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Multimodal process monitoring based on transition-constrained Gaussian mixture model

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Chinese Journal of Chemical Engineering 2020年第12期28卷 3070-3078页

作者： shutian chen Qingchao Jiang Xuefeng Yan Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education East China University of Science and TechnologyShanghai 200237China

Reliable process monitoring is important for ensuring process safety and product quality.A production process is generally characterized bymultiple operation modes,and monitoring thesemultimodal processes is *** multimodal monitoring methods rely on the assumption that the modes are independent of each other,which may not be appropriate for practical *** study proposes a transition-constrained Gaussian mixture model method for efficient multimodal process *** technique can reduce falsely and frequently occurring mode transitions by considering the time series information in the mode identification of historical and online *** process enables the identified modes to reflect the stability of actual working conditions,improve mode identification accuracy,and enhance monitoring reliability in cases of mode *** studies on a numerical simulation example and simulation of the penicillin fermentation process are provided to verify the effectiveness of the proposed approach inmultimodal process monitoring with mode overlap.

关键词： Multimodal process monitoring Gaussian mixture model State transition matrix Process control Process systems Systems engineering

Enhanced Natural Convection for Accelerating Melting of Phase Change Material in Cellular Structure through Inserting Fin

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Journal of Thermal Science 2024年第2期33卷 548-563页

作者： KONG Dekui ZHANG Yongcun LIU shutian State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian116024China

The design of thermal conductivity enhancers(TCE) is quite critical to overcoming the disadvantage of the poor thermal conductivity of phase change materials(PCM).The main contribution of this study is firstly to discuss how to actively enhance natural convection of the melted PCM in cellular structure by the fin formed in the structure under the condition of the same metal mass,apart from simultaneously improving heat conduction,which can boost the heat transfer ***,a tailored hybrid fin-lattice structure(HFS) as TCE is designed and fabricated by additive manufacturing(AM).A two-equation numerical method is applied to study the heat transfer of the PCM,and its feasibility is validated with the experimental *** numerical results indicate that enhanced natural convection and improved heat conduction can be obtained simultaneously when a well-designed fin is embedded into a lattice *** enhanced natural convection results in the improved melting rate and the decreased wall temperature;e.g.,the complete melting time and the wall temperature are reduced by 11.6% and 19.7%,respectively,because of the fin for metal ***,the parameters of HFS including the porosity,pore density,and fin dimension have a great impact on the heat *** enhancement effect of the fin for HFS on the melting rate of the PCM increases as the thermal conductivity of the base material *** example,when the fin is introduced into the lattice structure,the complete melting time is reduced by 24.1% for metal *** summary,this study enables us to obtain a good understanding of the mechanism of the heat transfer and provides necessary experimental data for the structural design of HFS fabricated by AM.

关键词： natural convection heat transfer enhancement phase change material additive manufacturing hybrid fin-lattice structure

Topology Optimization Method for Microscale Structures Described with Integral Nonlocal Theory

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Acta Mechanica Solida Sinica 2024年第1期37卷 63-71页

作者： Jiayu Li Quhao Li shutian Liu State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China

The integration of additive manufacturing and topology optimization makes it possible to fabricate complex configurations,especially for microscale structures,which can guarantee the realization of high-performance structural ***,topology results often contain microstructures(several multicellular scales)similar to the characteristic length of local macrostructures,leading to errors in structural performance analysis based on classical ***,it is necessary to consider the size effect in topology *** this paper,we establish a novel topology optimization model utilizing the integral nonlocal theory to account for the size *** approach consists of an integral constitutive model that incorporates a kernel function,enabling the description of stress at a specific point in relation to strain in a distant *** optimization structures based on nonlocal theory are presented for some benchmark examples,and the results are compared with those based on classical medium *** material layout exhibits significant differences between the two approaches,highlighting the necessity of topology optimization based on nonlocal theory and the effectiveness of the proposed method.

关键词： Topology optimization Microstructures Integral nonlocal theory Size effect

Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian shutian Zhang Ning Dai Hoon Jai Chun chengtang Chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai Jessica D.Eisner Li Xie Minhu chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China Department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda Development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CI<0%)was also *** 12 weeks,endoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

Modifiable risk factors for esophageal cancer in endoscopic screening population:A modeling study

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Chinese Medical Journal 2024年第3期137卷 350-352页

作者： Qian Zhang Fan Wang Hao Feng Jie Xing Shengtao Zhu Hao Zhang Yang Li Wenqiang Wei shutian Zhang Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseaseBeijing Digestive Disease CenterBeijing Key Laboratory for Precancerous Lesion of Digestive DiseaseBeijing 100050China Center for Applied Statistics and School of Statistics Renmin University of ChinaBeijing 100872China Statistical Consulting Center Renmin University of ChinaBeijing 100872China National Cancer Center National Clinical Research Center for CancerCancer InstituteChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Gastroenterology Jizhong Energy Fengfeng Group HospitalHandanHebei 056000China RSS and China-Re Life Joint Lab on Public Health and Risk Management Renmin University of ChinaBeijing 100872China

To the Editor:Esophageal cancer,one of the most common cancer types in China,with an estimated 346,633 new cases and 323,600 deaths in 2022,is becoming an increasingly serious clinical and public health problem.^([1])The successful promotion of the self-management strategy has indicated that lifestyle modifications can be valuable in the primary prevention of cancer *** a healthy lifestyle has become a novel strategy for primary prevention and risk reduction in high-risk *** epidemiological studies have identified several lifestyle-related risk factors for esophageal cancer,including smoking and diet.^([2])Each factor can typically explain a modest proportion of cancer ***,when combined,these known risk factors may substantially affect the risk of esophageal ***,some risk factors for esophageal cancer are non-modifiable,including age,low socioeconomic status,and family *** and how these non-modifiable risk factors affect primary cancer prevention by intervening with modifiable risk factors remain unclear.

关键词： esophageal prevention promotion

The Metamorphic and Deformational History of a Continental Collision Zone and its Geodynamic Process——as Evidenced by Qinling Complex,Western Henan,China

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Journal of Earth Science 1990年第1期9卷 62-76页

作者： You Zhendong Han Yujing Suo shutian chen Nensong Zhong ZenqiuDepartment of Geology, China University of Geosciences, Wuhan 430074

The Qinling orogenic belt is a collision zone between the North China and Yangtze cratons. The Qinling Complex is a Precambrian metamorphic complex, developed in the inner zone of the orogenic belt , which records the metamorphic and deformational history and PTt path of the regional meta-morphism of the collision zone . The present paper studies the metamorphic and deformational history and the PTt path of various tectono-metamorphic cycles in order to describe the geodynamic processes prevailing in that part of the Qinling orogenic belt since Proterozoic.The tectonometamorphic history and evolution of the Qinling Complex is divided into two stages: the stage of formation and the stage of modification During the stage of formation dated as Proterozoic,three deformational sequences are recognized. The amphibolite facies regional metamorphism is earlier than or synchronous with the first or second phase of folding. Three metamorphic zones, i.e. And-Ms ,Sil- Ms, Sil Kfs are delimited. During the stage of modification , the emplacement of Caledonian granite , superimposed thermal aureole (garnet K feldspar zone )and the development of ductile shear zones are major *** reactions are reconstructed in terms of analysis of re-equilibrium textures. Geothermobarometric calculations are conducted to calibrate the PT conditions of metamorphism .The metamorphic PTt paths have been estabh'shed. The PTt path of the Proterozoic tectonometamorphic cycle shows a clockwise pattern and is characterized by prominent decompression. The PTt path of the Caledonian tectonometamorphic cycle is characterized first by PT rising ,then isothermal decompression (rapid uplift), and finally by isobaric cooling The PTt path of the two tectonometamorphic cycles evidence the geodynamic processes: two major stages of collision and uplift in the Proterozoic and Caledonian Hercynian periods, respectively, during the evolution of Qinling orogenic belt.

关键词： Qinling orogenic belt metamorphic history ,tectonomet- am orphic cycle PTt path geodynamic processes .

基于因果正则化极限学习机的风电功率短期预测方法

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电力系统保护与控制 2024年第11期52卷 127-136页

作者：杨茂张书天王勃现代电力系统仿真控制与绿色电能新技术教育部重点实验室(东北电力大学) 吉林吉林132012 新能源与储能运行控制国家重点实验室(中国电力科学研究院有限公司) 北京100192

随着风电并网比例的逐年提高,电力系统对风电功率预测的准确性和稳定性提出了更高要求。对于同一风电场而言,为了避免不同特征选择方法所选择的风电场特征子集不同,从因果关系的角度出发,提出了一种基于因果正则化极限学习机(causal reg... 详细信息

随着风电并网比例的逐年提高,电力系统对风电功率预测的准确性和稳定性提出了更高要求。对于同一风电场而言,为了避免不同特征选择方法所选择的风电场特征子集不同,从因果关系的角度出发,提出了一种基于因果正则化极限学习机(causal regularized extreme learning machine, CRELM)的风电功率短期预测方法。首先将极限学习机(extreme learning machine, ELM)建模为结构因果模型(structural causal model, SCM),在此基础上计算隐藏层神经元与输出层神经元之间的平均因果效应向量。然后将该平均因果效应向量与输出层权重相结合构成因果正则化项,在最小化训练误差的同时最大化网络的因果关系,以进一步提升模型的预测准确性和预测稳定性。最后,以国内蒙西某风电场数据为例,与采用特征选择或不采用特征选择的预测模型相对比,验证了所提方法的有效性和适用性。

关键词：特征选择因果正则化结构因果模型平均因果效应向量极限学习机

长三角地区4个城市铁路车站食品安全管理模式的探讨

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铁路节能环保与安全卫生 2023年第6期13卷 20-23页

作者：鲁勇陈澍田梁茹中国铁路上海局集团有限公司上海铁路疾病预防控制所上海200071

了解辖区内直辖市和省会城市铁路车站内食品经营网点分布情况,探索食品安全管理模式。采用横断面调查方法,对2023年1—7月长三角地区4个车站的日均发送旅客和食品经营管理资料进行统计分析。结果显示,车站内食品经营有车站餐饮、互联网... 详细信息

了解辖区内直辖市和省会城市铁路车站内食品经营网点分布情况,探索食品安全管理模式。采用横断面调查方法,对2023年1—7月长三角地区4个车站的日均发送旅客和食品经营管理资料进行统计分析。结果显示,车站内食品经营有车站餐饮、互联网订餐、互联网特产食品预订、食品销售等种类;长三角地区人口密度高,车站客流量大,餐饮单位集中。进而提出完善卫生监督管理体系、落实不同经营业态管理重点、提升食品监督管理人员综合素质等多种控制措施,以降低食品安全风险。

关键词：长三角地区铁路车站食品安全管理探讨

知识经济时代的价值创造:企业科技关联会创造超额回报吗?

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中国软科学 2024年第1期 47-58页

作者：张少华梁舒恬广州大学经济与统计学院广东广州510006 广东培正学院数字经济研究所广东广州510830

在知识经济时代,企业科技关联会创造超额回报吗?研究揭示中国资本市场是否存在科技动量效应以及该效应的来源。研究发现:中国资本市场存在显著的科技动量效应。投资科技关联因子构建的多空投资策略可以带来1.06%~1.68%的月度超额回报。... 详细信息

在知识经济时代,企业科技关联会创造超额回报吗?研究揭示中国资本市场是否存在科技动量效应以及该效应的来源。研究发现:中国资本市场存在显著的科技动量效应。投资科技关联因子构建的多空投资策略可以带来1.06%~1.68%的月度超额回报。此超额回报不是风险补偿的结果,而是由于投资者有限注意力造成的错误定价,并且这种错误定价需要1~3个月才可以得到纠正。研究结果对于理解企业研发收益、企业技术溢出、投资组合构建以及中国资本市场有效性等有着重要的参考价值。

关键词：科技关联因子市场异象投资组合分析法 Fama-MacBeth回归分析