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Full recovery from chronic headache and hypopituitarism caused by lymphocytic hypophysitis:A case report

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World Journal of Clinical Cases 2022年第3期10卷 1041-1049页

作者： Mao-Guang Yang Han-Qing Cai si-si wang Lin Liu Chun-Mei wang Department of Endocrinology The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Radiology The First Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

BACKGROUND Lymphocytic hypophysitis(LYH)is an important condition to consider in the differential diagnosis of patients with a pituitary *** main clinical manifestations of LYH include headache,symptoms related to sellar compression,hypopituitarism,diabetes insipidus and ***,which is a frequent complaint of patients with LYH,is thought to be related to the occupying effect of the pituitary mass and is rapidly resolved with a good outcome after timely and adequate glucocorticoid treatment or *** SUMMARY Here,we report a patient with LYH whose initial symptom was headache and whose pituitary function assessment showed the presence of secondary hypoadrenalism,central hypothyroidism and hypogonadotropic *** magnetic resonance imaging showed symmetrical enlargement of the pituitary gland with suprasellar extension in a dumbbell shape with significant homogeneous enhancement after gadolinium *** size of the gland was approximately 17.7 mm×14.3 mm×13.8 *** pituitary stalk was thickened without deviation,and there was an elevation of the optimal *** lesion grew bilaterally toward the cavernous sinuses,and the parasternal dural caudal sign was *** patient presented with repeatedly worsening and prolonged headaches three times even though the hypopituitarism had fully resolved after glucocorticoid treatment during this *** This rare headache regression suggests that patients with chronic headaches should also be alerted to the possibility of LYH.

关键词： Lymphocytic hypophysitis Magnetic resonance imaging Hypopituitarism Headache Glucocorticoid Case report

Current carrying states in the disordered quantum anomalous Hall effect

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Chinese Physics B 2022年第9期31卷 476-481页

作者： Yi-Ming Dai si-si wang Yan Yu Ji-Huan Guan Hui-Hui wang Yan-Yang Zhang School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China Research Center for Advanced Information Materials Guangzhou UniversityGuangzhou 510006China School of Mathematics and Information Science Guangzhou UniversityGuangzhou 510006China SKLSM Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Beijing Academy of Quantum Information Sciences Beijing 100193China Huangpu Research and Graduate School of Guangzhou University Guangzhou 510700China

In a quantum Hall effect,flat Landau levels may be broadened by ***,it has been found that in the thermodynamic limit,all extended(or current carrying)states shrink to one single energy value within each Landau *** the other hand,a quantum anomalous Hall effect consists of dispersive bands with finite *** numerically investigate the picture of current carrying states in this *** size scaling,the spectrum width of these states in each bulk band still shrinks to a single energy value in the thermodynamic limit,in a power law *** magnitude of the scaling exponent at the intermediate disorder is close to that in the quantum Hall *** number of current carrying states obeys similar scaling rules,so that the density of states of current carrying states is *** states in the bulk band are localized and may contribute to the formation of a topological Anderson insulator.

关键词： quantum anomalous Hall effect Chern number disordered system localization

Optimal Cut-off Point of Waist to Height Ratio in Beijing and Its Association with Clusters of Metabolic Risk Factors

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Current Medical Science 2019年第2期39卷 330-336页

作者： Jing DONG si-si wang Xi CHU Jing ZHAO Ying-zhi LIANG Yong-bo YANG Yu-xiang YAN Physical Examination Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Epidemiology and Biostatistics School of Public HealthCapital Medical UniversityBeijing 100069China Municipal Key Laboratory of Clinical Epidemiology Beijing 100069China Department of Thoracic Surgery I Key Laboratory of Carcinogenesis and Translationat Research(Ministry of Education)Beijing Cancer HospitalPeking University School of OncologyBeijing 100142China

A host of studies found waist-to-height ratio(WHtR)having higher diagnostic value than other abdominal obesity anthropometric indicators for metabolic *** the cut-off points are still not *** study was aimed to explore the optimal cut-off point of WHtR in Chinese population and identify the association between WHtR and cluster of metabolic risk *** total,13379 Han adults(7553 men and 5726 women)from over 40 institutions who took physical examination in Xuanwu Hospital of Capital Medical University between January 2014 and January 2015 were involved in this cross-sectional *** with two or more components of metabolic syndrome(MetS)were considered to have multiple risk *** cut-off points of WHtR for cluster of metabolic risk factors were analyzed by receiver operating characteristic(ROC)curve *** optimal cut-off points of WHtR were 0.51 for men and 0.49 for *** with elevated WHtR had higher levels of metabolic risk *** the prevalence of individual and clusters of 5 risk factors were all higher among WHtR-defined abdominal obesity people than in normal *** optimal cut-off points of WHtR were 0.51 for men and 0.49 for *** conclusion,people with elevated *** susceptible to cluster of metabolic risk factors.

关键词： waist-to-height ratio abdominal obesity metabolism metabolic syndrome

Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu si wang Weiqi Zhang Jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

Challenges in the management of visual and tactile hallucinations in elderly people

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World Journal of Psychiatry 2025年第1期15卷 185-188页

作者： si-Sheng Huang Division of Geriatric Psychiatry Department of PsychiatryChanghua Christian HospitalChanghua 500Taiwan Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402Taiwan

This letter provides a concise review of the pertinent literature on visual and tactile hallucinations in elderly *** discussion addresses differential diagnoses and potential underlying mechanisms,as well as the psychopathology associated with tactile hallucinations,and emphasizes the necessity for invest-igation into the possibility of coexisting delusional infestation(parasitosis).These symptoms frequently manifest in patients with primary psychotic disorders,organic mental disorders,and substance use *** proposed pathophy-siological mechanisms may involve dopaminergic imbalances and dysfunction of the striatal dopamine transporter.

关键词： Delusional infestation Dementia Haptic hallucination Scratching behavior Tactile hallucination Visual hallucination Alzheimer’s disease

High Fe‑Loading single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： si Chen Fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli si Naijia Xue Yi Liu Ran Zheng Ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

科学数据伦理治理:政策框架与路径——以英国为例

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现代情报 2025年第1期45卷 112-123,134页

作者：刘先瑞司莉武汉大学信息管理学院湖北武汉430072

[目的/意义]完善科学数据伦理治理有助于规范科学数据收集、共享和使用,发挥数据作为科研的关键资源与要素的功能,优化科学数据管理服务。[方法/过程]本研究基于扎根理论分析英国科学数据伦理政策,总结其政策框架与内容,并通过矩阵编码... 详细信息

[目的/意义]完善科学数据伦理治理有助于规范科学数据收集、共享和使用,发挥数据作为科研的关键资源与要素的功能,优化科学数据管理服务。[方法/过程]本研究基于扎根理论分析英国科学数据伦理政策,总结其政策框架与内容,并通过矩阵编码与社会网络分析方法揭示治理特征,提出我国优化科学数据伦理治理的建议。[结果/结论]研究发现,伦理政策框架包括治理环境、主体与策略3层面。伦理治理环境内容分为适用领域、适用主体、概念定义、问题分析与现有政策;伦理治理主体内容涉及治理主体界定与促进主体协作;伦理治理策略内容涵盖治理指导与各阶段治理措施。其治理特征有3维度:注重定义概念,明确分配主体权责与促进协作,全面厘定治理策略与加强伦理风险防控。据此提出4条治理路径:形成治理体系,规范治理理论,明确各方权责与协作方式,细化各阶段治理措施。

关键词：科学数据数据伦理数据治理政策分析英国

电针对急慢性痛转化大鼠背根神经节EP1-TRPV1通路的干预机制研究

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World Journal of Acupuncture-Moxibustion 2023年第1期33卷 34-43页

作者：孙海榉李晓宇王思思邵晓梅杜俊英方剑乔房军帆浙江省针灸神经病学研究重点实验室浙江中医药大学附属第三医院第三临床医学院中国杭州310053

Objective:To observe the law of changes in mechanical paw-withdrawal threshold(MPWT) and thermal paw-withdrawal latency(TPWL) on the modeled side of rats with pain transition(hyperalgesic priming[HP]),and the expression of prostaglandin E receptor 1(EP1) and transient receptor potential vanilloid type 1(TRPV1) in the dorsal root ganglion(DRG) of the affected side of *** observe the effects of electroacupuncture(EA) on the TPWL on the modeled side of rats with pain transition and regulation of EP1 and TRPV1 expression in ***:Part 1:Eighteen SD rats were randomly divided into control,sham HP,and HP groups,with 6rats in each *** modeling comprised two *** rats in the HP group were subcutaneously injected with 1% carrageenan(100 μL) into the left hind paw in the first injection(those in the control and sham HP groups were injected with saline).The second injection was administered 8 days later by injecting prostaglandin E2(PGE2)(100 ng/25 μL) into the dorsum of the paw(the rats in the control group were administered with saline and those in the sham HP group PGE2),thereby developing a pain transition *** and MPWT were measured before rat modeling,4 h,and 1,2,3,and 7 days after the first injection,and 1,4,24,and 48 h after the second injection(8 days after the first injection).The expression rates of EP1-and TRPV1-positive cells in the affected DRG were measured by immunofluorescence(IF).Part 2:Eighteen SD rats were randomly divided into sham HP(6 rats),and HP groups(12rats),then the rats in HP group were randomly divided into HP(6 rats) and HP+EP1 antagonist(6 rats)groups for the detection of *** in the EP1 antagonist group were injected with EP1 antagonist5 min before PGE2 *** expression rate of TRPV1-positive cells in the affected DRG 48 h after PGE2 injection was detected using the IF *** 3:Twenty-four SD rats were randomly divided into sham HP(6 rats),and HP groups(18 rats),then the rats in HP group were ra

关键词： Electroacupuncture Pain EP1 TRPV1