Dynamic Changes of Antibodies to SARS-CoV-2 in COVID-19 Patients at Early Stage of Outbreak

作     者：Huaqing Shu Shuzhen Wang Shunan Ruan Yaxin Wang Jiancheng Zhang Yin Yuan Hong Liu Yongran Wu Ruiting Li Shangwen Pan Yaqi Ouyang Shiying Yuan Peng Zhou You Shang Huaqing Shu;Shuzhen Wang;Shunan Ruan;Yaxin Wang;Jiancheng Zhang;Yin Yuan;Hong Liu;Yongran Wu;Ruiting Li;Shangwen Pan;Yaqi Ouyang;Shiying Yuan;Peng Zhou;You Shang

作者机构：Department of Critical Care MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Institute of Anesthesiology and Critical Care MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Jin-Yin-Tan HospitalWuhan 430023China CAS Key Laboratory of Special PathogensWuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2020年第35卷第6期

页      面：744-751页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Coronavirus Antibody Serology 

摘      要：The coronavirus disease 2019(COVID-19),caused by SARS-CoV-2,has spread around the world with high *** diagnose promptly and accurately is the vital step to effectively control its *** characteristics of SARSCoV-2-specific antibodies which are important for diagnosis of infection have not been fully *** this retrospective,single-center,observational study,we enrolled the initial 131 confirmed cases of COVID-19 at Jin-Yin-Tan Hospital who had at least one-time antibody tested during their *** dynamic changes of IgM and IgG antibodies to SARS-CoV-2 nucleocapsid protein in 226 serum samples were detected by *** sensitivities of IgM and IgG ELISA detection were *** showed that the sensitivity of the IgG ELISA detection(92.5%)was significantly higher than that of the IgM(70.8%)(P\0.001).The meantimes of seroconversion for IgM and IgG were6 days and 3 days,*** IgM and IgG antibody levels peaked at around 18 days and 23 days,and then IgM fell to below the baseline level at about day 36,whereas IgG maintained at a relatively high *** conclusion,antibodies should be detected to aid in diagnosis of COVID-19 *** could be a sensitive indicator for retrospective diagnosis and contact tracing,while IgM could be an indicator of early infection.