082 上海海洋大学水产种质资源发掘与利用教育部重点实验室上海201306 上海海洋大学水产动物遗传育种中心上海市协同创新中心上海201306

水体富营养化和气候变暖加剧了入侵蓝藻的全球性扩张;化感作用在此类蓝藻的扩张中可能起到重要的作用,但对不同物种之间的化感竞争关系,仍研究不足。针对近年来上海地区水体出现的金孢藻水华现象,以卵孢金孢藻和2种土著浮游植物(铜绿微... 详细信息

水体富营养化和气候变暖加剧了入侵蓝藻的全球性扩张;化感作用在此类蓝藻的扩张中可能起到重要的作用,但对不同物种之间的化感竞争关系,仍研究不足。针对近年来上海地区水体出现的金孢藻水华现象,以卵孢金孢藻和2种土著浮游植物(铜绿微囊藻、四尾栅藻)为研究对象,通过滤液培养方式,观测藻类生物量、叶绿素a含量和光合作用荧光活力等指标的变化,探究卵孢金孢藻与2种微藻种间的化感竞争作用。结果表明,在室内BG11培养条件下,铜绿微囊藻滤液仅在实验前4 d对卵孢金孢藻的生长有抑制作用,其潜在最大光合效率(F_(v)/F_(m))和实际光合效率(Yield)先下降后上升,实验结束时与对照组相比无明显差异(P>0.05);卵孢金孢藻滤液随时间延长对铜绿微囊藻的抑制作用逐渐增强,4 d后比生长率和叶绿素a含量显著低于对照组(P0.05)。金孢藻与微囊藻和栅藻之间不同的化感响应,表明同一水体中的蓝藻可能更易成为金孢藻的化感抑制目标;同时,化感效应结果与不同物种的自身特性和水体营养水平有关。实验结果进一步探究了卵孢金孢藻与不同浮游植物之间的竞争关系,为进一步了解卵孢金孢藻的扩散和暴发机制积累了基础数据,可为我国新型蓝藻水华的防治提供理论参考。

关键词：卵孢金孢藻水华蓝藻化感作用光合活性

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一株毛红椿种腐病原菌JZF 02的分离鉴定及生物学特性研究

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种子 2019年第10期38卷 47-51页

作者：任师杰金泽枫郭晓燕尹思成何光文张露江西农业大学生物科学与工程学院南昌330045 江西农业大学江西特色林木资源培育与利用2011协同创新中心南昌330045

从江西九连山霉烂毛红椿种子上分离种腐病原菌,采用形态学和分子生物学方法对其进行鉴定,并采用菌落直径法研究其在不同培养基、温度、pH以及多种碳氮源条件下的生物学特性。结果表明:从霉烂毛红椿种子上分离到一株对毛红椿种子具有强... 详细信息

从江西九连山霉烂毛红椿种子上分离种腐病原菌,采用形态学和分子生物学方法对其进行鉴定,并采用菌落直径法研究其在不同培养基、温度、pH以及多种碳氮源条件下的生物学特性。结果表明:从霉烂毛红椿种子上分离到一株对毛红椿种子具有强致病性(编号为JZF02)的真菌,经鉴定为厚垣镰刀菌(Fusarium chlamydosporum);该菌菌丝在不同培养基上的生长速率表现为PSA>PDA/MA>CA>CD;该菌能利用多种碳氮源,但铵盐不适合该菌生长;在0~40℃均能生长,最适生长温度为25~30℃;在pH5~12条件下均能生长,其中最适pH为8。本研究为掌握厚垣镰刀菌引起的毛红椿种子病害发生规律及采取防控措施提供了理论依据。

关键词：毛红椿种腐病厚垣镰刀菌生物学特性

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circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan Yi He Pan Chen Ming Zhou Bo Xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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Current Status of PV in China and Its Future Forecast

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CSEE Journal of Power and Energy Systems 2020年第1期6卷 72-82页

作者： sicheng Wang Energy Research Institute of National Development and Reform Commission(NDRC) BeijingChina

Current status and the progress of PV in China are introduced with detailed data,covering PV manufacturing,market development,cost reduction and technology *** growing of PV industry in China is due to series of incentive policies provided by the Chinese government,which are provided in this paper as *** slow down the speed of PV development,the 5.31 new policy is issued on May 31,2018 by the Chinese government as a *** affections of the new policy and future PV market are *** target of energy transition of China and the role of PV are *** will have more broad space in development when it comes to grid parity in the future.

关键词： Energy transition feed-in tariff grid parity incentive policies PV renewable energy law renewable energy surcharge

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Sufficient conditions of Rayleigh-Taylor stability and instability in equatorial ionosphere

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Applied Mathematics and Mechanics(English Edition) 2016年第2期37卷 181-192页

作者： sicheng WANG Sixun HUANG Institute of Meteorology and Oceanography PLA University of Science and Technology State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyState Oceanic Administration

Rayleigh-Taylor （R-T） instability is known as the fundamental mechanism of equatorial plasma bubbles （EPBs）. However, the sufficient conditions of R-T instability and stability have not yet been derived. In the present paper, the sufficient conditions of R-T stability and instability are preliminarily^derived. Linear equations for small perturbation are first obtained from the electron/ion continuity equations, momentum equations, and the current continuity equation in the equatorial ionosphere. The linear equations can be casted as an eigenvalue equation using a normal mode method. The eigenvalue equation is a variable coefficient linear equation that can be solved using a variational approach. With this approach, the sufficient conditions can be obtained as follows： if the minimum systematic eigenvalue is greater than one, the ionosphere is R-T unstable; while if the maximum systematic eigenvalue is less than one, the ionosphere is R-T stable. An approximate numerical method for obtaining the systematic eigenvalues is introduced, and the R-T stable/unstable areas are calculated. Numerical experiments axe designed to validate the sufficient conditions. The results agree with the derived suf- ficient conditions.

关键词： Rayleigh-Taylor (R-T) instability sufficient condition equatorial iono-sphere variational approach

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Combined QSAR/QSPR, Molecular Docking, and Molecular Dynamics Study of Environmentally Friendly PBDEs with Improved Insulating Properties

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Chemical Research in Chinese Universities 2019年第3期35卷 478-484页

作者： LIU sicheng SUN Shijun School of Environment Northeast Normal UniversityChangchun 130117P.R.China

To improve the insulating properties of polybrominated diphenyl ethers(PBDEs), we studied the molecular structures and energy gap(Eg) values of 209 PBDEs using a three-dimensional quantitative structure-activity relationship(3D-QSAR) model, molecular docking, and molecular dynamics. We also analyzed the interaction mechanisms of PBDEs using a 2D-QSAR model, molecular substitution characteristics, and molecular docking. The 3D-QSAR model showed that the 2-, 4-, 5-, and 6-positions significantly influenced the PBDE insulating properties. Using BDE-34 as a template molecule, we designed six derivatives with 0.47%-28.44% higher insulation tlian BDE-34. Compared with BDE-34, the stability and flame retardancy of the above six derivatives were not adversely affected. These derivatives, except for 2,6-cyanomethyl-BDE, 2-cyanomethyl-BDE, and 2-aniinomethyl-BDE, were more toxic and biodegradable than BDE-34, but showed weaker bioaccumulation and migration abilities than BDE-34. Mechanism analysis showed that the highest occupied orbital energy, the most negative charge, and the dipole moment were the main quantitative parameters that aflected the PBDE insulating properties. PBDE insulation gradually decreased as the number of Br atoms increased. The level of similarity between the substitution patterns on the two benzene rings was significantly correlated with PBDE insulation, with hydrophobic groups having a more significant efiect on PBDE insulation.

关键词： Polybrominated diphenyl ether High insulation Tliree-dimensional quantitative structure-activity relationship Molecular docking Molecular dynamics Molecular modification

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Automated recognition and mapping of building management system (BMS) data points for building energy modeling (BEM)

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Building Simulation 2021年第1期14卷 43-52页

作者： sicheng Zhan Adrian Chong Bertrand Lasternas Department of Building School of Design and EnvironmentNational University of Singapore4 Architecture DriveSingapore117566Singapore

With the advance of the internet of things and building management system(BMS)in modern buildings,there is an opportunity of using the data to extend the use of building energy modeling(BEM)beyond the design *** applications include retrofit analysis,measurement and verification,and operations and ***,while BMS is collecting a vast amount of operation data,different suppliers and sensor installers typically apply their own customized or even random non-uniform rules to define the metadata,i.e.,the point *** results in a need to interpret and manually map any BMS data before using it for energy *** mapping process is labor-intensive,error-prone,and requires comprehensive prior ***,BMS metadata typically has considerable variety and limited context information,limiting the applicability of existing interpreting *** this paper,we proposed a text mining framework to facilitate interpreting and mapping BMS points to EnergyPlus *** framework is based on unsupervised density-based clustering(DBSCAN)and a novel fuzzy string matching algorithm“X-gram”.Therefore,it is generalizable among different buildings and naming *** compare the proposed framework against commonly used baselines that include morphological analysis and widely used text mining *** two building cases from Singapore and two from the United States,we demonstrated that the framework outperformed baseline methods by 25.5%,with the measurement extraction F-measure of 87.2%and an average mapping accuracy of 91.4%.

关键词： building management system(BMS) building energy modeling(BEM) auto-mapping DBSCAN metadata interpretation

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When aggregation-induced emission meets protein aggregates

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National Science Review 2021年第6期8卷 13-15页

作者： sicheng Tang Songtao Ye Xin Zhang Department of Chemistry The Pennsylvania State University Department of Biochemistry and Molecular Biology The Pennsylvania State University

Protein misfolding and aggregation have been associated with a number of human diseases. As a multistep process(Fig. 1 a), protein unfolding yields misfolded intermediates as either monomers or oligomers, which evolve into insoluble aggregates as amorphous aggregates or amyloid-β fibrils. Detection of protein aggregates is of great interest as it could generate unprecedented insights into biogenesis, regulation and pathology of protein aggregation.

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