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Food Bioscience 2022年第3期47卷 736-744页

作者： Yinxiao Zhang shuya zhu Chi Zhang Mohamed Mohamed Soliman He Li Xinqi Liu Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Engineering and Technology Research Center of Food AdditivesNational Soybean Processing Industry Technology Innovation CenterBeijing Technology and Business UniversityBeijing100048China Clinical Laboratory Sciences Department Turabah University CollegeTaif University21995Saudi Arabia

To further investigate the promoting effect of soybean protein and peptides on Lacticaseibacillus rhamnosus Lra05(L.rhamnosus Lra05),the overall changes of gene expression of it was investigated through transcriptome analysis treated with dPEP and dSPI The results showed that there were 890,113,and 1073 differentially expressed genes(DEGs)in dPEP/MRS,dSPI/MRS and dPEP/dSPI comparison,respectively.Besides,we found dPEP could promote the expression of acc and fab family genes related to fatty acid biosynthesis,but dSPI played the opposite role.Moreover,dPEP stimulated genes clustered in pur family and ribosome protein,responsible for purine and protein synthesis.Interestingly,dPEP suppressed genes regulating peptides and amino acids transportation and dSPI specially inhibited the pyr family genes involved in pyrimidine metabolism.These data revealed the knowledge about the metabolic pathways affected by dPEP and dSPI and provide a preliminary understanding of the relationship between soybean proteins and peptides and L.rhamnosus Lra05.

关键词： Lacticaseibacillus rhamnosus Soybean protein isolates Soybean peptides Transcriptome analysis

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论穴位敏化过程与痒觉感受器激活相关性

中华中医药杂志 2024年第4期39卷 1623-1626页

作者：王舒娅朱兵中国中医科学院针灸研究所北京100700

内脏病变通常以“牵涉性感觉异常”方式出现于体表特定部位,这些部位多与穴位相对应,而“按之快然”的穴位敏化属性及生物个体主动寻求按摩、抓挠的行为提示可能有“痒”的成分参与。新近发现的特异性痒觉感受器——表达Mas相关G蛋白偶... 详细信息

内脏病变通常以“牵涉性感觉异常”方式出现于体表特定部位,这些部位多与穴位相对应,而“按之快然”的穴位敏化属性及生物个体主动寻求按摩、抓挠的行为提示可能有“痒”的成分参与。新近发现的特异性痒觉感受器——表达Mas相关G蛋白偶联A3受体的神经元可能与穴位的“快然”特性相关,这类感受器在内脏病变时被激活,表现为诱发性痒觉敏化,促使我们渴望接受刺激以调控机能。痒觉感受器激活的动态过程与内脏牵涉性感觉异常所引发穴位“开合”属性的相关性研究,将为穴位敏化触发的自我刺激疗愈过程提供新的探索思路。

关键词：穴位敏化痒觉感受器牵涉性感觉异常外周敏化体表-内脏会聚

Step distribution of Yb filling fraction during microstructural evolution in skutterudites

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Journal of Advanced Ceramics 2019年第1期8卷 62-71页

作者： Jing MEI Zheng YAO shuya zhu Dongli HU Ying JIANG Juanjuan XING Hui GU Lidong CHEN School of Materials Science and Engineering and Materials Genome Institute Shanghai University State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences

To achieve a better material for thermoelectric power generation device, filled skutterudite Yb0.3 Co_4 Sb_(12) samples were fabricated by melting-quenching-annealing-spark plasma sintering(SPS)method. Two sets of samples, before and after SPS, were investigated. In both the two sets of samples,the average grain size of the samples increases monotonously with the increase of annealing time,while Yb filling fraction firstly increases and then decreases. Yb not filling into the skutterudite remains at the grain boundaries in the form of Yb_2 O_3 after SPS, which could be quantified by the spatially difference method of energy dispersive spectra. Step distribution of Yb filling fraction was observed in the samples annealed for 1 h, which was caused by the microstructural evolution from the peritectic phases to the skutterudite phase. The sample annealed for 3 days and SPS sintered possesses the maximum value of Yb filling fraction 0.249 and the maximum ZT value of 1.24 at 850 K. These results are helpful to better understand the microstructural evolution and Yb filling behavior in skutterudite materials.

关键词： skutterudite ytterbium filling fraction microstructure step distribution

p.Arg352Gln突变对Bw07转移酶影响的研究

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中华检验医学杂志 2024年第3期47卷 286-292页

作者：孔永奎朱鹏飞刘欣宋婕王莉王书亚杨乾坤郑州大学第一附属医院输血科郑州450052 郑州大学第一附属医院检验科郑州450052

目的探讨1例ABw07亚型先证者所携带的Bw07等位基因及其转移酶改变的分子生物学机制。方法选取1例2岁男性患儿为研究对象。先证者及其父母的外周血采用试管法鉴定ABO血型,并对三者进行ABO亚型PCR-SSP检测、ABO基因测序以确定其血型基因型... 详细信息

目的探讨1例ABw07亚型先证者所携带的Bw07等位基因及其转移酶改变的分子生物学机制。方法选取1例2岁男性患儿为研究对象。先证者及其父母的外周血采用试管法鉴定ABO血型,并对三者进行ABO亚型PCR-SSP检测、ABO基因测序以确定其血型基因型,最后通过模拟突变、DUET结构预测、分子动力学分析和体外细胞实验验证p.Arg352Gln突变对Bw07转移酶的影响。结果先证者及其母亲血清学表型分别为ABw和Bw,父亲为正常的A型,ABO亚型PCR-SSP检测确定三者基因型分别为Bw07/A、Bw07/O、A/A,Sanger测序进一步验证了先证者及其母亲携带有Bw07基因,模拟突变显示R352Q突变后分子间作用力减弱,DUET预测该p.Arg352Gln突变可以影响Bw07转移酶的热力学稳定性,分子动力学分析证实了热力学稳定性的改变主要是与125-133、193-198、336-354区域氨基酸骨架原子出现较大的波动性有关,体外细胞实验进一步验证了Bw07转移酶合成的抗原减弱。结论ABw07亚型的形成与Bw07转移酶上高度保守的Arg352突变成Gln有关。

关键词： ABO血型系统 Bw07 基因型 PCR-SSP 分子动力学

不同氮素形态对木薯生长及根际土壤养分与酶活性的影响

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热带作物学报 2024年第3期45卷 632-640页

作者：姜舒雅孙彬杰林萱刘文杰朱杰辉宋勇湖南农业大学园艺学院湖南长沙410128 湖南湘研种业有限公司湖南长沙410128 湖南农业大学东方科技学院湖南长沙410128 湖南省马铃薯工程技术研究中心湖南长沙410128 园艺作物种质创新与新品种选育教育部工程研究中心湖南长沙410128 蔬菜生物学湖南省重点实验室湖南长沙410128

通过研究不同氮素形态对华南9号(SC9)木薯生长及根际土壤养分、土壤酶活性的影响,为湖南地区木薯科学施肥提供理论依据。本试验设CK(不施氮肥)、T1(酰胺态氮-尿素)、T2(铵态氮-硫酸铵)、T3(硝态氮-硝酸钙)4个处理(土壤肥力水平一致,氮... 详细信息

通过研究不同氮素形态对华南9号(SC9)木薯生长及根际土壤养分、土壤酶活性的影响,为湖南地区木薯科学施肥提供理论依据。本试验设CK(不施氮肥)、T1(酰胺态氮-尿素)、T2(铵态氮-硫酸铵)、T3(硝态氮-硝酸钙)4个处理(土壤肥力水平一致,氮肥施用量均为180 kg/hm^(2))研究不同氮素形态处理对木薯的株高、茎粗、土壤养分、土壤酶活性及产量与品质的影响。结果表明:不同氮素处理较CK处理均提高了木薯的株高、茎粗、产量与品质,T2处理下木薯的株高、茎粗、产量、干物率、淀粉含量均最高,较CK处理分别显著提高13.51%、32.24%、61.72%、6.44%、19.86%。施氮改变了根际土壤养分含量,T2处理对木薯根际土壤养分含量促进效果最好;T2处理的土壤有机质、碱解氮含量均高于其他处理,块根形成和块根膨大期T2处理的速效钾含量高于其他处理;与CK处理相比,施氮提高了木薯根际土壤酶活性。随着生长期的推移,脲酶活性表现为逐渐升高,蔗糖酶活性表现为先降低后升高,过氧化氢酶和硝酸还原酶活性表现为先升高后降低。其中T2处理土壤蔗糖酶活性最高。综合来看,在湖南地区,氮素形态不同对木薯生长和土壤环境的影响具有差异性,施氮处理较CK处理提高土壤的肥力水平,进而提高了木薯地上部分的生长,从而提高了木薯产量与品质,其中以施用铵态氮肥更有利于木薯SC9生长和产量提高。

关键词：木薯氮素形态土壤养分土壤酶活产量品质

Referred Somatic Hyperalgesia Mediates Cardiac Regulation by the Activation of Sympathetic Nerves in a Rat Model of Myocardial Ischemia

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Neuroscience Bulletin 2022年第4期38卷 386-402页

作者： Xiang Cui Guang Sun Honglei Cao Qun Liu Kun Liu shuya Wang Bing zhu Xinyan Gao Department of Physiology Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China Research Center of Traditional Chinese Medicine The Affiliated Hospital of Changchun University of Chinese MedicineChangchunJilin 130021China Department of Cardiology Jining No.1 People’s HospitalJining 272100ShandongChina Department of Needling Manipulation Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China

Myocardial ischemia(MI)causes somatic referred pain and sympathetic hyperactivity,and the role of sensory inputs from referred areas in cardiac function and sympathetic hyperactivity remain unclear.Here,in a rat model,we showed that MI not only led to referred mechanical hypersensitivity on the forelimbs and upper back,but also elicited sympathetic sprouting in the skin of the referred area and C8–T6 dorsal root ganglia,and increased cardiac sympathetic tone,indicating sympathetic-sensory coupling.Moreover,intensifying referred hyperalgesic inputs with noxious mechanical,thermal,and electro-stimulation(ES)of the forearm augmented sympathetic hyperactivity and regulated cardiac function,whereas deafferentation of the left brachial plexus diminished sympathoexcitation.Intradermal injection of the α_(2) adrenoceptor(α_(2)AR)antagonist yohimbine and agonist dexmedetomidine in the forearm attenuated the cardiac adjustment by ES.Overall,these findings suggest that sensory inputs from the referred pain area contribute to cardiac functional adjustment via peripheral α_(2)AR-mediated sympathetic-sensory coupling.

关键词： Sympathetic-sensory coupling Neuromodulation Referred pain α_(2)adrenoceptor Cardioprotectio

河南开封柳园口省级湿地自然保护区及其南侧区域鸟类群落的多样性

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湿地科学 2024年第1期22卷 38-51页

作者：王鹏陈天恩隋佳容曹颍李书雅朱磊赵笑男赵海鹏河南大学生命科学学院河南开封475004 西藏大学生态环境学院西藏拉萨850000 武汉大学生命科学学院湖北武汉430072 开封市野生动植物保护站河南开封475000 国有济源市愚公林场河南济源459000 河南大别山森林生态系统国家野外科学观测研究站信阳生态研究院河南信阳464000

为了掌握河南开封柳园口省级湿地自然保护区中鸟类群落的多样性现状,分别于2019年9月至12月、2020年9月至12月、2021年3月至7月、2021年9月至2022年4月的每月中旬,采用样线法和样点法,在河南开封柳园口省级湿地自然保护区及其南侧10 km... 详细信息

为了掌握河南开封柳园口省级湿地自然保护区中鸟类群落的多样性现状,分别于2019年9月至12月、2020年9月至12月、2021年3月至7月、2021年9月至2022年4月的每月中旬,采用样线法和样点法,在河南开封柳园口省级湿地自然保护区及其南侧10 km范围内的区域中,开展了野外鸟类调查,研究了湖泊湿地、河流湿地、农田和灌丛中鸟类群落的物种组成、种群数量、多样性和相似性。研究结果表明,调查期间,在研究区中,分布着18目48科174种鸟类,以雀形目鸟类占优势,古北界物种的数量最多,鸟类群落的种群总数量为82 983只,鸟类群落的优势物种包括豆雁(Anser fabalis)、绿头鸭(Anas platyrhynchos)、灰鹤(Grus grus)、鸿雁(Anser cygnoid)、斑嘴鸭(Anas zonorhyncha)、麻雀(Passer montanus)、赤麻鸭(Tadorna ferruginea)、罗纹鸭(Mareca falcata)和白骨顶(Fulica atra);在研究区的湖泊湿地、河流湿地、农田和灌丛中,分别记录了14目34科69种、16目40科117种、17目40科93种和16目34科75种鸟类,河流湿地和农田的鸟类物种丰富度水平较高,4种生境中鸟类群落组成的相似性水平较低;在该保护区中,分布着中国特有物种黄腹山雀(Parus venustulus)和白头鹎(Pycnonotus sinensis)以及极危物种青头潜鸭(Aythya baeri);建议在河南开封柳园口省级湿地自然保护区中的黄河沿岸滩涂和靠近黄河的湖泊湿地,建立鸟类保护与监测区,增加对豆雁、灰鹤、鸿雁、斑嘴鸭和赤麻鸭等指示物种的野外调查频次;在鸟类的繁殖期和越冬期,减少人类活动对鸟类的干扰。

关键词：鸟类多样性自然保护区柳园口

KOH-assisted aqueous synthesis of bimetallic metal-organic frameworks and their derived selenide composites for efficient lithium storage

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矿物冶金与材料学报：英文版 2023年第4期30卷 601-610页

作者： shuya Zhang Yanchun Xue Yutang Zhang Chengxing zhu Xingmei Guo Fu Cao Xiangjun Zheng Qinghong Kong Junhao Zhang Tongxiang Fan School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Materials Science and Engineering Shanghai Jiaotong UniversityShanghai 200240China School of the Environment and Safety Engineering Jiangsu UniversityZhenjiang 212013China Foshan(Southern China)Institute for New Materials Foshan 528200China

To solve low efficiency,environmental pollution,and toxicity for synthesizing zeolitic imidazolate frameworks(ZIFs)in organic solvents,a KOH-assisted aqueous strategy is proposed to synthesize bimetallic ZIFs polyhedrons,which are used as precursors to prepare bimetallic selenide and N-doped carbon(NC)composites.Among them,Fe–Co–Se/NC retains the three-dimensional(3D)polyhedrons with mesoporous structure,and Fe–Co–Se nanoparticles are uniform in size and evenly distributed.When assessed as anode material for lithium-ion batteries,Fe–Co–Se/NC achieves an excellent initial specific capacity of 1165.9 m Ah·g^(-1)at 1.0 A·g^(-1),and the reversible capacity of Fe–Co–Se/NC anode is 1247.4 m Ah·g^(-1)after 550 cycles.It is attributed to that the uniform composite of bimetallic selenides and N-doped carbon can effectively tune redox active sites,the stable 3D structure of Fe–Co–Se/NCs guarantees the structural stability and wettability of the electrolyte,and the uniform distribution of Fe–Co–S nanoparticles in size esuppresses the volume expansion and accelerates the electrochemical reaction kinetics.

关键词： potassium hydroxide assisted aqueous strategy bimetallic zeolitic imidazolate frameworks bimetallic selenide lithium-ion batteries long cycle performance

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油气输送焊管串列超声检测的技术要求与应用

无损检测 2024年第6期46卷 84-88页

作者：任国庆于宾夏翠红李忠凯倪舒亚朱斌燕陈美周强华油钢管有限公司扬州分公司扬州025000

首先介绍了串列超声检测的原理,然后简述了国家石油天然气管网集团及中国石油天然气股份有限公司的相关企业标准、壳牌标准、DNV GL标准关于SAWL(直缝埋弧焊管)、SAWH(螺旋埋弧焊管)、HFW(高频电阻焊管)的串列超声检测要求、串列超声检... 详细信息

首先介绍了串列超声检测的原理,然后简述了国家石油天然气管网集团及中国石油天然气股份有限公司的相关企业标准、壳牌标准、DNV GL标准关于SAWL(直缝埋弧焊管)、SAWH(螺旋埋弧焊管)、HFW(高频电阻焊管)的串列超声检测要求、串列超声检测参考反射体的制备方法及相关计算,最后探讨了串列超声检测探头布置和串列超声检测自动探报警后的复查方法。并明确,在超声波自动检测中引入串列超声检测,能有效保障焊管焊缝区域的全覆盖,有助于提高焊管产品质量。

关键词：埋弧焊钢管高频电阻焊钢管参考反射体焊缝中部缺陷串列式检测

Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis

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Nano Research 2018年第11期11卷 6086-6101页

作者： Yuwei He Ruixiang Li Jianming Liang Ying zhu shuya Zhang Zicong Zheng Jing Qin Zhiqing Pang Jianxin Wang Department of Pharmaceutics School of Pharmacy Fudan University & Key Laboratory of Smart Drug Delivery Ministry of Education Shanghai 201203 China Institute of Clinical Pharmacology Guangzhou University of Traditional Chinese Medicine Guangzhou 510006 China

The effective drug treatment of rheumatoid arthritis (RA) is hindered by poor delivery efficiency to the diseased site and the serious side effects caused by wide-spread drug distribution. Traditional drug-targeting strategies, such as ligand modification, are complex, laborious, and inefficient. Inspired by the intrinsic relationship between platelets and RA, platelet-mimetic nanoparticles (PNPs) were developed for targeted drug delivery in RA. Through platelet receptor-mediated adhesion, an intact platelet membrane was coated onto poly (lactic-co-glycolic acid) nanoparticles, endowing the resulting PNPs with various functional receptors. By coating with platelet membranes, the nanoparticles were stabilized and had a better circulation profile, providing a benefit for passive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivo accumulation in joints of a collagen-induced arthritis (CIA) mouse model of RA were significantly improved via P-selectin and GVPI recognition, indicating that the PNPs could effectively target to RA tissues through multiple mechanisms, similar to natural platelets. Moreover, FK506, a model drug, was loaded into the PNPs and used to treat RA. Pharmacodynamic studies demonstrated that the FK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides a new biomimetic targeting strategy with great potential for the treatment of RA.

关键词： biomimetic nanoparticles platelet membrane rheumatoid arthritis targeted drug delivery