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Clinical efficacy of the modified Helicobacter pylori eradication therapy for Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma:a meta analysis

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Chinese Medical Journal 2020年第11期133卷 1337-1346页

作者： Ya-Lin Xie Chun-Yan He si-qi wei Wen-Ju Guan Zheng Jiang departm ent of Gastroenterology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Medical UniversityChongqing 400016China Department of Oncology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Medical UniversityChongqing 400016China

Background::Helicobacter pylori(HP)has been considered to be one of the primary causes of gastric mucosa-associated lymphoid tissue(MALT)lymphoma since ***-grade gastric MALT lymphoma with HP is widely treated with HP eradication therapy,according to each specific clinical ***,several studies and guidelines indicate that the modified HP eradication therapy is also valid for HP-negative gastric MALT *** aim of this study was to perform a meta-analysis of the clinical efficacy of the modified HP eradication therapy for gastric MALT lymphoma without ***::We searched studies that reported the response rate of the modified HP eradication therapy regimen for gastric MALT lymphoma without HP by using PubMed,Medline,and Ebsco from January 1971 until February *** statistical analyses were carried out using R 3.5.3(Mathsoft Company,Cambridge,MA,USA).The pooled response rate was expressed as a *** heterogeneity test was performed using the I-squared(I2)***::A total of 14 studies were selected with a total of 148 patients with HP-negative gastric MALT *** overall pooled response rate was 0.38(95%confidence interval[CI]:0.29-0.47).The combined estimate is I2=57%(Psidered an optional therapy for patients with low-grade HP-negative gastric MALT ***,several limitations were revealed in the *** systematic reviews and research are required.

关键词： Therapy Helicobacter pylori Gastric MALT lymphoma Meta-analysis

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磨料水射流冲击孔隙岩体的SPH模拟研究

岩土工程学报 2022年第4期44卷 731-739,I0007,I0008页

作者：周新超马小晶廖翔云齐思维李宏煜新疆大学电气工程学院新疆乌鲁木齐830047

针对磨料水射流冲击含孔隙岩体的动态过程,依据光滑粒子流体动力学(smoothed particle hydrodynamics,SPH)方法,将含磨料颗粒的水射流和具有孔隙的岩体离散为一系列的粒子,分别引入NULL型和H-J-C型本构关系描述磨料水射流和岩体的力学特... 详细信息

针对磨料水射流冲击含孔隙岩体的动态过程,依据光滑粒子流体动力学(smoothed particle hydrodynamics,SPH)方法,将含磨料颗粒的水射流和具有孔隙的岩体离散为一系列的粒子,分别引入NULL型和H-J-C型本构关系描述磨料水射流和岩体的力学特性,建立了磨料水射流冲击孔隙岩体模型,通过模拟射流冲击岩体问题,并与已有研究结果进行对比验证了所建模型的有效性,在此基础上,着重对磨料水射流冲击含孔隙岩体的动态破损过程进行模拟研究,分析了岩体的孔隙特性和射流参数对岩体破损效果的影响。计算结果表明,孔隙的尺寸和分布情况会影响岩体破损坑的形状,孔隙度对岩体的破损程度影响较大,其他因素对岩体的破损效果具有不同程度的影响。研究结果可为工程中提高射流破岩效率提供理论依据。

关键词：光滑粒子流体动力学磨料水射流离散孔隙构建填充物随机分布位置

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong Yang Haochen Shen Xiaoming Xiao Zhichao Li qi Zhou wei Yang Bin Jiang Yongli Sun Luhong Zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms

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World Journal of Psychiatry 2025年第1期15卷 63-71页

作者： qi-Hui Jiang wei-Dong Gong Department of Endocrinology and Metabolism Hengyang Central HospitalHengyang 421000Hunan ProvinceChina Breast Tumor Surgical Outpatient Hengyang Central HospitalHengyang 421000Hunan ProvinceChina

BACKGROUND The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia,especially thyroid *** To study the relationship between triiodothyronine(T3),thyroxine(T4),free T3(FT3),free T4(FT4),thyroid stimulating hormone(TSH)and *** In this study,100 schizophrenia patients were selected from our hospital between April 2022 and April *** clinical data were analyzed *** on the Positive and Negative Syndrome Scale(PANSS)score,patients were divided into mild(1-3 points,n=39),moderate(4 points,n=45),and severe groups(5-7 points,n=16).Additionally,55 healthy individuals served as a control *** blood samples were collected to measure T3,T4,FT3,FT4,TSH,and cortisol concentrations,analyzing their relationship with PANSS *** The serum levels of T3,FT3,FT4,TSH and cortisol in the schizophrenia group were lower than those in the control group(Psitively correlated with the PANSS score,while T3 and T4 were negatively correlated with the PANSS score(Psis of *** results showed that decreased T3 level,decreased T4 level,decreased TSH level and increased cortisol level may be independent risk factors for *** Thyroid hormone levels are associated with the severity of schizophrenia symptoms,which can provide new solutions for the diagnosis and treatment of schizophrenia.

关键词： Thyroid hormone Schizophrenia Symptom severity Positive and Negative Syndrome Scale score Cortisol

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混凝剂投量的RBF网络预测控制系统

系统仿真学报 2009年第17期21卷 5540-5543,5548页

作者：王军栋刘思远齐维贵哈尔滨工业大学电气工程及其自动化学院哈尔滨150001

净水厂水处理工艺中的混凝投药过程是一个大滞后、非线性的复杂系统。针对其特点并结合国内目前投药控制的现状,提出了一种带有前馈补偿的RBF神经网络预测控制新方法。该方法利用人工神经网络建立投药量的预测模型,然后用出水浊度与设... 详细信息

净水厂水处理工艺中的混凝投药过程是一个大滞后、非线性的复杂系统。针对其特点并结合国内目前投药控制的现状,提出了一种带有前馈补偿的RBF神经网络预测控制新方法。该方法利用人工神经网络建立投药量的预测模型,然后用出水浊度与设定值之间的预测偏差构成闭环控制系统。通过实时的在线滚动优化,实现了投药量的最优投加。经过仿真试验表明,出水浊度能够比较准确地跟踪设定值的变化,同时该方法所需混凝剂量减少,控制效果明显。

关键词：混凝投药浊度 RBF网络预测控制

粒子群算法在GMR-13G系统EVM求解中的应用研究

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通信技术 2017年第1期50卷 13-17页

作者：吕宗琦司伟立重庆邮电大学通信与信息工程学院重庆400065 北京中科晶上科技有限公司北京100190

针对GMR-1 3G中EVM(Error Vector Magnitude)算法在π/4-CQPSK调制后产生了误差参数关联性高且求解准确性低的问题,提出了应用粒子群的EVM算法。该算法通过粒子群算法同时估计多个参数,利用误差估计结果修正接收信号,从而得到参考信号,... 详细信息

针对GMR-1 3G中EVM(Error Vector Magnitude)算法在π/4-CQPSK调制后产生了误差参数关联性高且求解准确性低的问题,提出了应用粒子群的EVM算法。该算法通过粒子群算法同时估计多个参数,利用误差估计结果修正接收信号,从而得到参考信号,进而计算EVM结果。仿真结果表明,参考信号近似理想信号,该算法与R&S频谱分析仪FQS26相比,EVM差值为0.31%,EVM不确定度为0.022%。可见,该EVM算法可以应用于GMR-1 3G系统,并能够精确测量EVM。

关键词：粒子群 GMR-13G EVM 调制精度

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu wei Huang Jiayi Wen Xin Xiong Ting Xu qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan qi wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

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Nano Research 2025年第1期18卷 443-454页

作者： wei Wang Zi-qing Chen Yong-qi Li Yu-Long Wang Mei-Chen Liu Yun-Bo Ruan Yang Zhang Shu-Juan Liu qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric