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Health promoting activities and corresponding mechanism of(–)-epicatechin-3-gallate

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Food Science and Human Wellness 2022年第3期11卷 568-578页

作者： Zhiliang Li Changchun Feng Hongjin Dong Weibin Jin Wenying Zhang Jianfeng Zhan shuzhen wang College of Life Science Huanggang Normal UniversityHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive UtilizationHubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie MountainsHubei Zhongke Research Institute of Industrial TechnologyHuanggang 438000China College of Agriculture Yangtze UniversityJingzhou 434000China

(–)-Epicatechin-3-gallate(ECG),a bioactive polyphenolic compound,has contributed a lot to the health benefits of green tea.Great attention has been focused on(–)-epigallocatechin-3-gallate(EGCG),but limited research has been performed towards ECG.Like EGCG,ECG also possesses various pharmacological and physiological properties,such as mediation of antioxidant activities,anti-inflammation response,regulation of cell proliferation and apoptosis,as well as anticancer properties during angiogenesis,invasion and metastasis stages.Nontoxic ECG has various molecular targets within the cells,including CYP enzymes,phaseⅡdetoxification and antioxidant enzymes,as well as pro-inflammatory mediators.The antineoplastic mechanism contains inhibition of phase 1 CYP enzymes,induction of phaseⅡdetoxification and antioxidant enzymes,high anti-inflammatory efficacy,arrest of cell cycle progression,regulation of apoptosis,as well as mediation of metastasis processes.In particular,the gallate moiety of ECG is critical for mediating inhibitory effects towards cancer cells.Besides regulation of intracellular signaling pathways,ECG also inhibits RNase A and matrix metalloproteinase enzymatic activity via chelating metals(copper and zinc)in cancer cells.This review has summarized recent studies on pharmacological properties of ECG,and discussed corresponding mechanism on modulation of cellular signaling events by ECG,hoping to broaden its multiple usage.

关键词： (-)-Epicatechin-3-gallate Polyphenolic compounds Pharmacological properties Anticarcinogenic agent Natural antioxidants Antimicrobial properties

Multifunctional health-promoting effects of oolong tea and its products

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Food Science and Human Wellness 2022年第3期11卷 512-523页

作者： shuzhen wang Ting Zeng Shuang Zhao Yu Zhu Changchun Feng Jianfeng Zhan Shiming Li Chi-Tang Ho Alexander Gosslau Huanggang Normal University College of Life ScienceHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive UtilizationHubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie MountainsHubei Zhongke Research Institute of Industrial TechnologyHuanggang 438000China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Department of Food Science Rutgers UniversityNJ 08901USA Department of Science(Biology) City University of New YorkNY 10007USA

Oolong tea,partially fermented from Camellia sinensis leaves,exhibits significant antioxidative,anti-inflammatory,and anti-cancer activities as indicated in several in vitro and in vivo studies.However,studies on health promoting effects of oolong tea and its characteristic compounds are limited.The potential efficacy of bioactives derived from oolong tea and their roles as promising anticancer agents,their cardio-protective benefits during hypoxic conditions,effects in treating allergic disorders,potential prebiotic activities,improvement of blood lipid status in human beings,effectivity as oral hypoglycemic agent in the treatment of type 2 diabetes,and their potentials to reduce the risk of obesity have been discussed in this review.These promising studies mainly gained from animal studies might broaden the consumption and usage of the phenolic-enriched oolong tea and its products in food and pharmaceutical industries.However,potential health beneficial effects of oolong tea in humans should be further complemented by large-sized,randomized double-blind and placebo-controlled trials to consolidate potential therapeutic applications.

关键词： Oolong tea Anticancer potential Antioxidative activity Microbiota modulating activities Synergistic effects

中喜马拉雅陈塘地区基性麻粒岩变质作用、原岩特征及其地质意义

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岩石学报 2024年第5期40卷 1603-1627页

作者：王淑真张贵宾刘帅奇北京大学地球与空间科学学院造山带与地壳演化教育部重点实验室北京100871

本文对中喜马拉雅陈塘地区高压基性麻粒岩进行了岩石学、地球化学和锆石年代学及Hf同位素研究,确定了其变质P-T演化、原岩性质和构造背景。陈塘地区基性麻粒岩发生了明显部分熔融,基质中保存有单斜辉石和斜长石后成合晶,指示其可能经历... 详细信息

本文对中喜马拉雅陈塘地区高压基性麻粒岩进行了岩石学、地球化学和锆石年代学及Hf同位素研究,确定了其变质P-T演化、原岩性质和构造背景。陈塘地区基性麻粒岩发生了明显部分熔融,基质中保存有单斜辉石和斜长石后成合晶,指示其可能经历了榴辉岩相变质作用。根据基性麻粒岩的矿物组合识别出三个变质演化阶段:高压麻粒岩相矿物组合为石榴子石+单斜辉石+斜长石+金红石+石英,温压条件为1.0~1.3GPa、730~800℃;中压麻粒岩相矿物组合为石榴子石+单斜辉石+斜方辉石+角闪石+斜长石+钛铁矿+金红石+石英,温压条件为0.78~0.82GPa、820~890℃;而角闪岩相阶段以角闪石的大量出现为特征,变质温压条件为0.6~0.7GPa、660~740℃。锆石U-Pb年代学指示基性麻粒岩高压麻粒岩相的变质时代为15~14Ma,原岩时代为~1800Ma。另外,基于TiO_(2)含量可将基性麻粒岩划分为两组,一组具有低的TiO_(2)和高的ε_(Nd)(t),稀土元素配分模式与E-MORB一致,原岩为弧后盆地玄武岩。第二组基性麻粒岩相比于第一组,具有高的TiO_(2)、REE、Th/Ta和低的Mg^(#)、Nb/La和ε_(Nd)(t),其稀土元素配分模式与OIB一致。地球化学特征表明高Ti基性麻粒岩的原岩经历了显著的地壳混染,其形成与低Ti组基性麻粒岩原始岩浆上升过程混染壳源物质有关。中喜马拉雅Ama Drime地体-陈塘地区-Arun河谷沿南北方向上均出露的古元古代岩浆记录可能与新生代裂谷活动导致喜马拉雅造山带古元古代基底剥露至地表有关。另外,本研究证实印度大陆北缘在古元古代(1.9~1.8Ga)处于汇聚型板块边缘,伴生有广泛的弧/弧后岩浆作用,而非裂谷环境。

关键词：中喜马拉雅基性麻粒岩变质作用原岩特征构造意义

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Near field 3-D imaging approach for joint high-resolution imaging and phase error correction

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Journal of Systems Engineering and Electronics 2017年第2期28卷 199-211页

作者： Yang Fang Baoping wang Chao Sun Zuxun Song shuzhen wang School of Electronics and Information Northwestern Polytechnical University Xi’an 710072 China National Key Laboratory of Science and Technology on UAV Xi’an 710065 China School of Computer Science and Technology Xidian University Xi’an 710071 China

This paper combines compressed sensing (CS) imaging theory and range migration algorithm (RMA), and then proposes a near-field three-dimensional (3-D) imaging approach for joint high-resolution imaging and phase error correction. Firstly, a sparse measurement matrix construction method based on a logistic sequence is proposed, which conducts nonlinear transformation for the determined logistic sequence, making it obey uniform distribution, then conducts sign function mapping, and generates the pseudorandom sequence with Bernoulli distribution, thus leading to good signal recovery under down-sampling and easy availability for engineering realization. Secondly, in combination with the RMA imaging approach, the dictionary with all scene information and phase error correction is constructed for CS signal recovery and error correction. Finally, the non-quadratic solution model jointing imaging and phase error correction based on regularization is built, and it is solved by two steps - the separable surrogate functionals (SSF) iterative shrinkage algorithm is adopted to realize target scattering estimate; the iteration mode is adopted for the correction of the dictionary model, so as to achieve the goal of error correction and highly-focused imaging. The proposed approach proves to be effective through numerical simulation and real measurement in anechoic chamber. The results show that, the proposed approach can realize high-resolution imaging in the case of less data; the designed measurement matrix has better non-coherence and easy availability for engineering realization. The proposed approach can effectively correct the phase error, and achieve highly-focused target image. ? 2017 Beijing Institute of Aerospace Information.

关键词： Compressed sensing Error correction Image reconstruction Iterative methods Linear transformations Mathematical transformations Signal reconstruction Signal sampling

高速铁路钢轨波磨地段轴箱振动加速度时频特征分析

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铁道科学与工程学报 2024年第4期21卷 1275-1285页

作者：和振兴刘旭麒王玉魁封全保王淑珍兰州交通大学机电工程学院甘肃兰州730070 清华大学天津高端装备研究院天津300300

钢轨波磨是一种常见的高速铁路轨道病害。为了研究钢轨波磨参数与轴箱加速度响应时频特征之间的对应关系,从理论上探索通过轴箱振动加速度识别钢轨波磨的可行性,基于车辆-轨道耦合动力学理论建立了考虑车辆主要部件柔性化的刚柔耦合动... 详细信息

钢轨波磨是一种常见的高速铁路轨道病害。为了研究钢轨波磨参数与轴箱加速度响应时频特征之间的对应关系,从理论上探索通过轴箱振动加速度识别钢轨波磨的可行性,基于车辆-轨道耦合动力学理论建立了考虑车辆主要部件柔性化的刚柔耦合动力学模型。通过与实测数据的对比,验证了模型的准确性;在研究了钢轨波磨参数与轴箱振动加速度时域信号之间因应关系的基础上提出了一种基于VMD-SPWVD的钢轨波磨时频分析方法,并验证了该方法的有效性。研究结果表明,钢轨波磨会对轴箱振动加速度信号产生较大影响;不同波深和波长下的轴箱振动加速度最大值在时域信号中的位置具有随机性;钢轨波磨参数与轴箱振动加速度均方根之间的规律性较为明显,但其作为一种时域指标无法准确定位波磨区段的位置和严重程度;相较于时域分析方法,本文提出的基于VMD-SPWVD的时频分析方法能有效反映钢轨波磨参数与轴箱振动加速度之间的因应关系,时频分析结果能准确得到钢轨波磨的特征频率且不存在干扰成分,能量幅值与钢轨波磨波深之间呈正相关,该方法可以定位波磨存在的区段并能够体现同一区段不同位置波磨的严重程度。最后采用该方法对实测数据进行分析,进一步验证了本文所述方法通过轴箱振动加速度信号识别钢轨波磨的有效性。

关键词：高速铁路钢轨波磨轴箱加速度动力学响应时频特征

Zinc influences on brain development, pituitary and thyroid function in iodine-deficient pregnant and neonatal rats

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Neural Regeneration Research 2008年第9期3卷 985-990页

作者： Xiaoxia Yang Jianchao Bian Xin wang Haiming wang Yongping Liu shuzhen wang Zhichun Mu Xinluan Li Shandong Institute for Prevention and Treatment of Endemic Disease Jinan 250014 Shandong Province China Radioisotope Unit Qilu Hospital of Shandong University Jinan 250012 Shandong Province China Qingdao Administration for Entry-Exit Inspection and Quarantine Qingdao 266001 Shandong Province China SINOPEC Safety Engineering Institute Qingdao 266071 Shandong Province China

BACKGROUND： Zinc （Zn） has been shown to greatly influence brain development. Zn supplements may reduce injury to cell membranes of the thyroid gland due to iodine deficiency. OBJECTIVE： To establish an iodine deficiency rat model using low-iodine food, which was supplemented with compound Zn and Zn gluconate, to observe the effects of Zn on brain development, as well as pituitary gland and thyroid gland function in iodine-deficient rats. DESIGN, TIME AND SETTING： Randomized grouping study of neural development was performed in the central laboratory of Shandong Institute for Prevention and Treatment of Endemic Disease from 1998 to 1999. MATERIALS： A total of 270 Wistar, female rats, one month after weaning, were used in this study, including 150 pregnant and 120 neonatal rats. Rats were randomly divided into six groups： normal control, model, iodine, compound Zn, iodine and compound Zn, and zinc gluconate. Each group contained 25 pregnant rats and 20 neonatal rats. METHODS： The pregnant rats and 20 neonatal rats, and well as the normal group, were fed standard chow and allowed free access to tap water （containing 5 u g/L iodine and 1 mg/L Zn）. The remaining five groups were fed low-iodine chow. However, the model group received distilled water, the iodine group received potassium-iodide distilled water （containing 300 u g/L iodine）, the compound Zn group received distilled water and intragastrically administrated 10 mL/kg compound Zn solution, once per day, the iodine and compound Zn group received distilled water with 300 u g/L iodine and intragastrically administrated 10 mL/kg compound Zn solution, once per day. All treatments lasted 90 days. MAIN OUTCOME MEASURES： All pregnant rats were sacrificed on the day 21 of pregnancy. Body mass number and rate of fetal absorption, as well as fetal death and malformation, were determined. Thyroid and pituitary gland weights were measured, as well as serum levels of thyroid hormone, gonadotropin, and sex hormones. In the experimental study of neonatal rats, the animals n

关键词： growth disorder iodine rat thyroid zinc

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农村银行服务创新对农村金融发展的影响研究

商业观察 2024年第1期10卷 41-44页

作者：王书贞山东省农村信用社联合社山东济南250014

文章旨在探讨农村银行服务创新对农村金融发展的影响,并提出相关政策建议。通过文献综述和定性分析,发现农村银行服务创新可以增加农村金融的普惠性和便利性,满足多样化的金融需求,有助于推动农村经济发展和脱贫攻坚。此外,服务创新还... 详细信息

文章旨在探讨农村银行服务创新对农村金融发展的影响,并提出相关政策建议。通过文献综述和定性分析,发现农村银行服务创新可以增加农村金融的普惠性和便利性,满足多样化的金融需求,有助于推动农村经济发展和脱贫攻坚。此外,服务创新还可以提高风险管理和合规能力,推动农村金融机构的转型升级和可持续发展。基于研究结果,文章提出了政府加强政策支持、农村银行加强人才培养和管理,以及完善农村金融市场竞争机制等建议。未来的研究可扩大样本范围、采用定量分析方法,并探讨其与其他农村金融因素的相互作用,以提供更科学的决策参考。

关键词：农村银行服务创新农村金融发展政策建议可持续发展

ZSM-22分子筛合成及其正十二烷烃临氢异构化性能:模板剂和动态晶化的影响

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化工进展 2024年第1期43卷 414-421页

作者：张海鹏王树振马梦茜张巍向江南王玉婷王琰范彬彬郑家军李瑞丰太原理工大学化学工程与技术学院山西太原030024

以二乙胺(DEA)或1,6-己二胺(DAH)为模板剂,分别在静态或动态条件下合成具有不同形貌和聚集状态的ZSM-22分子筛,采用XRD、SEM、EDS、TEM、NH3-TPD及N2吸附/脱附表征手段对其进行表征分析。并负载Pt在Al2O3上和ZSM-22机械混合制备双功能... 详细信息

以二乙胺(DEA)或1,6-己二胺(DAH)为模板剂,分别在静态或动态条件下合成具有不同形貌和聚集状态的ZSM-22分子筛,采用XRD、SEM、EDS、TEM、NH3-TPD及N2吸附/脱附表征手段对其进行表征分析。并负载Pt在Al2O3上和ZSM-22机械混合制备双功能催化剂,考察其正十二烷的临氢异构化反应性能。结果表明,模板剂和动态晶化会改变ZSM-22分子筛的形貌及聚集状态,并且会影响其酸性、比表面积和临氢异构活性。其中,以二乙胺为模板剂,静态晶化72h合成的ZSM-22具有最优的催化性能,在310℃反应温度下,正十二烷异构化转化率为66%时,异构十二烷的选择性达到90%。但是,模板剂及动态晶化条件对单支链异构体的产物分布影响较小,异构体产物以支链靠近端位的2-甲基十一烷为主,且随着反应温度升高,2-甲基异构体选择性明显降低。

关键词：催化剂沸石分子筛 ZSM-22 正十二烷临氢异构化

Dynamic Changes of Antibodies to SARS-CoV-2 in COVID-19 Patients at Early Stage of Outbreak

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Virologica Sinica 2020年第6期35卷 744-751页

作者： Huaqing Shu shuzhen wang Shunan Ruan Yaxin wang Jiancheng Zhang Yin Yuan Hong Liu Yongran Wu Ruiting Li Shangwen Pan Yaqi Ouyang Shiying Yuan Peng Zhou You Shang Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Institute of Anesthesiology and Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Jin-Yin-Tan Hospital Wuhan 430023China CAS Key Laboratory of Special Pathogens Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China

The coronavirus disease 2019(COVID-19),caused by SARS-CoV-2,has spread around the world with high mortality.To diagnose promptly and accurately is the vital step to effectively control its pandemic.Dynamic characteristics of SARSCoV-2-specific antibodies which are important for diagnosis of infection have not been fully demonstrated.In this retrospective,single-center,observational study,we enrolled the initial 131 confirmed cases of COVID-19 at Jin-Yin-Tan Hospital who had at least one-time antibody tested during their hospitalization.The dynamic changes of IgM and IgG antibodies to SARS-CoV-2 nucleocapsid protein in 226 serum samples were detected by ELISA.The sensitivities of IgM and IgG ELISA detection were analyzed.Result showed that the sensitivity of the IgG ELISA detection(92.5%)was significantly higher than that of the IgM(70.8%)(P\0.001).The meantimes of seroconversion for IgM and IgG were6 days and 3 days,respectively.The IgM and IgG antibody levels peaked at around 18 days and 23 days,and then IgM fell to below the baseline level at about day 36,whereas IgG maintained at a relatively high level.In conclusion,antibodies should be detected to aid in diagnosis of COVID-19 infection.IgG could be a sensitive indicator for retrospective diagnosis and contact tracing,while IgM could be an indicator of early infection.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Coronavirus Antibody Serology