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Density Perturbation and Energy Flux of Internal Waves from Velocity Data

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Journal of Ocean University of China 2018年第4期17卷 727-732页

作者： wang shuya wang Jinhu CHEN Xu MENG Jing wang Huan Key Laboratory of Physical Oceanography Ocean University of China College of Information Science and Engineering Ocean University of China

Internal waves play a crucial role in ocean mixing, and density perturbation and energy flux are essential quantities to investigate the generation and propagation of internal waves. This paper presents a methodology for calculating density perturbation and energy flux of internal waves only using a velocity field that is based on linearized equations for internal waves. The method was tested by numerical simulations of internal waves generated by tidal flowing over a Gaussian topography in a stratified fluid. The density perturbations and energy fluxes determined using our method that only used velocity data agreed with density perturbations and energy fluxes determined by the equation of state based on temperature data. The mean relative error(MRE) and root mean square error(RMSE) between the two methods were lower than 5% and 10% respectively. In addition, an experiment was performed to exam our method using the velocity field measured by Particle Image Velocimetry(PIV), and the setup of the experiment is consistent with the numerical model. The results of the experiments calculated by the methods using PIV data were also generally equal to those of the numerical model.

关键词： internal waves density perturbation energy flux velocity field PIV

Nanomedicine-based treatment:An emerging therapeutical strategy for pulmonary hypertension

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Nano Research 2023年第5期16卷 7007-7029页

作者： shuya wang Qiaohui Chen Tianjiao Zhao Kelong Ai Changping Hu Department of Pharmacology Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha 410078China Hunan Provincial Key Laboratory of Cardiovascular Research Changsha 410078China

Pulmonary hypertension(PH)can cause breathing difficulty,a rapid decline of exercise capacity,heart failure,eventually death of the *** latest epidemiological study demonstrates that PH has a much higher incidence than previously *** is still a highly fatal disease due to the many disadvantages of the current drugs,such as short half-life,lack of targeting,potent side *** PH pathological features offer great opportunities for nanomedicines for ***,emerging nanomedicines demonstrated great advantages in the therapeutic effect of PH by enhancing the accumulation of drugs in PH lesion,optimizing drug efficacy,minimizing drug side ***,this promising field of cross-cutting research is far from being widely explored due to the huge professional *** solve this problem,we provide a comprehensive review for the latest progresses of nanomedicines in the treatment of ***,we systematical summarized the PH pathological features and the current clinical drug treatment of *** advantages of nanomedicines are also deeply discussed in the treatment of ***,we focused on the research progresses of nanomedicines in PH through three aspects:advanced nano-drug delivery system for traditional drugs and new target drugs,gene therapy-based nanomedicines,other nanomedicines for the treatment of ***,we also discussed the prospects and challenges for the clinical application of nanomedicines in PH,provided directions for the research and development of nanomedicines for PH treatment in the future.

关键词： pulmonary hypertension nanomedicines enhanced penetration and retention effects polymer liposome

Estimation of the Reflection of Internal Tides on a Slope

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Journal of Ocean University of China 2020年第3期19卷 489-496页

作者： wang shuya CAO Anzhou CHEN Xu LI Qiang SONG Jinbao MENG Jing Key Laboratory of Physical Oceanography Qingdao Collaborative Innovation Center of Marine Science and Technology(CIMST)Ocean University of Chinaand Qingdao National Laboratory for Marine Science and TechnologyQingdao 266100China Ocean College Zhejiang UniversityZhoushan 316021China Graduate School at Shenzhen Tsinghua UniversityShenzhen 518055China College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao 266100China

Reflection occurs when internal tides impact on a steep continental slope. Separating reflected internal tide signals from incident ones is crucial to develop the parameterization of internal tide-driven turbulent mixing on the continental slopes. In this study, the performances of three different methods for estimating internal tide reflections are examined by using two different cases. The Hilbert transform-based method is found to be more suitable than two other methods for both cases considered in this study. The two other methods are effective for westward-propagating mode-1 internal tides impacting a slope, but inappropriate in the case where internal tides radiate from a Gaussian ridge impact the slope because of their inaccurate estimation of incident internal tides in the latter case. Such inaccurate estimation further influences the extraction of reflected signals and calculation of the reflected and cross term of energy fluxes. In addition, it should be noted that, due to the use of filtering, the method based on Hilbert transform may result in slight bias when assessing the incident and reflected signals near topographic features.

关键词： internal tide reflection continental slope Hilbert transform energy flux filtering

On the Generation and Evolution of Internal Solitary Waves in the Andaman Sea

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Journal of Ocean University of China 2023年第2期22卷 335-348页

作者： YU Yujun XU Tao wang Jinhu wang shuya LI Qun MENG Jing CHEN Xu LU Kexiao wang Guixia Key Laboratory of Physical Oceanography Ocean University of China and Qingdao National Laboratory for Marine Science and TechnologyQingdao 266100China Polar Research Institute of China(PRIC)Shanghai 200000 China College of Mathematical Science Inner Mongolia Normal UniversityHohhot 010022China

Internal solitary waves(ISWs)are ubiquitous in the Andaman Sea,as revealed by synthetic aperture radar images;however,their generation mechanisms and corresponding influencing factors remain *** on a nonhydrostatic two-dimensional model,the generation of ISW packets along the transect of a channel lying between Batti Malv Island and Car Nicobar Island is ***,the influences of topographic characteristics,seasonal stratifications,and tidal forcings are analyzed through a series of sensitivity *** simulation results indicate that bidirectional rank-ordered ISW packets are generated by the nonlinear steepening of internal *** east-west ISW asymmetry is observed,which is attributed to distinct topographic *** surrounding sills can also generate internal wave beams,which modulate the intensity of ***,the topographic structure of the west flank of the ridge mainly contributes to the suppression of westward ISWs,which decreases the modulating effect of internal wave *** the spring tide,the generation of ISWs is *** the neap tide,ISWs are weak,and the east-west ISW asymmetry is less ***,seasonal stratification only has a minor effect on the generation and evolution of ISWs.

关键词： internal solitary wave numerical simulation Andaman Sea

Etching mechanism of barium strontium titanate (BST) thin films in CHF_3/Ar plasma

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Chinese Science Bulletin 2011年第21期56卷 2267-2271页

作者： DAI LiPing wang shuya SHU Ping ZHONG ZhiQin wang Gang ZHANG GuoJun State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 610054China

Reactive ion etching was used to etch barium strontium titanate thin films in a CHF3/Ar *** surfaces before and after etching were analyzed by X-ray photoelectron spectroscopy to investigate the reaction ion etching mechanism,and chemical reactions had occurred between the F plasma and the Ba,Sr and Ti metal *** of these metals were formed and remained on the surface during the etching *** was almost completely removed because the TiF4 by-product is *** quantities of Ti?F could still be detected by narrow scan X-ray photoelectron spectra,and Ti?F was thought to be present in the form of a *** species were investigated from O1s spectra,and a fluoride-rich surface was formed during ***2 and SrF2 residues were difficult to remove because of their high boiling *** etching rate was limited to 12.86 nm/min.C?F polymers were not found on the surface,indicating that the removal of BaF2 and SrF2 was important for further etching.A 1-min Ar/15 plasma physical sputtering was carried out for every 4 min of surface etching,which effectively removed remaining surface *** chemical reaction and sputtered etching is an effective etching method for barium strontium titanate films.

关键词：钛酸锶钡薄膜等离子蚀刻 BST 机制 X射线光电子能谱反应离子刻蚀 BaF2晶体金属氟化物

Referred Somatic Hyperalgesia Mediates Cardiac Regulation by the Activation of Sympathetic Nerves in a Rat Model of Myocardial Ischemia

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Neuroscience Bulletin 2022年第4期38卷 386-402页

作者： Xiang Cui Guang Sun Honglei Cao Qun Liu Kun Liu shuya wang Bing Zhu Xinyan Gao Department of Physiology Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China Research Center of Traditional Chinese Medicine The Affiliated Hospital of Changchun University of Chinese MedicineChangchunJilin 130021China Department of Cardiology Jining No.1 People’s HospitalJining 272100ShandongChina Department of Needling Manipulation Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China

Myocardial ischemia(MI)causes somatic referred pain and sympathetic hyperactivity,and the role of sensory inputs from referred areas in cardiac function and sympathetic hyperactivity remain ***,in a rat model,we showed that MI not only led to referred mechanical hypersensitivity on the forelimbs and upper back,but also elicited sympathetic sprouting in the skin of the referred area and C8–T6 dorsal root ganglia,and increased cardiac sympathetic tone,indicating sympathetic-sensory ***,intensifying referred hyperalgesic inputs with noxious mechanical,thermal,and electro-stimulation(ES)of the forearm augmented sympathetic hyperactivity and regulated cardiac function,whereas deafferentation of the left brachial plexus diminished *** injection of the α_(2) adrenoceptor(α_(2)AR)antagonist yohimbine and agonist dexmedetomidine in the forearm attenuated the cardiac adjustment by ***,these findings suggest that sensory inputs from the referred pain area contribute to cardiac functional adjustment via peripheral α_(2)AR-mediated sympathetic-sensory coupling.

关键词： Sympathetic-sensory coupling Neuromodulation Referred pain α_(2)adrenoceptor Cardioprotectio

A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein

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Asian Journal of Pharmaceutical Sciences 2019年第2期14卷 154-164页

作者： Jiaxin Pi shuya wang Wen Li Dereje Kebebe Ying Zhang Bing Zhang Dongli Qi Pan Guo Nan Li Zhidong Liu Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique Ministry of Education Tianjin University of Traditional Chinese Medicine Institute of health sciences Jimma University

Baicalein(BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. In this work, a nano-cocrystal strategy was successfully applied to improve the dissolution rate and bioavailability of BE. Baicalein-nicotinamide(BE-NCT) nanococrystals were prepared by high pressure homogenization and evaluated both in vitro and in vivo. Physical characterization results including scanning electron microscopy, dynamic light scattering, powder X-ray diffraction and differential scanning calorimetry demonstrated that BE-NCT nano-cocrystals were changed into amorphous state with mean particle size of 251.53 nm. In the dissolution test, the BE-NCT nano-cocrystals performed 2.17-fold and 2.54-fold enhancement than BE coarse powder in FaSSIF-V2 and FaSSGF. Upon oral administration, the integrated AUC0-t of BE-NCT nano-cocrystals(6.02-fold) was significantly higher than BE coarse powder(1-fold), BE-NCT cocrystals(2.87-fold) and BE nanocrystals(3.32-fold). Compared with BE coarse powder, BE-NCT cocrystals and BE nanocrystals, BENCT nano-cocrystals possessed excellent performance both in vitro and in vivo ***, it can be seen that nano-cocrystal is an appropriate novel strategy for improving dissolution rate and bioavailability of poor soluble natural products such as BE.

关键词： Baicalein Nano-cocrystals Cocrystals Bioavailability

生命教育融入大学生“三观”培塑的理论基础、可行性及路径探析

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中国医学伦理学 2024年第8期37卷 963-966页

作者：王姝亚杜萍海军军医大学基础医学院上海200433

生命教育作为一种重要的现代教育手段,可以指引人从生命周期的维度去看待人才培养。大学时期正是树立正确的世界观、人生观、价值观,系好人生第一粒扣子的关键时期。从终极目标看,“三观”培塑同生命教育同频共振。因此,适时将生命教育... 详细信息

生命教育作为一种重要的现代教育手段,可以指引人从生命周期的维度去看待人才培养。大学时期正是树立正确的世界观、人生观、价值观,系好人生第一粒扣子的关键时期。从终极目标看,“三观”培塑同生命教育同频共振。因此,适时将生命教育融入大学生的“三观”既有助于推动大学生生命教育内容的创新发展,又可以助力大学生正确认识世界、时代和个人,完成正向“三观”的塑造,肩负起时代所赋予青年的使命。

关键词：生命教育世界观人生观价值观

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太平天国公文语言的特点

南京师范大学文学院学报 2013年第4期 162-164页

作者：王舒雅南京师范大学文学院江苏南京210097

太平天国公文用语独具特色,在革命宣传方面发挥了重要作用。公文中诗歌句式方便了军民口口相传,使得革命思想深入人心。大量方言口语的运用增强了军民的凝聚力,革命隐语的巧妙使用间接地增强了太平天国公文的保密性。同时大量方言口语... 详细信息

太平天国公文用语独具特色,在革命宣传方面发挥了重要作用。公文中诗歌句式方便了军民口口相传,使得革命思想深入人心。大量方言口语的运用增强了军民的凝聚力,革命隐语的巧妙使用间接地增强了太平天国公文的保密性。同时大量方言口语和诗歌句式的使用也降低了作为政治载体的公文的权威性和指令性。

关键词：太平天国公文诗歌方言隐语