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The Biofunctions of Phytochemicals and Their Applications in Farm Animals： The Nrf2/Keap1 System as a Target

Engineering 2017年第5期3卷 738-752页

作者： si qin De-Xing Hou Key Laboratory for Food Science and Biotechnology of Hunan Province College of Food Science and Technology Hunan Agricultural University Changsha 410128 China Hun an Co-Innovation Center for Utilization of Botanical Functional Ingredients Hunan Agricultural University Changsha 410128 China The United Graduate School of Agricultural Sdences Faculty of Agriculture Kagoshima University Korimoto Kagoshima 890-0065 Japan

Reactive oxygen species （ROS） can be caused by mechanical, thermal, infectious, and chemical stimuli, and their negative effects on the health of humans and other animals are of considerable concern. The nuclear factor （erythroid-derived 2）-like 2/Kelch-like ECH-associated protein 1 （Nrf2/Keap1） system plays a major role in maintaining the balance between the production and elimination of ROS via the regulation of a series of detoxifying and antioxidant enzyme gene expressions by means of the antioxidant response element （ARE）. Dietary phytochemicals, which are generally found in vegetables, fruits, grains, and herbs, have been reported to have health benefits and to improve the growth performance and meat quality of farm animals through the regulation of Nrf2-mediated phase II enzymes in a variety of ways. However, the enormous quantity of somewhat chaotic data that is available on the effects of phytochemicals needs to be properly classified according to the functions or mechanisms of phytochemicals, in this review, we first introduce the antioxidant properties of phytochemicals and their relation to the Nrf2/Keap1 system. We then summarize the effects of phytochemicals on the growth performance, meat quality, and intestinal microbiota of farm animals via targeting the Nrf2/Keap1 system. These exhaustive data contribute to better illuminate the underlying biofunctional properties of phytochemicals in farm animals.

关键词： Phytochemical Biofunction Nrf2/Keap1 system Growth performance Meat quality Intestinal microbiota

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光动力抗肿瘤双层微针的数值模拟

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力学学报 2025年第1期57卷 237-248页

作者：谭昕卢少梅代诗威俞骁王成勇秦思袁志山广东工业大学机电工程学院广州510006 广东工业大学广东省微创手术器械设计与精密制造重点实验室广州510006 广东工业大学高性能工具全国重点实验室广州510006 广东工业大学智慧医疗创新技术中心广州510006 广东省第二人民医院皮肤科广州518025

针对目前光动力治疗皮肤癌中光敏剂传递效率低及光穿透深度不足的问题,提出一种用于光动力抗肿瘤的双层微针,双层微针由可溶针尖和不溶基底两部分组成.可溶针尖能够精准地将光敏剂递送至肿瘤组织内部,提高传递效率.针尖溶解后留存在组... 详细信息

针对目前光动力治疗皮肤癌中光敏剂传递效率低及光穿透深度不足的问题,提出一种用于光动力抗肿瘤的双层微针,双层微针由可溶针尖和不溶基底两部分组成.可溶针尖能够精准地将光敏剂递送至肿瘤组织内部,提高传递效率.针尖溶解后留存在组织内的不溶基底为高能光子提供稳定的光传输通道,增强光穿透深度,以激活深层光敏剂.为设计递送性能及光导性能良好的光动力抗肿瘤双层微针,采用COMSOL Multiphysics软件建立双层微针针尖结构在皮肤组织内的光敏剂扩散模型,研究针尖几何尺寸与药物扩散浓度的关系.同时,基于蒙特卡洛方法建立双层微针基底结构的皮肤黑色素瘤组织光学模型,研究基底几何尺寸对光导性能的影响.最终获得性能最优的双层微针几何尺寸.借助ANSYS Workbench软件建立其力学模型以验证该微针的刺入性能.研究结果表明:本文所设计的光动力抗肿瘤双层微针具备良好的力学性能,能够顺利刺穿皮肤组织,并通过可溶针尖将光敏剂靶向递送至肿瘤部位.不溶基底在肿瘤组织内建立稳定光导路径,有效促进光子传输.该微针设计建立了高效光动力抗肿瘤治疗方案,拓展了肿瘤非手术治疗的新途径.

关键词：双层微针光动力疗法药物扩散光分布刺入力

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Resolving the Bethe–Salpeter Kernel

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Chinese Physics Letters 2021年第7期38卷 17-22页

作者： si-Xue qin Craig D.Roberts Department of Physics Chongqing UniversityChongqing 401331China School of Physics Nanjing UniversityNanjing 210093China Institute for Nonperturbative Physics Nanjing UniversityNanjing 210093China

A novel method for constructing a kernel for the meson bound-state problem is *** produces a closed form that is symmetry-consistent(discrete and continuous)with the gap equation defined by any admissible gluon-quark vertex,Γ.Applicable even when the diagrammatic content ofΓis unknown,the scheme can foster new synergies between continuum and lattice approaches to strong *** framework is illustrated by showing that the presence of a dressed-quark anomalous magnetic moment inΓ,an emergent feature of strong interactions,can remedy many defects of widely used meson bound-state kernels,including the mass splittings between vector and axial-vector mesons and the level ordering of pseudoscalar and vector meson radial excitations.

关键词： meson quark admissible

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Impressions of the Continuum Bound State Problem in QCD

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Chinese Physics Letters 2020年第12期37卷 17-23页

作者： si-Xue qin C.D.Roberts Department of Physics Chongqing UniversityChongqing 401331China School of Physics Nanjing UniversityNanjing 210093China Institute for Nonperturbative Physics Nanjing UniversityNanjing 210093China

Modern and anticipated facilities will deliver data that promises to reveal the innermost workings of quantum chromodynamics(QCD).In order to fulfill that promise,phenomenology and theory must reach a new level,limiting and overcoming model-dependence,so that clean lines can be drawn to connect the data with QCD *** in that direction,made using continuum methods for the hadron bound-state problem,is sketched herein.

关键词： QCD sketch limiting

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Design and experimental study of a practical Osculating Inward Cone Waverider Inlet

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Chinese Journal of Aeronautics 2016年第6期29卷 1582-1590页

作者： He Xuzhao Zhou Zheng qin si Wei Feng Le Jialing Science and Technology on Scramjet Laboratory Hypervelocity Aerodynamics Institute of CARDC

A design method based on tip to tail streamline tracing and osculating inward cone methods is discussed for designing the integrated Osculating Inward Cone Waverider Inlet（OICWI）. A practical geometrical constrained experimental model of OICWI is designed based on the validated design method. It has a total contraction ratio of 4.61 and inner contraction ratio is 2.0. Wind-tunnel tests have been conducted for the OICWI model at free stream Mach number（Ma） of 4.0, 3.5 and 3.0 respectively. The experimental results show that the OICWI has high flow capture ratio and compression abilities. It can self-start at Ma= 3.5 and 4.0 and its flow capture ratio is 0.73 at Ma= 4.0, and Angle of Attack（AOA） 0°. The research results show that the OICWI has advantages of inward cone waverider and streamline tracing inlet. Present OICWI is a novel approach for waverider inlet integration studies and it will promote the use of waverider inlet integration configuration in the studies of airbreathing hypersonic vehicles.

关键词： Inlet Integration design Inward turning cone Waverider Wind tunnel experiment

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Enhancement of Flow Boiling Heat Transfer with Surfactant

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Journal of Central South University 2000年第4期12卷 219-222页

作者： QIU Yun-ren CHEN Wei-ping si qin College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Editorial Office of Journal of Central South University of Technology Central South UniversityChangsha 410083China College of Chemical Engineering Tianjin UniversityTianjin 300072China

The surfactant additive octadecylamine (ODA) was used to enhance the flow boiling heat transfer of water in vertical copper tube, and the effects of the aqueous solution properties, mass fraction of ODA, mass flux and heat flux etc. on flow boiling heat transfer were investigated. In order to analyze the mechanism of enhancement on boiling heat transfer with ODA, the copper surface was detected by XPS, and the diagram of binding energy was obtained. The results show that ODA can be adsorbed on the surface of the copper wall, and affects the properties of the heating surfaces and enhances the flow boiling heat transfer of water. Only in low heat flux and in a suitable range of concentration, can ODA aqueous solution enhance flow boiling heat transfer, and the suitable mass fraction of ODA is in the range of 1×10 -5 5×10 -5 . In addition, compared with water, ODA aqueous solution does not increase the flow drag under the same experimental conditions.

关键词： flow boiling heat transfer flow drag enhancement additive

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Progress in ab initio in-medium similarity renormalization group and coupled-channel method with coupling to the continuum

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Nuclear Science and Techniques 2024年第12期35卷 312-342页

作者： Xin‑Yu Xu si‑qin Fan Qi Yuan Bai‑Shan Hu Jian‑Guo Li si‑Min Wang Fu‑Rong Xu School of Physics and State Key Laboratory of Nuclear Physics and TechnologyPeking UniversityBeijing 100871China Southern Center for Nuclear‑Science Theory(SCNT)Institute of Modern Physics Chinese Academy of SciencesHuizhou 516000China National Center for Computational Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Physics Division Oak Ridge National LaboratoryOak RidgeTN 37831USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Modern Physics Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Fudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China

Over the last decade,nuclear theory has made dramatic progress in few-body and ab initio many-body *** great advances stem from chiral efective feld theory(xEFT),which provides an efcient expansion and consistent treatment of nuclear forces as inputs of modern many-body calculations,among which the in-medium similarity renormalization group(IMSRG)and its variants play a vital *** the other hand,signifcant eforts have been made to provide a unifed description of the structure,decay,and reactions of the nuclei as open quantum *** a fully comprehensive and microscopic model has yet to be realized,substantial progress over recent decades has enhanced our understanding of open quantum systems around the dripline,which are often characterized by exotic structures and decay *** study these interesting phenomena,Gamow coupled-channel(GCC)method,in which the open quantum nature of few-body valence nucleons coupled to a deformed core,has been *** review focuses on the developments of the advanced IMSRG and GCC and their applications to nuclear structure and reactions.

关键词： Ab initio calculations Chiral efective feld theory In-medium similarity renormalization group Gamow coupled channel Resonance and continuum Open quantum systems

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拓展内分泌科临床教学主阵地的思考与探索

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中国继续医学教育 2025年第1期17卷 176-180页

作者：秦思张尹棣倪银星钟健重庆医科大学附属第三医院内分泌疾病中心重庆401120

内分泌学作为内科学的重要学科分支,具有病种多、疾病复杂、知识抽象等特点,在信息化、数字化时代,单一的传统临床实习教学模式已经跟不上时代发展的需要,为有效提高临床教学中实习生的内分泌专业综合素质,基于网络信息化技术的远程实... 详细信息

内分泌学作为内科学的重要学科分支,具有病种多、疾病复杂、知识抽象等特点,在信息化、数字化时代,单一的传统临床实习教学模式已经跟不上时代发展的需要,为有效提高临床教学中实习生的内分泌专业综合素质,基于网络信息化技术的远程实习教学提供了一种新的教学模式。目前,远程实习教学实施中存在设备设施及教学资源准备不足、质量管控难度大等问题,必须依托现有信息化、数字化技术,最大限度模拟还原真实临床实践情景,科学、系统地设计一整套基于信息化技术的临床教学课程体系建设、师资队伍培养方案、临床教学设备设施建立、信息化管理平台构建及创新性教学方法等,使临床教学向更广、更深的方向拓展。

关键词：内分泌科临床教学实习主阵地远程教学信息化

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IGF2BP3 Enhances the Growth of Hepatocellular Carcinoma Tumors by Regulating the Properties of Macrophages and CD8^(+)T Cells in the Tumor Microenvironment

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Journal of Clinical and Translational Hepatology 2023年第6期11卷 1308-1320页

作者： Lingyu Ma Jiayu Jiang qin si Chong Chen Zhaojun Duan Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijingChina

Background and Aims:Overexpression of IGF2BP3 is associated with the prognosis of hepatocellular carcinoma(HCC).However,its role in regulating tumor immune microenvironment(TME)is not well ***,we investigated the effects of IGF2BP3 on macrophages and CD8^(+)T cells within the TME of ***:The relationship between IGF2BP3 and immune cell infiltration was analyzed using online bioinformatics *** of IGF2BP3 in mouse hepatoma cell line Hepa1-6 was established using CRISPR/Cas9 *** vitro cell coculture and subcutaneously implanted hepatoma mice model were used to explore the effects of IGF2BP3 on immune *** of CCL50l transforming growth factor beta 1(TGF-β1)was detected with quantitative real-time polymerase chain reaction,western blotting,and enzyme-linked immunosorbent *** binding of IGF2BP3 and its target RNA was verified by trimolecular fluorescence complementation system and RNA immunoprecipitation followed by quantitative or semiquantitative polymerase chain ***:IGF2BP3 expression was elevated in HCC and was positively correlated with macrophage *** with higher IGF2BP3 expression and lower macrophage infiltration had a better survival *** found that IGF2BP3 could bind to the mRNA of CCL5 or TGF-β1,increasing their expression,and inducing macrophage infiltration and M2 polarization while inhibiting the activation of CD8^(+)T ***,inhibition of IGF2BP3 combined with anti-CD47 antibody treatment significantly suppressed the growth of hepatoma in Hepa1-6 xenograft tu-mor ***:IGF2BP3 promoted the infiltration and M2-polarization of macrophages and suppressed CD8^(+)T activation by enhancing CCL5 and TGF-β1 expression,which facilitated the progression of Hepa1-6 xenograft tumor.

关键词： Hepatocellular carcinoma IGF2BP3 TGF-β1 CCL5 M2 macrophage CD8^(+)T cell

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Polysaccharide extract from Rosa laevigata fruit attenuates inflammatory obesity by targeting redox balance and gut interface in high-fat diet-fed rats

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Food Science and Human Wellness 2023年第2期12卷 442-453页

作者： Xuejiao Zhang Chenzhong Jin Han Liu Yihong Hu Yunyun Zhou Weiguo Wu si qin Lab of Food Function and Nutrigenomics College of Food Science and TechnologyHunan Agricultural UniversityChangsha 410128China College of Food and Chemical Engineering Shaoyang UniversityShaoyang 422000China Collaborative Innovation Center for Field Weeds Control Hunan University of HumanitiesScience and TechnologyLoudi 417000China

Low-molecular-weight polysaccharides(RLPs)extracted from Rosa laevigata fruits showed multiple biofunctions in *** study aimed to investigate its anti-inflammatory obesity effect in high-fat dietfed rats and further elucidated the underlying molecular mechanism by multi-omics *** results showed that RLPs administration had significantly restored immune organ indexes and reduced body weight ***-seq revealed that the effect of RLPs was partially attributed to its regulation on PPARs signaling by increasing the expressions of Scd,Acox3 and Hmgcs2,and on other redox-related pathways by decreasing the expressions of Cyp2 e1,Il1-r1 and ***,16 S rRNA sequencing coupled with metagenome sequencing showed that RLPs had significantly reduced the ratio of Firmicutes/Bacteroidetes from 8.01 to2.37,and significantly increased the relative abundances of Alistipes,Prevotella,and Akkermansia from 0.36%,1.10%and 2.61%to 0.65%,2.37%and 4.42%,*** correlation analysis result indicated that the abundances of Lachnospiraceae,Prevotella and Bacteroidales were significantly negatively correlated with obesity phenotype,liver function and inflammatory *** results revealed that RLPs exerted significant anti-inflammatory obesity property partially via regulation on gut microbiota interface and the redox ***,RLPs could be a promising functional food resource with the potential for redox imb alance-related diseases chemoprevention.

关键词： Rosa laevigata Polysaccharides Multi-omics Redox Gut microbiota

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