When aggregation-induced emission meets protein aggregates

作     者：Sicheng Tang Songtao Ye Xin Zhang Sicheng Tang;Songtao Ye;Xin Zhang

作者机构：Department of ChemistryThe Pennsylvania State University Department of Biochemistry and Molecular BiologyThe Pennsylvania State University 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2021年第8卷第6期

页      面：13-15页

核心收录：

学科分类：081704[工学-应用化学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 10[医学] 

基　　金：support from the Burroughs Welcome Fund Career Award at the Scientific Interface 1013904 (X.Z.) Sloan Research Fellowship FG-2018-10958 (X.Z.) PEW Biomedical Scholars Program 00033066 (X.Z.) National Institute of Health R35 GM133484 (X.Z.) 

摘      要：Protein misfolding and aggregation have been associated with a number of human diseases. As a multistep process(Fig. 1 a), protein unfolding yields misfolded intermediates as either monomers or oligomers, which evolve into insoluble aggregates as amorphous aggregates or amyloid-β fibrils. Detection of protein aggregates is of great interest as it could generate unprecedented insights into biogenesis, regulation and pathology of protein aggregation.