Perinatal stem cells: A promising cell resource for tissue engineering of craniofacial bone
Perinatal stem cells: A promising cell resource for tissue engineering of craniofacial bone作者机构：Department of Oral and Craniomaxillofacial Science Shanghai Ninth People’s Hospital College of Stomatology Shanghai Jiao Tong University School of Medicine
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2015年第7卷第1期
页 面：149-159页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
基 金：National Natural Science Foundation of China,No.81271122 and No.81371122 Shanghai Leading Academic Discipline Project,No.S30206
主 题：Craniofacial bone regeneration Bone tissueengineering Extraembryonic tissue Perinatal stem cells
摘 要：In facing the mounting clinical challenge and suboptimal techniques of craniofacial bone defects resulting from various conditions, such as congenital malformations, osteomyelitis, trauma and tumor resection, the ongoing research of regenerative medicine using stem cells and concurrent advancement in biotechnology have shifted the focus from surgical reconstruction to a novel stem cell-based tissue engineering strategy for customized and functional craniofacial bone regeneration. Given the unique ontogenetical and cell biological properties of perinatal stem cells, emerging evidence has suggested these extraembryonic tissue-derived stem cells to be a promising cell source for extensive use in regenerative medicine and tissue engineering. In this review, we summarize the current achievements and obstacles in stem cell-based craniofacial bone regeneration and subsequently we address the characteristics of various types of perinatal stem cells and their novel application in tissue engineering of craniofacial bone. We propose the promising feasibility and scope of perinatal stem cell-based craniofacial bone tissue engineering for future clinical application.
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