检索结果-南通市图书馆

Changes in pulse pressure × heart rate, hs-CRP, and arterial stiffness progression in the Chinese general population: a cohort study involving 3978 employees of the Kailuan Company

引用

Journal of Geriatric Cardiology 2019年第9期16卷 710-716页

作者： Hao XUE Jun-Juan LI Jian-Li WANG shuo-hua chen Jing-Sheng GAO Yun-Dai chen Shou-Ling WU Department of Cardiology Chinese People’s Liberation Army General Hospital Beijing China Department of Cardiology Kailuan Hospital Hebei United University Tangshan China

Background Pulse wave velocity(PWV) is a marker of arterial stiffness, which represents sub-clinical atherosclerosis. Pulsatile stress and high-sensitivity C-reactive protein(hs-CRP) are associated with arteriosclerosis. However, there is no prospective data confirming whether changes in pulsatile stress and inflammatory markers affect the progression of arterial stiffness. The aim of this study was to investigate the relationships over time between the effects of changes in pulsatile stress and hs-CRP, and arterial stiffness progression during a 2-year follow-up. Methods We performed a longitudinal study involving 3978 participants. All participants underwent a physical examination in 2010–2011 and 2012–2013, during which we measured participants’ hs-CRP levels, brachial–ankle pulse wave velocity(ba PWV), and pulsatile stress. Results Baseline hs-CRP was correlated with ba PWV(r = 0.18, P = 0.000);however the correlation was weaker than that with systolic blood pressure(r = 0.65), pulsatile stress(r = 0.57), and rate-pressure product(r = 0.58). Multiple linear regression analysis demonstrated that changes in pulsatile stress, mean arterial pressure, and low-density lipoprotein-C(LDL-C) were positively correlated with changes in ba PWV, with correlation coefficients of 0.27, 0.25, and 0.07, respectively, but not with changes in hs-CRP. Moreover, each 100-a U increase in pulsatile stress, 1 mm Hg increase in mean blood pressure, and 1 mmol/L increase in LDL-C was associated with a 3 cm/s, 4.78 cm/s, and 17.37 cm/s increase in ba PWV, respectively. Conclusions Pulsatile stress increases are associated with arterial stiffness progression, but that changes in hs-CRP had no effect on arterial stiffness progression. Hs-CRP may simply be a marker of inflammation in arterial stiffness and has no association with arterial stiffness progression.

关键词： Atherosclerosis Blood vessels Brachial–ankle index C-reactive protein Pulse wave velocity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correlation of the history of stroke and the retinal artery occlusion: a nested case-control study

引用

International Journal of Ophthalmology(English edition) 2020年第3期13卷 431-437页

作者： Yue-Yan Xiao Wen-Bin Wei Ya-Xing Wang Ai-Dong Lu shuo-hua chen Lu Song Shou-Ling Wu Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Department of Cardiology Kailuan General HospitalTangshan 063000Hebei ProvinceChina

AIM:To analyze the systemic factors including stroke history related to the retinal artery occlusion(RAO).METHODS:Patients with an exact diagnosis of RAO in the medical database of the Kailuan Corporation were identified as the case *** patients without RAO were added for each case from the Kailuan Study and matched for sex and age(age±2)as the control *** Kailuan Study is a general population-based cohort study in northern China,in which a total of 101510 individuals(81110 men)aged 18-98 y were recruited to participate in the *** the participants were bi-annually *** database of both groups was from Kailuan study of 2010 *** the information,including the demographic characteristics,lifestyle behaviors,medical comorbidities,medical history,family medical history,drug usage,anthropometric measurements,blood pressure measurement,blood sample laboratory assessment,urine tests,and other physical examinations were all collected.A retrospective nested case-control method was used for this *** multivariate logistic regression was used to analyze the risk factors with SPSS 13.0 software and SAS 9.3 ***:A total of 45 patients were included as the case group,and the control group included 225 *** the case group,28 patients(62.2%)had a central retinal artery occlusion(CRAO),and 17 patients(37.8%)had a branch retinal artery occlusion(BRAO).A total of 18 patients(40.0%)had a stroke before the RAO(mean 4.04±3.88 y before the RAO),and 31 patients(81.6%)had infarctions or malacia identified by the cranial computed tomography(CT)*** basal ganglia and centrum semiovale were the most frequently involved *** in the common carotid artery were present in 32 patients(88.9%).Conditional multivariate logistic regression analysis showed that the RAO was found to be associated with the history of stroke(P=0.0023,OR=28.794;95%CI:3.322-249.586).CONCLUSION:A history of stroke can significantly increase the

关键词： retinal artery occlusion stroke risk factor embolic source carotid plaque

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Retinal nerve fiber layer defects and chronic kidney disease:the Kailuan Eye Study

引用

International Journal of Ophthalmology(English edition) 2024年第9期17卷 1696-1706页

作者： Qian-Qian Wan Jin-Qiong Zhou Li-Jian Fang Ya-Xing Wang Ye-Nan Wang Qian Wang Yan-Ni Yan Xuan Yang Shou-Ling Wu shuo-hua chen Jost B Jonas Wen-Bin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology the Second Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of Ophthalmology Beijing Liangxiang HospitalCapital Medical UniversityBeijing 102400China Beijing Institute of Ophthalmology Beijing Key Laboratory of Ophthalmology and Visual SciencesBeijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100730China Department of Cardiology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Health Care Center Kailuan GroupTangshan 063000Hebei ProvinceChina Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University of HeidelbergHeidelberg 69117Germany

AIM:To investigate whether retinal nerve fiber layer defects(RNFLDs)is a potential risk factor for chronic kidney disease(CKD)in Chinese ***:The Kailuan Eye Study was a populationbased study that included 14440 *** participants underwent detailed assessments,RNFLDs were diagnosed using color fundus ***:Overall,12507 participants[8533 males(68.23%)]had complete systemic examination data and at least one evaluable fundus *** were found in 621 participants[5.0%;95%confidence interval(CI):4.6%-5.34%],and 70 cases of multiple RNFLDs were found(11.27%).After adjusting multiple factors,RNFLDs was significantly associated with CKD severity,the ORs of CKD stage 3,stage 4 and stage 5 were 1.698,4.167,and 9.512,*** RNFLDs were also associated with CKD severity after adjusting multiple factors,the ORs of CKD stage 3 and stage 5 were 4.465 and 11.833 ***,2294 participants had CKD(18.34%,95%CI:17.68%-18.99%).After adjusting for other factors,CKD presence was significantly correlated with the presence of ***:The strongest risk factors for RNFLDs are CKD and ***,RNFLDs can be an ocular feature in patients with *** can help detect systemic diseases,and assessment for RNFLDs should be considered in CKD patients.

关键词： chronic kidney disease retinal nerve fiber layer defects Kailuan Eye Study fundus examination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship of sleep duration and annual changes in sleep duration with the incidence of gastrointestinal cancers:a prospective cohort study

引用

Chinese Medical Journal 2021年第24期134卷 2976-2984页

作者： Yu-Heng chen Zhang-Yan Lyu Gang Wang Xiao-Shuang Feng Shuang-hua Xie shuo-hua chen Jian Yin Jian-Song Ren Zi-Han Mi Shen Wang Shou-Ling Wu Ni Li Min Dai Cancer Foundation of China National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Oncology Kailuan General HospitalTangshanHebei 063000China Health Department of Kailuan(Group) TangshanHebei 063000China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjingJiangsu 211166China

Background:Prospective analyses have yet to identify a consistent relationship between sleep duration and the incidence of gastrointestinal(GI)*** effect of changes in sleep duration on GI cancer incidence has scarcely been ***,we aimed to examine the association between baseline sleep duration and annual changes in sleep duration and GI cancer risk in a large population-based cohort ***:A total of 123,495 participants with baseline information and 83,511 participants with annual changes in sleep duration information were prospectively observed from 2006 to 2015 for cancer *** proportional-hazards models were used to calculate hazard ratios(HRs)and their confidence intervals(CIs)for GI cancers according to sleep duration and annual changes in sleep ***:In baseline sleep duration analyses,short sleep duration(≤5 h)was significantly associated with a lower risk of GI cancer in females(HR:0.31,95%CI:0.10-0.90),and a linear relationship between baseline sleep duration and GI cancer was observed(P=0.010),especially in males and in the>50-year-old *** the annual changes in sleep duration analyses,with stable category(0 to-15 min/year)as the control group,decreased sleep duration(≤-15 min/year)was significantly associated with the development of GI cancer(HR:1.29;95%CI:1.04-1.61),especially in the>50-year-old group(HR:1.32;95%CI:1.01-1.71),and increased sleep duration(>0 min/year)was significantly associated with GI cancer in females(HR:2.89;95%CI:1.14-7.30).Conclusions:Both sleep duration and annual changes in sleep duration were associated with the incidence of GI cancer.

关键词： Gastrointestinal cancer Sleep duration Annual changes Prospective cohort Cancer risk

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

引用

Chinese Medical Journal 2018年第19期131卷 2357-2359页

作者： Yue-Yan Xiao Wen-Bin Wei Ya-Xing Wang Ai-Dong Lu shuo-hua chen Lu Song Shou-Ling Wu Beijing rongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Ophthalmology Beijing Airport Hospital Beijing 101318 China Department of Ophthalmology Kailuan General Hospital Tangshan Hebei 063000 China Department of Cardiology Kailuan General Hospital Tangshan Hebei 063000 China Department of Respiratory Kailuan General Hospital Tangshan Hebei 063000 China

To the Editor： Nonarteritic anterior ischemic optic neuropathy （NAION） is an acute optic neuropathy disease that is common in the elderly. The incidence of NA1ON is approximately （2.3-10.2）/100,000, and both eyes are involved in many patients. Xu et al. reported that the incidence in the Chinese population was 1/16,000. Acute visual acuity （VA） damage without any pain and a poor prognosis are the main features of NAION. This study aimed to find the related risk factors for NAION in average individuals to promote the prevention or early diagnosis of NAION.

关键词：

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Anemia and insomnia: a cross-sectional study and meta-analysis

引用

Chinese Medical Journal 2021年第6期134卷 675-681页

作者： Samantha N.Neumann Jun-Juan Li Xiao-Dong Yuan shuo-hua chen Chao-Ran Ma Laura E.Murray-Kolb Yun Shen Shou-Ling Wu Xiang Gao Eberly College of Science The Pennsylvania State UniversityUniversity ParkPAUnited States West Virginia School of Osteopathic Medicine LewisburgVWUnited States Department of Nephrology Kailuan General HospitalTangshanHebei 063000China Department of Cardiology Kailuan General HospitalTangshanHebei 063000China Department of Nutritional Sciences The Pennsylvania State UniversityUniversity ParkPAUnited States Department ot Neurology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China

Background: Several recent genome-wide association studies suggested insomnia and anemia may share some common genetic components. We thus examined whether adults with anemia had higher odds of having insomnia relative to those without anemia in a cross-sectional study and a ***: Included in this cross-sectional study were 12,614 Chinese adults who participated in an ongoing cohort, the Kailuan Study. Anemia was defined as hemoglobin levels below 12.0 g/dL in women and 13.0 g/dL in men. Insomnia was assessed using the Chinese version of the Athens Insomnia Scale (AIS). A total AIS score ≥6 was considered insomnia. The association between anemia and insomnia was assessed using a logistic regression model, adjusting for potential confounders such as age, sex, chronic disease status, and plasma C-reactive protein concentrations. A meta-analysis was conducted using the fixed effects model to pool results from our study and three previously published cross-sectional studies on this topic in adult ***: Individuals with anemia had greater odds of having insomnia (adjusted odds ratio [OR]: 1.32;95% confidence interval [CI]: 1.03-1.70) compared with individuals without anemia. A significant association persisted after we excluded individuals with chronic inflammation, as suggested by C-reactive protein levels >1 mg/L (adjusted OR: 1.68;95% CI: 1.22-2.32). The meta-analysis results, including 22,134 participants, also identified a positive association between anemia and insomnia (pooled OR: 1.39;95% CI: 1.22-1.57).Conclusions: The presence of anemia was significantly associated with a higher likelihood of having insomnia in adults. Due to the nature of the cross-sectional study design, results should be interpreted with caution.

关键词： Anemia Insomnia C-reactive protein Inflammation Cohort

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of risk and protective factors associated with retinal nerve fiber layer defect in a Chinese adult population

引用

International Journal of Ophthalmology(English edition) 2023年第3期16卷 427-433页

作者： Ye-Nan Wang Ya-Xing Wang Jin-Qiong Zhou Qian-Qian Wan Li-Jian Fang Hai-Wei Wang Jing-Yan Yang Li Dong Jin-Yuan Wang Xuan Yang Yan-Ni Yan Qian Wang Shou-Ling Wu shuo-hua chen Jing-Yuan Zhu Wen-Bin Wei Jost B.Jonas Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Ophthalmology the Second Hospital of Anhui Medical UniversityHefei 230011Anhui ProvinceChina Department of Ophthalmology Beijing Liangxiang HospitalCapital Medical UniversityBeijing 102401China Department of Ophthalmology Fuxing HospitalCapital Medical UniversityBeijing 100045China Cardiology Department Kailuan General HospitalTangshan 063001Hebei ProvinceChina Health Care Center Kailuan GroupTangshan 063000Hebei ProvinceChina Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University of HeidelbergHeidelberg 68167Germany

AIM:To investigate the risk and protective factors associated with the retinal nerve fiber layer defect(RNFLD)in a Chinese adult ***:This study was a cross-sectional populationbased investigation including employees and retirees of a coal mining company in Kailuan City,Hebei *** the study participants underwent a comprehensive systemic and ophthalmic *** was diagnosed on fundus *** logistic regression was used to investigate the risk and protective factors associated with the ***:The community-based study included 14440 *** were 10473 participants in our study,including 7120 males(68.0%)and 3353 females(32.0%).The age range was 45-108y,averaging 59.56±*** 568 participants had RNFLD and the prevalence rate was 5.42%.A higher prevalence of RNFLD was associated with older age[P<0.001,odds ratio(OR):1.032;95%confidence interval(CI):1.018-1.046],longer axial length(P=0.010,OR:1.190;95%CI:1.042-1.359),hypertension(P=0.007,OR:0.639;95%CI:0.460-0.887),and diabetes mellitus(P=0.019,OR:0.684;95%CI:0.499-0.939).The protective factors of RNFLD were visual acuity(P=0.038,OR:0.617;95%CI:0.391-0.975),and central anterior chamber depth(P=0.046,OR:0.595;95%CI:0.358-0.990).CONCLUSION:In our cross-sectional community-based study,with an age range of 45-108y,RNFLD is associated with older age,longer axial length,hypertension,and diabetes *** protective factors of RNFLD are visual acuity and central anterior chamber *** can help to predict and evaluate RNFLD related diseases and identify high-risk populations early.

关键词： retinal nerve fiber layer defect retinal nerve fiber layer age axial length hypertension diabetes mellitus visual acuity central anterior chamber depth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： shuo chen Shengpeng Su Yanfang huang Bingbing Liu Hu Sun Shuzhen Yang Guihong Han School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extraction,a separation and purification technology,is crucial in critical metal *** solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental *** solvents have been recognized as potential alternatives to these harmful organic *** the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low *** this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically ***,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively ***,future opportunities and challenges of DESs were explored in the current research *** conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

关键词： deep eutectic solvents preparations properties separation and purification critical metal metallurgy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

引用

World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： Xiao-Man chen shuo Zhang Shi-Qi Gao Michael Xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic response characteristics of a circular lined tunnel under anisotropy frost heave of overlying soil at the tunnel portal section in cold regions

引用

Journal of Mountain Science 2023年第5期20卷 1424-1440页

作者： ZHANG shuo-cheng chen Wen-hua School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China

The rapid development of traffic engineering in cold regions and its consequent problems need to be *** this paper,the dynamic response characteristics of the tunnel portal section in cold regions with harmonic load acting on the lining were studied in the frequency *** lining is in close contact with the frozen soil,and there is relative movement between the frozen and unfrozen soil due to the phase *** analytical solution of the vibration of tunnel portal section caused by the harmonic load acting on the lining was derived under the consideration of the anisotropy frost heave of overlying *** on the continuity conditions and boundary conditions,the undetermined coefficients were obtained,and the analytical solutions for different medium displacements and stresses of the cold-region tunnel system were *** vertical pressure coefficient was equivalently simplified as a variable that could be used to replace the thickness of the overlying soil above the *** analysis of the parameter model shows that the change of the medium parameters(lining,frozen,and unfrozen soil)affects the circumferential stresses,the radial displacements and their peak frequencies of the *** example,the increase of density ratio of tunnel lining to frozen soil decreases the radial stresses of the frozen and unfrozen soil;the increase of volumetric frost heaving strain of the frozen soil increases the radial displacements of the frozen surface and decreases the stability of the frozen surface;the increasing of thickness of the frozen soil significantly reduces the radial displacement of unfrozen soil at dimensionless radius η=4.5 compared with that of frozen soil at η=1.5.

关键词： Frost heave Tunnel portal section Relative movement Dynamic response characteristics Cold region

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：