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Effects of size variation and spatial structure on plastic response of plant height to light competition

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Chinese Science Bulletin 2010年第12期55卷 1135-1141页

作者： chen shuyan ZHANG JiaLin JIA Peng XU Jin WANG Gang XIAO Sa Key Laboratory of Arid and Grassland Ecology of Ministry of Education School of Life Science Lanzhou University Lanzhou 730000 China

Plants only interact with neighbors over restricted distances,so local conditions are of great significance for *** this study,a spatially-explicit,individual-based model was constructed to explore the effects of size variation and spatial structure on adaptive plasticity of plant height in response to light *** the model a plant maintains its height at an optimal value in order to maximize its growth rate,and this optimal height increases with the increase of the intensity of light competition experienced by the individual *** the spatial pattern of the population is non-uniform or there is size variation among individual plants,the height growth curves of individuals different from each other vary due to the differences in the local light environment,and there is also variation in the allocation of photosynthate to height growth among the individual *** is no ESS height or height growth strategy on which all plants will *** results indicate that the plasticity of plants' height growth reactions to the light competition should be considered at the individual level and they argue strongly for the importance of the spatial pattern and neighborhood effects in generating the diversity of heights and height growth strategies in plant population.

关键词：空间结构光响应竞争塑料株高空间分布格局变异单株生长曲线

Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice

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Journal of Genetics and Genomics 2024年第4期51卷 407-418页

作者： Yaling Wang Xueying Huang Guoying Sun Jingwen chen Bangguo Wu Jiahui Luo shuyan Tang Peng Dai Feng Zhang Jinsong Li Lingbo Wang Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Institute of Reproduction and Development Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Shanghai Key Laboratory of Maternal and Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

During spermiogenesis,haploid spermatids undergo dramatic morphological changes to form slender sperm flagella and cap-like acrosomes,which are required for successful *** deformities in flagella cause a male infertility syndrome,multiple morphological abnormalities of the flagella(MMAF),while acrosomal hypoplasia in some cases leads to sub-optimal embryonic developmental ***,evidence regarding the occurrence of acrosomal hypoplasia in MMAF is ***,we report the generation of base-edited mice knocked out for coiled-coil domain-containing 38(Ccdc38)via inducing a nonsense mutation and find that the males are *** Ccdc38-KO sperm display acrosomal hypoplasia and typical MMAF *** find that the acrosomal membrane is loosely anchored to the nucleus and fibrous sheaths are disorganized in Ccdc38-KO *** analyses reveal that Ccdc38 knockout causes a decreased level of TEKT3,a protein associated with acrosome biogenesis,in testes and an aberrant distribution of TEKT3 in *** finally show that intracytoplasmic sperm injection overcomes Ccdc38-related *** study thus reveals a previously unknown role for CCDC38 in acrosome biogenesis and provides additional evidence for the occurrence of acrosomal hypoplasia in MMAF.

关键词： Acrosomal hypoplasia Multiple morphological abnormalities of the flagella(MMAF) Infertility Sperm motility Asthenoteratozoospermia Disease modeling

Deleterious variants in RNF111 impair female fertility and induce premature ovarian insufficiency in humans and mice

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Science China(Life Sciences) 2024年第7期67卷 1325-1337页

作者： chengcheng Song Yingying Qin Yan Li Bingyi Yang Ting Guo Wenqing Ma Dian Xu Keyan Xu Fangfang Fu Li Jin Yanhua Wu shuyan Tang Xiaojun chen Feng Zhang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic EngineeringInstitute of Medical Genetics and GenomicsFudan UniversityShanghai 200011China Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250021China State Key Laboratory of Reproductive Medicine and Offspring Health Key Laboratory of Reproductive Endocrinology of Ministry of EducationNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthShandong UniversityJinan 250021China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Demonstration Center for Experimental Biology Education School of Life SciencesFudan UniversityShanghai 200433China Department of Gynecology the Tenth People’s Hospital of Tongji UniversityShanghai 200072China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health Hospital of China Welfare InstituteShanghai 200030China

Premature ovarian insufficiency(POI)is a heterogeneous female disorder characterized by the loss of ovarian function before the age of *** represents a significant detriment to female ***,the known POI-causative genes currently account for only a fraction of *** elucidate the genetic factors underlying POI,we conducted whole-exome sequencing on a family with three fertile POI patients and identified a deleterious missense variant in *** a subsequent replication study involving 1,030 POI patients,this variant was not only confirmed but also accompanied by the discovery of three additional predicted deleterious RNF111 *** variants collectively account for eight cases,representing 0.78%of the study cohort.A further study involving 500 patients with diminished ovarian reserve also identified two additional RNF111 ***,RNF111 encodes an E3 ubiquitin ligase with a regulatory role in the TGF-β/BMP signaling *** analysis revealed that RNF111/RNF111 is predominantly expressed in the oocytes of mice,monkeys,and *** further investigate the functional implications of RNF111 variants,we generated two mouse models:one with a heterozygous missense mutation(Rnf111+/M)and another with a heterozygous null mutation(Rnf111^(+/-)).Both mouse models exhibited impaired female fertility,characterized by reduced litter sizes and small ovarian ***,RNA-seq and quantitative proteomics analysis unveiled that Rnf111 haploinsufficiency led to dysregulation in female gonad development and negative regulation of the BMP signaling pathway within mouse *** conclusion,our findings strongly suggest that monoallelic deleterious variants in RNF111 can impair female fertility and induce POI in both humans and mice.

关键词： POI RNF111 female fertility ovarian reserve

Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics

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Protein & Cell 2024年第7期15卷 530-546页

作者： Tao chen Yiliang Xu Xiaocui Xu Jianzhang Wang Zhiruo Qiu Yayuan Yu Xiaohong Jiang Wanqi Shao Dandan Bai Mingzhu Wang shuyan Mei Tao cheng Li Wu Shaorong Gao Xuan Che Department of Obstetrics and Gynecology Affiliated Women and Children Hospital of Jiaxing UniversityJiaxing 314000China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Key Laboratory of Animal Bioengineering and Disease Prevention of Shandong Province College of Animal Science and TechnologyShandong Agricultural UniversityTaian 271018China Women’s Hospital School of MedicineZhejiang UniversityHangzhou 310013China Postgraduate training base Alliance of Wenzhou Medical University Wenzhou Medical UniversityWenzhou 325035China Jiaxing University Master Degree Cultivation Base Zhejiang Chinese Medical UniversityHangzhou 310053China Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal-Fetal Medicine and Gynecologic OncologyClinical and Translational Research CenterShanghai First Maternity and Infant HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Adenomyosis is a poorly understood gynecological disorder lacking effective *** persists regarding“invagination”and“metaplasia”*** endometrial-myometrial junction(EMJ)connects the endometrium and myometrium and is important for diagnosing and classifying adenomyosis,but its in-depth study is just *** single-cell RNA sequencing and spatial profiling,we mapped transcriptional alterations across eutopic endometrium,lesions,and *** lesions,we identified unique epithelial(LGR5+)and invasive stromal(PKIB+)subpopulations,along with WFDC1+progenitor cells,supporting a complex interplay between“invagination”and“metaplasia”theories of ***,we observed endothelial cell heterogeneity and abnormal angiogenic signaling involving vascular endothelial growth factor and angiopoietin ***-cell communication differed markedly between ectopic and eutopic endometrium,with aberrant signaling in lesions involving pleiotrophin,TWEAK,and WNT *** study reveals unique stem cell-like and invasive cell subpopulations within adenomyosis lesions identified,dysfunctional signaling,and EMJ abnormalities critical to developing precise diagnostic and therapeutic strategies.

关键词： adenomyosis single-cell RNA sequencing spatial transcriptomics endometrial-myometrial junction progenitor cells

INVERSE SCATTERING METHOD AND APPLICATIONS

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Annals of Applied Mathematics 2020年第4期36卷 331-355页

作者： Boling Guo shuyan chen Institute of Applied Physics and Computational Mathematics Beijing 100088PR China

We briefly introduce the applications of the inverse scattering method to some particular class of problems,which yield the exact solution or long time asymptotics in terms of the unique solution of a matrix Riemann-H... 详细信息

关键词： inverse scattering Riemann-Hilbert problem long-time asymptotics initial value problem(IVP) initial boundary value problem(IBVP)

葡萄糖在目标范围内时间与糖尿病肾脏疾病的相关性研究

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中国全科医学 2023年第15期26卷 1873-1879页

作者：舒涛郭正王飞陈书艳上海交通大学医学院附属新华医院全科医学科上海市200092 上海交通大学医学院附属新华医院老年医学科上海市200092

背景葡萄糖在目标范围内时间(TIR)是近年兴起的糖尿病血糖管理的新指标。研究证实TIR与糖尿病慢性并发症存在密切联系。目前对TIR与糖尿病肾脏疾病(DKD)的研究主要集中在蛋白尿方面,常忽视了估算肾小球滤过率(eGFR)在其中的作用,且对TI... 详细信息

背景葡萄糖在目标范围内时间(TIR)是近年兴起的糖尿病血糖管理的新指标。研究证实TIR与糖尿病慢性并发症存在密切联系。目前对TIR与糖尿病肾脏疾病(DKD)的研究主要集中在蛋白尿方面,常忽视了估算肾小球滤过率(eGFR)在其中的作用,且对TIR评价血糖控制的切点划分的研究较少。目的探讨TIR与2型糖尿病(T2DM)发生DKD的关系,为临床及时发现、诊治T2DM患者出现DKD提供理论依据。方法纳入2021年7—12月在上海交通大学医学院附属新华医院内分泌科住院的214例T2DM患者,收集患者一般资料、实验室检查指标及用药情况。根据尿白蛋白/肌酐比值(UACR)和eGFR结果,将患者分为DKD组[UACR≥30 mg/g和/或e GFR85%,n=90)、TIR2组(70%

关键词：糖尿病肾脏疾病 2型糖尿病葡萄糖在目标范围内时间肾小球滤过率影响因素分析 Logistic模型

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扩大慢性乙型肝炎初始治疗:降低ALT治疗阈值

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临床肝胆病杂志 2023年第1期39卷 27-30页

作者：张佳怡陈姝延尤红首都医科大学附属北京友谊医院肝病中心北京100050

为实现世界卫生组织制定的2030年全球消除病毒性肝炎公共卫生危害的目标,扩大慢性乙型肝炎的治疗人群尤为重要。近些年,各种研究表明,ALT与肝脏炎症、纤维化、肝细胞癌和肝病终点事件均有关。降低ALT治疗阈值作为扩大抗病毒治疗的策略,... 详细信息

为实现世界卫生组织制定的2030年全球消除病毒性肝炎公共卫生危害的目标,扩大慢性乙型肝炎的治疗人群尤为重要。近些年,各种研究表明,ALT与肝脏炎症、纤维化、肝细胞癌和肝病终点事件均有关。降低ALT治疗阈值作为扩大抗病毒治疗的策略,可减少肝硬化、肝细胞癌及肝病相关死亡事件的发生。在2022年我国《扩大慢性乙型肝炎抗病毒治疗的专家意见》中,对于慢性乙型肝炎患者的治疗适应证已更新为血清HBV DNA阳性,ALT高于治疗阈值(男性30 U/L,女性19 U/L),且排除其他原因。

关键词：慢性乙型肝炎扩大治疗 ALT治疗阈值

探索中国风景园林申报《人类非物质文化遗产代表作名录》的可行性

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中国园林 2022年第10期38卷 50-55页

作者：张柔然陈淑妍陈欣何昉深圳大学建筑与城市规划学院风景园林系深圳518000 剑桥大学麦克唐纳考古研究所国际古迹遗址理事会国际文化旅游科学委员会华南理工大学建筑学院广州510641 深圳大学建筑与城市规划学院广州510641 北京林业大学园林学院北京100083 深圳媚道风景园林与城市规划设计院

中国风景园林申报《人类非物质文化遗产代表作名录》从国内层面对弘扬中国文化、传播中国声音具有重大意义,从国际层面能够呼应联合国教科文组织倡导的非物质文化遗产与物质遗产融合。从梳理中国风景园林的相关文献出发,参考已申报成功... 详细信息

中国风景园林申报《人类非物质文化遗产代表作名录》从国内层面对弘扬中国文化、传播中国声音具有重大意义,从国际层面能够呼应联合国教科文组织倡导的非物质文化遗产与物质遗产融合。从梳理中国风景园林的相关文献出发,参考已申报成功的国内外案例经验,分析申报原则和标准,从中国风景园林哲学理念和造园技法两大方面探索申报非遗的可行性,并提出申遗策略。申报非遗的关键是梳理符合《保护非物质文化遗产公约》5个非遗类型的相关证据,并按照《实施〈保护非物质文化遗产公约〉业务指南》完善现有保护和管理措施。

关键词：风景园林中国风景园林哲学理念造园技法《人类非物质文化遗产代表作名录》申遗可行性

创新生态系统视角下数字技术对区域创新绩效的影响效应研究

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科研管理 2024年第5期45卷 94-104页

作者：王京陈晶李舒妍哈尔滨理工大学经济与管理学院黑龙江哈尔滨150040

创新生态系统是加快形成区域高质量发展经济格局的重要支撑,加速释放的数字生产力为区域创新带来了巨大红利。基于2013—2019年的省级面板数据,使用多重中介模型、调节模型、门槛回归模型及空间模型,结合生态位理论和协同理论等,在创新... 详细信息

创新生态系统是加快形成区域高质量发展经济格局的重要支撑,加速释放的数字生产力为区域创新带来了巨大红利。基于2013—2019年的省级面板数据,使用多重中介模型、调节模型、门槛回归模型及空间模型,结合生态位理论和协同理论等,在创新生态系统视角下探究数字技术与区域创新绩效的关系,得出以下结论:(1)创新生态系统视角下数字技术能够显著提高区域创新绩效,且对技术子系统绩效的影响最大,其次是商业子系统和科学子系统。(2)数字技术影响区域创新绩效的路径中,各子系统的生态位适宜度和子系统间协同不仅存在并行中介作用,也存在链式中介作用。(3)技术子系统和商业子系统的生态位宽度能够正向调节数字技术和区域创新绩效的关系。(4)数字技术发展强化了创新极化的格局。本文拓展了数字技术驱动区域创新相关研究的理论视角,也为各区域通过数字技术塑造多维生态优势提供了参考与启示。

关键词：数字技术区域创新生态系统生态位多重中介模型