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Prostate-specific membrane antigen expression in hepatocellular carcinoma,cholangiocarcinoma,and liver cirrhosis

World Journal of Gastroenterology 2020年第48期26卷 7664-7678页

作者： Li-Xing Chen si-juan zou Dan Li Jian-Yuan Zhou Zhao-Ting Cheng Jun Zhao Yuan-Li Zhu Dong Kuang Xiao-Hua Zhu Department of Nuclear Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina School of Basic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Primary liver cancer includes three subtypes:Hepatocellular carcinoma(HCC),intrahepatic cholangiocarcinoma(CCA),and combined hepatocellular *** with primary liver cancer experienced poor prognosis and high mortality,so early detection of liver cancer and improved management of metastases are both key strategies to reduce the death toll from liver ***-specific membrane antigen(PSMA)expression in the tumor-associated neovasculature of nonprostate malignancies including liver cancer has been reported recently,but conclusive evidence of PSMA expression based on the pathological type of liver cancer remains *** To study the expression of PSMA in HCC,CCA,and liver *** A total of 446 formalin-fixed paraffin-embedded(FFPE)liver tumor and liver cirrhosis tissue samples were obtained retrospectively from the Pathology Department of Tongji *** was used to detect PSMA expression in these 446 FFPE liver biopsy specimens(213 HCC,203 CCA,and 30 liver cirrhosis).The tumor compartment and the associated neovascular endothelium were separately *** expression was examined by two certified pathologists,and the final results were presented in a 4-point scoring system(0-3 points).Correlation between PSMA expression and clinicopathological information was also *** PSMA was expressed primarily in the neovascular endothelium associated with *** positive rate of PSMA staining in HCC was significantly higher than that in CCA(86.8%vs 79.3%;P=0.001)but was only 6.6%in liver cirrhosis(P=0.000).HCC cases had more 3-score PSMA staining than CCA had(89/213,41.8%vs 35/203,17.2%;P=0.001).PSMA expression correlated positively with the stage and grade of HCC and *** both liver cancer subtypes,there were more PSMA+cases in stages III–V diseases than in stages I and *** staining intensity of PSMA was more frequently observed in liver cancers at high grade and advanced *** was

关键词： Prostate-specific membrane antigen Hepatocellular carcinoma Cholangiocarcinoma Liver cirrhosis Neovasculature Immunohistochemistry

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Creatine Pyruvate Enhances Lipolysis and Protein Synthesis in Broiler Chicken

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Agricultural Sciences in China 2011年第12期10卷 1977-1985页

作者： CHEN juan MA Hai-tian WANG Man KONG Yi-li zou si-xiang Key Laboratory of Animal Physiology ＆ Biochemistry College of Veterinary Medicine Nanjing Agricultural University Nanjing 210095 P.R. China

To assess the effects ofcreatine pyruvate （Cr-Pyr） on lipid and protein metabolism in broiler chickens, a total of 400 1-day-old male birds （Aconred） were randomly allocated to four groups, with each group replicating four times and each replicate involving 25 birds. The broilers were provided with a commercial diet supplemented with Cr-Pyr at 0, 1, 5, or 10% of the diet, respectively, for a period of 3 wk ad libitum （from 22 to 42 d）. In the present study, body weight （BW） and average daily gain （ADG） of broilers decreased in 10% Cr-Pyr group （P〈0.01）, whereas the relative leg and pectoral muscle weights were significantly higher than they were in the control group （P〈0.05）. 5 or 10% Cr-Pyr of diets decreased the abdominal fat rate （AFR, abdominal fat/live weight） of the broilers. The serum or hepatic triglyceride （TG） concentrations were significantly lower in the 5 and 10% groups （P〈0.01）. In contrast, Cr-Pyr caused a marked increase in the serum nonesterified fatty acid （NEFA）, high-density lipoprotein cholesterol （HDL-C） and creatine kinase （CK） concentrations （P〈0.01）. Supplementation with Cr-Pyr （5 and 10%） in the diet also increased glucagons （GLU）, insulin （INS） or leptin （LEP） contents （P〈0.01）. The expression of hepatic peroxisomal proliferators-activated receptor α （PPAR-α） and carnitine palmitoyl transferase-I （CPT-I）, muscle insulin-like growth factor I （IGF-I） were significantly elevated and myostatin mRNA level was reduced in the 5 and 10% groups （P〈0.05）. It was found that supplementation with 5% Cr-Pyr improves both lipid and protein metabolism by regulating various metabolic parameters of broilers, while not adversely affects growth performance in broiler chickens.

关键词： creatine pyruvate (Cr-Pyr) lipid metabolism protein metabolism liver muscle broiler chickens

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Is combined lipid-regulating therapy safe and feasible for the very old patients with mixed dyslipidemia?

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Journal of Geriatric Cardiology 2013年第4期10卷 349-354页

作者： Xiao zou Quan-Jin si The First Department of the Geriatric Cardiology Chinese PLA General Hospital NO.28 Fuxing Road Beijing 100853 China

OBJECTIVES: To detect the efficacy and safety of combined lipid-regulating therapies in the very old patients with mixed dyslipidemia and determine an appropriate therapy for them。 METHODS: Four hundred and fifty patients aged over 75 with mixed dyslipidemia were divided into five groups according to different combination therapies。 Lipid levels and drug related adverse events were tested during the study。 RESULTS: Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were reduced in every group compared to baseline: statin + ezetimibe: -30.0% and -55.5%; statin + policosanol: -31.1% and -51.2%; statin + fibrates: -23.7% and -44.6%; statin + niacin: -25.2% and -43.0%; and niacin + fibrates: -11。3% and -23.5%。 The target achievement rates of LDL-C all exceeded 50%, except in niacin + fibrates (42.0%); statin + ezetimibe: 57.0%; statin + policosanol: 56.0%; statin + niacin: 52.0%; and statin + fibrates: 50.0%。 However, overall, the niacin + fibrates group was the most effective in decreasing triglyceride (TG) and increasing high-density lipoprotein cholesterol (HDL-C) as follows: niacin + fibrates: -39.3% and 28.6%; statin + fibrates: -29.3% and 18.4%; statin + niacin: -18.5% and 16.7%; statin + ezetimibe: -17.1% and 7.1%; and statin + policosanol: -15.6% and 9.5%。 The achievement rates of TG and HDL-C levels in niacin + fibrates (58.0% and 39.0%) were better than the other four groups: statin + niacin (34.0% and 34.0%), statin + fibrates (43.0% and 28.0%), statin + policosanol (30.0% and 24.0%) and statin + ezetimibe (28.0% and 25.0%)。 Patients in all five groups experiencing drug adverse events were only 2% and no severe adverse events occurred。 CONCLUsiONS: Statin + ezetimibe was the most effective group in lowering TC and LDL-C levels, while niacin + fibrates was the most effective in decreasing TG and increasing HDL-C levels。 The commonly used combined lipid-regulating therapies with common dosages in this study were all quite safe and fea

关键词： Combination therapies Elderly patients Mixed dyslipidemia Safety

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Impact of FY-3A MWTS radiances on prediction in GRAPES with comparison of two quality control schemes

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Frontiers of Earth Science 2014年第2期8卷 251-263页

作者： juan LI Xiaolei zou National Meteorological Center China Meteorological Administration Beijing 100081 China Department of Earth Ocean and Atmospheric Sciences Florida State University Tallahassee 32306 USA

The impact of Microwave Temperature Sounder （MWTS） radiances on the prediction of the Chinese Numerical Weather prediction （NWP） system-GRAPES （Global and Regional Assimilation and PrEdiction System） with comparison of two Quality Control （QC） schemes was researched. The main differences between the two schemes are cloud detection, O-B （brightness temperature difference between observation and model simulation） check and thinning. To evaluate the impact of the two QC schemes on GRAPES, a typhoon case study and cycle experiments were conducted. In the typhoon case study, two experiments were conducted using both the new and old QC schemes. The results show that outliers are removed in the new QC while they exist in the old QC. The analysis and the model forecast are subsequently generated after assimilating data from the two QC schemes. The model-predicted steering flows more southward with the new QC scheme, and as a result, the forecast track in the experiments is more southward, i.e., closer to the best track than the old scheme. In addition to the case study, four impact cycle experiments were conducted for 25-day periods. The results show that the new QC scheme removed nearly all the biases whereas the old scheme could not. Furthermore, the mean and standard deviation of analysis increments with the new scheme is much smaller than those of O-B. In contrast, the old scheme values are either slightly smaller or the same. Verifications indicate that forecast skill is improved after applying the new scheme. The largest improvements are found in the Southern Hemisphere. According to the results above, MWTS with the new QC scheme can improve the GRAPES forecast.

关键词： FY-3 MWTS typhoon GRAPES

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Streaming Algorithms for Non-Submodular Maximizationon the Integer Lattice

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Tsinghua Science and Technology 2023年第5期28卷 888-895页

作者： Jingjing Tan Yue Sun Yicheng Xu juan zou School of Mathematics and Information Science Weifang UniversityWeifang 261061China Beijing Institute for Scientific and Engineering Computing Beijing University of TechnologyBeijing 100124China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China School of Mathematical Sciences Qufu Normal UniversityQufu 273165China

Many practical problems emphasize the importance of not only knowing whether an element is selectedbut also deciding to what extent it is selected,which imposes a challenge on submodule *** this study,we consider the monotone,nondecreasing,and non-submodular maximization on the integer lattice with a *** first design a two-pass streaming algorithm by refining the estimation interval of the optimal *** element,the algorithm not only decides whether to save the element but also gives the number of ***,we introduce the binary search as a subroutine to reduce the time ***,we obtain a one-passstreaming algorithm by dynamically updating the estimation interval of optimal ***,we improve the memorycomplexity of this algorithm.

关键词： integer lattice non-submodular streaming algorithm cardinality constraint

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Towards a New Paradigm for Brain-inspired Computer Vision

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Machine Intelligence Research 2022年第5期19卷 412-424页

作者： Xiao-Long zou Tie-Jun Huang si Wu Beijing Academy of Artificial Intelligence Beijing 100084China School of Psychology and Cognitive Sciences IDG/McGovern Institute for Brain ResearchCenter for Quantitative BiologyPKU-Tsinghua Center for Life SciencesPeking UniversityBeijing 100084China National Engineering Research Center of Visual Technology School of Computer SciencePeking UniversityBeijing 100871China Institute for Artificial Intelligence Peking UniversityBeijing 100871China

Brain-inspired computer vision aims to learn from biological systems to develop advanced image processing ***,its progress so far is not *** recognize that a main obstacle comes from that the current paradigm for brain-inspired computer vision has not captured the fundamental nature of biological vision,i.e.,the biological vision is targeted for processing spatio-temporal ***,a new paradigm for developing brain-inspired computer vision is emerging,which emphasizes on the spatio-temporal nature of visual signals and the brain-inspired models for processing this type of *** this paper,we review some recent primary works towards this new paradigm,including the development of spike cameras which acquire spiking signals directly from visual scenes,and the development of computational models learned from neural systems that are specialized to process spatio-temporal patterns,including models for object detection,tracking,and *** also discuss about the future directions to improve the paradigm.

关键词： Brain-inspired computer vision spatio-temporal patterns object detection object tracking object recognition

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锆基金属有机框架捕获黄连中的生物碱类药物活性成分

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分析测试学报 2025年第1期44卷 188-194页

作者：司甜甜赵薇王慧张红玉刘小烨容蓉冯娟娟山东中医药大学药学院山东济南250355 济南大学化学化工学院山东济南250022

采用溶剂热法制备了锆基MOF-808,利用其结构优势实现了中药黄连中生物碱类药物活性成分的富集与捕获,并结合其结构特点探讨了其协同低共熔溶剂捕获生物碱类活性成分过程中的相互作用。通过优化孵育捕获等条件,对黄连粗提液中药根碱的回... 详细信息

采用溶剂热法制备了锆基MOF-808,利用其结构优势实现了中药黄连中生物碱类药物活性成分的富集与捕获,并结合其结构特点探讨了其协同低共熔溶剂捕获生物碱类活性成分过程中的相互作用。通过优化孵育捕获等条件,对黄连粗提液中药根碱的回收率达到85.78%,结合高效液相色谱技术建立了检测黄连粗提液中5种生物碱类活性成分的方法。方法的线性范围为0.1~300μg·L^(-1),检出限为0.02~0.05μg·L^(-1),相对标准偏差为0.40%~4.7%,加标回收率达到69.7%~128%。该研究实现了中药黄连中生物碱类活性成分的高效、快速富集与捕获,为MOFs材料在选择性捕获与富集中药有效成分等领域的研究提供了新思路。

关键词：金属有机框架选择性富集色谱分离生物碱活性成分黄连

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Detection of radio-frequency interference signals from AMSR-E data over the United States with snow cover

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Frontiers of Earth Science 2016年第2期10卷 195-204页

作者： Chengcheng FENG Xiaolei zou juan ZHAO Center of Data Assimilation for Research and Application Nanjing University of Information Science & Technology Nanjing 210044 China Earth System Science Interdisciplinary Center University of Maryland College Park MD 20740-3823 USA China Meteorological Administration Training Centre Beijing 100081 China

Radio Frequency Interference （RFI） causes severe contamination to passive and active microwave sensing observations and corresponding retrieval products. RFI signals should be detected and filtered before applying the microwave data to retrieval and data assimilation. It is difficult to detect RFI over land surfaces covered by snow because of the scattering effect of snow surface. The double principal component analysis （DPCA） method is adopted in this study, and its ability in identifying RFI signals in AMSR-E data over snow covered regions is investigated. Results show that the DPCA method can detect RFI signals effectively in spite of the impact of snow scattering, and the detected RFI signals persistent over time. Compared to other methods, such as PCA and normalized PCA, DPCA is more robust and suitable for operational application.

关键词： Radio Frequency Interference (RFI) AMSR-E double principal component analysis (DPCA)

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Novel high-resolution DOA estimation using subspace projection method

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The Journal of China Universities of Posts and Telecommunications 2012年第4期19卷 110-116页

作者： si Wei-jian LAN Xiao-yu zou Yan College of Information and Communication Engineering Harbin Engineering University Harbin 150001 China No. 91404 Army Qinhuangdao 066000 China

The performance of multiple signal classification （MUsiC） algorithm with regard to solving closely spaced direction of arrivals （DOAs） depends strongly upon the signal-to-noise ratio （SNR） and snapshots. In order to solve this problem, a method by reconstructing the spatial spectrum function with both noise subspace and signal subspace is presented in this paper. The key idea is to apply the full information contained in covariance matrix and change the projection weights of steering vector on the noise and signal subspace by their revised eigenvalues, respectively. Comparing with the MUsiC algorithm, it does not increase any computational complexity either, and remarkably, it has the advantages of simultaneously reducing noise and keeping the high-resolution ability under low SNR and small sample sized scenarios. simulation and experiment results are included to demonstrate the superior performance of the proposed algorithm.

关键词： direction &arrival (DOA) multiple signal classification low SNR resolution subspace projection

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Crystallographic Characteristic of Intermetallic Compounds in Al-si-Mg Casting Alloys Using Electron Backscatter Diffraction

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Chinese Journal of Mechanical Engineering 2010年第3期23卷 305-311页

作者： zou Yongzhi XU Zhengbing HE juan ZENG Jianmin State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi＇ an 710072 China Key Laboratory of Nonferrous Materials and New Processing Technology of Ministry of Education Guangxi University Nanning 530004 China

The Al-si-Mg alloy which can be strengthened by heat treatment is widely applied to the key components of aerospace and aeronautics. Iron-rich intermetallic compounds are well known to be strongly influential on mechanical properties in Al-si-Mg alloys. But intermetallic compounds in cast Al-si-Mg alloy intermetallics are often misidentified in previous metallurgical studies. It was described as many different compounds, such as AlFesi, Al8Fe2si, Al5（Fe, Mn）3si2 and so on. For the purpose of solving this problem, the intermetallic compounds in cast Al-si alloys containing 0.5% Mg were investigated in this study. The iron-rich compounds in Al-si-Mg casting alloys were characterized by optical microscope（OM）, scanning electron microscope（SEM）, energy dispersive X-ray spectrometer（EDS）, electron backscatter diffraction（EBSD） and X-ray powder diffraction（XRD）. The electron backscatter diffraction patterns were used to assess the crystallographic characteristics of intermetallic compounds. The compound which contains Fe/Mg-rich particles with coarse morphologies was Al8FeMg3si6 in the alloy by using EBSD. The compound belongs to hexagonal system, space group P6_2m, with the lattice parameter a=0.662 nm, c=0.792 nm. The β-phase is indexed as tetragonal Al3Fesi2, space group I4/mcm, a=0.607 nm and c=0.950 nm. The XRD data indicate that Al8FeMg3si6 and Al3Fesi2 are present in the microstructure of Al-7si-Mg alloy, which confirms the identification result of EBSD. The present study identified the iron-rich compound in Al-si-Mg alloy, which provides a reliable method to identify the intermetallic compounds in short time in Al-si-Mg alloy. Study results are helpful for identification of complex compounds in alloys.

关键词： Al-si-Mg alloys intermetallic compound electron backscatter diffraction(EBSD) X-ray powder diffraction(XRD)

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