Prostate-specific membrane antigen expression in hepatocellular carcinoma,cholangiocarcinoma,and liver cirrhosis

作     者：Li-Xing Chen Si-Juan Zou Dan Li Jian-Yuan Zhou Zhao-Ting Cheng Jun Zhao Yuan-Li Zhu Dong Kuang Xiao-Hua Zhu 

作者机构：Department of Nuclear MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of PathologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第48期

页      面：7664-7678页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Natural Science Foundation of China,No.81873903,No.81671718,No.91959119 and No.81271600 Natural Science Foundation of Hubei Province in China,No.2016CFB687 

主　　题：Prostate-specific membrane antigen Hepatocellular carcinoma Cholangiocarcinoma Liver cirrhosis Neovasculature Immunohistochemistry 

摘      要：BACKGROUND Primary liver cancer includes three subtypes:Hepatocellular carcinoma(HCC),intrahepatic cholangiocarcinoma(CCA),and combined hepatocellular *** with primary liver cancer experienced poor prognosis and high mortality,so early detection of liver cancer and improved management of metastases are both key strategies to reduce the death toll from liver ***-specific membrane antigen(PSMA)expression in the tumor-associated neovasculature of nonprostate malignancies including liver cancer has been reported recently,but conclusive evidence of PSMA expression based on the pathological type of liver cancer remains *** To study the expression of PSMA in HCC,CCA,and liver *** A total of 446 formalin-fixed paraffin-embedded(FFPE)liver tumor and liver cirrhosis tissue samples were obtained retrospectively from the Pathology Department of Tongji *** was used to detect PSMA expression in these 446 FFPE liver biopsy specimens(213 HCC,203 CCA,and 30 liver cirrhosis).The tumor compartment and the associated neovascular endothelium were separately *** expression was examined by two certified pathologists,and the final results were presented in a 4-point scoring system(0-3 points).Correlation between PSMA expression and clinicopathological information was also *** PSMA was expressed primarily in the neovascular endothelium associated with *** positive rate of PSMA staining in HCC was significantly higher than that in CCA(86.8%vs 79.3%;P=0.001)but was only 6.6%in liver cirrhosis(P=0.000).HCC cases had more 3-score PSMA staining than CCA had(89/213,41.8%vs 35/203,17.2%;P=0.001).PSMA expression correlated positively with the stage and grade of HCC and *** both liver cancer subtypes,there were more PSMA+cases in stages III–V diseases than in stages I and *** staining intensity of PSMA was more frequently observed in liver cancers at high grade and advanced *** was