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Retrospect and reflection on the construction of large-scale technology platform of the State Key Laboratory of Natural and Biomimetic Drugs in 2018–2020

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Journal of Chinese Pharmaceutical Sciences 2019年第12期28卷 878-884页

作者： shuxiang song State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China

The State Key Laboratory of Natural and Biomimetic Drugs was approved for a funding of nearly 100 million yuan specifically aimed at the purchase and maintenance of equipment and instruments from 2018 to 2020,which is a record *** Laboratory focuses on two major directions of scientific research,the"basic scientific problems of drug resistance of complex components of natural products"and the"key biomimetic scientific problems of endogenous substances therapeutic functions".The selection of scientific instruments and equipment,trial production,upgrading,as well as high level of technical and management personnel allocation and other aspects are critical to meet the development needs of the Key Laboratory and to maintain the advantages and leading role in these two major directions of scientific research.

关键词： Instrument platform construction Optimization of resource allocation Scientific research service

Design of a Surface Plasmon Resonance Sensor Based on Grating Connection

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Photonic Sensors 2015年第2期5卷 159-165页

作者： Jun ZHU Liuli QIN shuxiang song Junwen ZHONG Siyuan LIN College of Electronic Engineering Guangxi Normal University Guilin 541004 China College of Mathematics and Statistics Guangxi Normal University Guilin 541004 China

Nowdays, the study of measurement of the biological field focuses on the research of improving surface plasmon resonance （SPR） in the fields of integration and detection sensitivity. We designed a kind of grating connected surface plasmon resonance sensor. Theoretically, we analyzed the wave vector and the. effective refractive index relations with the diffraction grating structure. Then we obtained the nanoparticles enhancement SPR structure with a resolution 10times higher than that of traditional SPR sensors. Also, we used the finite-difference time-domain （FDTD） analysis and simulation which showed that it was obvious with coupling effect by the nanoparticles enhancement SPR structure that the reflectance spectral bandwidth results validated the structure significantly which improved the sensitivity. Experimental results showed that the dynamic response of the designed sensor reached 10^-6 RIU （refractive index unit）. This study has the certain significance to long-distance and special sensing applications.

关键词： Surface plasmon resonance waveguide grating mode coupling sensitivity resolution

Construction and open access management of large-scale instrument platform

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Journal of Chinese Pharmaceutical Sciences 2020年第2期29卷 130-138页

作者： shuxiang song State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China

Due to the new situation of continuous expansion of scientific and technological resources in universities and the urgent demand for hardware resources for science and technology innovation it is imperative to strengthen the construction of large-scale instrument service platforms and open access *** is not only the requirements for the development of instrument service platforms,but also the resources for science and technology of *** the present paper,we first summarized the current equipment management,open access and major experience,then raised the problems in the construction and management process on the basis of the large instrument platform construction and open access management regulations,and finally proposed countermeasures for these problems:increasing funding input,streamlining the management system,improving the performance evaluation mechanism,and strengthening the management and operation team construction,***,this paper provided reference and enlightenment for the construction and open access management of similar large-scale instrument platforms.

关键词： Large-scale instrument platform Open access management Experience Countermeasure

The group of *** Jia have realized the first total synthesis of natural product(–)-glaucocalyxin A

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Journal of Chinese Pharmaceutical Sciences 2020年第6期29卷 439-440页

作者： shuxiang song 北京大学药学院天然药物及仿生药物国家重点实验室

6月15日,《德国应用化学》(Angew. Chem. Int. Ed.)期刊在线刊登了我院天然药物及仿生药物国家重点实验室贾彦兴教授团队在天然产物全合成领域的最新研究成果:"Total Synthesis of(–)-glaucocalyxin A"。该工作同时被编辑选为Hot Pape... 详细信息

6月15日,《德国应用化学》(Angew. Chem. Int. Ed.)期刊在线刊登了我院天然药物及仿生药物国家重点实验室贾彦兴教授团队在天然产物全合成领域的最新研究成果:"Total Synthesis of(–)-glaucocalyxin A"。该工作同时被编辑选为Hot Paper。二萜类天然产物由于具有复杂的化学结构和良好的生物活性,其全合成一直是合成化学的热门研究领域。然而,具有14-羟基[3.2.1]桥环结构的二萜(图a),由于其连续手性中心多、合成挑战性更高,而鲜有全合成报道。蓝萼甲素(Glaucocalyxin A)则是该类二萜的代表分子之一,其不仅具有良好的抗肿瘤与抗炎活性,而且结构复杂,包含四个全碳环和7个连续的手性中心,至今没有全合成报道。

关键词：蓝萼甲素全合成手性中心合成化学天然产物二萜抗炎活性应用化学

Research progress of surface plasmon resonance technology in drug discovery

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Journal of Chinese Pharmaceutical Sciences 2020年第7期29卷 504-513页

作者： Jing Wang Qian Wang shuxiang song State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China

Surface plasmon resonance(SPR)technology is a powerful and sensitive tool for investigating molecular *** improvements in recent years have brought new functionality to SPR apparatuses that can be widely applied at multiple stages of the drug discovery *** technology allows users to conduct ligand fishing and offers rich and in-depth information regarding the affinity,specificity,kinetics,concentration and identification of covalent/allosteric/competitive binding *** present review highlights the principle,sample types,detection ranges,experimental methods,strengths,limitations,and the latest research progress on the application of SPR technology in the drug discovery process.

关键词： Surface plasmon resonance SPR Drug discovery Molecular interaction

Surface-assisted laser desorption/ionization mass spectrometry for drug and metabolite analysis

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Journal of Chinese Pharmaceutical Sciences 2020年第8期29卷 577-590页

作者： Wen Ma shuxiang song Jun Li State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China

Surface-assisted laser desorption/ionization mass spectrometry(SALDI-MS)uses inorganic nanomaterials as matrixes to facilitate desorption and ionization of *** with the traditional matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)technique,SALDI-MS has the advantages of less interference in the low mass range,better reproducibility and higher salt *** is highly suitable for the analysis of small molecule *** recent years,researchers have developed a range of nanomaterials that are successfully applied to the field of small molecule drug and metabolite analysis including drug screening and quantification,drug delivery,metabolite profiling,biomarker discovery and so *** review summarizes the latest progress of SALDI-MS matrix materials such as metal-based,carbon-based,silica-based nanomaterials and organic framework nanomaterials and their *** addition,our perspective of SALDI-MS technology is also discussed for further advancement.

关键词： Laser desorption/ionization mass spectrometry Drug analysis Metabolite detection Nanomaterial

SPASER技术的MIM波导放大器特性分析(英文)

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红外与激光工程 2016年第3期45卷 148-154页

作者：朱君秦柳丽宋树祥广西师范大学电子工程学院广西桂林541004 广西师范大学数学与统计学院广西桂林541004

SPASER是所报道的最小的、第一个在可见光或更宽的波长范围内工作的纳米级的有源器件。采用双稳态方法,将SPASER技术引入到改进的MIM波导结构实现表面等离子波放大器的设计,理论上采用SPASER的激光理论的Bloch方程推导得出:泵浦速率小... 详细信息

SPASER是所报道的最小的、第一个在可见光或更宽的波长范围内工作的纳米级的有源器件。采用双稳态方法,将SPASER技术引入到改进的MIM波导结构实现表面等离子波放大器的设计,理论上采用SPASER的激光理论的Bloch方程推导得出:泵浦速率小于阈值时,增益介质反转粒子数保持为0,在泵浦速率大于阈值时,反转粒子数随泵浦速率线性增长;系统的几何特性完全由本征模式函数描述,在给定本征模式下,其性质完全取决于材料参数;选择合适的材料参数,可以使各状态的驰豫特征时间都在亚皮秒量级。模型计算结果表明:改进结构不会改变SPPs的强局域化特性;器件解决了SPASER内反馈造成的表面等离子净增益消除的难题。研究成果可应用到生物传感、波谱检测、显微成像、超快通信等领域。

关键词：表面等离子受激辐射放大泵浦速率反转粒子数

High-throughput screening technologies for ion channel drug discovery

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Journal of Chinese Pharmaceutical Sciences 2021年第10期30卷 785-793页

作者： Guifang Duan Bo Xu Xia Yuan shuxiang song State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China

Ion channels are attractive targets for drug discovery as an increasing number of new ion channel targets have been uncovered in diseases, such as pain, cardiovascular disease, and neurological disorders. Despite their relevance in diseases and the variety of physiological functions they are involved in, ion channels still remain underexploited as drug targets. This, to a large extent, is attributed to the absence of screening technologies that ensure both the quality and the throughput of data. However, an increasing number of assays and technologies have evolved rapidly in the past decades. In this review, we summarized the currently available high-throughput screening technologies in ion channel drug discovery.

关键词： Ion channels Drug discovery High-throughput screening

电流模式n阶MOCCII-RC的全通滤波器设计

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仪器仪表学报 2008年第9期29卷 1972-1976页

作者：宋树祥严国萍曹华华中科技大学电子与信息工程系武汉430074

本文提出了一种新的基于MOCCII的n阶等电容和等电阻全通电流模式滤波器综合方法。通过对n阶全通滤波传输函数进行分析将其分解成一系列能用无损积分器实现的表达式,由低阶向高阶进行电路综合。该滤波电路包含n+2个有源器件、2n+4个接地... 详细信息

本文提出了一种新的基于MOCCII的n阶等电容和等电阻全通电流模式滤波器综合方法。通过对n阶全通滤波传输函数进行分析将其分解成一系列能用无损积分器实现的表达式,由低阶向高阶进行电路综合。该滤波电路包含n+2个有源器件、2n+4个接地无源元件,整个电路的部分无源元件灵敏度之和与全部无源元件灵敏度之和为0。文中对一个3阶全通滤波器进行了PSPICE模拟验证。

关键词： n阶滤波器全通滤波器多输出端第二代电流传输器模拟电路设计