检索结果-南通市图书馆

Perinatal stem cells: A promising cell resource for tissue engineering of craniofacial bone

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2015年第1期7卷 149-159页

作者： jia-Wen si Xu-Dong Wang Steve GF Shen Department of Oral and Craniomaxillofacial Science Shanghai Ninth People’s Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine

In facing the mounting clinical challenge and suboptimal techniques of craniofacial bone defects resulting from various conditions, such as congenital malformations, osteomyelitis, trauma and tumor resection, the ongoing research of regenerative medicine using stem cells and concurrent advancement in biotechnology have shifted the focus from surgical reconstruction to a novel stem cell-based tissue engineering strategy for customized and functional craniofacial bone regeneration. Given the unique ontogenetical and cell biological properties of perinatal stem cells, emerging evidence has suggested these extraembryonic tissue-derived stem cells to be a promising cell source for extensive use in regenerative medicine and tissue engineering. In this review, we summarize the current achievements and obstacles in stem cell-based craniofacial bone regeneration and subsequently we address the characteristics of various types of perinatal stem cells and their novel application in tissue engineering of craniofacial bone. We propose the promising feasibility and scope of perinatal stem cell-based craniofacial bone tissue engineering for future clinical application.

关键词： Craniofacial bone regeneration Bone tissueengineering Extraembryonic tissue Perinatal stem cells

Migration regularities of impurities C,O,Fe,Co and Ni and effect of crystal transition on C,O and Fe in purification of metal La by solid-state electrotransport

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2021年第10期40卷 2985-2992页

作者： jia-Min Zhong De-Hong Chen si-Ming Pang Zong-An Li Lin Zhou Zhi-Qiang Wang National Engineering Research Center for Rare Earth Materials Grirem Advanced Materials Co.Ltd.Beijing 100088China

Migration regularities of impurities C,O,Fe,Co and Ni and the effect of crystal transition on C,O and Fe in purification of metal La by solid-state electrotransport(SSE)were *** impurity migration direction,removal extent and difficulty were intuitively judged by impurity residual rate distribution *** is indicated that major impurities Fe,Co,Ni,C and O in metal La are found to significantly migrate to anode and migration effects are much better with the increase in temperature and prolongation of time in purification of La by *** Fe,Co and Ni in La may be fast diffusion elements,which are very extreme to be removed,and removal difficulty is in the order of Fehe residual rates of impurity Fe,Co,Ni,O and C are 0.25%,10.10%,40.04%,64.00%and 70.04%,*** crystal transition of La,transformed from fcc crystal to bcc crystal,has significant effect on migration of interstitial impurities,and removal effect of interstitial impurities C and O can be significantly improved when purification was performed above crystal transition temperature of 865℃of ***,there is little effect on *** La was migrated at 880℃for 100 h,residual rates of impurities C and O are,respectively,19.90%and 32.67%lower than those at 820℃for 100 h,while that of Fe is lower than0.25%in both ***,more pure metal La can be obtained through further increasing temperature,especially above crystal transition temperature of 865℃of La.

关键词： Solid-state electrotransport Puriﬁcation Lanthanum Impurity distribution Residual rate Crystal transition

Etoposide Induces Mitochondria-Associated Apoptotic Cell Death in Human Gastric Carcinoma Cells

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2008年第5期24卷 597-602页

作者： LI Jing-hua CheN Yue WANG jia-si KONG Wei JIN Ying-hua Key Laboratory for Molecular Enzymology and Engineering Ministry of Education College of Life Science School of Public health Jilin University Changchun 130012 P R. China

Recent observations indicate that the resistance of apoptosis is an important process of tumor metastasis and metastases are the cause of 90% of human cancer death. Etoposide, a semisynthetic derivative of the podophyllotoxins, is a clinically used anti-cancer reagent, but the effects of it on metastatic gastric carcinoma cells are totally unknown. In this study, etoposide induced apoptotic cell death in human gastric adenocarcinoma cell line SGC-7901, derived from metastatic lymph nodes, as evidenced by the analysis of DNA fragmentation, apoptotic body formation, caspase activation, and apoptosis specific changes in cell morphology is demonstrated. The depolarization of mitochondrial membrane and the release of cytochrome c were most early events in etoposide treated SGC-7901 cells, and were followed by caspase-3 activation and PARP cleavage. Caspase-8 activation was not detected under the same condition. Thus, it was proposed that etoposide induces caspase-associated apoptotic cell death in human metastatic gastric carcinoma, which is initiated by mitochondrial cytochrome c release.

关键词： Apoptosis Caspase Cytochrome c Etoposide SGC-7901 cells

Mesh repair of sacrococcygeal hernia via a combined laparoscopic and sacrococcygeal approach: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第2期8卷 362-369页

作者： Yuan-Qiang Dong Li-jia Liu Zan Fu si-Meng Chen Department of General Surgery The First Affiliated Hospital of Nanjing Medical University

BACKGROUND Sacrococcygeal hernia is a very rare condition that is usually secondary to sacrococcygectomy, and its ideal treatment regimen is unclear. herein, we report a case of sacrococcygeal hernia occurring in a patient who had no history of sacrococcygeal operation, present the operative procedures of mesh repair via a combined laparoscopic and sacrococcygeal approach that has not been described,and discuss our experience in diagnosis and treatment with a review of the *** SUMMARY A 54-year-old woman who chiefly complained of a 10-year history of a reversible bulge in her right sacrococcygeal region was admitted to our hospital. The physical examination revealed a bulge in the right sacrococcygeal region upon standing, which disappeared in the prone position but relapsed when performing the Valsalva manoeuvre. Computed tomography displayed an abnormality in the structure of the tissues between the midline of the sacrococcygeal region and the right gluteus muscle. The patient was diagnosed with sacrococcygeal hernia and received hernia repair with mesh through a combined laparoscopic and sacrococcygeal approach. On laparoscopy, the rectum was dissected posterolaterally, and a defect was identified in the right anterior sacrococcygeal region through which part of the rectum protruded. This was followed by the placement of a self-gripping polyester mesh via a sacrococcygeal approach. There were no postoperative complications. The patient was discharged on postoperative day 7 and was followed for more than 6 mo with no *** Laparoscopic mesh repair is recommended as a priority of surgical options for sacrococcygeal hernias, while choosing a self-gripping mesh can help avoid the risk of presacral vessel injury by reducing suture fixation.

关键词： Sacrococcygeal region hernia Mesh repair Surgical approach Laparoscopy Case report

Combination therapy with toripalimab and anlotinib in advanced esophageal squamous cell carcinoma:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第27期11卷 6579-6586页

作者： si-Cong Chen Dong-heng Ma jia-jian Zhong hepatobiliary and Pancreatic Surgery Huazhong University of Science and Technology Union Shenzhen HospitalShenzhen 518052Guangdong ProvinceChina

BACKGROUND Toripalimab and anlotinib have shown good response in esophageal cancer,with high objective response rate and progression free ***,they have been approved as second-line or above-line therapy for advanced or unresectable esophageal *** of these two drugs may have synergistic effects,but evidence of which is *** SUMMARY here,we report on a 73-year-old male,newly diagnosed with advanced esophageal squamous cell carcinoma(ESCC),who received a combination of toripalimab and *** response was achieved after treatment for 3 mo and remission was maintained up to 14 *** The combination therapy of toripalimab and anlotinib is a promising treatment for unresectable ESCC and related clinical trials are warranted.

关键词： Esophageal squamous cell carcinoma Toripalimab Anlotinib Complete response Case report

PET imaging of cerebral metabolic change in tinnitususing ^(18)F-FDG

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2000年第4期11卷 247-252页

作者： TIAN jia-he, WANG Hong-Tian, YIN Da-Yi, YAO Shu-Lin, SHAO Ming-Zhe, YANG Wei-Yan, jiaNG si-Chang (The PLA General Hospital, Beijing 100853) 解放军总医院北京 100853

Tinnitus is an auditory disorder hardly assessable by clinical technology. PET imaging of the brain in 13 cases with and 10 without tinnitus was undertaken at 40 min after injection of 280-440 MBq 18F-FDG. To ensure the quality of the PET study, all cases followed a normalized procedure with visual and auditory blockage. CT/MRI imaging and routine acoustic tests were carried out in all subjects. PET revealed that an increased uptake of 18F-FDG at left med-temporal lobe (primary auditory center, PAC) present exclusively in tinnitus, regardless the side of hearing hallucination. significant asymmetry was noted between left and right PAC, but not at other cortex area. While control cases showed no asymmetric uptake between two hemispheres. The abnormal PAC uptake did not respond to external pure sound stimulus, nor did it relate to the seventy of hearing loss assessed by acoustic tests. No anatomical or morphological alteration could be proven on CT/MRI. In conclusion, PET/18F-FDG objectively revealed an increased metabolic change at left PAC in tinnitus, which is of diagnostic value; and there is evidence suggesting tinnitus is most likely induced by a functional change in the brain.

关键词： PET ^18F-FDC 氟18 放射性核素标记正电子发射X线断层摄影术放射性核素显像耳鸣诊断

An Efficient Plant Regeneration System of Hydrangea bretschneideri Dipp via Stem Segments as Explants

在线全文

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2021年第2期90卷 595-604页

作者： si ran Wang jia Yan Bu er Ha Yu’e Bai Institute of Forest Tree Genetic Breeding Forestry CollegeInner Mongolia Agricultural UniversityHohhot010000China

Hydrangea bretschneideri Dipp is a highly popular ornamental plant for garden *** engineering technology has been successfully used in many plant species,but it is limited in *** we established an efficient regeneration system by using stem segments as explants for the first *** our study,the plant growth regulators(PGRs)were evaluated at the different regeneration processes,including axillary shoots regeneration and root *** found that the optimal concentration for axillary buds’induction was 2.0 mgL^(-1)6-BA and 0.5 mgL^(-1)1 IAA,its highest induction rate was 70%.Moreover,the highest axillary shoots proliferation coefficient was 10.7 on the Murashige and Skoog(MS)medium with 2.0 mgL^(-1)6-benzyladenine(BA),0.2 mgL^(-1)indole-3-butyric acid(IBA),and 1.0 mgL^(-1)gibberellin A3(GA3).The highest frequency of root induction was 80.0±0.06%by culturing the elongated shoots in 1/2 MS medium containing 0.1 mgL^(-1)*** summary,our study will provide an effective technology for large-scale propagation and important pathway for promoting the popularization and application of Hydrangea bretschneideri Dipp.

关键词： Hydrangea bretschneideri Dipp stem segments regeneration

Electromagnetic Ion Beam Instability in the Solar Corona

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第2期24卷 171-179页

作者： Wen Liu Jin-Song Zhao De-Jin Wu Huan-Yu jia si-Ming Liu School of Mechanics and Aeronautics Southwest Jiaotong UniversityChengdu 610000China School of Physical Science and Technology Southwest Jiaotong UniversityChengdu 610000China Key Laboratory of Planetary Sciences Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China

Remote-sensing measurements indicate that heavy ions in the corona undergo an anisotropic and mass-charge dependent energization.A popular explanation to this phenomenon is the damping of the Alfven/ion cyclotron *** this paper,we propose that the ion beam instability can be an important source of the Alfven/ion cyclotron waves,and we study the excitation of the ion beam instability in the corona at the heliocentric distance~3R_(⊙)and the corresponding energy transfer process therein ba sed on plasma kinetic *** results indicate that the existence of the motionless heavy ions inhibits the ion beam ***,the anisotropic beams of heavy ions promote the excitation of the ion beam ***,the existence ofαbeams can provide a second energy source for exciting beam ***,when both the proton beam and the a beam reach the instability excitation threshold,the proton beam driven instability excites ***,the excitation threshold of the Alfven/ion cyclotron instability driven by ion beam is of the local Alfven speed or even less in the corona.

关键词： plasmas-instabilities-waves-Sun corona

CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2020年第2期17卷 357-370页

作者： Ting Li si Wu Lei jia Wenfeng Cao Yuan Yao Gang Zhao Hui Li Department of Gastrointestinal Cancer Biology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Key Laboratory of Cancer Immunology and Biotherapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Pathology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China

Objective:The E3 ligase,CRL4,plays diverse roles in different cellular processes,such as DNA damage,transcriptional regulation,cell cycle progression,and cell *** previous study showed that CUL4A and CUL4B had a strong association with tobacco smoking risk in lung squamous cell carcinoma(SCC)and small cell lung carcinoma(SCLC).This study aimed to define the potential mechanism underlying the roles of CUL4A and CUL4B in the development of SCC and ***:We determined the role of CUL4A and CUL4B in the cell cycle and apoptosis of SCC and SCLC,and identified the key apoptosis-related gene involved in the oncogenic activity of CUL4B by Western blot,immunohistochemical staining,flow cytometry,and enzyme inhibition ***:We found that depletion of CUL4A and CUL4B reduced the proliferation of SCC and SCLC ***4Aknockdown but not CUL4Bknockdown arrested cells in Gl phase while upregulating P21 and cU L4Bknockdown promoted cell apoptosis through upregulation o f ***,CUL4B decreased FO X03A expression by activating the ERK signaling pathway and mediating FOXO3A degradation via the ubiquitin-proteasome ***:These results identified the function of E3 ligase CRL4 in regulating SCC and SCLC cell proliferation,which provides a potential strategy for cancer therapy by targeting FOXO3A and the E3 ligase,CRL4.

关键词： Squamous cell lung cancer small cell lung cancer CUL4A CUL4B P21 FOXO3A